• mGAP: The Macaque Genotype and Phenotype Resource, A Framework For Accessing and Interpreting Macaque Variant Data, and Identifying New Models Of Human Disease

The mGAP resource is the first public website providing searchable, annotated macaque variant data and includes a catalog of high confidence variants derived from whole genome sequence from hundreds of rhesus macaques processed in a consistent manner. A custom pipeline was developed to enable annotation of the macaque variants, leveraging human data sources that include regulatory elements, known disease- or phenotype-associated variants, predicted impact, and sequence conservation. The mGAP resource (https://mgap.ohsu.edu) presents an unprecedented opportunity to investigate potential genetic associations with currently characterized disease models and to uncover new macaque models based on parallels with human risk alleles.