Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao, China; others
Keywords: SARS-CoV-2, virus receptor proteins, ocular hypertension, immunofluorescence, humans and primates
Summary of Study: Expression of SARS-CoV-2 Receptor ACE2 and Protease TMPRSS2 in Ocular Hypertension
References: PMID: 38212998 DOI: 10.1080/02713683.2023.2291749
Contact Info: Jun-Li: doctor_li@126.com
URL: https://www.tandfonline.com/doi/full/10.1080/02713683.2023.2291749
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao, China; others
Keywords: SARS-CoV-2, virus receptor proteins, ocular hypertension, immunofluorescence, humans and primates
Summary of Study: Expression of SARS-CoV-2 Receptor ACE2 and Protease TMPRSS2 in Ocular Hypertension
References: PMID: 38212998 DOI: 10.1080/02713683.2023.2291749
Contact Info: Jun-Li: doctor_li@126.com
URL: https://www.tandfonline.com/doi/full/10.1080/02713683.2023.2291749
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai 200032, China; others
Keywords: SARS-CoV-2, receptor-binding domain, virus variants, immune response, primates
Summary of Study: Neutralization of SARS-CoV-2 BA.2.86 and JN.1 by CF501 adjuvant-enhanced immune responses targeting the conserved epitopes in ancestral RBD
References: PMID: 38428429 PMCID: PMC10983032 DOI: 10.1016/j.xcrm.2024.101445
Contact Info: Lu Lu: lul@fudon@edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S2666379124000685?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai 200032, China; others
Keywords: SARS-CoV-2, receptor-binding domain, virus variants, immune response, primates
Summary of Study: Neutralization of SARS-CoV-2 BA.2.86 and JN.1 by CF501 adjuvant-enhanced immune responses targeting the conserved epitopes in ancestral RBD
References: PMID: 38428429 PMCID: PMC10983032 DOI: 10.1016/j.xcrm.2024.101445
Contact Info: Lu Lu: lul@fudon@edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S2666379124000685?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: Research & Development-Science, Research and Innovation, Medicines and Healthcare products Regulatory Agency, South Mimms, Hertfordshire EN6 3QG, UK.
Keywords: SARS-CoV-2, host genetics, emerging viruses, global public health, primates
Summary of Study: Host immunogenetics on infectious disease studies
References: PMID: 38257982 PMCID: PMC10818626 DOI: 10.3390/microorganisms12010155
Contact Info: Neil Berry: neil.berry@mhra.gov.uk
URL: https://www.mdpi.com/2076-2607/12/1/155
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: Research & Development-Science, Research and Innovation, Medicines and Healthcare products Regulatory Agency, South Mimms, Hertfordshire EN6 3QG, UK.
Keywords: SARS-CoV-2, host genetics, emerging viruses, global public health, primates
Summary of Study: Host immunogenetics on infectious disease studies
References: PMID: 38257982 PMCID: PMC10818626 DOI: 10.3390/microorganisms12010155
Contact Info: Neil Berry: neil.berry@mhra.gov.uk
URL: https://www.mdpi.com/2076-2607/12/1/155
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; others
Keywords: SARS-CoV-2, mRNA delivery, jet injector; lipid nanoparticle, mRNA vaccine, primates
Summary of Study: Carrier-free mRNA vaccine induces robust immunity
References: PMID: 38569556 DOI: 10.1016/j.ymthe.2024.03.022
Contact Info: Satoshi Uchida: uchida.anme@tmd.ac.jp
URL: https://www.sciencedirect.com/science/article/pii/S1525001624001631?via%3Dihub=
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; others
Keywords: SARS-CoV-2, mRNA delivery, jet injector; lipid nanoparticle, mRNA vaccine, primates
Summary of Study: Carrier-free mRNA vaccine induces robust immunity
References: PMID: 38569556 DOI: 10.1016/j.ymthe.2024.03.022
Contact Info: Satoshi Uchida: uchida.anme@tmd.ac.jp
URL: https://www.sciencedirect.com/science/article/pii/S1525001624001631?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden; others
Keywords: SARS-CoV-2, Novavax’s protein vaccines, immune response, virus variants, primates
Summary of Study: Novavax protein vaccines increase antibody breadth and provide durable protection
References: PMID: 38245545 PMCID: PMC10799869 DOI: 10.1038/s41541-024-00806-2
Contact Info: Karin Loré: karin.lore@ki.se
URL: https://www.nature.com/articles/s41541-024-00806-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden; others
Keywords: SARS-CoV-2, Novavax’s protein vaccines, immune response, virus variants, primates
Summary of Study: Novavax protein vaccines increase antibody breadth and provide durable protection
References: PMID: 38245545 PMCID: PMC10799869 DOI: 10.1038/s41541-024-00806-2
Contact Info: Karin Loré: karin.lore@ki.se
URL: https://www.nature.com/articles/s41541-024-00806-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, sooty mangabeys
Year Published: 2024
Study Type/Review: therapeutics, review
NPRC/Institute: Laboratory of Liver Infectious Diseases, Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Keywords: SARS-CoV-2, preclinical animal model, therapeutic antibodies, immune response, rodents, primates
Summary of Study: Preclinical animal models to evaluate therapeutic antiviral antibodies
References: PMID: 38548022 DOI: 10.1016/j.antiviral.2024.105843
Contact Info: Phlip Meuleman: meuleman@ugent.be
URL: https://www.sciencedirect.com/science/article/pii/S0166354224000512?via%3Dihub=
NHP Species: rhesus macaques, cynomolgus macaques, sooty mangabeys
Year Published: 2024
Study Type/Review: therapeutics, review
NPRC/Institute: Laboratory of Liver Infectious Diseases, Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Keywords: SARS-CoV-2, preclinical animal model, therapeutic antibodies, immune response, rodents, primates
Summary of Study: Preclinical animal models to evaluate therapeutic antiviral antibodies
References: PMID: 38548022 DOI: 10.1016/j.antiviral.2024.105843
Contact Info: Phlip Meuleman: meuleman@ugent.be
URL: https://www.sciencedirect.com/science/article/pii/S0166354224000512?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., 11-13 Walkley Avenue, Warradale, SA 5046, Australia; BIOQUAL, Inc., 9600 Medical Center Drive, Rockville, MD 20850-3336, USA
Keywords: SARS-CoV-2, recombinant protein vaccine, immune response, virus variants, primates
Summary of Study: Recombinant protein-based vaccine delivered by intramuscular and mucosal routes
References: PMID: 38262808 DOI: 10.1016/j.vaccine.2024.01.034
Contact Info: Nikolai Petrovsky: nikolai.petrovsky@vaxine.net
URL: https://www.sciencedirect.com/science/article/pii/S0264410X24000343?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., 11-13 Walkley Avenue, Warradale, SA 5046, Australia; BIOQUAL, Inc., 9600 Medical Center Drive, Rockville, MD 20850-3336, USA
Keywords: SARS-CoV-2, recombinant protein vaccine, immune response, virus variants, primates
Summary of Study: Recombinant protein-based vaccine delivered by intramuscular and mucosal routes
References: PMID: 38262808 DOI: 10.1016/j.vaccine.2024.01.034
Contact Info: Nikolai Petrovsky: nikolai.petrovsky@vaxine.net
URL: https://www.sciencedirect.com/science/article/pii/S0264410X24000343?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Guangzhou Laboratory, Bio-island, Guangzhou, China: others
Keywords: SARS-CoV-2, Siglec-9, bivalent vaccines, immune response, primates
Summary of Study: Receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis
References: PMID: 38454157 DOI: 10.1038/s41590-024-01776-2
Contact Info: Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.nature.com/articles/s41590-024-01776-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Guangzhou Laboratory, Bio-island, Guangzhou, China: others
Keywords: SARS-CoV-2, Siglec-9, bivalent vaccines, immune response, primates
Summary of Study: Receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis
References: PMID: 38454157 DOI: 10.1038/s41590-024-01776-2
Contact Info: Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.nature.com/articles/s41590-024-01776-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Keywords: SARS-CoV-2, aerosols, inoculation route, virus replication, tropism, primates
Summary of Study: Upper vs. lower respiratory virus replication
References: PMID: 38261786 DOI: 10.1093/infdis/jiae018
Contact Info: Neeltje van Doremalen: neeltje.vandoremalen@nih.gov
URL: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae018/7585664…
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Keywords: SARS-CoV-2, aerosols, inoculation route, virus replication, tropism, primates
Summary of Study: Upper vs. lower respiratory virus replication
References: PMID: 38261786 DOI: 10.1093/infdis/jiae018
Contact Info: Neeltje van Doremalen: neeltje.vandoremalen@nih.gov
URL: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae018/7585664…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China; others
Keywords: SARS-CoV-2, mRNA vaccine, lipopolyplex, immunogenicity, virus variants, primates
Summary of Study: Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex
References: PMID: 38557908 PMCID: PMC11008869 DOI: 10.1371/journal.ppat.1012116
Contact Info: George Fu Gao: gaof@im.ac.cn
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012116
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China; others
Keywords: SARS-CoV-2, mRNA vaccine, lipopolyplex, immunogenicity, virus variants, primates
Summary of Study: Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex
References: PMID: 38557908 PMCID: PMC11008869 DOI: 10.1371/journal.ppat.1012116
Contact Info: George Fu Gao: gaof@im.ac.cn
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012116
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510182, China; others
Keywords: SARS-CoV-2, animal models, immune response, multiomics, variety of animal species, primates
Summary of Study: Immunity in animal models
References: PMID: 38238440 PMCID: PMC10806257 DOI: 10.1038/s41423-023-01122-w
Contact Info: Jing Sun: sj-ji@163.com
URL: https://www.nature.com/articles/s41423-023-01122-w
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510182, China; others
Keywords: SARS-CoV-2, animal models, immune response, multiomics, variety of animal species, primates
Summary of Study: Immunity in animal models
References: PMID: 38238440 PMCID: PMC10806257 DOI: 10.1038/s41423-023-01122-w
Contact Info: Jing Sun: sj-ji@163.com
URL: https://www.nature.com/articles/s41423-023-01122-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, Fontenay-aux-Roses, France; others
Keywords: SARS-CoV-2, VLA2001 vaccine, immunogenicity, pathology, primates
Summary of Study: Immunogenicity and efficacy of VLA2001 vaccine
References: PMID: 38570605 PMCID: PMC10991505 DOI: 10.1038/s43856-024-00488-w
Contact Info: Roger LeGrand: roger.le-grand@cea.fr
URL: https://www.nature.com/articles/s43856-024-00488-w
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, Fontenay-aux-Roses, France; others
Keywords: SARS-CoV-2, VLA2001 vaccine, immunogenicity, pathology, primates
Summary of Study: Immunogenicity and efficacy of VLA2001 vaccine
References: PMID: 38570605 PMCID: PMC10991505 DOI: 10.1038/s43856-024-00488-w
Contact Info: Roger LeGrand: roger.le-grand@cea.fr
URL: https://www.nature.com/articles/s43856-024-00488-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan; others
Keywords: SARS-CoV-2, olfactory mucosa, immune response, melanocytes primates
Summary of Study: Inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway
References: PMID: 38237527 DOI: 10.1016/j.jneuroim.2024.578288
Contact Info: Shino Shimizu: sshino@belle.shiga-med.ac.jp
URL: https://www.sciencedirect.com/science/article/pii/S0165572824000067?via%3Dihub=
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan; others
Keywords: SARS-CoV-2, olfactory mucosa, immune response, melanocytes primates
Summary of Study: Inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway
References: PMID: 38237527 DOI: 10.1016/j.jneuroim.2024.578288
Contact Info: Shino Shimizu: sshino@belle.shiga-med.ac.jp
URL: https://www.sciencedirect.com/science/article/pii/S0165572824000067?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan; Central Research Laboratory, Shiga University of Medical Science, Otsu, Japan.; others
Keywords: SARS-CoV-2, CD38, endothelial cells, lungs, immune response, primates
Summary of Study: Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection
References: PMID: 38507920 DOI: 10.1016/j.virol.2024.110052
Contact Info: Yasushi Itoh: yasushii@belle.shiga-med.ac.jp
URL: https://www.sciencedirect.com/science/article/pii/S0042682224000734?via%3Dihub=
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan; Central Research Laboratory, Shiga University of Medical Science, Otsu, Japan.; others
Keywords: SARS-CoV-2, CD38, endothelial cells, lungs, immune response, primates
Summary of Study: Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection
References: PMID: 38507920 DOI: 10.1016/j.virol.2024.110052
Contact Info: Yasushi Itoh: yasushii@belle.shiga-med.ac.jp
URL: https://www.sciencedirect.com/science/article/pii/S0042682224000734?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxart, Inc., South San Francisco, CA 94080, USA
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity, mucosal, primates
Summary of Study: Adenoviral Vaccine Elicits Mucosal and Systemic Immunogenicity and Reduces Viral Shedding
References: PMID: 38400116 PMCID: PMC10893453 DOI: 10.3390/vaccines12020132
Contact Info: Becca Flitter: bflitter@vaxart.com
URL: https://www.mdpi.com/2076-393X/12/2/132
NHP Species: african green monkeys
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxart, Inc., South San Francisco, CA 94080, USA
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity, mucosal, primates
Summary of Study: Adenoviral Vaccine Elicits Mucosal and Systemic Immunogenicity and Reduces Viral Shedding
References: PMID: 38400116 PMCID: PMC10893453 DOI: 10.3390/vaccines12020132
Contact Info: Becca Flitter: bflitter@vaxart.com
URL: https://www.mdpi.com/2076-393X/12/2/132
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Vaccine and Immunotherapy Center, the Wistar Institute of Anatomy and Biology, Philadelphia, PA; others
Keywords: SARS-CoV-2, monoclonal antibody, DNA-encoded, immune response, pathology, primates
Summary of Study: Engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis
References: PMID: 38165394 DOI: 10.1080/22221751.2023.2294860
Contact Info: Heinz Feldman: feldmannh@niaid.nih.gov
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2294860
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Vaccine and Immunotherapy Center, the Wistar Institute of Anatomy and Biology, Philadelphia, PA; others
Keywords: SARS-CoV-2, monoclonal antibody, DNA-encoded, immune response, pathology, primates
Summary of Study: Engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis
References: PMID: 38165394 DOI: 10.1080/22221751.2023.2294860
Contact Info: Heinz Feldman: feldmannh@niaid.nih.gov
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2294860
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, bone marrow LLPCs, spike protein vaccine, immune response, primates
Summary of Study: Adjuvanted spike protein vaccination elicits long-lived plasma cells
References: PMID: 38170789 DOI: 10.1126/scitranslmed.add5960
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://www.science.org/doi/10.1126/scitranslmed.add5960?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, bone marrow LLPCs, spike protein vaccine, immune response, primates
Summary of Study: Adjuvanted spike protein vaccination elicits long-lived plasma cells
References: PMID: 38170789 DOI: 10.1126/scitranslmed.add5960
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://www.science.org/doi/10.1126/scitranslmed.add5960?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Keywords: SARS-CoV-2, pregnancy, pathogenesis, different viruses, animal species, primates
Summary of Study: Pathogenesis of viral infections during pregnancy
References: PMID: 38421182 DOI: 10.1128/cmr.00073-23
Contact Info: Sabra Klein: sklein2@jhu.edu
URL: https://journals.asm.org/doi/10.1128/cmr.00073-23?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Keywords: SARS-CoV-2, pregnancy, pathogenesis, different viruses, animal species, primates
Summary of Study: Pathogenesis of viral infections during pregnancy
References: PMID: 38421182 DOI: 10.1128/cmr.00073-23
Contact Info: Sabra Klein: sklein2@jhu.edu
URL: https://journals.asm.org/doi/10.1128/cmr.00073-23?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; others
Keywords: SARS-CoV-2, spike Ferritin Nanoparticle (SpFN) vaccine, neutralizing antibodies, primates
Summary of Study: Neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination
References: PMID: 38172512 PMCID: PMC10764318 DOI: 10.1038/s41467-023-44265-0
Contact Info: Shelly Krebs: skrebs@hivresearch.org
URL: https://www.nature.com/articles/s41467-023-44265-0
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; others
Keywords: SARS-CoV-2, spike Ferritin Nanoparticle (SpFN) vaccine, neutralizing antibodies, primates
Summary of Study: Neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination
References: PMID: 38172512 PMCID: PMC10764318 DOI: 10.1038/s41467-023-44265-0
Contact Info: Shelly Krebs: skrebs@hivresearch.org
URL: https://www.nature.com/articles/s41467-023-44265-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Research & Development Center, Cellid Co., Ltd., Seoul 08826, Republic of Korea; others
Keywords: SARS-CoV-2, multivalent vaccine, adenovirus vector, immune response, primates
Summary of Study: Multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform
References: PMID: 38408238 PMCID: PMC10927586 DOI: 10.1073/pnas.2313681121
Contact Info: Chang-Yuil Kang: cykang@snu.ac.kr
URL: https://www.pnas.org/doi/abs/10.1073/pnas.2313681121?url_ver=Z39.88-2003&rfr_id…
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Research & Development Center, Cellid Co., Ltd., Seoul 08826, Republic of Korea; others
Keywords: SARS-CoV-2, multivalent vaccine, adenovirus vector, immune response, primates
Summary of Study: Multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform
References: PMID: 38408238 PMCID: PMC10927586 DOI: 10.1073/pnas.2313681121
Contact Info: Chang-Yuil Kang: cykang@snu.ac.kr
URL: https://www.pnas.org/doi/abs/10.1073/pnas.2313681121?url_ver=Z39.88-2003&rfr_id…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Medical biology, Chinese Academy of Medical Sciences and Peking Union Medical School (IMBCAMS&PUMC), 5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China; others
Keywords: SARS-CoV-2, gastrointestinal infection, virus variants, immune response, microbiota, primates
Summary of Study: Gastrointestinal microbiota and metabolites possibly contribute to distinct pathogenicity
References: PMID: 38563680 PMCID: PMC10989708 DOI: 10.1080/19490976.2024.2334970
Contact Info: Xiaozhong Peng: pengxiaozhong@pumc.edu.cn
URL: https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2334970
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Medical biology, Chinese Academy of Medical Sciences and Peking Union Medical School (IMBCAMS&PUMC), 5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China; others
Keywords: SARS-CoV-2, gastrointestinal infection, virus variants, immune response, microbiota, primates
Summary of Study: Gastrointestinal microbiota and metabolites possibly contribute to distinct pathogenicity
References: PMID: 38563680 PMCID: PMC10989708 DOI: 10.1080/19490976.2024.2334970
Contact Info: Xiaozhong Peng: pengxiaozhong@pumc.edu.cn
URL: https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2334970
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA; others
Keywords: SARS-CoV-2, bivalent mRNA vaccine, virus variants, SIV, immune response, primates
Summary of Study: Neutralizing antibody response to bivalent mRNA vaccine
References: PMID: 38528837 PMCID: PMC10987079 (available on 2025-03-01) DOI: 10.1002/jmv.29520
Contact Info: Huanbin Xu: hxu@tulane.edu; Shan-Lu Lui: liu.6244@osu.edu
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.29520
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA; others
Keywords: SARS-CoV-2, bivalent mRNA vaccine, virus variants, SIV, immune response, primates
Summary of Study: Neutralizing antibody response to bivalent mRNA vaccine
References: PMID: 38528837 PMCID: PMC10987079 (available on 2025-03-01) DOI: 10.1002/jmv.29520
Contact Info: Huanbin Xu: hxu@tulane.edu; Shan-Lu Lui: liu.6244@osu.edu
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.29520
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Stemirna Therapeutics, Shanghai 201206, China; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, safety profile, rodents, primates
Summary of Study: Inoculation site-retained mRNA vaccine
References: PMID: 38184234 DOI: 10.1016/j.jconrel.2024.01.002
Contact Info: Haifa Shen: haifashen@gmail.com
URL: https://www.sciencedirect.com/science/article/pii/S0168365924000063?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Stemirna Therapeutics, Shanghai 201206, China; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, safety profile, rodents, primates
Summary of Study: Inoculation site-retained mRNA vaccine
References: PMID: 38184234 DOI: 10.1016/j.jconrel.2024.01.002
Contact Info: Haifa Shen: haifashen@gmail.com
URL: https://www.sciencedirect.com/science/article/pii/S0168365924000063?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands; others
Keywords: SARS-CoV-2, antibody therapy, filamentous fungus expression system, immune response, primates
Summary of Study: Filamentous fungus-produced human monoclonal antibody provides protection
References: PMID: 38485931 PMCID: PMC10940701 DOI: 10.1038/s41467-024-46443-0
Contact Info: Bart L. Haagmans: b.haagmans@erasmusmc.nl
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940701/
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands; others
Keywords: SARS-CoV-2, antibody therapy, filamentous fungus expression system, immune response, primates
Summary of Study: Filamentous fungus-produced human monoclonal antibody provides protection
References: PMID: 38485931 PMCID: PMC10940701 DOI: 10.1038/s41467-024-46443-0
Contact Info: Bart L. Haagmans: b.haagmans@erasmusmc.nl
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940701/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland; Adimab LLC, Lebanon, New Hampshire; Invivyd, Inc., Waltham, Massachusetts; others
Keywords: SARS-CoV-2, Adintrevimab, prophylactics, viral load, pathology, hamsters, primates
Summary of Study: Monoclonal Antibody Adintrevimab Protects against COVID-19
References: doi: 10.1128/aac.01353-22
Contact Info: Kristin Narayan: knarayan@invivyd.com
URL: https://journals.asm.org/doi/10.1128/aac.01353-22
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland; Adimab LLC, Lebanon, New Hampshire; Invivyd, Inc., Waltham, Massachusetts; others
Keywords: SARS-CoV-2, Adintrevimab, prophylactics, viral load, pathology, hamsters, primates
Summary of Study: Monoclonal Antibody Adintrevimab Protects against COVID-19
References: doi: 10.1128/aac.01353-22
Contact Info: Kristin Narayan: knarayan@invivyd.com
URL: https://journals.asm.org/doi/10.1128/aac.01353-22
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai , China; Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease and Biosecurity, others.
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus protection, primates
Summary of Study: Pan-sarbecovirus vaccines against sarbecoviruses, including SARS-CoV-2 and its variants
References: doi: 10.1073/pnas.2221713120
Contact Info: LuLu: lul@fudan.edu.cn (and other authors
URL: https://www.pnas.org/doi/10.1073/pnas.2221713120
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai , China; Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease and Biosecurity, others.
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus protection, primates
Summary of Study: Pan-sarbecovirus vaccines against sarbecoviruses, including SARS-CoV-2 and its variants
References: doi: 10.1073/pnas.2221713120
Contact Info: LuLu: lul@fudan.edu.cn (and other authors
URL: https://www.pnas.org/doi/10.1073/pnas.2221713120
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, others
Keywords: SARS-CoV-2, nelfinavir, prophylactics, virus protection, humans, primates
Summary of Study: Nelfinavir preventive and therapeutic effects
References: PMID: 37095086 / doi: 10.1038/s41392-023-01429-0
Contact Info: Weiliang Zhu: wlzhu@simm.ac.cn
URL: https://www.nature.com/articles/s41392-023-01429-0
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, others
Keywords: SARS-CoV-2, nelfinavir, prophylactics, virus protection, humans, primates
Summary of Study: Nelfinavir preventive and therapeutic effects
References: PMID: 37095086 / doi: 10.1038/s41392-023-01429-0
Contact Info: Weiliang Zhu: wlzhu@simm.ac.cn
URL: https://www.nature.com/articles/s41392-023-01429-0
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institut Pasteur, Université Paris Cité, National Reference Center for Respiratory Viruses, Paris, France; others
Keywords: SARS-CoV-2, monoclonal antibody treatment, immune response, primates
Summary of Study: Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model.
References: DOI: 10.1016/j.heliyon.2023.e16664
Contact Info: Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.sciencedirect.com/science/article/pii/S2405844023038719?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institut Pasteur, Université Paris Cité, National Reference Center for Respiratory Viruses, Paris, France; others
Keywords: SARS-CoV-2, monoclonal antibody treatment, immune response, primates
Summary of Study: Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model.
References: DOI: 10.1016/j.heliyon.2023.e16664
Contact Info: Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.sciencedirect.com/science/article/pii/S2405844023038719?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China; others
Keywords: SARS-CoV-2, transcriptome analysis, virus variants, subgenomic RNA, primates
Summary of Study: Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs
References: doi:10.1016/j.gpb.2023.06.002
Contact Info: Xiaozhong Peng: pengxiaozhong@pumc.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S1672022923000955?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China; others
Keywords: SARS-CoV-2, transcriptome analysis, virus variants, subgenomic RNA, primates
Summary of Study: Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs
References: doi:10.1016/j.gpb.2023.06.002
Contact Info: Xiaozhong Peng: pengxiaozhong@pumc.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S1672022923000955?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France
Keywords: SARS-CoV-2, intestinal mucosal barrier, inflammation, pathology, primates
Summary of Study: Intestinal immunological events of acute and resolved infection
References: DOI: 10.1016/j.mucimm.2023.10.001
Contact Info: Mariangela Cavarelli: mariangela.cavarelli@cea.fr
URL: https://www.sciencedirect.com/science/article/pii/S193302192300079X?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France
Keywords: SARS-CoV-2, intestinal mucosal barrier, inflammation, pathology, primates
Summary of Study: Intestinal immunological events of acute and resolved infection
References: DOI: 10.1016/j.mucimm.2023.10.001
Contact Info: Mariangela Cavarelli: mariangela.cavarelli@cea.fr
URL: https://www.sciencedirect.com/science/article/pii/S193302192300079X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: NIAID, Boston University, many others
Keywords: SARS-CoV-2, gorilla adenovirus (GRAd) S-2P vaccine, airways, immunogenicity, primates
Summary of Study: Airway immunity achieved with GRAd) S-2P vaccine in nhps
References: bioRxiv. 2023 Nov 22:2023.11.22.567930. doi: 10.1101/2023.11.22.567930. Preprint
Contact Info: Nancy Sullivan: njsull@bu.edu
URL: https://www.biorxiv.org/content/10.1101/2023.11.22.567930v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: NIAID, Boston University, many others
Keywords: SARS-CoV-2, gorilla adenovirus (GRAd) S-2P vaccine, airways, immunogenicity, primates
Summary of Study: Airway immunity achieved with GRAd) S-2P vaccine in nhps
References: bioRxiv. 2023 Nov 22:2023.11.22.567930. doi: 10.1101/2023.11.22.567930. Preprint
Contact Info: Nancy Sullivan: njsull@bu.edu
URL: https://www.biorxiv.org/content/10.1101/2023.11.22.567930v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA; others
Keywords: SARS-CoV-2, tetravalent S1 subunit protein vaccine, immune response, virus variants, primates
Summary of Study: Tetravalent S1 subunit protein vaccination elicits robust humoral and cellular immune responses
References: doi: 10.1101/2023.03.15.532808. Preprint
Contact Info: Christian Apetrei: apetreic@pitt.edu
URL: https://www.biorxiv.org/content/10.1101/2023.03.15.532808v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA; others
Keywords: SARS-CoV-2, tetravalent S1 subunit protein vaccine, immune response, virus variants, primates
Summary of Study: Tetravalent S1 subunit protein vaccination elicits robust humoral and cellular immune responses
References: doi: 10.1101/2023.03.15.532808. Preprint
Contact Info: Christian Apetrei: apetreic@pitt.edu
URL: https://www.biorxiv.org/content/10.1101/2023.03.15.532808v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Patronus Biotech Co. Ltd., Yantai, China
Keywords: SARS-CoV-2, RBD virus-like particle vaccine, immune response, virus infection, mice, primates
Summary of Study: RBD virus-like particle vaccine induces cross-variant antibody responses
References: PMID: 37120453 / doi: 10.1038/s41392-023-01425-4
Contact Info: Yuanyuan Li: liyuanyuan@luye.com
URL: https://www.nature.com/articles/s41392-023-01425-4
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Patronus Biotech Co. Ltd., Yantai, China
Keywords: SARS-CoV-2, RBD virus-like particle vaccine, immune response, virus infection, mice, primates
Summary of Study: RBD virus-like particle vaccine induces cross-variant antibody responses
References: PMID: 37120453 / doi: 10.1038/s41392-023-01425-4
Contact Info: Yuanyuan Li: liyuanyuan@luye.com
URL: https://www.nature.com/articles/s41392-023-01425-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Pathology, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Liège, Belgium; others
Keywords: SARS-CoV-2, macrophages, single-cell RNA-seq analysis, immune response, hamsters, primates
Summary of Study: Central role of lung macrophages in SARS-CoV-2 physiopathology: a cross-model single-cell RNA-seq perspective.
References: DOI: 10.3389/fimmu.2023.1197588
Contact Info: Thibaut Olivier: t.olivier@uliege.be
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197588/full
NHP Species: african green monkeys
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Pathology, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Liège, Belgium; others
Keywords: SARS-CoV-2, macrophages, single-cell RNA-seq analysis, immune response, hamsters, primates
Summary of Study: Central role of lung macrophages in SARS-CoV-2 physiopathology: a cross-model single-cell RNA-seq perspective.
References: DOI: 10.3389/fimmu.2023.1197588
Contact Info: Thibaut Olivier: t.olivier@uliege.be
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197588/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitas Airlangga, Surabaya, Indonesia
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine candidate immunization
References: DOI: 10.1016/j.heliyon.2023.e18039
Contact Info: Fedik Abdul Rantam: fedik-a-r@fkh.unair.ac.id
URL: https://www.sciencedirect.com/science/article/pii/S2405844023052477?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitas Airlangga, Surabaya, Indonesia
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine candidate immunization
References: DOI: 10.1016/j.heliyon.2023.e18039
Contact Info: Fedik Abdul Rantam: fedik-a-r@fkh.unair.ac.id
URL: https://www.sciencedirect.com/science/article/pii/S2405844023052477?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA; University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania, USA; others
Keywords: SARS-CoV-2, tetravalent vaccine, adjuvant, immune response, primates
Summary of Study: Tetravalent SARS-CoV-2 S1 subunit protein vaccination
References: DOI: 10.1128/mbio.02070-23
Contact Info: Andrea Gambotto: gambottoa@upmc.edu
URL: https://journals.asm.org/doi/full/10.1128/mbio.02070-23?rfr_dat=cr_pub%20%200pu…
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA; University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania, USA; others
Keywords: SARS-CoV-2, tetravalent vaccine, adjuvant, immune response, primates
Summary of Study: Tetravalent SARS-CoV-2 S1 subunit protein vaccination
References: DOI: 10.1128/mbio.02070-23
Contact Info: Andrea Gambotto: gambottoa@upmc.edu
URL: https://journals.asm.org/doi/full/10.1128/mbio.02070-23?rfr_dat=cr_pub%20%200pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, The Ministry of Health of the Republic of Kazakhstan
Keywords: SARS-CoV-2, subunit vaccine; antigens; toxicity; safety; immunizing dose; immunogenicity, primates
Summary of Study: Coronavirus protein-based subunit vaccine safety and immunogenicity
References: PMID: 38140175 PMCID: PMC10748237 DOI: 10.3390/vaccines11121771
Contact Info: Ainur Nurpeisova: ainurnurpeisova@mail.ru
URL: https://www.mdpi.com/2076-393X/11/12/1771
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, The Ministry of Health of the Republic of Kazakhstan
Keywords: SARS-CoV-2, subunit vaccine; antigens; toxicity; safety; immunizing dose; immunogenicity, primates
Summary of Study: Coronavirus protein-based subunit vaccine safety and immunogenicity
References: PMID: 38140175 PMCID: PMC10748237 DOI: 10.3390/vaccines11121771
Contact Info: Ainur Nurpeisova: ainurnurpeisova@mail.ru
URL: https://www.mdpi.com/2076-393X/11/12/1771
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Texas Biomedical Research Institute, Institute of Science and Technology on Biomodels, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Keywords: SARS-CoV-2, review, coinfections, primate models, housing, screening
Summary of Study: Eliminating Potential Effects of Other Infections During Selection of Nonhuman Primates for COVID-19 Research
References: doi: 10.30802/AALAS-CM-21-000086
Contact Info: Marcia Andrade: marcia.andrade@fiocruz.br
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00003…
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Texas Biomedical Research Institute, Institute of Science and Technology on Biomodels, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Keywords: SARS-CoV-2, review, coinfections, primate models, housing, screening
Summary of Study: Eliminating Potential Effects of Other Infections During Selection of Nonhuman Primates for COVID-19 Research
References: doi: 10.30802/AALAS-CM-21-000086
Contact Info: Marcia Andrade: marcia.andrade@fiocruz.br
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00003…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Mymetics SA, Epalinges, Switzerland; Department of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, influenza virosomes, vaccine, immune response, primates
Summary of Study: Low dose RBD and TLR7/8 agonist displayed on influenza virosome particles is protective
References: doi: 10.1038/s41598-023-31818-y
Contact Info: Sylvain Fleury: sylvain.fleury@mymetics.com
URL: https://pubmed.ncbi.nlm.nih.gov/36977691/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Mymetics SA, Epalinges, Switzerland; Department of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, influenza virosomes, vaccine, immune response, primates
Summary of Study: Low dose RBD and TLR7/8 agonist displayed on influenza virosome particles is protective
References: doi: 10.1038/s41598-023-31818-y
Contact Info: Sylvain Fleury: sylvain.fleury@mymetics.com
URL: https://pubmed.ncbi.nlm.nih.gov/36977691/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune, India
Keywords: SARS-CoV-2, immune response, virus variants, vaccine, primates
Summary of Study: Immune response in aged monkeys post vaccine
References: doi: 10.3389/fimmu.2023.1161571
Contact Info: Pragya Yadov: hellopragya22@gmail.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161571/full
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune, India
Keywords: SARS-CoV-2, immune response, virus variants, vaccine, primates
Summary of Study: Immune response in aged monkeys post vaccine
References: doi: 10.3389/fimmu.2023.1161571
Contact Info: Pragya Yadov: hellopragya22@gmail.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161571/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; others
Keywords: SARS-CoV-2, mRNA-lipid nanoparticle vaccine candidate, safety, immune response, mice, primate
Summary of Study: Characterization of stability, safety and immunogenicity of the mRNA lipid nanoparticle vaccine Iribovax® against COVID-19 in nonhuman primates.
References: DOI: 10.1016/j.jconrel.2023.06.025
Contact Info: Sina Mozaffari-Jovin: Mozaffaris@mums.ac.ir
URL: https://www.sciencedirect.com/science/article/pii/S016836592300398X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; others
Keywords: SARS-CoV-2, mRNA-lipid nanoparticle vaccine candidate, safety, immune response, mice, primate
Summary of Study: Characterization of stability, safety and immunogenicity of the mRNA lipid nanoparticle vaccine Iribovax® against COVID-19 in nonhuman primates.
References: DOI: 10.1016/j.jconrel.2023.06.025
Contact Info: Sina Mozaffari-Jovin: Mozaffaris@mums.ac.ir
URL: https://www.sciencedirect.com/science/article/pii/S016836592300398X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Bioqual, Rockville, MD; NHLBI, NIAID, others
Keywords: SARS-CoV-2, clonal hematopoiesis, transplantation, immune response, pathology, primates
Summary of Study: Impact of clonal hematopoiesis on severity and pathophysiology
References: DOI: 10.3389/fvets.2023.1182197
Contact Info: Tae-Hoon Shin: shinlab@jejunu.ac.kr
URL: https://www.frontiersin.org/articles/10.3389/fvets.2023.1182197/full
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Bioqual, Rockville, MD; NHLBI, NIAID, others
Keywords: SARS-CoV-2, clonal hematopoiesis, transplantation, immune response, pathology, primates
Summary of Study: Impact of clonal hematopoiesis on severity and pathophysiology
References: DOI: 10.3389/fvets.2023.1182197
Contact Info: Tae-Hoon Shin: shinlab@jejunu.ac.kr
URL: https://www.frontiersin.org/articles/10.3389/fvets.2023.1182197/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institute of Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA; others
Keywords: SARS-CoV-2, review, preclinical models, neuropathic physiology, several species, primates
Summary of Study: Preclinical models for studying COVID-19 neurologic diseases
References: DOI: 10.1021/acsptsci.3c00127
Contact Info: Hu Wang: jhmi.edu
URL: https://pubs.acs.org/doi/full/10.1021/acsptsci.3c00127
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institute of Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA; others
Keywords: SARS-CoV-2, review, preclinical models, neuropathic physiology, several species, primates
Summary of Study: Preclinical models for studying COVID-19 neurologic diseases
References: DOI: 10.1021/acsptsci.3c00127
Contact Info: Hu Wang: jhmi.edu
URL: https://pubs.acs.org/doi/full/10.1021/acsptsci.3c00127
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, China, many others
Keywords: SARS-CoV-2, aerosol immunization, immune response, virus variants, primates
Summary of Study: Inhaled vaccine for single-dose dry powder aerosol immunization
References: PMID: 38093012 DOI: 10.1038/s41586-023-06809-8
Contact Info: Wei Wei: weiwei@ipe.ac.cn
URL: https://www.nature.com/articles/s41586-023-06809-8
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, China, many others
Keywords: SARS-CoV-2, aerosol immunization, immune response, virus variants, primates
Summary of Study: Inhaled vaccine for single-dose dry powder aerosol immunization
References: PMID: 38093012 DOI: 10.1038/s41586-023-06809-8
Contact Info: Wei Wei: weiwei@ipe.ac.cn
URL: https://www.nature.com/articles/s41586-023-06809-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: kelsey.carpenter2@wayne.edu
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00006
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: kelsey.carpenter2@wayne.edu
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00006
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven Belgium
Keywords: SARS-CoV-2, review, vaccine development, mice, hamsters, primates
Summary of Study: Do we need nasal vaccines against COVID 19
References: doi: 10.1111/1751-7915.14181
Contact Info: Harald Brüssow: haraldbruessow@yahoo.com
URL: https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14181
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven Belgium
Keywords: SARS-CoV-2, review, vaccine development, mice, hamsters, primates
Summary of Study: Do we need nasal vaccines against COVID 19
References: doi: 10.1111/1751-7915.14181
Contact Info: Harald Brüssow: haraldbruessow@yahoo.com
URL: https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14181
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2023
Study Type/Review:
NPRC/Institute: Center for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, Louisiana; Tulane National Primate Research Center, Covington, Louisiana, others
Keywords: SARS-CoV-2, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal fluid protein markers indicate neuro-damage
References: doi: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: jfan5@tulane.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
NHP Species: rhesus macaques, african green monkeys
Year Published: 2023
Study Type/Review:
NPRC/Institute: Center for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, Louisiana; Tulane National Primate Research Center, Covington, Louisiana, others
Keywords: SARS-CoV-2, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal fluid protein markers indicate neuro-damage
References: doi: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: jfan5@tulane.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, Oregon National Primate Research Center, University of California, Irvine
Keywords: SARS-CoV-2, alcohol, lung, scRNA-seq, inflammation, primates
Summary of Study: Alcohol consumption dysregulates immune response in lungs
References: doi: 10.1101/2023.05.02.539139. Preprint
Contact Info: Ilhelm Messaoudi: ilhelmmessaoudi@uky.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187161/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, Oregon National Primate Research Center, University of California, Irvine
Keywords: SARS-CoV-2, alcohol, lung, scRNA-seq, inflammation, primates
Summary of Study: Alcohol consumption dysregulates immune response in lungs
References: doi: 10.1101/2023.05.02.539139. Preprint
Contact Info: Ilhelm Messaoudi: ilhelmmessaoudi@uky.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187161/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., Warradale, Australia; Flinders University, Bedford Park, Australia; others
Keywords: SARS-CoV-2, spike protein, adjuvanted vaccine, immune response, primates
Summary of Study: Advax-CpG55.2™ adjuvanted recombinant spike protein vaccine protects cynomolgus macaques from a homologous SARS-CoV-2 virus challenge.
References: DOI: 10.1016/j.vaccine.2023.06.063
Contact Info: Nikolai Petrovsky: nikolai.petrovsky@vaxine.net
URL: https://www.sciencedirect.com/science/article/pii/S0264410X2300748X?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., Warradale, Australia; Flinders University, Bedford Park, Australia; others
Keywords: SARS-CoV-2, spike protein, adjuvanted vaccine, immune response, primates
Summary of Study: Advax-CpG55.2™ adjuvanted recombinant spike protein vaccine protects cynomolgus macaques from a homologous SARS-CoV-2 virus challenge.
References: DOI: 10.1016/j.vaccine.2023.06.063
Contact Info: Nikolai Petrovsky: nikolai.petrovsky@vaxine.net
URL: https://www.sciencedirect.com/science/article/pii/S0264410X2300748X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: NIAID, Bethesda MD; Weizmann Inst. Of Science, Rehovot, Israel; others
Keywords: SARS-CoV-2, in vitro evolution, ACE2 binding affinity, airways, immune response, primates
Summary of Study: RBD-based high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
References: DOI: 10.1101/2023.06.09.544432
Contact Info: Daniel Douek: ddouek@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2023.06.09.544432v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: NIAID, Bethesda MD; Weizmann Inst. Of Science, Rehovot, Israel; others
Keywords: SARS-CoV-2, in vitro evolution, ACE2 binding affinity, airways, immune response, primates
Summary of Study: RBD-based high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
References: DOI: 10.1101/2023.06.09.544432
Contact Info: Daniel Douek: ddouek@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2023.06.09.544432v1