Researchers at Yale School Medicine quantified regional distribution of over 5000 proteins in gray matter tissue samples of developing human brain. By integrating the protein data with existing whole-transcriptome sequencing from the BrainSpan project, they noted larger regional differences in protein abundance than in RNA abundance. Comparison of structurally similar neocortical regions indicated presence of potential “protein only” region markers. Two ORIP-funded instruments were used in the study: a liquid chromatography system (S10OD019967) and a mass spectrometer (S10OD018034). Over the years, these instruments supported many projects funded by NIGMS, NINDS, NIDDK, NCI, NIAID, NHLBI, NIDA, NIAMS, NEI, and NIA.
Strategic Plan Section
Accelerating Research Discoveries by Providing Access to State-of-the-Art Instrumentation - Continue to accelerate research discoveries by providing access to state-of-the-art instrumentation