Coronavirus Studies in Nonhuman Primate Models

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; others
Keywords: SARS-CoV-2, spike Ferritin Nanoparticle (SpFN) vaccine, neutralizing antibodies, primates
Summary of Study: Neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination
References: PMID: 38172512 PMCID: PMC10764318 DOI: 10.1038/s41467-023-44265-0
Contact Info: Shelly Krebs: [email protected]
URL: https://www.nature.com/articles/s41467-023-44265-0

Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Research & Development Center, Cellid Co., Ltd., Seoul 08826, Republic of Korea; others
Keywords: SARS-CoV-2, multivalent vaccine, adenovirus vector, immune response, primates
Summary of Study: Multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform
References: PMID: 38408238 PMCID: PMC10927586 DOI: 10.1073/pnas.2313681121
Contact Info: Chang-Yuil Kang: [email protected]
URL: https://www.pnas.org/doi/abs/10.1073/pnas.2313681121?url_ver=Z39.88-2003&rfr_id…

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Medical biology, Chinese Academy of Medical Sciences and Peking Union Medical School (IMBCAMS&PUMC), 5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China; others
Keywords: SARS-CoV-2, gastrointestinal infection, virus variants, immune response, microbiota, primates
Summary of Study: Gastrointestinal microbiota and metabolites possibly contribute to distinct pathogenicity
References: PMID: 38563680 PMCID: PMC10989708 DOI: 10.1080/19490976.2024.2334970
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2334970

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA; others
Keywords: SARS-CoV-2, bivalent mRNA vaccine, virus variants, SIV, immune response, primates
Summary of Study: Neutralizing antibody response to bivalent mRNA vaccine
References: PMID: 38528837 PMCID: PMC10987079 (available on 2025-03-01) DOI: 10.1002/jmv.29520
Contact Info: Huanbin Xu: [email protected]; Shan-Lu Lui: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.29520

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Stemirna Therapeutics, Shanghai 201206, China; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, safety profile, rodents, primates
Summary of Study: Inoculation site-retained mRNA vaccine
References: PMID: 38184234 DOI: 10.1016/j.jconrel.2024.01.002
Contact Info: Haifa Shen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0168365924000063?via%3Dihub

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands; others
Keywords: SARS-CoV-2, antibody therapy, filamentous fungus expression system, immune response, primates
Summary of Study: Filamentous fungus-produced human monoclonal antibody provides protection
References: PMID: 38485931 PMCID: PMC10940701 DOI: 10.1038/s41467-024-46443-0
Contact Info: Bart L. Haagmans: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940701/

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao, China; others
Keywords: SARS-CoV-2, virus receptor proteins, ocular hypertension, immunofluorescence, humans and primates
Summary of Study: Expression of SARS-CoV-2 Receptor ACE2 and Protease TMPRSS2 in Ocular Hypertension
References: PMID: 38212998 DOI: 10.1080/02713683.2023.2291749
Contact Info: Jun-Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/02713683.2023.2291749

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai 200032, China; others
Keywords: SARS-CoV-2, receptor-binding domain, virus variants, immune response, primates
Summary of Study: Neutralization of SARS-CoV-2 BA.2.86 and JN.1 by CF501 adjuvant-enhanced immune responses targeting the conserved epitopes in ancestral RBD
References: PMID: 38428429 PMCID: PMC10983032 DOI: 10.1016/j.xcrm.2024.101445
Contact Info: Lu Lu: lul@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379124000685?via%3Dihub

Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: Research & Development-Science, Research and Innovation, Medicines and Healthcare products Regulatory Agency, South Mimms, Hertfordshire EN6 3QG, UK.
Keywords: SARS-CoV-2, host genetics, emerging viruses, global public health, primates
Summary of Study: Host immunogenetics on infectious disease studies
References: PMID: 38257982 PMCID: PMC10818626 DOI: 10.3390/microorganisms12010155
Contact Info: Neil Berry: [email protected]
URL: https://www.mdpi.com/2076-2607/12/1/155

Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; others
Keywords: SARS-CoV-2, mRNA delivery, jet injector; lipid nanoparticle, mRNA vaccine, primates
Summary of Study: Carrier-free mRNA vaccine induces robust immunity
References: PMID: 38569556 DOI: 10.1016/j.ymthe.2024.03.022
Contact Info: Satoshi Uchida: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001624001631?via%3Dihub

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden; others
Keywords: SARS-CoV-2, Novavax’s protein vaccines, immune response, virus variants, primates
Summary of Study: Novavax protein vaccines increase antibody breadth and provide durable protection
References: PMID: 38245545 PMCID: PMC10799869 DOI: 10.1038/s41541-024-00806-2
Contact Info: Karin Loré: [email protected]
URL: https://www.nature.com/articles/s41541-024-00806-2

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, sooty mangabeys
Year Published: 2024
Study Type/Review: therapeutics, review
NPRC/Institute: Laboratory of Liver Infectious Diseases, Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Keywords: SARS-CoV-2, preclinical animal model, therapeutic antibodies, immune response, rodents, primates
Summary of Study: Preclinical animal models to evaluate therapeutic antiviral antibodies
References: PMID: 38548022 DOI: 10.1016/j.antiviral.2024.105843
Contact Info: Phlip Meuleman: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354224000512?via%3Dihub

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., 11-13 Walkley Avenue, Warradale, SA 5046, Australia; BIOQUAL, Inc., 9600 Medical Center Drive, Rockville, MD 20850-3336, USA
Keywords: SARS-CoV-2, recombinant protein vaccine, immune response, virus variants, primates
Summary of Study: Recombinant protein-based vaccine delivered by intramuscular and mucosal routes
References: PMID: 38262808 DOI: 10.1016/j.vaccine.2024.01.034
Contact Info: Nikolai Petrovsky: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X24000343?via%3Dihub

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Guangzhou Laboratory, Bio-island, Guangzhou, China: others
Keywords: SARS-CoV-2, Siglec-9, bivalent vaccines, immune response, primates
Summary of Study: Receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis
References: PMID: 38454157 DOI: 10.1038/s41590-024-01776-2
Contact Info: Hui Zhang: [email protected]
URL: https://www.nature.com/articles/s41590-024-01776-2

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Keywords: SARS-CoV-2, aerosols, inoculation route, virus replication, tropism, primates
Summary of Study: Upper vs. lower respiratory virus replication
References: PMID: 38261786 DOI: 10.1093/infdis/jiae018
Contact Info: Neeltje van Doremalen: [email protected]
URL: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae018/7585664…

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China; others
Keywords: SARS-CoV-2, mRNA vaccine, lipopolyplex, immunogenicity, virus variants, primates
Summary of Study: Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex
References: PMID: 38557908 PMCID: PMC11008869 DOI: 10.1371/journal.ppat.1012116
Contact Info: George Fu Gao: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012116

Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510182, China; others
Keywords: SARS-CoV-2, animal models, immune response, multiomics, variety of animal species, primates
Summary of Study: Immunity in animal models
References: PMID: 38238440 PMCID: PMC10806257 DOI: 10.1038/s41423-023-01122-w
Contact Info: Jing Sun: [email protected]
URL: https://www.nature.com/articles/s41423-023-01122-w

Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, Fontenay-aux-Roses, France; others
Keywords: SARS-CoV-2, VLA2001 vaccine, immunogenicity, pathology, primates
Summary of Study: Immunogenicity and efficacy of VLA2001 vaccine
References: PMID: 38570605 PMCID: PMC10991505 DOI: 10.1038/s43856-024-00488-w
Contact Info: Roger LeGrand: [email protected]
URL: https://www.nature.com/articles/s43856-024-00488-w

Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan; others
Keywords: SARS-CoV-2, olfactory mucosa, immune response, melanocytes primates
Summary of Study: Inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway
References: PMID: 38237527 DOI: 10.1016/j.jneuroim.2024.578288
Contact Info: Shino Shimizu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0165572824000067?via%3Dihub

Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan; Central Research Laboratory, Shiga University of Medical Science, Otsu, Japan.; others
Keywords: SARS-CoV-2, CD38, endothelial cells, lungs, immune response, primates
Summary of Study: Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection
References: PMID: 38507920 DOI: 10.1016/j.virol.2024.110052
Contact Info: Yasushi Itoh: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0042682224000734?via%3Dihub

Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxart, Inc., South San Francisco, CA 94080, USA
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity, mucosal, primates
Summary of Study: Adenoviral Vaccine Elicits Mucosal and Systemic Immunogenicity and Reduces Viral Shedding
References: PMID: 38400116 PMCID: PMC10893453 DOI: 10.3390/vaccines12020132
Contact Info: Becca Flitter: [email protected]
URL: https://www.mdpi.com/2076-393X/12/2/132

Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Vaccine and Immunotherapy Center, the Wistar Institute of Anatomy and Biology, Philadelphia, PA; others
Keywords: SARS-CoV-2, monoclonal antibody, DNA-encoded, immune response, pathology, primates
Summary of Study: Engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis
References: PMID: 38165394 DOI: 10.1080/22221751.2023.2294860
Contact Info: Heinz Feldman: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2294860

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, bone marrow LLPCs, spike protein vaccine, immune response, primates
Summary of Study: Adjuvanted spike protein vaccination elicits long-lived plasma cells
References: PMID: 38170789 DOI: 10.1126/scitranslmed.add5960
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.add5960?url_ver=Z39.88-2003&rf…

Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Keywords: SARS-CoV-2, pregnancy, pathogenesis, different viruses, animal species, primates
Summary of Study: Pathogenesis of viral infections during pregnancy
References: PMID: 38421182 DOI: 10.1128/cmr.00073-23
Contact Info: Sabra Klein: [email protected]
URL: https://journals.asm.org/doi/10.1128/cmr.00073-23?url_ver=Z39.88-2003&rfr_id=or…

Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD, others
Keywords: SARS-CoV-2, recombinant vaccine, immune response, virus variants, mice, primates
Summary of Study: Recombinant prefusion-stabilized spike (rS) protein vaccine based on Beta/B.1.351 (rS-Beta) produces robust anamnestic response
References: doi: 10.1038/s41467-022-35606-6
Contact Info: Matthew Freiman: [email protected]
URL: https://www.nature.com/articles/s41467-022-35606-6

Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub

Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine, Tulane National Primate Research Center, others
Keywords: SARS-CoV-2, CSF, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates.
References: DOI: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/

Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Vaccine Research Institute, Créteil, France; Université Paris Cité, IAME, Inserm, Paris, France; others
Keywords: SARS-CoV-2, mathematical model, viral dynamic, primates
Summary of Study: Impact of variants of concern on SARS-CoV-2 viral dynamics
References: DOI: 10.1371/journal.pcbi.1010721
Contact Info: Aurélien Marc: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010721

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
Keywords: SARS-CoV-2, attenuated murine pneumonia virus vector, vaccine immune response, primates
Summary of Study: Mucosal prime-boost immunization with live murine pneumonia virus-vectored vaccine
References: DOI: 10.21203/rs.3.rs-3278289/v1
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.researchsquare.com/article/rs-3278289/v1

Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center, Covington, Louisiana; others
Keywords: SARS-CoV-2, SIV-Induced Immunodeficiency, immune response, coinfection, primates
Summary of Study: Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection
References: bioRxiv.2023 Nov 16:2023.11.15.567132. doi: 10.1101/2023.11.15.567132. Preprint. PMID: 38014096 PMCID: PMC10680717 DOI: 10.1101/2023.11.15.567132
Contact Info: Nicholas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.15.567132v1

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing, China; Cell Culture Engineering Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Keywords: SARS-CoV-2, nanoparticle vaccine, immunogenicity, toxicity, primates
Summary of Study: COVID-19 vaccine showed high immunogenicity and low toxicity in animal models
References: doi: 10.3390/vaccines11030526
Contact Info: Liangzhi Xie: [email protected]
URL: https://www.mdpi.com/2076-393X/11/3/526

Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Seattle, Washington USA; HDT Bio, Washington National Primate Research Center, others
Keywords: SARS-CoV-2, replicon RNA vaccine, immune response and protection, primates
Summary of Study: Replicon RNA vaccine for durable protective immunity
References: PMID: 37075079 / doi: 10.1371/journal.ppat.1011298
Contact Info: Jesse Erasmus: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011298

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China; others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Preclinical safety evaluation of intradermal SARS-CoV-2 inactivated vaccine (Vero cells) administration in macaques.
References: DOI: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub

Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Molecular Genetics, University of Toronto; Toronto, Canada; Icosagen Cell Factory OÜ; Tartu, Estonia; others
Keywords: SARS-CoV-2, humanized antibodies, immune response, vaccine, primates
Summary of Study: bnAb protection through inhalation-based delivery
References: DOI: 10.1371/journal.ppat.1011532
Contact Info: Mart Ustav, Jr.: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011532

Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, Production Division, Havana, Cuba
Keywords: SARS-CoV-2, chimeric antigen, vaccine, immune response, mice, primates
Summary of Study: chimeric antigen, based on nucleocapsid of SARS-CoV-2 fused to the extracellular domain of human CD154 in HEK-293 cells
References: DOI: 10.1371/journal.pone.0288006
Contact Info: Mario Pablo Estrada: [email protected]; Yamila Carpio: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288006

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Republic of Korea; others
Keywords: SARS-CoV-2, pulmonary lesions, histopathology, primates
Summary of Study: Histopathological pulmonary lesions in SARS-CoV-2
References: PMID: 38007889 DOI: 10.1016/j.jcpa.2023.10.008
Contact Info: Jae-Hak Park: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021997523002967?via%3Dihub

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, Durham, NC; others
Keywords: SARS-CoV-2, spike protein, mRNA vaccine, immune response, virus variants, conserved epitopes, primates
Summary of Study: Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination
References: bioRxiv PMID: 38187726 PMCID: PMC10769253 DOI: 10.1101/2023.12.18.572191
Contact Info: Kevin O. Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.12.18.572191v1

Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland; Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Mary
Keywords: SARS-CoV-2, deep learning, computerized tomography, lung lesions, primates
Summary of Study: Modeling whole lung and lung lesions to detect and quantify disease
References: doi: 10.1016/j.acra.2023.02.027
Contact Info: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/36966070/

Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia and others
Keywords: SARS-CoV-2, nucleocapsid (N) protein, vaccine, immune response, pathology, mice, hamsters, primates
Summary of Study: Recombinant nucleocapsid-based vaccine Convacell®.
References: PMID: 37112786 / doi: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874

Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; others
Keywords: SARS-CoV-2, spatial transcriptomic profiling, lungs, virus variants, primates
Summary of Study: Comparative spatial transcriptomic profiling of severe acute respiratory syndrome coronavirus 2 Delta and Omicron variants infections in the lungs of cynomolgus macaques.
References: DOI: 10.1002/jmv.28847
Contact Info: Jung Joo Hong: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28847

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Neurobiology and Aging, Biomedical Primate Research Centre (BPRC), Lange Kleiweg 161, 2288GJ, Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, neuroinflammation, positron emission tomography, brain, primates
Summary of Study: Widespread neuroinflammation in SARS-CoV-2 infection
References: DOI: 10.1186/s12974-023-02857-z
Contact Info: Jinte Middeldorp: [email protected]
URL: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02857-z

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, University of California Irvine, USA
Keywords: SARS-CoV-2, alcohol, lung, scRNA sequencing, flow cytometry, primates
Summary of Study: Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lung
References: DOI: 10.1016/j.ebiom.2023.104812
Contact Info: Ilhem Messaoudi: ilhem@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S235239642300378X?via%3Dihub

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; others
Keywords: SARS-CoV-2, Beta-spike-containing boosters, immune response, primates
Summary of Study: Beta-spike-containing boosters induce robust and functional antibody responses
References: PMID: 38007686 DOI: 10.1016/j.celrep.2023.113292
Contact Info: Ryan McNamara: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124723013049?via%3Dihub

Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxxinity, Inc., Merritt Island, FL, USA; University of Texas Medical Branch, Galveston, TX, USA; others
Keywords: SARS-CoV-2, subunit vaccine, Fc-mediated effector function, immune response, primates
Summary of Study: RBD-Protein/Peptide Vaccine UB-612 Elicits Mucosal and Fc-Mediated Antibody Responses
References: PMID: 38250853 PMCID: PMC10818657 DOI: 10.3390/vaccines12010040
Contact Info: Shixia Wang: [email protected]
URL: https://www.mdpi.com/2076-393X/12/1/40

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven Belgium
Keywords: SARS-CoV-2, review, vaccine development, mice, hamsters, primates
Summary of Study: Do we need nasal vaccines against COVID 19
References: doi: 10.1111/1751-7915.14181
Contact Info: Harald Brüssow: [email protected]
URL: https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14181

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Veterinary Research Institute, Lahore, Pakistan; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan; others
Keywords: SARS-CoV-2, inactivated vaccine, efficacy, immunogenicity, virus variant, rabbits, primates
Summary of Study: Molecular characterization and selection of delta variant for vaccine
References: doi: 10.3390/vaccines11030607
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2076-393X/11/3/607

Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand and others
Keywords: SARS-CoV-2, recombinant plant-based RBD vaccine, immunogenicity, efficacy, safety, mice, primates
Summary of Study: Recombinant plant based RBD vaccine formulated with 3M-052-Alum adjuvant
References: PMID: 36963999 / doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University School of Medicine; Emory, Oregon and Tulane NPRCs; numerous others
Keywords: SARS-CoV-2, IFN-I, immune response, pathology, primates
Summary of Study: Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation
References: DOI: 10.1126/sciimmunol.adg0033
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg0033

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Research Institute of Cardiology and Internal Medicine, Almaty, KazakhstanInternational Center for Vaccinology, Kazakh National Agrarian Research University (KazNARU), Almaty, Kazakhstan; others
Keywords: SARS-CoV-2, vaccine, adjuvant, immune response, safety, hamsters, primates
Summary of Study: Evaluation of spike protein ectodomain subunit vaccine with squalene emulsion adjuvant
References: DOI: 10.1080/21645515.2023.2258571
Contact Info: Kairat Tabynov: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2023.2258571