ORIP supports high-quality animal models, and specialized animal research facilities, to meet the needs of biomedical researchers. Through the small business program, ORIP is funding research aimed at developing new technologies to improve those animal models and facilities.

Examples of ORIP supported new technologies include the Collagen Hybridizing Peptide, that provides a versatile tool for developmental biology research and histology-based disease diagnosis, staging, and therapeutic screening of collagen, and the Embryo Cradle device used to grow and study the behavior of human gastric epithelial spheroids (organoids) generated from adult tissue samples.