Researchers at University of Pittsburgh used the ORIP-funded confocal microscope (S10OD021540) in the study of the role of the astrocytic NHE1 protein in development of reactive astrogliosis and neurovascular damage after ischemic stroke. In a mouse model, deletion of astrocytic Nhe1 gene inhibited astrogliosis, reduced stroke volume, prevented blood-brain-barrier damage, and improved regional cerebral blood flow after ischemic stroke, providing evidence of causative role of the NHE1 protein in reactive astrogliosis and neurovascular damage after ischemic injury. The instrument, placed in Center for Biologic Imaging, supports projects in diverse fields such as cell biology, developmental biology, neurobiology, and infectious disease.
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Accelerating Research Discoveries by Providing Access to State-of-the-Art Instrumentation - Continue to accelerate research discoveries by providing access to state-of-the-art instrumentation