Pregnant rhesus macaques infected subcutaneously with ZIKV demonstrated outwardly normal fetal growth, but persistent fetal-placenta-maternal infection and adverse effects on placental oxygen reserve and decreased oxygen permeability. Uteroplacental pathology that affects oxygen delivery to the fetus may be involved in Congenital Zika Syndrome.
Strategic Plan Section
Developing Models of Human Diseases - Continue to develop and enhance human disease models and research-related resource programs to advance medical research