Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, Fontenay-aux-Roses, France; others
Keywords: SARS-CoV-2, VLA2001 vaccine, immunogenicity, pathology, primates
Summary of Study: Immunogenicity and efficacy of VLA2001 vaccine
References: PMID: 38570605 PMCID: PMC10991505 DOI: 10.1038/s43856-024-00488-w
Contact Info: Roger LeGrand: [email protected]
URL: https://www.nature.com/articles/s43856-024-00488-w
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, Fontenay-aux-Roses, France; others
Keywords: SARS-CoV-2, VLA2001 vaccine, immunogenicity, pathology, primates
Summary of Study: Immunogenicity and efficacy of VLA2001 vaccine
References: PMID: 38570605 PMCID: PMC10991505 DOI: 10.1038/s43856-024-00488-w
Contact Info: Roger LeGrand: [email protected]
URL: https://www.nature.com/articles/s43856-024-00488-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Medical biology, Chinese Academy of Medical Sciences and Peking Union Medical School (IMBCAMS&PUMC), 5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China; others
Keywords: SARS-CoV-2, gastrointestinal infection, virus variants, immune response, microbiota, primates
Summary of Study: Gastrointestinal microbiota and metabolites possibly contribute to distinct pathogenicity
References: PMID: 38563680 PMCID: PMC10989708 DOI: 10.1080/19490976.2024.2334970
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2334970
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Medical biology, Chinese Academy of Medical Sciences and Peking Union Medical School (IMBCAMS&PUMC), 5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China; others
Keywords: SARS-CoV-2, gastrointestinal infection, virus variants, immune response, microbiota, primates
Summary of Study: Gastrointestinal microbiota and metabolites possibly contribute to distinct pathogenicity
References: PMID: 38563680 PMCID: PMC10989708 DOI: 10.1080/19490976.2024.2334970
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2334970
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands; others
Keywords: SARS-CoV-2, antibody therapy, filamentous fungus expression system, immune response, primates
Summary of Study: Filamentous fungus-produced human monoclonal antibody provides protection
References: PMID: 38485931 PMCID: PMC10940701 DOI: 10.1038/s41467-024-46443-0
Contact Info: Bart L. Haagmans: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940701/
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands; others
Keywords: SARS-CoV-2, antibody therapy, filamentous fungus expression system, immune response, primates
Summary of Study: Filamentous fungus-produced human monoclonal antibody provides protection
References: PMID: 38485931 PMCID: PMC10940701 DOI: 10.1038/s41467-024-46443-0
Contact Info: Bart L. Haagmans: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940701/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Research & Development Center, Cellid Co., Ltd., Seoul 08826, Republic of Korea; others
Keywords: SARS-CoV-2, multivalent vaccine, adenovirus vector, immune response, primates
Summary of Study: Multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform
References: PMID: 38408238 PMCID: PMC10927586 DOI: 10.1073/pnas.2313681121
Contact Info: Chang-Yuil Kang: [email protected]
URL: https://www.pnas.org/doi/abs/10.1073/pnas.2313681121?url_ver=Z39.88-2003&rfr_id…
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Research & Development Center, Cellid Co., Ltd., Seoul 08826, Republic of Korea; others
Keywords: SARS-CoV-2, multivalent vaccine, adenovirus vector, immune response, primates
Summary of Study: Multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform
References: PMID: 38408238 PMCID: PMC10927586 DOI: 10.1073/pnas.2313681121
Contact Info: Chang-Yuil Kang: [email protected]
URL: https://www.pnas.org/doi/abs/10.1073/pnas.2313681121?url_ver=Z39.88-2003&rfr_id…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, sooty mangabeys
Year Published: 2024
Study Type/Review: therapeutics, review
NPRC/Institute: Laboratory of Liver Infectious Diseases, Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Keywords: SARS-CoV-2, preclinical animal model, therapeutic antibodies, immune response, rodents, primates
Summary of Study: Preclinical animal models to evaluate therapeutic antiviral antibodies
References: PMID: 38548022 DOI: 10.1016/j.antiviral.2024.105843
Contact Info: Phlip Meuleman: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354224000512?via%3Dihub=
NHP Species: rhesus macaques, cynomolgus macaques, sooty mangabeys
Year Published: 2024
Study Type/Review: therapeutics, review
NPRC/Institute: Laboratory of Liver Infectious Diseases, Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Keywords: SARS-CoV-2, preclinical animal model, therapeutic antibodies, immune response, rodents, primates
Summary of Study: Preclinical animal models to evaluate therapeutic antiviral antibodies
References: PMID: 38548022 DOI: 10.1016/j.antiviral.2024.105843
Contact Info: Phlip Meuleman: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354224000512?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Stemirna Therapeutics, Shanghai 201206, China; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, safety profile, rodents, primates
Summary of Study: Inoculation site-retained mRNA vaccine
References: PMID: 38184234 DOI: 10.1016/j.jconrel.2024.01.002
Contact Info: Haifa Shen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0168365924000063?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Stemirna Therapeutics, Shanghai 201206, China; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, safety profile, rodents, primates
Summary of Study: Inoculation site-retained mRNA vaccine
References: PMID: 38184234 DOI: 10.1016/j.jconrel.2024.01.002
Contact Info: Haifa Shen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0168365924000063?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China; others
Keywords: SARS-CoV-2, mRNA vaccine, lipopolyplex, immunogenicity, virus variants, primates
Summary of Study: Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex
References: PMID: 38557908 PMCID: PMC11008869 DOI: 10.1371/journal.ppat.1012116
Contact Info: George Fu Gao: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012116
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China; others
Keywords: SARS-CoV-2, mRNA vaccine, lipopolyplex, immunogenicity, virus variants, primates
Summary of Study: Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex
References: PMID: 38557908 PMCID: PMC11008869 DOI: 10.1371/journal.ppat.1012116
Contact Info: George Fu Gao: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012116
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: Research & Development-Science, Research and Innovation, Medicines and Healthcare products Regulatory Agency, South Mimms, Hertfordshire EN6 3QG, UK.
Keywords: SARS-CoV-2, host genetics, emerging viruses, global public health, primates
Summary of Study: Host immunogenetics on infectious disease studies
References: PMID: 38257982 PMCID: PMC10818626 DOI: 10.3390/microorganisms12010155
Contact Info: Neil Berry: [email protected]
URL: https://www.mdpi.com/2076-2607/12/1/155
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: Research & Development-Science, Research and Innovation, Medicines and Healthcare products Regulatory Agency, South Mimms, Hertfordshire EN6 3QG, UK.
Keywords: SARS-CoV-2, host genetics, emerging viruses, global public health, primates
Summary of Study: Host immunogenetics on infectious disease studies
References: PMID: 38257982 PMCID: PMC10818626 DOI: 10.3390/microorganisms12010155
Contact Info: Neil Berry: [email protected]
URL: https://www.mdpi.com/2076-2607/12/1/155
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Keywords: SARS-CoV-2, pregnancy, pathogenesis, different viruses, animal species, primates
Summary of Study: Pathogenesis of viral infections during pregnancy
References: PMID: 38421182 DOI: 10.1128/cmr.00073-23
Contact Info: Sabra Klein: [email protected]
URL: https://journals.asm.org/doi/10.1128/cmr.00073-23?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Keywords: SARS-CoV-2, pregnancy, pathogenesis, different viruses, animal species, primates
Summary of Study: Pathogenesis of viral infections during pregnancy
References: PMID: 38421182 DOI: 10.1128/cmr.00073-23
Contact Info: Sabra Klein: [email protected]
URL: https://journals.asm.org/doi/10.1128/cmr.00073-23?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; others
Keywords: SARS-CoV-2, mRNA delivery, jet injector; lipid nanoparticle, mRNA vaccine, primates
Summary of Study: Carrier-free mRNA vaccine induces robust immunity
References: PMID: 38569556 DOI: 10.1016/j.ymthe.2024.03.022
Contact Info: Satoshi Uchida: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001624001631?via%3Dihub=
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; others
Keywords: SARS-CoV-2, mRNA delivery, jet injector; lipid nanoparticle, mRNA vaccine, primates
Summary of Study: Carrier-free mRNA vaccine induces robust immunity
References: PMID: 38569556 DOI: 10.1016/j.ymthe.2024.03.022
Contact Info: Satoshi Uchida: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001624001631?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao, China; others
Keywords: SARS-CoV-2, virus receptor proteins, ocular hypertension, immunofluorescence, humans and primates
Summary of Study: Expression of SARS-CoV-2 Receptor ACE2 and Protease TMPRSS2 in Ocular Hypertension
References: PMID: 38212998 DOI: 10.1080/02713683.2023.2291749
Contact Info: Jun-Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/02713683.2023.2291749
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao, China; others
Keywords: SARS-CoV-2, virus receptor proteins, ocular hypertension, immunofluorescence, humans and primates
Summary of Study: Expression of SARS-CoV-2 Receptor ACE2 and Protease TMPRSS2 in Ocular Hypertension
References: PMID: 38212998 DOI: 10.1080/02713683.2023.2291749
Contact Info: Jun-Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/02713683.2023.2291749
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., 11-13 Walkley Avenue, Warradale, SA 5046, Australia; BIOQUAL, Inc., 9600 Medical Center Drive, Rockville, MD 20850-3336, USA
Keywords: SARS-CoV-2, recombinant protein vaccine, immune response, virus variants, primates
Summary of Study: Recombinant protein-based vaccine delivered by intramuscular and mucosal routes
References: PMID: 38262808 DOI: 10.1016/j.vaccine.2024.01.034
Contact Info: Nikolai Petrovsky: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X24000343?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., 11-13 Walkley Avenue, Warradale, SA 5046, Australia; BIOQUAL, Inc., 9600 Medical Center Drive, Rockville, MD 20850-3336, USA
Keywords: SARS-CoV-2, recombinant protein vaccine, immune response, virus variants, primates
Summary of Study: Recombinant protein-based vaccine delivered by intramuscular and mucosal routes
References: PMID: 38262808 DOI: 10.1016/j.vaccine.2024.01.034
Contact Info: Nikolai Petrovsky: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X24000343?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden; others
Keywords: SARS-CoV-2, Novavax’s protein vaccines, immune response, virus variants, primates
Summary of Study: Novavax protein vaccines increase antibody breadth and provide durable protection
References: PMID: 38245545 PMCID: PMC10799869 DOI: 10.1038/s41541-024-00806-2
Contact Info: Karin Loré: [email protected]
URL: https://www.nature.com/articles/s41541-024-00806-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden; others
Keywords: SARS-CoV-2, Novavax’s protein vaccines, immune response, virus variants, primates
Summary of Study: Novavax protein vaccines increase antibody breadth and provide durable protection
References: PMID: 38245545 PMCID: PMC10799869 DOI: 10.1038/s41541-024-00806-2
Contact Info: Karin Loré: [email protected]
URL: https://www.nature.com/articles/s41541-024-00806-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan; Central Research Laboratory, Shiga University of Medical Science, Otsu, Japan.; others
Keywords: SARS-CoV-2, CD38, endothelial cells, lungs, immune response, primates
Summary of Study: Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection
References: PMID: 38507920 DOI: 10.1016/j.virol.2024.110052
Contact Info: Yasushi Itoh: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0042682224000734?via%3Dihub=
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan; Central Research Laboratory, Shiga University of Medical Science, Otsu, Japan.; others
Keywords: SARS-CoV-2, CD38, endothelial cells, lungs, immune response, primates
Summary of Study: Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection
References: PMID: 38507920 DOI: 10.1016/j.virol.2024.110052
Contact Info: Yasushi Itoh: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0042682224000734?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxart, Inc., South San Francisco, CA 94080, USA
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity, mucosal, primates
Summary of Study: Adenoviral Vaccine Elicits Mucosal and Systemic Immunogenicity and Reduces Viral Shedding
References: PMID: 38400116 PMCID: PMC10893453 DOI: 10.3390/vaccines12020132
Contact Info: Becca Flitter: [email protected]
URL: https://www.mdpi.com/2076-393X/12/2/132
NHP Species: african green monkeys
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxart, Inc., South San Francisco, CA 94080, USA
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity, mucosal, primates
Summary of Study: Adenoviral Vaccine Elicits Mucosal and Systemic Immunogenicity and Reduces Viral Shedding
References: PMID: 38400116 PMCID: PMC10893453 DOI: 10.3390/vaccines12020132
Contact Info: Becca Flitter: [email protected]
URL: https://www.mdpi.com/2076-393X/12/2/132
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA; others
Keywords: SARS-CoV-2, bivalent mRNA vaccine, virus variants, SIV, immune response, primates
Summary of Study: Neutralizing antibody response to bivalent mRNA vaccine
References: PMID: 38528837 PMCID: PMC10987079 (available on 2025-03-01) DOI: 10.1002/jmv.29520
Contact Info: Huanbin Xu: [email protected]; Shan-Lu Lui: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.29520
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA; others
Keywords: SARS-CoV-2, bivalent mRNA vaccine, virus variants, SIV, immune response, primates
Summary of Study: Neutralizing antibody response to bivalent mRNA vaccine
References: PMID: 38528837 PMCID: PMC10987079 (available on 2025-03-01) DOI: 10.1002/jmv.29520
Contact Info: Huanbin Xu: [email protected]; Shan-Lu Lui: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.29520
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Guangzhou Laboratory, Bio-island, Guangzhou, China: others
Keywords: SARS-CoV-2, Siglec-9, bivalent vaccines, immune response, primates
Summary of Study: Receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis
References: PMID: 38454157 DOI: 10.1038/s41590-024-01776-2
Contact Info: Hui Zhang: [email protected]
URL: https://www.nature.com/articles/s41590-024-01776-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Guangzhou Laboratory, Bio-island, Guangzhou, China: others
Keywords: SARS-CoV-2, Siglec-9, bivalent vaccines, immune response, primates
Summary of Study: Receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis
References: PMID: 38454157 DOI: 10.1038/s41590-024-01776-2
Contact Info: Hui Zhang: [email protected]
URL: https://www.nature.com/articles/s41590-024-01776-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510182, China; others
Keywords: SARS-CoV-2, animal models, immune response, multiomics, variety of animal species, primates
Summary of Study: Immunity in animal models
References: PMID: 38238440 PMCID: PMC10806257 DOI: 10.1038/s41423-023-01122-w
Contact Info: Jing Sun: [email protected]
URL: https://www.nature.com/articles/s41423-023-01122-w
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510182, China; others
Keywords: SARS-CoV-2, animal models, immune response, multiomics, variety of animal species, primates
Summary of Study: Immunity in animal models
References: PMID: 38238440 PMCID: PMC10806257 DOI: 10.1038/s41423-023-01122-w
Contact Info: Jing Sun: [email protected]
URL: https://www.nature.com/articles/s41423-023-01122-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; others
Keywords: SARS-CoV-2, spike Ferritin Nanoparticle (SpFN) vaccine, neutralizing antibodies, primates
Summary of Study: Neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination
References: PMID: 38172512 PMCID: PMC10764318 DOI: 10.1038/s41467-023-44265-0
Contact Info: Shelly Krebs: [email protected]
URL: https://www.nature.com/articles/s41467-023-44265-0
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; others
Keywords: SARS-CoV-2, spike Ferritin Nanoparticle (SpFN) vaccine, neutralizing antibodies, primates
Summary of Study: Neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination
References: PMID: 38172512 PMCID: PMC10764318 DOI: 10.1038/s41467-023-44265-0
Contact Info: Shelly Krebs: [email protected]
URL: https://www.nature.com/articles/s41467-023-44265-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Vaccine and Immunotherapy Center, the Wistar Institute of Anatomy and Biology, Philadelphia, PA; others
Keywords: SARS-CoV-2, monoclonal antibody, DNA-encoded, immune response, pathology, primates
Summary of Study: Engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis
References: PMID: 38165394 DOI: 10.1080/22221751.2023.2294860
Contact Info: Heinz Feldman: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2294860
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Vaccine and Immunotherapy Center, the Wistar Institute of Anatomy and Biology, Philadelphia, PA; others
Keywords: SARS-CoV-2, monoclonal antibody, DNA-encoded, immune response, pathology, primates
Summary of Study: Engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis
References: PMID: 38165394 DOI: 10.1080/22221751.2023.2294860
Contact Info: Heinz Feldman: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2294860
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan; others
Keywords: SARS-CoV-2, olfactory mucosa, immune response, melanocytes primates
Summary of Study: Inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway
References: PMID: 38237527 DOI: 10.1016/j.jneuroim.2024.578288
Contact Info: Shino Shimizu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0165572824000067?via%3Dihub=
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan; others
Keywords: SARS-CoV-2, olfactory mucosa, immune response, melanocytes primates
Summary of Study: Inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway
References: PMID: 38237527 DOI: 10.1016/j.jneuroim.2024.578288
Contact Info: Shino Shimizu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0165572824000067?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai 200032, China; others
Keywords: SARS-CoV-2, receptor-binding domain, virus variants, immune response, primates
Summary of Study: Neutralization of SARS-CoV-2 BA.2.86 and JN.1 by CF501 adjuvant-enhanced immune responses targeting the conserved epitopes in ancestral RBD
References: PMID: 38428429 PMCID: PMC10983032 DOI: 10.1016/j.xcrm.2024.101445
Contact Info: Lu Lu: lul@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379124000685?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai 200032, China; others
Keywords: SARS-CoV-2, receptor-binding domain, virus variants, immune response, primates
Summary of Study: Neutralization of SARS-CoV-2 BA.2.86 and JN.1 by CF501 adjuvant-enhanced immune responses targeting the conserved epitopes in ancestral RBD
References: PMID: 38428429 PMCID: PMC10983032 DOI: 10.1016/j.xcrm.2024.101445
Contact Info: Lu Lu: lul@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379124000685?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Keywords: SARS-CoV-2, aerosols, inoculation route, virus replication, tropism, primates
Summary of Study: Upper vs. lower respiratory virus replication
References: PMID: 38261786 DOI: 10.1093/infdis/jiae018
Contact Info: Neeltje van Doremalen: [email protected]
URL: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae018/7585664…
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Keywords: SARS-CoV-2, aerosols, inoculation route, virus replication, tropism, primates
Summary of Study: Upper vs. lower respiratory virus replication
References: PMID: 38261786 DOI: 10.1093/infdis/jiae018
Contact Info: Neeltje van Doremalen: [email protected]
URL: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae018/7585664…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, bone marrow LLPCs, spike protein vaccine, immune response, primates
Summary of Study: Adjuvanted spike protein vaccination elicits long-lived plasma cells
References: PMID: 38170789 DOI: 10.1126/scitranslmed.add5960
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.add5960?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, bone marrow LLPCs, spike protein vaccine, immune response, primates
Summary of Study: Adjuvanted spike protein vaccination elicits long-lived plasma cells
References: PMID: 38170789 DOI: 10.1126/scitranslmed.add5960
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.add5960?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Massachusetts General Hospital, Charlestown, Massachusetts USA; Brigham and Women's Hospital, Boston, Massachusetts, and others
Keywords: SARS-CoV-2, review, brain autopsies, neuropathological findings, humans, animal models, primates
Summary of Study: Review: What Can We Still Learn from Brain Autopsies in COVID-19?
References: PMID: 37023787 / doi: 10.1055/s-0043-1767716
Contact Info: Shibani Mukerji: [email protected]
URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-17677…
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Massachusetts General Hospital, Charlestown, Massachusetts USA; Brigham and Women's Hospital, Boston, Massachusetts, and others
Keywords: SARS-CoV-2, review, brain autopsies, neuropathological findings, humans, animal models, primates
Summary of Study: Review: What Can We Still Learn from Brain Autopsies in COVID-19?
References: PMID: 37023787 / doi: 10.1055/s-0043-1767716
Contact Info: Shibani Mukerji: [email protected]
URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-17677…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Virology and Immunology, Graduate School of Medicine, Osaka University, Osaka, 565-0871 Japan, others
Keywords: SARS-CoV-2, vaccine, Spike (S) receptor binding domain, immune response, primates
Summary of Study: saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity
References: doi: 10.1038/s41467-023-38457-x
Contact Info: Takuya Yamamoto: [email protected]
URL: https://www.nature.com/articles/s41467-023-38457-x
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Virology and Immunology, Graduate School of Medicine, Osaka University, Osaka, 565-0871 Japan, others
Keywords: SARS-CoV-2, vaccine, Spike (S) receptor binding domain, immune response, primates
Summary of Study: saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity
References: doi: 10.1038/s41467-023-38457-x
Contact Info: Takuya Yamamoto: [email protected]
URL: https://www.nature.com/articles/s41467-023-38457-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, Oregon National Primate Research Center, University of California, Irvine
Keywords: SARS-CoV-2, alcohol, lung, scRNA-seq, inflammation, primates
Summary of Study: Alcohol consumption dysregulates immune response in lungs
References: doi: 10.1101/2023.05.02.539139. Preprint
Contact Info: Ilhelm Messaoudi: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187161/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, Oregon National Primate Research Center, University of California, Irvine
Keywords: SARS-CoV-2, alcohol, lung, scRNA-seq, inflammation, primates
Summary of Study: Alcohol consumption dysregulates immune response in lungs
References: doi: 10.1101/2023.05.02.539139. Preprint
Contact Info: Ilhelm Messaoudi: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187161/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand and others
Keywords: SARS-CoV-2, recombinant plant-based RBD vaccine, immunogenicity, efficacy, safety, mice, primates
Summary of Study: Recombinant plant based RBD vaccine formulated with 3M-052-Alum adjuvant
References: PMID: 36963999 / doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand and others
Keywords: SARS-CoV-2, recombinant plant-based RBD vaccine, immunogenicity, efficacy, safety, mice, primates
Summary of Study: Recombinant plant based RBD vaccine formulated with 3M-052-Alum adjuvant
References: PMID: 36963999 / doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200438, China., many others
Keywords: SARS-CoV-2, vaccine, mRNA-based T-cell-inducing antigen, immune response, primates
Summary of Study: mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine
References: doi: 10.1038/s41467-023-38751-8
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.nature.com/articles/s41467-023-38751-8
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200438, China., many others
Keywords: SARS-CoV-2, vaccine, mRNA-based T-cell-inducing antigen, immune response, primates
Summary of Study: mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine
References: doi: 10.1038/s41467-023-38751-8
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.nature.com/articles/s41467-023-38751-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310000, China, others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Delta (B.1.617.2) inactivated vaccine candidate elicits neutralizing antibodies
References: doi: 10.1016/j.virs.2023.05.009
Contact Info: Keda Chen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X23000573?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310000, China, others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Delta (B.1.617.2) inactivated vaccine candidate elicits neutralizing antibodies
References: doi: 10.1016/j.virs.2023.05.009
Contact Info: Keda Chen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X23000573?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chan Zuckerberg Biohub, Stanford University, others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, virus variants, primates
Summary of Study: Ferritin-based nanoparticle vaccine
References: PMID: 37069151 / doi: 10.1038/s41467-023-37417-9
Contact Info: Peter S Kim: [email protected]
URL: https://www.nature.com/articles/s41467-023-37417-9
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chan Zuckerberg Biohub, Stanford University, others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, virus variants, primates
Summary of Study: Ferritin-based nanoparticle vaccine
References: PMID: 37069151 / doi: 10.1038/s41467-023-37417-9
Contact Info: Peter S Kim: [email protected]
URL: https://www.nature.com/articles/s41467-023-37417-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi, Vaccines R&D, Marcy l'Etoile, France, and others
Keywords: SARS-CoV-2, bivalent vaccine, virus variants, immune response, primates
Summary of Study: Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization
References: doi: 10.1038/s43856-023-00302-z
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212738/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi, Vaccines R&D, Marcy l'Etoile, France, and others
Keywords: SARS-CoV-2, bivalent vaccine, virus variants, immune response, primates
Summary of Study: Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization
References: doi: 10.1038/s43856-023-00302-z
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212738/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Consortium on Pathogen Readiness, Boston, MA USA and others
Keywords: SARS-CoV-2, omicron spike protein encoding vaccine, boosters, immune response, primates
Summary of Study: Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy
References: PMID: 37029141 / 10.1038/s41467-023-37715-2
Contact Info: Frank Wegmann: [email protected]
URL: https://www.nature.com/articles/s41467-023-37715-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Consortium on Pathogen Readiness, Boston, MA USA and others
Keywords: SARS-CoV-2, omicron spike protein encoding vaccine, boosters, immune response, primates
Summary of Study: Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy
References: PMID: 37029141 / 10.1038/s41467-023-37715-2
Contact Info: Frank Wegmann: [email protected]
URL: https://www.nature.com/articles/s41467-023-37715-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Emory National Primate Research Center, Emory School of Medicine, others
Keywords: SARS-CoV-2, vaccine comparison, immune response, nasopharynx, primates
Summary of Study: Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines
References: doi: 10.1126/sciimmunol.adg7015
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg7015
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Emory National Primate Research Center, Emory School of Medicine, others
Keywords: SARS-CoV-2, vaccine comparison, immune response, nasopharynx, primates
Summary of Study: Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines
References: doi: 10.1126/sciimmunol.adg7015
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg7015
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Oklahoma Health Sciences Center, Oklahoma City, OK USA and others.
Keywords: SARS-CoV-2, air–liquid interface, airway epithelium, immune response, innate immunity, inflammation, primates
Summary of Study: Isolation and in vitro differentiation of primary fetal baboon tracheal epithelial cells for studying host-virus Interactions
References: PMID: 37112842 / doi: 10.3390/v15040862
Contact Info: Matthew Walters: [email protected]
URL: https://www.mdpi.com/1999-4915/15/4/862
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Oklahoma Health Sciences Center, Oklahoma City, OK USA and others.
Keywords: SARS-CoV-2, air–liquid interface, airway epithelium, immune response, innate immunity, inflammation, primates
Summary of Study: Isolation and in vitro differentiation of primary fetal baboon tracheal epithelial cells for studying host-virus Interactions
References: PMID: 37112842 / doi: 10.3390/v15040862
Contact Info: Matthew Walters: [email protected]
URL: https://www.mdpi.com/1999-4915/15/4/862
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune, India
Keywords: SARS-CoV-2, immune response, virus variants, vaccine, primates
Summary of Study: Immune response in aged monkeys post vaccine
References: doi: 10.3389/fimmu.2023.1161571
Contact Info: Pragya Yadov: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161571/full
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune, India
Keywords: SARS-CoV-2, immune response, virus variants, vaccine, primates
Summary of Study: Immune response in aged monkeys post vaccine
References: doi: 10.3389/fimmu.2023.1161571
Contact Info: Pragya Yadov: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161571/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; others
Keywords: SARS-CoV-2, spatial transcriptomic profiling, lungs, virus variants, primates
Summary of Study: Comparative spatial transcriptomic profiling of severe acute respiratory syndrome coronavirus 2 Delta and Omicron variants infections in the lungs of cynomolgus macaques.
References: DOI: 10.1002/jmv.28847
Contact Info: Jung Joo Hong: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28847
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; others
Keywords: SARS-CoV-2, spatial transcriptomic profiling, lungs, virus variants, primates
Summary of Study: Comparative spatial transcriptomic profiling of severe acute respiratory syndrome coronavirus 2 Delta and Omicron variants infections in the lungs of cynomolgus macaques.
References: DOI: 10.1002/jmv.28847
Contact Info: Jung Joo Hong: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28847
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
Keywords: SARS-CoV-2, vaccine, immune response, primates
Summary of Study: Humoral immunogenicity of DNA vaccine delivered using needle-free jet injection
References: Doi: 10.1371/journal.pone.0275082
Contact Info: Jay Hooper: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0275082
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
Keywords: SARS-CoV-2, vaccine, immune response, primates
Summary of Study: Humoral immunogenicity of DNA vaccine delivered using needle-free jet injection
References: Doi: 10.1371/journal.pone.0275082
Contact Info: Jay Hooper: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0275082
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China; others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Preclinical safety evaluation of intradermal SARS-CoV-2 inactivated vaccine (Vero cells) administration in macaques.
References: DOI: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China; others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Preclinical safety evaluation of intradermal SARS-CoV-2 inactivated vaccine (Vero cells) administration in macaques.
References: DOI: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China and others
Keywords: SARS-CoV-2, intradermal inactivated vaccine, immune response, virus variants, primates
Summary of Study: Preclinical safety evaluation of Intradermal inactivated vaccine (vero cells) administration
References: PMID: 37003910 / doi: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China and others
Keywords: SARS-CoV-2, intradermal inactivated vaccine, immune response, virus variants, primates
Summary of Study: Preclinical safety evaluation of Intradermal inactivated vaccine (vero cells) administration
References: PMID: 37003910 / doi: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Stanford University, Scripps Research Institute, others
Keywords: SARS-CoV-2, virus variants, vaccine, immune response, primates
Summary of Study: Extremely potent monoclonal antibodies (mAbs) neutralize multiple sarbecoviruses from macaques vaccinated with AS03-adjuvanted monovalent subunit vaccines.
References: doi: 10.1126/scitranslmed.adg7404
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adg7404
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Stanford University, Scripps Research Institute, others
Keywords: SARS-CoV-2, virus variants, vaccine, immune response, primates
Summary of Study: Extremely potent monoclonal antibodies (mAbs) neutralize multiple sarbecoviruses from macaques vaccinated with AS03-adjuvanted monovalent subunit vaccines.
References: doi: 10.1126/scitranslmed.adg7404
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adg7404
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA USA
Keywords: SARS-CoV-2, favipiravir, biodistribution and pharmacokinetics, positron emission tomography, mice, primates
Summary of Study: Evaluating Favipiravir in rodents and nonhuman primates (NHP) with positron emission tomography
References: PMID: 37111280 / doi: 10.3390/ph16040524
Contact Info: Steven Liang: [email protected]
URL: https://www.mdpi.com/1424-8247/16/4/524
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA USA
Keywords: SARS-CoV-2, favipiravir, biodistribution and pharmacokinetics, positron emission tomography, mice, primates
Summary of Study: Evaluating Favipiravir in rodents and nonhuman primates (NHP) with positron emission tomography
References: PMID: 37111280 / doi: 10.3390/ph16040524
Contact Info: Steven Liang: [email protected]
URL: https://www.mdpi.com/1424-8247/16/4/524
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Mymetics SA, Epalinges, Switzerland; Department of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, influenza virosomes, vaccine, immune response, primates
Summary of Study: Low dose RBD and TLR7/8 agonist displayed on influenza virosome particles is protective
References: doi: 10.1038/s41598-023-31818-y
Contact Info: Sylvain Fleury: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/36977691/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Mymetics SA, Epalinges, Switzerland; Department of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, influenza virosomes, vaccine, immune response, primates
Summary of Study: Low dose RBD and TLR7/8 agonist displayed on influenza virosome particles is protective
References: doi: 10.1038/s41598-023-31818-y
Contact Info: Sylvain Fleury: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/36977691/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University, Emory National Primate Research Center, others
Keywords: SARS-CoV-2, innate immune system, airway inflammation, humans, primates
Summary of Study: TREM2+ and interstitial-like macrophages orchestrate airway inflammation
References: PMID: 37024448 / doi: 10.1038/s41467-023-37425-9
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.nature.com/articles/s41467-023-37425-9
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University, Emory National Primate Research Center, others
Keywords: SARS-CoV-2, innate immune system, airway inflammation, humans, primates
Summary of Study: TREM2+ and interstitial-like macrophages orchestrate airway inflammation
References: PMID: 37024448 / doi: 10.1038/s41467-023-37425-9
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.nature.com/articles/s41467-023-37425-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Patronus Biotech Co. Ltd., Yantai, China
Keywords: SARS-CoV-2, RBD virus-like particle vaccine, immune response, virus infection, mice, primates
Summary of Study: RBD virus-like particle vaccine induces cross-variant antibody responses
References: PMID: 37120453 / doi: 10.1038/s41392-023-01425-4
Contact Info: Yuanyuan Li: [email protected]
URL: https://www.nature.com/articles/s41392-023-01425-4
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Patronus Biotech Co. Ltd., Yantai, China
Keywords: SARS-CoV-2, RBD virus-like particle vaccine, immune response, virus infection, mice, primates
Summary of Study: RBD virus-like particle vaccine induces cross-variant antibody responses
References: PMID: 37120453 / doi: 10.1038/s41392-023-01425-4
Contact Info: Yuanyuan Li: [email protected]
URL: https://www.nature.com/articles/s41392-023-01425-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, others
Keywords: SARS-CoV-2, nelfinavir, prophylactics, virus protection, humans, primates
Summary of Study: Nelfinavir preventive and therapeutic effects
References: PMID: 37095086 / doi: 10.1038/s41392-023-01429-0
Contact Info: Weiliang Zhu: [email protected]
URL: https://www.nature.com/articles/s41392-023-01429-0
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, others
Keywords: SARS-CoV-2, nelfinavir, prophylactics, virus protection, humans, primates
Summary of Study: Nelfinavir preventive and therapeutic effects
References: PMID: 37095086 / doi: 10.1038/s41392-023-01429-0
Contact Info: Weiliang Zhu: [email protected]
URL: https://www.nature.com/articles/s41392-023-01429-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine, Tulane National Primate Research Center, others
Keywords: SARS-CoV-2, CSF, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates.
References: DOI: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine, Tulane National Primate Research Center, others
Keywords: SARS-CoV-2, CSF, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates.
References: DOI: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/