NPRC/Institute
University of Washington; Washington National Primate Research Center; HDT Bio
Summary of Study
SARS-CoV-2 alphavirus-derived replicon RNA vaccine formulated with a novel Lipid InOrganic Nanoparticle (LION) emulsion (repRNA-CoV2S) induced robust cellular and humoral immune responses after a single immunization in immunocompromised SIV-infected animals as a highly relevant model of untreated HIV infection in humans.
Year Published
2022
References
PMID: 34992610 / doi: 10.3389/fimmu.2021.800723
Contact Info
Deborah Fuller: fullerdh@uw.edu
Keywords
SARS-CoV-2, immunocompromised animals, SIV, RNA vaccine, immunogenicity, primates
Coronavirus Investigated*
NHP Species
date entered
Study Type