Transplantation of aggregates containing rhesus primordial germ cell-like cells (rPGCLCs) from induced pluripotent stem cells into mouse and nonhuman primate testicles overcomes a major bottleneck in rPGCLC differentiation. The findings suggest that immature rPGCLCs once transplanted into an adult gonadal niche commit to differentiate towards late rhesus primordial germ cells that initiate epigenetic reprogramming but do not complete the conversion into spermatogonia.
Strategic Plan Section
Developing Models of Human Diseases - Continue to develop and enhance human disease models and research-related resource programs to advance medical research