Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxart, Inc., South San Francisco, CA 94080, USA
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity, mucosal, primates
Summary of Study: Adenoviral Vaccine Elicits Mucosal and Systemic Immunogenicity and Reduces Viral Shedding
References: PMID: 38400116 PMCID: PMC10893453 DOI: 10.3390/vaccines12020132
Contact Info: Becca Flitter: [email protected]
URL: https://www.mdpi.com/2076-393X/12/2/132
NHP Species: african green monkeys
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxart, Inc., South San Francisco, CA 94080, USA
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity, mucosal, primates
Summary of Study: Adenoviral Vaccine Elicits Mucosal and Systemic Immunogenicity and Reduces Viral Shedding
References: PMID: 38400116 PMCID: PMC10893453 DOI: 10.3390/vaccines12020132
Contact Info: Becca Flitter: [email protected]
URL: https://www.mdpi.com/2076-393X/12/2/132
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Vaccine and Immunotherapy Center, the Wistar Institute of Anatomy and Biology, Philadelphia, PA; others
Keywords: SARS-CoV-2, monoclonal antibody, DNA-encoded, immune response, pathology, primates
Summary of Study: Engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis
References: PMID: 38165394 DOI: 10.1080/22221751.2023.2294860
Contact Info: Heinz Feldman: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2294860
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Vaccine and Immunotherapy Center, the Wistar Institute of Anatomy and Biology, Philadelphia, PA; others
Keywords: SARS-CoV-2, monoclonal antibody, DNA-encoded, immune response, pathology, primates
Summary of Study: Engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis
References: PMID: 38165394 DOI: 10.1080/22221751.2023.2294860
Contact Info: Heinz Feldman: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2294860
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, bone marrow LLPCs, spike protein vaccine, immune response, primates
Summary of Study: Adjuvanted spike protein vaccination elicits long-lived plasma cells
References: PMID: 38170789 DOI: 10.1126/scitranslmed.add5960
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.add5960?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, bone marrow LLPCs, spike protein vaccine, immune response, primates
Summary of Study: Adjuvanted spike protein vaccination elicits long-lived plasma cells
References: PMID: 38170789 DOI: 10.1126/scitranslmed.add5960
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.add5960?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Keywords: SARS-CoV-2, pregnancy, pathogenesis, different viruses, animal species, primates
Summary of Study: Pathogenesis of viral infections during pregnancy
References: PMID: 38421182 DOI: 10.1128/cmr.00073-23
Contact Info: Sabra Klein: [email protected]
URL: https://journals.asm.org/doi/10.1128/cmr.00073-23?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Keywords: SARS-CoV-2, pregnancy, pathogenesis, different viruses, animal species, primates
Summary of Study: Pathogenesis of viral infections during pregnancy
References: PMID: 38421182 DOI: 10.1128/cmr.00073-23
Contact Info: Sabra Klein: [email protected]
URL: https://journals.asm.org/doi/10.1128/cmr.00073-23?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; others
Keywords: SARS-CoV-2, spike Ferritin Nanoparticle (SpFN) vaccine, neutralizing antibodies, primates
Summary of Study: Neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination
References: PMID: 38172512 PMCID: PMC10764318 DOI: 10.1038/s41467-023-44265-0
Contact Info: Shelly Krebs: [email protected]
URL: https://www.nature.com/articles/s41467-023-44265-0
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; others
Keywords: SARS-CoV-2, spike Ferritin Nanoparticle (SpFN) vaccine, neutralizing antibodies, primates
Summary of Study: Neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination
References: PMID: 38172512 PMCID: PMC10764318 DOI: 10.1038/s41467-023-44265-0
Contact Info: Shelly Krebs: [email protected]
URL: https://www.nature.com/articles/s41467-023-44265-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Research & Development Center, Cellid Co., Ltd., Seoul 08826, Republic of Korea; others
Keywords: SARS-CoV-2, multivalent vaccine, adenovirus vector, immune response, primates
Summary of Study: Multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform
References: PMID: 38408238 PMCID: PMC10927586 DOI: 10.1073/pnas.2313681121
Contact Info: Chang-Yuil Kang: [email protected]
URL: https://www.pnas.org/doi/abs/10.1073/pnas.2313681121?url_ver=Z39.88-2003&rfr_id…
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Research & Development Center, Cellid Co., Ltd., Seoul 08826, Republic of Korea; others
Keywords: SARS-CoV-2, multivalent vaccine, adenovirus vector, immune response, primates
Summary of Study: Multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform
References: PMID: 38408238 PMCID: PMC10927586 DOI: 10.1073/pnas.2313681121
Contact Info: Chang-Yuil Kang: [email protected]
URL: https://www.pnas.org/doi/abs/10.1073/pnas.2313681121?url_ver=Z39.88-2003&rfr_id…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Medical biology, Chinese Academy of Medical Sciences and Peking Union Medical School (IMBCAMS&PUMC), 5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China; others
Keywords: SARS-CoV-2, gastrointestinal infection, virus variants, immune response, microbiota, primates
Summary of Study: Gastrointestinal microbiota and metabolites possibly contribute to distinct pathogenicity
References: PMID: 38563680 PMCID: PMC10989708 DOI: 10.1080/19490976.2024.2334970
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2334970
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Medical biology, Chinese Academy of Medical Sciences and Peking Union Medical School (IMBCAMS&PUMC), 5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China; others
Keywords: SARS-CoV-2, gastrointestinal infection, virus variants, immune response, microbiota, primates
Summary of Study: Gastrointestinal microbiota and metabolites possibly contribute to distinct pathogenicity
References: PMID: 38563680 PMCID: PMC10989708 DOI: 10.1080/19490976.2024.2334970
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2334970
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA; others
Keywords: SARS-CoV-2, bivalent mRNA vaccine, virus variants, SIV, immune response, primates
Summary of Study: Neutralizing antibody response to bivalent mRNA vaccine
References: PMID: 38528837 PMCID: PMC10987079 (available on 2025-03-01) DOI: 10.1002/jmv.29520
Contact Info: Huanbin Xu: [email protected]; Shan-Lu Lui: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.29520
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA; others
Keywords: SARS-CoV-2, bivalent mRNA vaccine, virus variants, SIV, immune response, primates
Summary of Study: Neutralizing antibody response to bivalent mRNA vaccine
References: PMID: 38528837 PMCID: PMC10987079 (available on 2025-03-01) DOI: 10.1002/jmv.29520
Contact Info: Huanbin Xu: [email protected]; Shan-Lu Lui: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.29520
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Stemirna Therapeutics, Shanghai 201206, China; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, safety profile, rodents, primates
Summary of Study: Inoculation site-retained mRNA vaccine
References: PMID: 38184234 DOI: 10.1016/j.jconrel.2024.01.002
Contact Info: Haifa Shen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0168365924000063?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Stemirna Therapeutics, Shanghai 201206, China; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, safety profile, rodents, primates
Summary of Study: Inoculation site-retained mRNA vaccine
References: PMID: 38184234 DOI: 10.1016/j.jconrel.2024.01.002
Contact Info: Haifa Shen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0168365924000063?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands; others
Keywords: SARS-CoV-2, antibody therapy, filamentous fungus expression system, immune response, primates
Summary of Study: Filamentous fungus-produced human monoclonal antibody provides protection
References: PMID: 38485931 PMCID: PMC10940701 DOI: 10.1038/s41467-024-46443-0
Contact Info: Bart L. Haagmans: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940701/
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands; others
Keywords: SARS-CoV-2, antibody therapy, filamentous fungus expression system, immune response, primates
Summary of Study: Filamentous fungus-produced human monoclonal antibody provides protection
References: PMID: 38485931 PMCID: PMC10940701 DOI: 10.1038/s41467-024-46443-0
Contact Info: Bart L. Haagmans: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940701/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao, China; others
Keywords: SARS-CoV-2, virus receptor proteins, ocular hypertension, immunofluorescence, humans and primates
Summary of Study: Expression of SARS-CoV-2 Receptor ACE2 and Protease TMPRSS2 in Ocular Hypertension
References: PMID: 38212998 DOI: 10.1080/02713683.2023.2291749
Contact Info: Jun-Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/02713683.2023.2291749
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao, China; others
Keywords: SARS-CoV-2, virus receptor proteins, ocular hypertension, immunofluorescence, humans and primates
Summary of Study: Expression of SARS-CoV-2 Receptor ACE2 and Protease TMPRSS2 in Ocular Hypertension
References: PMID: 38212998 DOI: 10.1080/02713683.2023.2291749
Contact Info: Jun-Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/02713683.2023.2291749
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai 200032, China; others
Keywords: SARS-CoV-2, receptor-binding domain, virus variants, immune response, primates
Summary of Study: Neutralization of SARS-CoV-2 BA.2.86 and JN.1 by CF501 adjuvant-enhanced immune responses targeting the conserved epitopes in ancestral RBD
References: PMID: 38428429 PMCID: PMC10983032 DOI: 10.1016/j.xcrm.2024.101445
Contact Info: Lu Lu: lul@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379124000685?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai 200032, China; others
Keywords: SARS-CoV-2, receptor-binding domain, virus variants, immune response, primates
Summary of Study: Neutralization of SARS-CoV-2 BA.2.86 and JN.1 by CF501 adjuvant-enhanced immune responses targeting the conserved epitopes in ancestral RBD
References: PMID: 38428429 PMCID: PMC10983032 DOI: 10.1016/j.xcrm.2024.101445
Contact Info: Lu Lu: lul@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379124000685?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: Research & Development-Science, Research and Innovation, Medicines and Healthcare products Regulatory Agency, South Mimms, Hertfordshire EN6 3QG, UK.
Keywords: SARS-CoV-2, host genetics, emerging viruses, global public health, primates
Summary of Study: Host immunogenetics on infectious disease studies
References: PMID: 38257982 PMCID: PMC10818626 DOI: 10.3390/microorganisms12010155
Contact Info: Neil Berry: [email protected]
URL: https://www.mdpi.com/2076-2607/12/1/155
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: Research & Development-Science, Research and Innovation, Medicines and Healthcare products Regulatory Agency, South Mimms, Hertfordshire EN6 3QG, UK.
Keywords: SARS-CoV-2, host genetics, emerging viruses, global public health, primates
Summary of Study: Host immunogenetics on infectious disease studies
References: PMID: 38257982 PMCID: PMC10818626 DOI: 10.3390/microorganisms12010155
Contact Info: Neil Berry: [email protected]
URL: https://www.mdpi.com/2076-2607/12/1/155
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; others
Keywords: SARS-CoV-2, mRNA delivery, jet injector; lipid nanoparticle, mRNA vaccine, primates
Summary of Study: Carrier-free mRNA vaccine induces robust immunity
References: PMID: 38569556 DOI: 10.1016/j.ymthe.2024.03.022
Contact Info: Satoshi Uchida: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001624001631?via%3Dihub=
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; others
Keywords: SARS-CoV-2, mRNA delivery, jet injector; lipid nanoparticle, mRNA vaccine, primates
Summary of Study: Carrier-free mRNA vaccine induces robust immunity
References: PMID: 38569556 DOI: 10.1016/j.ymthe.2024.03.022
Contact Info: Satoshi Uchida: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001624001631?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden; others
Keywords: SARS-CoV-2, Novavax’s protein vaccines, immune response, virus variants, primates
Summary of Study: Novavax protein vaccines increase antibody breadth and provide durable protection
References: PMID: 38245545 PMCID: PMC10799869 DOI: 10.1038/s41541-024-00806-2
Contact Info: Karin Loré: [email protected]
URL: https://www.nature.com/articles/s41541-024-00806-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden; others
Keywords: SARS-CoV-2, Novavax’s protein vaccines, immune response, virus variants, primates
Summary of Study: Novavax protein vaccines increase antibody breadth and provide durable protection
References: PMID: 38245545 PMCID: PMC10799869 DOI: 10.1038/s41541-024-00806-2
Contact Info: Karin Loré: [email protected]
URL: https://www.nature.com/articles/s41541-024-00806-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, sooty mangabeys
Year Published: 2024
Study Type/Review: therapeutics, review
NPRC/Institute: Laboratory of Liver Infectious Diseases, Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Keywords: SARS-CoV-2, preclinical animal model, therapeutic antibodies, immune response, rodents, primates
Summary of Study: Preclinical animal models to evaluate therapeutic antiviral antibodies
References: PMID: 38548022 DOI: 10.1016/j.antiviral.2024.105843
Contact Info: Phlip Meuleman: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354224000512?via%3Dihub=
NHP Species: rhesus macaques, cynomolgus macaques, sooty mangabeys
Year Published: 2024
Study Type/Review: therapeutics, review
NPRC/Institute: Laboratory of Liver Infectious Diseases, Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Keywords: SARS-CoV-2, preclinical animal model, therapeutic antibodies, immune response, rodents, primates
Summary of Study: Preclinical animal models to evaluate therapeutic antiviral antibodies
References: PMID: 38548022 DOI: 10.1016/j.antiviral.2024.105843
Contact Info: Phlip Meuleman: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354224000512?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., 11-13 Walkley Avenue, Warradale, SA 5046, Australia; BIOQUAL, Inc., 9600 Medical Center Drive, Rockville, MD 20850-3336, USA
Keywords: SARS-CoV-2, recombinant protein vaccine, immune response, virus variants, primates
Summary of Study: Recombinant protein-based vaccine delivered by intramuscular and mucosal routes
References: PMID: 38262808 DOI: 10.1016/j.vaccine.2024.01.034
Contact Info: Nikolai Petrovsky: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X24000343?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., 11-13 Walkley Avenue, Warradale, SA 5046, Australia; BIOQUAL, Inc., 9600 Medical Center Drive, Rockville, MD 20850-3336, USA
Keywords: SARS-CoV-2, recombinant protein vaccine, immune response, virus variants, primates
Summary of Study: Recombinant protein-based vaccine delivered by intramuscular and mucosal routes
References: PMID: 38262808 DOI: 10.1016/j.vaccine.2024.01.034
Contact Info: Nikolai Petrovsky: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X24000343?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Guangzhou Laboratory, Bio-island, Guangzhou, China: others
Keywords: SARS-CoV-2, Siglec-9, bivalent vaccines, immune response, primates
Summary of Study: Receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis
References: PMID: 38454157 DOI: 10.1038/s41590-024-01776-2
Contact Info: Hui Zhang: [email protected]
URL: https://www.nature.com/articles/s41590-024-01776-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Guangzhou Laboratory, Bio-island, Guangzhou, China: others
Keywords: SARS-CoV-2, Siglec-9, bivalent vaccines, immune response, primates
Summary of Study: Receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis
References: PMID: 38454157 DOI: 10.1038/s41590-024-01776-2
Contact Info: Hui Zhang: [email protected]
URL: https://www.nature.com/articles/s41590-024-01776-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Keywords: SARS-CoV-2, aerosols, inoculation route, virus replication, tropism, primates
Summary of Study: Upper vs. lower respiratory virus replication
References: PMID: 38261786 DOI: 10.1093/infdis/jiae018
Contact Info: Neeltje van Doremalen: [email protected]
URL: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae018/7585664…
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Keywords: SARS-CoV-2, aerosols, inoculation route, virus replication, tropism, primates
Summary of Study: Upper vs. lower respiratory virus replication
References: PMID: 38261786 DOI: 10.1093/infdis/jiae018
Contact Info: Neeltje van Doremalen: [email protected]
URL: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae018/7585664…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China; others
Keywords: SARS-CoV-2, mRNA vaccine, lipopolyplex, immunogenicity, virus variants, primates
Summary of Study: Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex
References: PMID: 38557908 PMCID: PMC11008869 DOI: 10.1371/journal.ppat.1012116
Contact Info: George Fu Gao: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012116
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China; others
Keywords: SARS-CoV-2, mRNA vaccine, lipopolyplex, immunogenicity, virus variants, primates
Summary of Study: Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex
References: PMID: 38557908 PMCID: PMC11008869 DOI: 10.1371/journal.ppat.1012116
Contact Info: George Fu Gao: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012116
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510182, China; others
Keywords: SARS-CoV-2, animal models, immune response, multiomics, variety of animal species, primates
Summary of Study: Immunity in animal models
References: PMID: 38238440 PMCID: PMC10806257 DOI: 10.1038/s41423-023-01122-w
Contact Info: Jing Sun: [email protected]
URL: https://www.nature.com/articles/s41423-023-01122-w
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510182, China; others
Keywords: SARS-CoV-2, animal models, immune response, multiomics, variety of animal species, primates
Summary of Study: Immunity in animal models
References: PMID: 38238440 PMCID: PMC10806257 DOI: 10.1038/s41423-023-01122-w
Contact Info: Jing Sun: [email protected]
URL: https://www.nature.com/articles/s41423-023-01122-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, Fontenay-aux-Roses, France; others
Keywords: SARS-CoV-2, VLA2001 vaccine, immunogenicity, pathology, primates
Summary of Study: Immunogenicity and efficacy of VLA2001 vaccine
References: PMID: 38570605 PMCID: PMC10991505 DOI: 10.1038/s43856-024-00488-w
Contact Info: Roger LeGrand: [email protected]
URL: https://www.nature.com/articles/s43856-024-00488-w
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, Fontenay-aux-Roses, France; others
Keywords: SARS-CoV-2, VLA2001 vaccine, immunogenicity, pathology, primates
Summary of Study: Immunogenicity and efficacy of VLA2001 vaccine
References: PMID: 38570605 PMCID: PMC10991505 DOI: 10.1038/s43856-024-00488-w
Contact Info: Roger LeGrand: [email protected]
URL: https://www.nature.com/articles/s43856-024-00488-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan; others
Keywords: SARS-CoV-2, olfactory mucosa, immune response, melanocytes primates
Summary of Study: Inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway
References: PMID: 38237527 DOI: 10.1016/j.jneuroim.2024.578288
Contact Info: Shino Shimizu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0165572824000067?via%3Dihub=
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan; others
Keywords: SARS-CoV-2, olfactory mucosa, immune response, melanocytes primates
Summary of Study: Inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway
References: PMID: 38237527 DOI: 10.1016/j.jneuroim.2024.578288
Contact Info: Shino Shimizu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0165572824000067?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan; Central Research Laboratory, Shiga University of Medical Science, Otsu, Japan.; others
Keywords: SARS-CoV-2, CD38, endothelial cells, lungs, immune response, primates
Summary of Study: Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection
References: PMID: 38507920 DOI: 10.1016/j.virol.2024.110052
Contact Info: Yasushi Itoh: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0042682224000734?via%3Dihub=
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan; Central Research Laboratory, Shiga University of Medical Science, Otsu, Japan.; others
Keywords: SARS-CoV-2, CD38, endothelial cells, lungs, immune response, primates
Summary of Study: Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection
References: PMID: 38507920 DOI: 10.1016/j.virol.2024.110052
Contact Info: Yasushi Itoh: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0042682224000734?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: [email protected]
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00006
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: [email protected]
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00006
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Massachusetts General Hospital, Charlestown, Massachusetts USA; Brigham and Women's Hospital, Boston, Massachusetts, and others
Keywords: SARS-CoV-2, review, brain autopsies, neuropathological findings, humans, animal models, primates
Summary of Study: Review: What Can We Still Learn from Brain Autopsies in COVID-19?
References: PMID: 37023787 / doi: 10.1055/s-0043-1767716
Contact Info: Shibani Mukerji: [email protected]
URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-17677…
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Massachusetts General Hospital, Charlestown, Massachusetts USA; Brigham and Women's Hospital, Boston, Massachusetts, and others
Keywords: SARS-CoV-2, review, brain autopsies, neuropathological findings, humans, animal models, primates
Summary of Study: Review: What Can We Still Learn from Brain Autopsies in COVID-19?
References: PMID: 37023787 / doi: 10.1055/s-0043-1767716
Contact Info: Shibani Mukerji: [email protected]
URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-17677…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200438, China., many others
Keywords: SARS-CoV-2, vaccine, mRNA-based T-cell-inducing antigen, immune response, primates
Summary of Study: mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine
References: doi: 10.1038/s41467-023-38751-8
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.nature.com/articles/s41467-023-38751-8
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200438, China., many others
Keywords: SARS-CoV-2, vaccine, mRNA-based T-cell-inducing antigen, immune response, primates
Summary of Study: mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine
References: doi: 10.1038/s41467-023-38751-8
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.nature.com/articles/s41467-023-38751-8
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: prevention
NPRC/Institute: Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, 889-2155, Japan; Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, 305-0843, Japan.; others
Keywords: SARS-CoV-2, ACE2 decoy, immune response, pathology, mice, hamsters, primates
Summary of Study: Inhaled ACE2 decoy confers protection
References: DOI: 10.1126/scitranslmed.adi2623
Contact Info: Atsushi Hoshino: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adi2623
NHP Species:
Year Published: 2023
Study Type/Review: prevention
NPRC/Institute: Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, 889-2155, Japan; Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, 305-0843, Japan.; others
Keywords: SARS-CoV-2, ACE2 decoy, immune response, pathology, mice, hamsters, primates
Summary of Study: Inhaled ACE2 decoy confers protection
References: DOI: 10.1126/scitranslmed.adi2623
Contact Info: Atsushi Hoshino: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adi2623
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Executive Office, Shanghai BravoBio Co., Ltd., Shanghai, China; BravoVax Co., Ltd., Wuhan, China
Keywords: SARS-CoV-2, adenovirus vaccine, aerosol inhalation, immune response, primates
Summary of Study: Aerosol Inhalation of Chimpanzee Adenovirus Vectors (ChAd68) Expressing Ancestral or Omicron BA.1 Stabilized Pre-Fusion Spike Glycoproteins
References: DOI: 10.3390/vaccines11091427
Contact Info: Ke Wu: [email protected]
URL: https://www.mdpi.com/2076-393X/11/9/1427
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Executive Office, Shanghai BravoBio Co., Ltd., Shanghai, China; BravoVax Co., Ltd., Wuhan, China
Keywords: SARS-CoV-2, adenovirus vaccine, aerosol inhalation, immune response, primates
Summary of Study: Aerosol Inhalation of Chimpanzee Adenovirus Vectors (ChAd68) Expressing Ancestral or Omicron BA.1 Stabilized Pre-Fusion Spike Glycoproteins
References: DOI: 10.3390/vaccines11091427
Contact Info: Ke Wu: [email protected]
URL: https://www.mdpi.com/2076-393X/11/9/1427
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Cognitive and Neural Science Program, Department of Psychology, University of South Carolina, Columbia, SC, 29208, USA; others
Keywords: SARS-CoV-2, nervous system, pathophysiology, virus persistence, primates
Summary of Study: Viral persistence in central nervous system despite clinical recovery
References: PMID: 37934362 PMCID: PMC10630293 DOI: 10.1186/s43556-023-00153-z
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630293/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Cognitive and Neural Science Program, Department of Psychology, University of South Carolina, Columbia, SC, 29208, USA; others
Keywords: SARS-CoV-2, nervous system, pathophysiology, virus persistence, primates
Summary of Study: Viral persistence in central nervous system despite clinical recovery
References: PMID: 37934362 PMCID: PMC10630293 DOI: 10.1186/s43556-023-00153-z
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630293/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: NIAID, NIH, Bethesda, MD 20892, USA.
Keywords: SARS-CoV-2, murine pneumonia virus-vectored vaccine, immune response, primates
Summary of Study: Intranasal murine pneumonia virus-vectored vaccine induces mucosal and serum antibodies
References: PMID: 38144450 PMCID: PMC10746510 DOI: 10.1016/j.isci.2023.108490
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004223025671?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: NIAID, NIH, Bethesda, MD 20892, USA.
Keywords: SARS-CoV-2, murine pneumonia virus-vectored vaccine, immune response, primates
Summary of Study: Intranasal murine pneumonia virus-vectored vaccine induces mucosal and serum antibodies
References: PMID: 38144450 PMCID: PMC10746510 DOI: 10.1016/j.isci.2023.108490
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004223025671?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, 46113 Valencia, Spain; others
Keywords: SARS-CoV-2, captive animals, one health, serological testing, primates
Summary of Study: Molecular and serological studies
References: PMID: 38200871 PMCID: PMC10778278 DOI: 10.3390/ani14010140
Contact Info: Consuelo Rubio-Guerri: [email protected]
URL: https://www.mdpi.com/2076-2615/14/1/140
NHP Species: lemurs
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, 46113 Valencia, Spain; others
Keywords: SARS-CoV-2, captive animals, one health, serological testing, primates
Summary of Study: Molecular and serological studies
References: PMID: 38200871 PMCID: PMC10778278 DOI: 10.3390/ani14010140
Contact Info: Consuelo Rubio-Guerri: [email protected]
URL: https://www.mdpi.com/2076-2615/14/1/140
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane NPRC; Duke University Medical Center
Keywords: SARS-CoV-2, prophylactic administration, convalescent plasma, disease progression and severity, primates
Summary of Study: Convalescent plasma administration results in suboptimal prophylaxis against SARS-CoV-2 infection
References: doi: 10.3389/fimmu.2023.1085883
Contact Info: Chad Roy: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1085883/full
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane NPRC; Duke University Medical Center
Keywords: SARS-CoV-2, prophylactic administration, convalescent plasma, disease progression and severity, primates
Summary of Study: Convalescent plasma administration results in suboptimal prophylaxis against SARS-CoV-2 infection
References: doi: 10.3389/fimmu.2023.1085883
Contact Info: Chad Roy: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1085883/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University, Emory National Primate Research Center, others
Keywords: SARS-CoV-2, innate immune system, airway inflammation, humans, primates
Summary of Study: TREM2+ and interstitial-like macrophages orchestrate airway inflammation
References: PMID: 37024448 / doi: 10.1038/s41467-023-37425-9
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.nature.com/articles/s41467-023-37425-9
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University, Emory National Primate Research Center, others
Keywords: SARS-CoV-2, innate immune system, airway inflammation, humans, primates
Summary of Study: TREM2+ and interstitial-like macrophages orchestrate airway inflammation
References: PMID: 37024448 / doi: 10.1038/s41467-023-37425-9
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.nature.com/articles/s41467-023-37425-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310000, China, others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Delta (B.1.617.2) inactivated vaccine candidate elicits neutralizing antibodies
References: doi: 10.1016/j.virs.2023.05.009
Contact Info: Keda Chen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X23000573?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310000, China, others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Delta (B.1.617.2) inactivated vaccine candidate elicits neutralizing antibodies
References: doi: 10.1016/j.virs.2023.05.009
Contact Info: Keda Chen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X23000573?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: KRIBB School of Bioscience, Korea University of Science & Technology (UST), Daejeon, Republic of Korea; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungcheongbuk, Republic of Korea.; others
Keywords: SARS-CoV-2, spatial transcriptome atlas, lungs, immune response, primates
Summary of Study: Pulmonary microstructure-specific COVID-19 gene signatures
References: DOI: 10.1038/s42003-023-05253-8
Contact Info: Jung Joo Hong: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462721/
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: KRIBB School of Bioscience, Korea University of Science & Technology (UST), Daejeon, Republic of Korea; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungcheongbuk, Republic of Korea.; others
Keywords: SARS-CoV-2, spatial transcriptome atlas, lungs, immune response, primates
Summary of Study: Pulmonary microstructure-specific COVID-19 gene signatures
References: DOI: 10.1038/s42003-023-05253-8
Contact Info: Jung Joo Hong: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462721/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of South Carolina; Tulane National Primate Research Center
Keywords: SARS-CoV-2, brain, pathology, in situ hybridization, primates
Summary of Study: SARS-CoV-2 RNA Persists in the Central Nervous System despite clinical recovery
References: DOI: 10.1101/2023.08.29.555368
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491216/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of South Carolina; Tulane National Primate Research Center
Keywords: SARS-CoV-2, brain, pathology, in situ hybridization, primates
Summary of Study: SARS-CoV-2 RNA Persists in the Central Nervous System despite clinical recovery
References: DOI: 10.1101/2023.08.29.555368
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491216/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, Adenoviral-vectored Vaccine Boosting, immune response, primates
Summary of Study: Mucosal adenoviral-vectored vaccine boosting prevents XBB.1.16 infection
References: bioRxiv. 2023 Nov 8:2023.11.06.565765. doi: 10.1101/2023.11.06.565765. Preprint. PMID: 37986823 PMCID: PMC10659340 DOI: 10.1101/2023.11.06.565765
Contact Info: Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.06.565765v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, Adenoviral-vectored Vaccine Boosting, immune response, primates
Summary of Study: Mucosal adenoviral-vectored vaccine boosting prevents XBB.1.16 infection
References: bioRxiv. 2023 Nov 8:2023.11.06.565765. doi: 10.1101/2023.11.06.565765. Preprint. PMID: 37986823 PMCID: PMC10659340 DOI: 10.1101/2023.11.06.565765
Contact Info: Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.06.565765v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510300, P. R. China, many others
Keywords: SARS-CoV-2, mosaic RBD nanoparticle vaccine, immune response, primates
Summary of Study: Mosaic RBD nanoparticles elicit protective immunity
References: PMID: 38105421 DOI: 10.1002/advs.202303366
Contact Info: Jincun Zhao: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10916629/
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510300, P. R. China, many others
Keywords: SARS-CoV-2, mosaic RBD nanoparticle vaccine, immune response, primates
Summary of Study: Mosaic RBD nanoparticles elicit protective immunity
References: PMID: 38105421 DOI: 10.1002/advs.202303366
Contact Info: Jincun Zhao: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10916629/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, subunit vaccine, virus strains, primates
Summary of Study: Immunogenicity and protective efficacy of GBP510/AS03 vaccine
References: doi: 10.1038/s41541-023-00622-0
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41541-023-00622-0
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, subunit vaccine, virus strains, primates
Summary of Study: Immunogenicity and protective efficacy of GBP510/AS03 vaccine
References: doi: 10.1038/s41541-023-00622-0
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41541-023-00622-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Consortium on Pathogen Readiness, Boston, MA USA and others
Keywords: SARS-CoV-2, omicron spike protein encoding vaccine, boosters, immune response, primates
Summary of Study: Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy
References: PMID: 37029141 / 10.1038/s41467-023-37715-2
Contact Info: Frank Wegmann: [email protected]
URL: https://www.nature.com/articles/s41467-023-37715-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Consortium on Pathogen Readiness, Boston, MA USA and others
Keywords: SARS-CoV-2, omicron spike protein encoding vaccine, boosters, immune response, primates
Summary of Study: Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy
References: PMID: 37029141 / 10.1038/s41467-023-37715-2
Contact Info: Frank Wegmann: [email protected]
URL: https://www.nature.com/articles/s41467-023-37715-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi, Vaccines R&D, Marcy l'Etoile, France, and others
Keywords: SARS-CoV-2, bivalent vaccine, virus variants, immune response, primates
Summary of Study: Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization
References: doi: 10.1038/s43856-023-00302-z
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212738/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi, Vaccines R&D, Marcy l'Etoile, France, and others
Keywords: SARS-CoV-2, bivalent vaccine, virus variants, immune response, primates
Summary of Study: Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization
References: doi: 10.1038/s43856-023-00302-z
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212738/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany; Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany; others
Keywords: SARS-CoV-2, review, tuberculosis, pathogenesis, several species, primates
Summary of Study: Animal models for COVID-19 and tuberculosis
References: DOI: 10.3389/fimmu.2023.1223260
Contact Info: Björn Corleis: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223260/full
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany; Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany; others
Keywords: SARS-CoV-2, review, tuberculosis, pathogenesis, several species, primates
Summary of Study: Animal models for COVID-19 and tuberculosis
References: DOI: 10.3389/fimmu.2023.1223260
Contact Info: Björn Corleis: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223260/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: West China Hospital Sichuan University Chengdu China; Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan China; others
Keywords: SARS-CoV-2, spheroid-embryonoid stem cells, viral variants, immune response, primates
Summary of Study: 3D-engineered multifunctional biologics to reverse immune system evasion
References: DOI: 10.1002/btm2.10554
Contact Info: Xiancheng Chen: [email protected]
URL: https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10554
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: West China Hospital Sichuan University Chengdu China; Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan China; others
Keywords: SARS-CoV-2, spheroid-embryonoid stem cells, viral variants, immune response, primates
Summary of Study: 3D-engineered multifunctional biologics to reverse immune system evasion
References: DOI: 10.1002/btm2.10554
Contact Info: Xiancheng Chen: [email protected]
URL: https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10554
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Frederick National Laboratory for Cancer Research, Frederick, MD, USA; others
Keywords: SARS-CoV-2, machine-learning, radiomics, biomarkers, immune response, disease progression, primates
Summary of Study: Novel machine-learning analysis of infection using radiomics and blood biomarkers
References: PMID: 37950044 PMCID: PMC10638262 DOI: 10.1038/s41598-023-46694-9
Contact Info: Jeffrey Solomon: [email protected]
URL: https://www.nature.com/articles/s41598-023-46694-9
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Frederick National Laboratory for Cancer Research, Frederick, MD, USA; others
Keywords: SARS-CoV-2, machine-learning, radiomics, biomarkers, immune response, disease progression, primates
Summary of Study: Novel machine-learning analysis of infection using radiomics and blood biomarkers
References: PMID: 37950044 PMCID: PMC10638262 DOI: 10.1038/s41598-023-46694-9
Contact Info: Jeffrey Solomon: [email protected]
URL: https://www.nature.com/articles/s41598-023-46694-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Bremen, Bremen, Germany and others
Keywords: SARS-CoV-2, mRNA vaccination, elderly animals, immune response, primates
Summary of Study: Monitoring vaccination in laboratory rhesus monkeys
References: doi: 10.1038/s41598-023-30473-7
Contact Info: Detlef Wegener: [email protected]
URL: https://www.nature.com/articles/s41598-023-30473-7
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Bremen, Bremen, Germany and others
Keywords: SARS-CoV-2, mRNA vaccination, elderly animals, immune response, primates
Summary of Study: Monitoring vaccination in laboratory rhesus monkeys
References: doi: 10.1038/s41598-023-30473-7
Contact Info: Detlef Wegener: [email protected]
URL: https://www.nature.com/articles/s41598-023-30473-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chan Zuckerberg Biohub, Stanford University, others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, virus variants, primates
Summary of Study: Ferritin-based nanoparticle vaccine
References: PMID: 37069151 / doi: 10.1038/s41467-023-37417-9
Contact Info: Peter S Kim: [email protected]
URL: https://www.nature.com/articles/s41467-023-37417-9
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chan Zuckerberg Biohub, Stanford University, others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, virus variants, primates
Summary of Study: Ferritin-based nanoparticle vaccine
References: PMID: 37069151 / doi: 10.1038/s41467-023-37417-9
Contact Info: Peter S Kim: [email protected]
URL: https://www.nature.com/articles/s41467-023-37417-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
Keywords: SARS-CoV-2, vaccine, immune response, primates
Summary of Study: Humoral immunogenicity of DNA vaccine delivered using needle-free jet injection
References: Doi: 10.1371/journal.pone.0275082
Contact Info: Jay Hooper: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0275082
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
Keywords: SARS-CoV-2, vaccine, immune response, primates
Summary of Study: Humoral immunogenicity of DNA vaccine delivered using needle-free jet injection
References: Doi: 10.1371/journal.pone.0275082
Contact Info: Jay Hooper: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0275082
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: SingHealth Duke-NUS Global Health Institute, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; others
Keywords: SARS-CoV-2, mast cells, lungs, pathology, mice, primates, humans.
Summary of Study: Mast cell activation in lungs and severe COVID-19
References: DOI: 10.1172/JCI149834
Contact Info: Ashley L. St. John: [email protected]
URL: https://www.jci.org/articles/view/149834
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: SingHealth Duke-NUS Global Health Institute, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; others
Keywords: SARS-CoV-2, mast cells, lungs, pathology, mice, primates, humans.
Summary of Study: Mast cell activation in lungs and severe COVID-19
References: DOI: 10.1172/JCI149834
Contact Info: Ashley L. St. John: [email protected]
URL: https://www.jci.org/articles/view/149834
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Intelligence & Technology Lab, Inc., Kaizu, Japan; Innovation Research Center, EPS Holdings, Inc., Tokyo, Japan.
Keywords: SARS-CoV-2, sublingual vaccine, receptor binding domain, immune response, primates
Summary of Study: sublingual vaccine with RBD antigen and poly(I:C) adjuvant
References: DOI: 10.1093/biomethods/bpad017
Contact Info: Shin Nakamura: [email protected]
URL: https://academic.oup.com/biomethods/article/8/1/bpad017/7266774
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Intelligence & Technology Lab, Inc., Kaizu, Japan; Innovation Research Center, EPS Holdings, Inc., Tokyo, Japan.
Keywords: SARS-CoV-2, sublingual vaccine, receptor binding domain, immune response, primates
Summary of Study: sublingual vaccine with RBD antigen and poly(I:C) adjuvant
References: DOI: 10.1093/biomethods/bpad017
Contact Info: Shin Nakamura: [email protected]
URL: https://academic.oup.com/biomethods/article/8/1/bpad017/7266774