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Hybrid Rat Diversity Program

Grant Number: R24OD024617

Research Emphasis/ObjectivesHXb/BXH Recombinant inbred panel (30 strains), Divergent classic inbred strains (35 strains), FXLE/LEXF Recombinant inbred strains (34 strains)

The Hybrid Rat Diversity Program (HRDP) is a panel of genetically and phenotypically diverse inbred rat strains consisting of two panels of recombinant inbred strains and a group of classic inbred strains. The overall goal of this program is to establish this panel of 96 strains as a foundation for powerful complex trait mapping, correlation analysis, and transcription network analysis. The 96-strain HRDP panel includes the HXB/BXH recombinant inbred panel from the Czech Republic and the LEXF/FXLE recombinant inbred panel from Japan, as well as 33 classic inbred strains. These diverse but stable genetic strains provide the platform for reproducible experiments in both males and females to test the effects of genetic background or environmental conditions, as well as systems genetics. The HRDP program is establishing the panel of rats through rederivation; performing whole-genome sequencing; characterizing the strains and biobanking tissues; and distributing rats, tissues, and data to the scientific community.

Services Provided

The Hybrid Rat Diversity Program provides live rats, embryos, tissues, phenotypic data, and genomic data to investigators. The HRDP currently maintains living colonies of the strains rederived as part of the HRDP program. Investigators can request rats using the Medical College of Wisconsin Rat Request form (mcw.edu/-/media/MCW/Departments/Genomic-Sciences-and-Precision-Medicine-Center/externalratrequest.pdf?la=en). Investigators interested in tissues should contact ratrequest@mcw.edu. Genomic and phenotypic data for each of the 96 strains included in the HRDP can be accessed through the HRDP Portal at the Rat Genome Database (rgd.mcw.edu/wg/hrdp_panel/).

Contact Information

Hybrid Rat Diversity Program (Melinda Dwinell)
8701 Watertown Plank Road
Milwaukee, WI 53226
rgd.mcw.edu/wg/hrdp_panel/

Principal Investigator

Melinda Dwinell, Ph.D.
Phone: 414-955-4498
Fax: 414-955-6516
mrdwinel@mcw.edu

Other/Resource Contacts

Rat Requests (Including Tissues)
Phone: 414-955-4066
Fax: 414-955-6516
ratrequest@mcw.edu