Exogenous estradiol treatment cannot elicit an LH surge in ovariectomized NHPs whose endogenous estradiol is suppressed with an aromatase inhibitor. These results indicate the obligatory role of hypothalamic estradiol production in stimulating the LH surge and subsequent ovulation.
Strategic Plan Section
Developing Models of Human Diseases - Continue to develop and enhance human disease models and research-related resource programs to advance medical research