Tryptophan metabolites suppress host immunity and Mtb induces expression of indoleamine 2,3-dioxygenase (IDO) enzyme, which is involved in tryptophan catabolism. Suppression of the IDO enzyme in Mtb-infected macaques reduced bacterial burden, pathology, and clinical signs of tuberculous (TB) suggesting inhibition of IDO has potential for an effective and clinically relevant host-directed therapy for TB.
Strategic Plan Section
Developing Models of Human Diseases - Continue to develop and enhance human disease models and research-related resource programs to advance medical research