• Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains
• Antiretroviral drug metabolism in humanized PXR-CAR-CYP₃A-NOG
• Creation of a long-acting nanoformulated dolutegravir
• Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles

The Center for Humanized Mice Development (University of Nebraska Medical Center) is developing improved animal models as resources to study human immunity, human-specific infections, vaccines, and human-specific drug interactions.

A new mouse model with human liver enzymes provided the opportunity to test therapeutic activity and toxicity of anti-retroviral drug metabolites.

Humanized mice were also used to test new eradication strategies using CRIPR/cas9 excision and long-acting, slow effective release therapies.