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Mutant Mouse Resource & Research Center at UNC-Chapel Hill

Grant Number: U42OD010924

Research Emphasis/Objectives

The research emphasis/objectives of the Mutant Mouse Research & Resource Center at The University of North Carolina at Chapel Hill (MMRRC-UNC) are the following:

  • Provide the mouse community access to updated computational tools to facilitate mouse genomics research.
  • Improve and standardize genome background analysis and reporting.
  • Develop a speed congenic analysis pipeline as the basis for a potential new service for the mouse genomics community.
  • Identify genomic regions in the mature sperm epigenome that differ by diet treatment and can be used as biomarkers to detect and reduce diet-induced variability in the MMRRC repository.
  • Measure the impact of changing from donor institution diet to MMRRC diet on sperm quality and epigenetics status.
  • Identify microbes required for colitis phenotype in collaborative cross strain.
  • Evaluate and validate the causative and functional role of identified hybrid microbiota and/or consortia in the pathogenesis of spontaneous colitis.

Services Provided

  1. Import, archive, distribute genetically engineered mouse strains, embryonic stem cell lines, and mouse embryonic fibroblast lines.
  2. Systems genetics for predictive mouse biology platforms, pipelines, and tools.
  3. Ensure quality control (genotype and genomic quality, health status, microbiome analysis).
  4. Consultation.
  5. Research and partnerships.
  6. Broad mouse services available from the UNC mouse program: collaborative cross, Gnotobiotic Rodent Resource, behavioral genetics, regenerative medicine, whole-animal imaging, high-throughput sequencing and informatics, systems immunogenetics, Mouse Phase I Unit, Animal Models Core, translational science.

Contact Information

MMRRC-UNC
CB#7519
Chapel Hill, NC 27599-7519
med.unc.edu/mmrrc

Principal Investigator

Terry Magnuson
Phone: 919-962-1319
Fax: 919-962-1476
tmagnuson@unc.edu