New cryo-EM detectors allow collecting high-quality data, yielding previously non-attainable high-resolution structures of proteins such as ion channels. Here, researchers at Duke and Scripps report a 4.1 A resolution structure of a member of the transient receptor potential melastatin cation channel family. This result contributes to fundamental understanding of channel activation, gating, and interfacial interactions in the context of cold-sensing. Data were analyzed with an ORIP-awarded computer cluster (S10OD021634). The cluster (awarded in 2016, installed in 2017) made a mark on research supported by NIBIB, NIGMS, and NINDS, and reported in 4 high-profile publications.
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Accelerating Research Discoveries by Providing Access to State-of-the-Art Instrumentation - Continue to accelerate research discoveries by providing access to state-of-the-art instrumentation