Investigators used gene mapping and a novel cell-based reporter assay system to characterize a rhesus CMV encoded IgG-Fc gamma (Fcɣ) binding glycoprotein, which acts as a potent antagonist of rhesus FcγR activation. This viral Fcγ receptor is not required to overcome anti-CMV immunity in establishing secondary infections. Future studies of the in vivo consequences of CMV evasion from IgG responses will be explored in nonhuman primate models.
81 Words (Oregon NPRC)
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