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Immune-compromised Zebrafish for Cell Transplantation

Grant Number: R24OD016761

Research Emphasis/Objectivesgraphics showing an immune compromised zebrafish and imagery of immunotherapy, pharmacokinetics, therapy responses, single cell imaging, drug discovery and robust engraftment

Our resource develops much-needed optically clear immune-compromised zebrafish for use in allograft and xenograft cell transplantation. These models facilitate direct visualization of engrafted cells at single-cell resolution, can be reared at 37ºC facilitating engraftment of human tissues, and are amenable to large-scale transplantation studies. These models are being optimized for preclinical validation of small molecule, biologics, and immunotherapies for the treatment of cancer and other diseases.

Services Provided

We develop and distribute a wide array of immune-deficient zebrafish lines to investigators around the world. We also optimize engraftment procedures and husbandry to efficiently grow human tissues within adult zebrafish.

Contact Information

Immune-deficient Zebrafish Resource Stock Center
149 13th Street
Charlestown, MA 02180
langenaulab.com/fish-orders

Principal Investigator

David Langenau, Ph.D.
Phone: 617-643-6508
dlangenau@mgh.harvard.edu