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Coronavirus Studies in Nonhuman Primate Models

This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing, China; Cell Culture Engineering Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Keywords: SARS-CoV-2, nanoparticle vaccine, immunogenicity, toxicity, primates
Summary of Study: COVID-19 vaccine showed high immunogenicity and low toxicity in animal models
References: doi: 10.3390/vaccines11030526
Contact Info: Liangzhi Xie: LX@sinocelltech.com
URL: https://www.mdpi.com/2076-393X/11/3/526
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Seattle, Washington USA; HDT Bio, Washington National Primate Research Center, others
Keywords: SARS-CoV-2, replicon RNA vaccine, immune response and protection, primates
Summary of Study: Replicon RNA vaccine for durable protective immunity
References: PMID: 37075079 / doi: 10.1371/journal.ppat.1011298
Contact Info: Jesse Erasmus: jesse.erasmus@hdt.bio
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011298
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China; others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Preclinical safety evaluation of intradermal SARS-CoV-2 inactivated vaccine (Vero cells) administration in macaques.
References: DOI: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: liqihan@imbcams.com.cn
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Molecular Genetics, University of Toronto; Toronto, Canada; Icosagen Cell Factory OÜ; Tartu, Estonia; others
Keywords: SARS-CoV-2, humanized antibodies, immune response, vaccine, primates
Summary of Study: bnAb protection through inhalation-based delivery
References: DOI: 10.1371/journal.ppat.1011532
Contact Info: Mart Ustav, Jr.: mart.ustav.jr@icosagen.com
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011532
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, Production Division, Havana, Cuba
Keywords: SARS-CoV-2, chimeric antigen, vaccine, immune response, mice, primates
Summary of Study: chimeric antigen, based on nucleocapsid of SARS-CoV-2 fused to the extracellular domain of human CD154 in HEK-293 cells
References: DOI: 10.1371/journal.pone.0288006
Contact Info: Mario Pablo Estrada: mario.pablo@cigb.edu.cu; Yamila Carpio: yamila.carpio@cigb.edu.cu
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288006
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven Belgium
Keywords: SARS-CoV-2, review, vaccine development, mice, hamsters, primates
Summary of Study: Do we need nasal vaccines against COVID 19
References: doi: 10.1111/1751-7915.14181
Contact Info: Harald Brüssow: haraldbruessow@yahoo.com
URL: https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14181
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland; Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Mary
Keywords: SARS-CoV-2, deep learning, computerized tomography, lung lesions, primates
Summary of Study: Modeling whole lung and lung lesions to detect and quantify disease
References: doi: 10.1016/j.acra.2023.02.027
Contact Info: Jeffrey.solomon@nih.gov
URL: https://pubmed.ncbi.nlm.nih.gov/36966070/
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia and others
Keywords: SARS-CoV-2, nucleocapsid (N) protein, vaccine, immune response, pathology, mice, hamsters, primates
Summary of Study: Recombinant nucleocapsid-based vaccine Convacell®.
References: PMID: 37112786 / doi: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: sevastyan@rabdano.ru
URL: https://www.mdpi.com/2076-393X/11/4/874
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; others
Keywords: SARS-CoV-2, spatial transcriptomic profiling, lungs, virus variants, primates
Summary of Study: Comparative spatial transcriptomic profiling of severe acute respiratory syndrome coronavirus 2 Delta and Omicron variants infections in the lungs of cynomolgus macaques.
References: DOI: 10.1002/jmv.28847
Contact Info: Jung Joo Hong: hong75@kribb.re.kr
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28847
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Neurobiology and Aging, Biomedical Primate Research Centre (BPRC), Lange Kleiweg 161, 2288GJ, Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, neuroinflammation, positron emission tomography, brain, primates
Summary of Study: Widespread neuroinflammation in SARS-CoV-2 infection
References: DOI: 10.1186/s12974-023-02857-z
Contact Info: Jinte Middeldorp: middeldorp@bprc.nl
URL: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02857-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, University of California Irvine, USA
Keywords: SARS-CoV-2, alcohol, lung, scRNA sequencing, flow cytometry, primates
Summary of Study: Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lung
References: DOI: 10.1016/j.ebiom.2023.104812
Contact Info: Ilhem Messaoudi: ilhem@messaoudi@uky.edu
URL: https://www.sciencedirect.com/science/article/pii/S235239642300378X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX; Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX; others
Keywords: SARS-CoV-2, Molnupiravir, efficacy, oral administration, primates
Summary of Study: Evaluation of the drug molnupiravir (EIDD-2801) for mild to moderate COVID-19
References: doi: 10.1016/j.antiviral.2022.105492
Contact Info: Jason Comer: jscomer@utmb.edu
URL: https://www.sciencedirect.com/science/article/pii/S0166354222002613?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Veterinary Research Institute, Lahore, Pakistan; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan; others
Keywords: SARS-CoV-2, inactivated vaccine, efficacy, immunogenicity, virus variant, rabbits, primates
Summary of Study: Molecular characterization and selection of delta variant for vaccine
References: doi: 10.3390/vaccines11030607
Contact Info: Tahir Yaqub: tahiryaqub@uvas.edu.pk
URL: https://www.mdpi.com/2076-393X/11/3/607
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand and others
Keywords: SARS-CoV-2, recombinant plant-based RBD vaccine, immunogenicity, efficacy, safety, mice, primates
Summary of Study: Recombinant plant based RBD vaccine formulated with 3M-052-Alum adjuvant
References: PMID: 36963999 / doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: Waranyoo.P@chula.ac.th
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: lushuaiyao-km@163.com
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University School of Medicine; Emory, Oregon and Tulane NPRCs; numerous others
Keywords: SARS-CoV-2, IFN-I, immune response, pathology, primates
Summary of Study: Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation
References: DOI: 10.1126/sciimmunol.adg0033
Contact Info: Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.science.org/doi/10.1126/sciimmunol.adg0033
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Research Institute of Cardiology and Internal Medicine, Almaty, KazakhstanInternational Center for Vaccinology, Kazakh National Agrarian Research University (KazNARU), Almaty, Kazakhstan; others
Keywords: SARS-CoV-2, vaccine, adjuvant, immune response, safety, hamsters, primates
Summary of Study: Evaluation of spike protein ectodomain subunit vaccine with squalene emulsion adjuvant
References: DOI: 10.1080/21645515.2023.2258571
Contact Info: Kairat Tabynov: ktabynov@gmail.com
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2023.2258571
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland; Adimab LLC, Lebanon, New Hampshire; Invivyd, Inc., Waltham, Massachusetts; others
Keywords: SARS-CoV-2, Adintrevimab, prophylactics, viral load, pathology, hamsters, primates
Summary of Study: Monoclonal Antibody Adintrevimab Protects against COVID-19
References: doi: 10.1128/aac.01353-22
Contact Info: Kristin Narayan: knarayan@invivyd.com
URL: https://journals.asm.org/doi/10.1128/aac.01353-22
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi and GSK
Keywords: SARS-CoV-2, booster vaccine candidates, immune response, virus variants, primates
Summary of Study: Beta variant COVID-19 protein booster vaccine elicits durable cross-neutralization against SARS-CoV-2 variants
References: doi: 10.1038/s41467-023-36908-z
Contact Info: Valerie Lecouturier: valerie.lecouturier@sanofi.com
URL: https://www.nature.com/articles/s41467-023-36908-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China and others
Keywords: SARS-CoV-2, intradermal inactivated vaccine, immune response, virus variants, primates
Summary of Study: Preclinical safety evaluation of Intradermal inactivated vaccine (vero cells) administration
References: PMID: 37003910 / doi: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: liqihan@imbcams.com.cn
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: lushuaiyao-km@163.com
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain; others
Keywords: SARS-CoV-2, PHH-1V, vaccine, immune response, airways, primates
Summary of Study: Preclinical evaluation of PHH-1V vaccine candidate
References: DOI: 10.1016/j.isci.2023.107224
Contact Info: Antoni Prenafeta: antoni.prenafata@hipra.com
URL: https://www.sciencedirect.com/science/article/pii/S2589004223013019?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Dhirubhai Ambani Life Sciences Centre, Reliance Life Sciences Pvt. Ltd., Rabale, Navi Mubai, India
Keywords: SARS-CoV-2, vaccine, dual receptor binding domain, immune response, safety, several species, primates
Summary of Study: Safety, immunogenicity and efficacy of Relcovax®
References: DOI: 10.1016/j.vaccine.2023.10.006
Contact Info: R.L. Ramnath: ramnath.l@relbio.com
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23011763?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai , China; Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease and Biosecurity, others.
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus protection, primates
Summary of Study: Pan-sarbecovirus vaccines against sarbecoviruses, including SARS-CoV-2 and its variants
References: doi: 10.1073/pnas.2221713120
Contact Info: LuLu: lul@fudan.edu.cn (and other authors
URL: https://www.pnas.org/doi/10.1073/pnas.2221713120
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, others
Keywords: SARS-CoV-2, nelfinavir, prophylactics, virus protection, humans, primates
Summary of Study: Nelfinavir preventive and therapeutic effects
References: PMID: 37095086 / doi: 10.1038/s41392-023-01429-0
Contact Info: Weiliang Zhu: wlzhu@simm.ac.cn
URL: https://www.nature.com/articles/s41392-023-01429-0
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institut Pasteur, Université Paris Cité, National Reference Center for Respiratory Viruses, Paris, France; others
Keywords: SARS-CoV-2, monoclonal antibody treatment, immune response, primates
Summary of Study: Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model.
References: DOI: 10.1016/j.heliyon.2023.e16664
Contact Info: Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.sciencedirect.com/science/article/pii/S2405844023038719?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China; others
Keywords: SARS-CoV-2, transcriptome analysis, virus variants, subgenomic RNA, primates
Summary of Study: Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs
References: doi:10.1016/j.gpb.2023.06.002
Contact Info: Xiaozhong Peng: pengxiaozhong@pumc.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S1672022923000955?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France
Keywords: SARS-CoV-2, intestinal mucosal barrier, inflammation, pathology, primates
Summary of Study: Intestinal immunological events of acute and resolved infection
References: DOI: 10.1016/j.mucimm.2023.10.001
Contact Info: Mariangela Cavarelli: mariangela.cavarelli@cea.fr
URL: https://www.sciencedirect.com/science/article/pii/S193302192300079X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Texas Biomedical Research Institute, Institute of Science and Technology on Biomodels, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Keywords: SARS-CoV-2, review, coinfections, primate models, housing, screening
Summary of Study: Eliminating Potential Effects of Other Infections During Selection of Nonhuman Primates for COVID-19 Research
References: doi: 10.30802/AALAS-CM-21-000086
Contact Info: Marcia Andrade: marcia.andrade@fiocruz.br
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00003…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA; others
Keywords: SARS-CoV-2, tetravalent S1 subunit protein vaccine, immune response, virus variants, primates
Summary of Study: Tetravalent S1 subunit protein vaccination elicits robust humoral and cellular immune responses
References: doi: 10.1101/2023.03.15.532808. Preprint
Contact Info: Christian Apetrei: apetreic@pitt.edu
URL: https://www.biorxiv.org/content/10.1101/2023.03.15.532808v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Patronus Biotech Co. Ltd., Yantai, China
Keywords: SARS-CoV-2, RBD virus-like particle vaccine, immune response, virus infection, mice, primates
Summary of Study: RBD virus-like particle vaccine induces cross-variant antibody responses
References: PMID: 37120453 / doi: 10.1038/s41392-023-01425-4
Contact Info: Yuanyuan Li: liyuanyuan@luye.com
URL: https://www.nature.com/articles/s41392-023-01425-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Pathology, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Liège, Belgium; others
Keywords: SARS-CoV-2, macrophages, single-cell RNA-seq analysis, immune response, hamsters, primates
Summary of Study: Central role of lung macrophages in SARS-CoV-2 physiopathology: a cross-model single-cell RNA-seq perspective.
References: DOI: 10.3389/fimmu.2023.1197588
Contact Info: Thibaut Olivier: t.olivier@uliege.be
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197588/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitas Airlangga, Surabaya, Indonesia
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine candidate immunization
References: DOI: 10.1016/j.heliyon.2023.e18039
Contact Info: Fedik Abdul Rantam: fedik-a-r@fkh.unair.ac.id
URL: https://www.sciencedirect.com/science/article/pii/S2405844023052477?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA; University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania, USA; others
Keywords: SARS-CoV-2, tetravalent vaccine, adjuvant, immune response, primates
Summary of Study: Tetravalent SARS-CoV-2 S1 subunit protein vaccination
References: DOI: 10.1128/mbio.02070-23
Contact Info: Andrea Gambotto: gambottoa@upmc.edu
URL: https://journals.asm.org/doi/full/10.1128/mbio.02070-23?rfr_dat=cr_pub%20%200pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: kelsey.carpenter2@wayne.edu
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00006
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Mymetics SA, Epalinges, Switzerland; Department of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, influenza virosomes, vaccine, immune response, primates
Summary of Study: Low dose RBD and TLR7/8 agonist displayed on influenza virosome particles is protective
References: doi: 10.1038/s41598-023-31818-y
Contact Info: Sylvain Fleury: sylvain.fleury@mymetics.com
URL: https://pubmed.ncbi.nlm.nih.gov/36977691/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune, India
Keywords: SARS-CoV-2, immune response, virus variants, vaccine, primates
Summary of Study: Immune response in aged monkeys post vaccine
References: doi: 10.3389/fimmu.2023.1161571
Contact Info: Pragya Yadov: hellopragya22@gmail.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161571/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; others
Keywords: SARS-CoV-2, mRNA-lipid nanoparticle vaccine candidate, safety, immune response, mice, primate
Summary of Study: Characterization of stability, safety and immunogenicity of the mRNA lipid nanoparticle vaccine Iribovax® against COVID-19 in nonhuman primates.
References: DOI: 10.1016/j.jconrel.2023.06.025
Contact Info: Sina Mozaffari-Jovin: Mozaffaris@mums.ac.ir
URL: https://www.sciencedirect.com/science/article/pii/S016836592300398X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Bioqual, Rockville, MD; NHLBI, NIAID, others
Keywords: SARS-CoV-2, clonal hematopoiesis, transplantation, immune response, pathology, primates
Summary of Study: Impact of clonal hematopoiesis on severity and pathophysiology
References: DOI: 10.3389/fvets.2023.1182197
Contact Info: Tae-Hoon Shin: shinlab@jejunu.ac.kr
URL: https://www.frontiersin.org/articles/10.3389/fvets.2023.1182197/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: various
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institute of Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA; others
Keywords: SARS-CoV-2, review, preclinical models, neuropathic physiology, several species, primates
Summary of Study: Preclinical models for studying COVID-19 neurologic diseases
References: DOI: 10.1021/acsptsci.3c00127
Contact Info: Hu Wang: jhmi.edu
URL: https://pubs.acs.org/doi/full/10.1021/acsptsci.3c00127
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven Belgium
Keywords: SARS-CoV-2, review, vaccine development, mice, hamsters, primates
Summary of Study: Do we need nasal vaccines against COVID 19
References: doi: 10.1111/1751-7915.14181
Contact Info: Harald Brüssow: haraldbruessow@yahoo.com
URL: https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14181
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2023
Study Type/Review:
NPRC/Institute: Center for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, Louisiana; Tulane National Primate Research Center, Covington, Louisiana, others
Keywords: SARS-CoV-2, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal fluid protein markers indicate neuro-damage
References: doi: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: jfan5@tulane.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, Oregon National Primate Research Center, University of California, Irvine
Keywords: SARS-CoV-2, alcohol, lung, scRNA-seq, inflammation, primates
Summary of Study: Alcohol consumption dysregulates immune response in lungs
References: doi: 10.1101/2023.05.02.539139. Preprint
Contact Info: Ilhelm Messaoudi: ilhelmmessaoudi@uky.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187161/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., Warradale, Australia; Flinders University, Bedford Park, Australia; others
Keywords: SARS-CoV-2, spike protein, adjuvanted vaccine, immune response, primates
Summary of Study: Advax-CpG55.2™ adjuvanted recombinant spike protein vaccine protects cynomolgus macaques from a homologous SARS-CoV-2 virus challenge.
References: DOI: 10.1016/j.vaccine.2023.06.063
Contact Info: Nikolai Petrovsky: nikolai.petrovsky@vaxine.net
URL: https://www.sciencedirect.com/science/article/pii/S0264410X2300748X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: NIAID, Bethesda MD; Weizmann Inst. Of Science, Rehovot, Israel; others
Keywords: SARS-CoV-2, in vitro evolution, ACE2 binding affinity, airways, immune response, primates
Summary of Study: RBD-based high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
References: DOI: 10.1101/2023.06.09.544432
Contact Info: Daniel Douek: ddouek@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2023.06.09.544432v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, Islamabad, Pakistan; Department of Pathology and Laboratory Medicine, University of California, Davis, Davis, California, USA; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, humans, primates
Summary of Study: Immune responses in nonhuman primates and humans immunized with COVID-19 vaccines
References: DOI: 10.1371/journal.pone.0287377
Contact Info: Imran H. Khan: ihkahn@ucdavis.edu
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287377
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX; Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX; others
Keywords: SARS-CoV-2, Molnupiravir, efficacy, oral administration, primates
Summary of Study: Evaluation of the drug molnupiravir (EIDD-2801) for mild to moderate COVID-19
References: doi: 10.1016/j.antiviral.2022.105492
Contact Info: Jason Comer: jscomer@utmb.edu
URL: https://www.sciencedirect.com/science/article/pii/S0166354222002613?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Social and Administrative Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Center of Excellence in Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok, Thailand; others.
Keywords: SARS-CoV-2, plant-produced subunit vaccine, receptor binding domain, neutralizing antibody, primates
Summary of Study: Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based vaccine
References: doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: Waranyoo.P@chula.ac.th
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Stanford University, Scripps Research Institute, others
Keywords: SARS-CoV-2, virus variants, vaccine, immune response, primates
Summary of Study: Extremely potent monoclonal antibodies (mAbs) neutralize multiple sarbecoviruses from macaques vaccinated with AS03-adjuvanted monovalent subunit vaccines.
References: doi: 10.1126/scitranslmed.adg7404
Contact Info: Bali Pulendran: bpulend@stanford.edu
URL: https://www.science.org/doi/10.1126/scitranslmed.adg7404
Coronavirus Investigated:
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College Yunnan China.; State Key Laboratory of Common Mechanism Research for Major Diseases Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing China; others
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, liver, virus variants, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS?CoV?2?associated liver injury
References: DOI: 10.1002/mco2.358
Contact Info: Juntao Yang: yangjt@pumc.edu.cn
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458660/