Stage-specific modulation of antimüllerian hormone (AMH) promotes primate follicular development and oocyte maturation in the matrix-free three-dimensional culture Using a rhesus macaque model, investigators cultured primary and secondary follicles in a matrix-free system to determine whether different stages of follicular growth and oocyte maturation would be improved by the addition of AMH. AMH supplementation at the preantral stage and depletion at the antral stage enhanced primate follicular development and oocyte competence in vitro. The improved embryonic development supports in vitro follicle maturation as a potential approach for fertility preservation.
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