California National Primate Research Center (SPF Program)

Production of Pedigreed Specific-Pathogen-Free Rhesus Macaques

Grant Number: U42 OD010990

Research Emphasis/Objectives

The objective of this program at the California National Primate Research Center (CNPRC) is to produce pedigreed rhesus macaques of Indian origin that are free of selected viral pathogens. These agents include Cercopithecine herpesvirus 1 (herpes B), simian immunodeficiency virus (SIV), simian T-lymphotropic virus 1, type D retrovirus, and simian foamy virus (SFV). These animals are of known pedigrees confirmed by microsatellite testing and also are typed for Mamu-A*01 alleles by the University of California, Davis (UC Davis), Veterinary Genetics Laboratory. Colony status is confirmed by frequent viral screening through the Simian Retroviral Core Laboratory.

Research programs are in place to use assisted reproductive technology strategies to expand numbers of Mamu-A*01-positive animals and other genotypes that may be of specific research interest. The CNPRC is also identifying additional viral pathogens to be excluded from the specific-pathogen-free (SPF) population. Genetic studies are underway to determine whether A*01-positive individuals are heterozygous or homozygous.

Services Provided

Animals

Scientists wishing to use pedigreed Indian-origin rhesus macaques should contact the principal investigator. Scientists wishing to conduct research at the CNPRC should contact the director. Information for research access to the primate center is available on CNPRC's website.

Other Services

Pedigree analysis and major histocompatibility complex (MHC) typing for rhesus macaques is available through the UC Davis Veterinary Genetics Laboratory.

Contact Information

California National Primate Research Center
University of California, Davis
One Shields Avenue
Davis, CA 95616-8542
cnprc.ucdavis.edu

Principal Investigator

Jeffrey A. Roberts, D.V.M.
Phone: 530-752-6490
jaroberts@ucdavis.edu

Last updated: 09-15-2021