Recent scientific and technological advances, such as affordable whole genome sequencing and molecular profiling, enable us to study the genetics and pathogenesis of many human diseases. The goal of using this information is to provide patient-precise treatments based on their unique genetic composition and molecular phenotype. Obstacles to this goal are the absence of an effective means to interpret patient genetic/omic data for clinical use in diverse patient populations. Creating animal models to generate reliable preclinical data for human studies is a fundamental step needed to reach the goal.

In response, the ORIP Division of Comparative Medicine initiated the Pilot Centers for Precision Disease Modeling program to provide advanced animal models to the biomedical community for: 1) examining the causal relationships of genetics and omic information to human biology and disease; 2) validating disease-associated genetic variations and biomarkers; 3) reducing drug candidate attrition; and 4) developing new individualized therapies for monogenic and complex disorders. These Centers are creating pipelines for pre-clinical scientific discovery, disease modeling, and development of interventions based on innovative animal models. Eventually these preclinical pipelines may play an integral role in patient diagnostics, care and therapeutic treatment.