BioGRID: Biological General Repository for Interaction Datasets

Grant Number: R01 OD010929

BioGRID LogoResearch Emphasis/Objectives

The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein interaction data from model organisms and humans. BioGRID currently holds over 1,400,000 interactions curated from both high-throughput datasets and individual focused studies, as derived from over 57,000 publications in the primary literature. Complete coverage of the entire literature is maintained for budding yeast (S. cerevisiae), fission yeast (S. pombe), and thale cress (A. thaliana), and efforts to expand curation across multiple metazoan species are underway.

Services Provided

Current curation drives are focused on particular areas of biology to enable insights into conserved networks and pathways that are relevant to human health. The BioGRID 3.2 web interface contains new search and display features that enable rapid queries across multiple data types and sources. BioGRID provides interaction data to several model organism databases, resources such as Entrez-Gene, SGD, TAIR, FlyBase, and other interaction meta-databases. The entire BioGRID 3.2 data collection may be downloaded in multiple file formats, including IMEx compatible PSI MI XML. For developers, BioGRID interactions are also available via a REST-based Web Service and Cytoscape plugin. All BioGRID documentation is available online in the BioGRID Wiki.

Contact Information

Mount Sinai Hospital
Lunenfeld-Tanenbaum Research Institute
600 University Avenue
Toronto, Ontario CAN M5G 1X5

Principal Investigator

Mike Tyers
Phone: 416-586-4800

Last updated: 08-16-2021