Marmosets infected with the Brazilian strain of ZIKV during early gestation exhibited asymptomatic seroconversion and persistent viremia. Spontaneous pregnancy loss was observed 16–18 days post-infection and accompanied by active placental viral replication and fetal neurocellular disorganization, a similar finding to humans. These results suggest a key role for the placenta in fetal infection and demonstrate the utility of marmoset model.
Strategic Plan Section
Developing Models of Human Diseases - Continue to develop and enhance human disease models and research-related resource programs to advance medical research