Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Vaccine and Immunotherapy Center, the Wistar Institute of Anatomy and Biology, Philadelphia, PA; others
Keywords: SARS-CoV-2, monoclonal antibody, DNA-encoded, immune response, pathology, primates
Summary of Study: Engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis
References: PMID: 38165394 DOI: 10.1080/22221751.2023.2294860
Contact Info: Heinz Feldman: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2294860
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Vaccine and Immunotherapy Center, the Wistar Institute of Anatomy and Biology, Philadelphia, PA; others
Keywords: SARS-CoV-2, monoclonal antibody, DNA-encoded, immune response, pathology, primates
Summary of Study: Engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis
References: PMID: 38165394 DOI: 10.1080/22221751.2023.2294860
Contact Info: Heinz Feldman: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2294860
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, bone marrow LLPCs, spike protein vaccine, immune response, primates
Summary of Study: Adjuvanted spike protein vaccination elicits long-lived plasma cells
References: PMID: 38170789 DOI: 10.1126/scitranslmed.add5960
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.add5960?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, bone marrow LLPCs, spike protein vaccine, immune response, primates
Summary of Study: Adjuvanted spike protein vaccination elicits long-lived plasma cells
References: PMID: 38170789 DOI: 10.1126/scitranslmed.add5960
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.add5960?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Keywords: SARS-CoV-2, pregnancy, pathogenesis, different viruses, animal species, primates
Summary of Study: Pathogenesis of viral infections during pregnancy
References: PMID: 38421182 DOI: 10.1128/cmr.00073-23
Contact Info: Sabra Klein: [email protected]
URL: https://journals.asm.org/doi/10.1128/cmr.00073-23?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Keywords: SARS-CoV-2, pregnancy, pathogenesis, different viruses, animal species, primates
Summary of Study: Pathogenesis of viral infections during pregnancy
References: PMID: 38421182 DOI: 10.1128/cmr.00073-23
Contact Info: Sabra Klein: [email protected]
URL: https://journals.asm.org/doi/10.1128/cmr.00073-23?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; others
Keywords: SARS-CoV-2, spike Ferritin Nanoparticle (SpFN) vaccine, neutralizing antibodies, primates
Summary of Study: Neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination
References: PMID: 38172512 PMCID: PMC10764318 DOI: 10.1038/s41467-023-44265-0
Contact Info: Shelly Krebs: [email protected]
URL: https://www.nature.com/articles/s41467-023-44265-0
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; others
Keywords: SARS-CoV-2, spike Ferritin Nanoparticle (SpFN) vaccine, neutralizing antibodies, primates
Summary of Study: Neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination
References: PMID: 38172512 PMCID: PMC10764318 DOI: 10.1038/s41467-023-44265-0
Contact Info: Shelly Krebs: [email protected]
URL: https://www.nature.com/articles/s41467-023-44265-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Research & Development Center, Cellid Co., Ltd., Seoul 08826, Republic of Korea; others
Keywords: SARS-CoV-2, multivalent vaccine, adenovirus vector, immune response, primates
Summary of Study: Multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform
References: PMID: 38408238 PMCID: PMC10927586 DOI: 10.1073/pnas.2313681121
Contact Info: Chang-Yuil Kang: [email protected]
URL: https://www.pnas.org/doi/abs/10.1073/pnas.2313681121?url_ver=Z39.88-2003&rfr_id…
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Research & Development Center, Cellid Co., Ltd., Seoul 08826, Republic of Korea; others
Keywords: SARS-CoV-2, multivalent vaccine, adenovirus vector, immune response, primates
Summary of Study: Multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform
References: PMID: 38408238 PMCID: PMC10927586 DOI: 10.1073/pnas.2313681121
Contact Info: Chang-Yuil Kang: [email protected]
URL: https://www.pnas.org/doi/abs/10.1073/pnas.2313681121?url_ver=Z39.88-2003&rfr_id…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Medical biology, Chinese Academy of Medical Sciences and Peking Union Medical School (IMBCAMS&PUMC), 5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China; others
Keywords: SARS-CoV-2, gastrointestinal infection, virus variants, immune response, microbiota, primates
Summary of Study: Gastrointestinal microbiota and metabolites possibly contribute to distinct pathogenicity
References: PMID: 38563680 PMCID: PMC10989708 DOI: 10.1080/19490976.2024.2334970
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2334970
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Medical biology, Chinese Academy of Medical Sciences and Peking Union Medical School (IMBCAMS&PUMC), 5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China; others
Keywords: SARS-CoV-2, gastrointestinal infection, virus variants, immune response, microbiota, primates
Summary of Study: Gastrointestinal microbiota and metabolites possibly contribute to distinct pathogenicity
References: PMID: 38563680 PMCID: PMC10989708 DOI: 10.1080/19490976.2024.2334970
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2334970
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA; others
Keywords: SARS-CoV-2, bivalent mRNA vaccine, virus variants, SIV, immune response, primates
Summary of Study: Neutralizing antibody response to bivalent mRNA vaccine
References: PMID: 38528837 PMCID: PMC10987079 (available on 2025-03-01) DOI: 10.1002/jmv.29520
Contact Info: Huanbin Xu: [email protected]; Shan-Lu Lui: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.29520
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA; others
Keywords: SARS-CoV-2, bivalent mRNA vaccine, virus variants, SIV, immune response, primates
Summary of Study: Neutralizing antibody response to bivalent mRNA vaccine
References: PMID: 38528837 PMCID: PMC10987079 (available on 2025-03-01) DOI: 10.1002/jmv.29520
Contact Info: Huanbin Xu: [email protected]; Shan-Lu Lui: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.29520
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Stemirna Therapeutics, Shanghai 201206, China; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, safety profile, rodents, primates
Summary of Study: Inoculation site-retained mRNA vaccine
References: PMID: 38184234 DOI: 10.1016/j.jconrel.2024.01.002
Contact Info: Haifa Shen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0168365924000063?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Stemirna Therapeutics, Shanghai 201206, China; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, safety profile, rodents, primates
Summary of Study: Inoculation site-retained mRNA vaccine
References: PMID: 38184234 DOI: 10.1016/j.jconrel.2024.01.002
Contact Info: Haifa Shen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0168365924000063?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands; others
Keywords: SARS-CoV-2, antibody therapy, filamentous fungus expression system, immune response, primates
Summary of Study: Filamentous fungus-produced human monoclonal antibody provides protection
References: PMID: 38485931 PMCID: PMC10940701 DOI: 10.1038/s41467-024-46443-0
Contact Info: Bart L. Haagmans: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940701/
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: therapeutics
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands; others
Keywords: SARS-CoV-2, antibody therapy, filamentous fungus expression system, immune response, primates
Summary of Study: Filamentous fungus-produced human monoclonal antibody provides protection
References: PMID: 38485931 PMCID: PMC10940701 DOI: 10.1038/s41467-024-46443-0
Contact Info: Bart L. Haagmans: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940701/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao, China; others
Keywords: SARS-CoV-2, virus receptor proteins, ocular hypertension, immunofluorescence, humans and primates
Summary of Study: Expression of SARS-CoV-2 Receptor ACE2 and Protease TMPRSS2 in Ocular Hypertension
References: PMID: 38212998 DOI: 10.1080/02713683.2023.2291749
Contact Info: Jun-Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/02713683.2023.2291749
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao, China; others
Keywords: SARS-CoV-2, virus receptor proteins, ocular hypertension, immunofluorescence, humans and primates
Summary of Study: Expression of SARS-CoV-2 Receptor ACE2 and Protease TMPRSS2 in Ocular Hypertension
References: PMID: 38212998 DOI: 10.1080/02713683.2023.2291749
Contact Info: Jun-Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/02713683.2023.2291749
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai 200032, China; others
Keywords: SARS-CoV-2, receptor-binding domain, virus variants, immune response, primates
Summary of Study: Neutralization of SARS-CoV-2 BA.2.86 and JN.1 by CF501 adjuvant-enhanced immune responses targeting the conserved epitopes in ancestral RBD
References: PMID: 38428429 PMCID: PMC10983032 DOI: 10.1016/j.xcrm.2024.101445
Contact Info: Lu Lu: lul@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379124000685?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai 200032, China; others
Keywords: SARS-CoV-2, receptor-binding domain, virus variants, immune response, primates
Summary of Study: Neutralization of SARS-CoV-2 BA.2.86 and JN.1 by CF501 adjuvant-enhanced immune responses targeting the conserved epitopes in ancestral RBD
References: PMID: 38428429 PMCID: PMC10983032 DOI: 10.1016/j.xcrm.2024.101445
Contact Info: Lu Lu: lul@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379124000685?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: Research & Development-Science, Research and Innovation, Medicines and Healthcare products Regulatory Agency, South Mimms, Hertfordshire EN6 3QG, UK.
Keywords: SARS-CoV-2, host genetics, emerging viruses, global public health, primates
Summary of Study: Host immunogenetics on infectious disease studies
References: PMID: 38257982 PMCID: PMC10818626 DOI: 10.3390/microorganisms12010155
Contact Info: Neil Berry: [email protected]
URL: https://www.mdpi.com/2076-2607/12/1/155
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: Research & Development-Science, Research and Innovation, Medicines and Healthcare products Regulatory Agency, South Mimms, Hertfordshire EN6 3QG, UK.
Keywords: SARS-CoV-2, host genetics, emerging viruses, global public health, primates
Summary of Study: Host immunogenetics on infectious disease studies
References: PMID: 38257982 PMCID: PMC10818626 DOI: 10.3390/microorganisms12010155
Contact Info: Neil Berry: [email protected]
URL: https://www.mdpi.com/2076-2607/12/1/155
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; others
Keywords: SARS-CoV-2, mRNA delivery, jet injector; lipid nanoparticle, mRNA vaccine, primates
Summary of Study: Carrier-free mRNA vaccine induces robust immunity
References: PMID: 38569556 DOI: 10.1016/j.ymthe.2024.03.022
Contact Info: Satoshi Uchida: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001624001631?via%3Dihub=
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; others
Keywords: SARS-CoV-2, mRNA delivery, jet injector; lipid nanoparticle, mRNA vaccine, primates
Summary of Study: Carrier-free mRNA vaccine induces robust immunity
References: PMID: 38569556 DOI: 10.1016/j.ymthe.2024.03.022
Contact Info: Satoshi Uchida: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001624001631?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden; others
Keywords: SARS-CoV-2, Novavax’s protein vaccines, immune response, virus variants, primates
Summary of Study: Novavax protein vaccines increase antibody breadth and provide durable protection
References: PMID: 38245545 PMCID: PMC10799869 DOI: 10.1038/s41541-024-00806-2
Contact Info: Karin Loré: [email protected]
URL: https://www.nature.com/articles/s41541-024-00806-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden; others
Keywords: SARS-CoV-2, Novavax’s protein vaccines, immune response, virus variants, primates
Summary of Study: Novavax protein vaccines increase antibody breadth and provide durable protection
References: PMID: 38245545 PMCID: PMC10799869 DOI: 10.1038/s41541-024-00806-2
Contact Info: Karin Loré: [email protected]
URL: https://www.nature.com/articles/s41541-024-00806-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, sooty mangabeys
Year Published: 2024
Study Type/Review: therapeutics, review
NPRC/Institute: Laboratory of Liver Infectious Diseases, Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Keywords: SARS-CoV-2, preclinical animal model, therapeutic antibodies, immune response, rodents, primates
Summary of Study: Preclinical animal models to evaluate therapeutic antiviral antibodies
References: PMID: 38548022 DOI: 10.1016/j.antiviral.2024.105843
Contact Info: Phlip Meuleman: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354224000512?via%3Dihub=
NHP Species: rhesus macaques, cynomolgus macaques, sooty mangabeys
Year Published: 2024
Study Type/Review: therapeutics, review
NPRC/Institute: Laboratory of Liver Infectious Diseases, Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Keywords: SARS-CoV-2, preclinical animal model, therapeutic antibodies, immune response, rodents, primates
Summary of Study: Preclinical animal models to evaluate therapeutic antiviral antibodies
References: PMID: 38548022 DOI: 10.1016/j.antiviral.2024.105843
Contact Info: Phlip Meuleman: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354224000512?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., 11-13 Walkley Avenue, Warradale, SA 5046, Australia; BIOQUAL, Inc., 9600 Medical Center Drive, Rockville, MD 20850-3336, USA
Keywords: SARS-CoV-2, recombinant protein vaccine, immune response, virus variants, primates
Summary of Study: Recombinant protein-based vaccine delivered by intramuscular and mucosal routes
References: PMID: 38262808 DOI: 10.1016/j.vaccine.2024.01.034
Contact Info: Nikolai Petrovsky: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X24000343?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., 11-13 Walkley Avenue, Warradale, SA 5046, Australia; BIOQUAL, Inc., 9600 Medical Center Drive, Rockville, MD 20850-3336, USA
Keywords: SARS-CoV-2, recombinant protein vaccine, immune response, virus variants, primates
Summary of Study: Recombinant protein-based vaccine delivered by intramuscular and mucosal routes
References: PMID: 38262808 DOI: 10.1016/j.vaccine.2024.01.034
Contact Info: Nikolai Petrovsky: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X24000343?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Guangzhou Laboratory, Bio-island, Guangzhou, China: others
Keywords: SARS-CoV-2, Siglec-9, bivalent vaccines, immune response, primates
Summary of Study: Receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis
References: PMID: 38454157 DOI: 10.1038/s41590-024-01776-2
Contact Info: Hui Zhang: [email protected]
URL: https://www.nature.com/articles/s41590-024-01776-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Guangzhou Laboratory, Bio-island, Guangzhou, China: others
Keywords: SARS-CoV-2, Siglec-9, bivalent vaccines, immune response, primates
Summary of Study: Receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis
References: PMID: 38454157 DOI: 10.1038/s41590-024-01776-2
Contact Info: Hui Zhang: [email protected]
URL: https://www.nature.com/articles/s41590-024-01776-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Keywords: SARS-CoV-2, aerosols, inoculation route, virus replication, tropism, primates
Summary of Study: Upper vs. lower respiratory virus replication
References: PMID: 38261786 DOI: 10.1093/infdis/jiae018
Contact Info: Neeltje van Doremalen: [email protected]
URL: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae018/7585664…
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Keywords: SARS-CoV-2, aerosols, inoculation route, virus replication, tropism, primates
Summary of Study: Upper vs. lower respiratory virus replication
References: PMID: 38261786 DOI: 10.1093/infdis/jiae018
Contact Info: Neeltje van Doremalen: [email protected]
URL: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae018/7585664…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China; others
Keywords: SARS-CoV-2, mRNA vaccine, lipopolyplex, immunogenicity, virus variants, primates
Summary of Study: Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex
References: PMID: 38557908 PMCID: PMC11008869 DOI: 10.1371/journal.ppat.1012116
Contact Info: George Fu Gao: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012116
NHP Species: rhesus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China; others
Keywords: SARS-CoV-2, mRNA vaccine, lipopolyplex, immunogenicity, virus variants, primates
Summary of Study: Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex
References: PMID: 38557908 PMCID: PMC11008869 DOI: 10.1371/journal.ppat.1012116
Contact Info: George Fu Gao: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012116
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510182, China; others
Keywords: SARS-CoV-2, animal models, immune response, multiomics, variety of animal species, primates
Summary of Study: Immunity in animal models
References: PMID: 38238440 PMCID: PMC10806257 DOI: 10.1038/s41423-023-01122-w
Contact Info: Jing Sun: [email protected]
URL: https://www.nature.com/articles/s41423-023-01122-w
NHP Species: multiple species
Year Published: 2024
Study Type/Review: pathogenesis, review
NPRC/Institute: State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510182, China; others
Keywords: SARS-CoV-2, animal models, immune response, multiomics, variety of animal species, primates
Summary of Study: Immunity in animal models
References: PMID: 38238440 PMCID: PMC10806257 DOI: 10.1038/s41423-023-01122-w
Contact Info: Jing Sun: [email protected]
URL: https://www.nature.com/articles/s41423-023-01122-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, Fontenay-aux-Roses, France; others
Keywords: SARS-CoV-2, VLA2001 vaccine, immunogenicity, pathology, primates
Summary of Study: Immunogenicity and efficacy of VLA2001 vaccine
References: PMID: 38570605 PMCID: PMC10991505 DOI: 10.1038/s43856-024-00488-w
Contact Info: Roger LeGrand: [email protected]
URL: https://www.nature.com/articles/s43856-024-00488-w
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, Fontenay-aux-Roses, France; others
Keywords: SARS-CoV-2, VLA2001 vaccine, immunogenicity, pathology, primates
Summary of Study: Immunogenicity and efficacy of VLA2001 vaccine
References: PMID: 38570605 PMCID: PMC10991505 DOI: 10.1038/s43856-024-00488-w
Contact Info: Roger LeGrand: [email protected]
URL: https://www.nature.com/articles/s43856-024-00488-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan; others
Keywords: SARS-CoV-2, olfactory mucosa, immune response, melanocytes primates
Summary of Study: Inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway
References: PMID: 38237527 DOI: 10.1016/j.jneuroim.2024.578288
Contact Info: Shino Shimizu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0165572824000067?via%3Dihub=
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan; others
Keywords: SARS-CoV-2, olfactory mucosa, immune response, melanocytes primates
Summary of Study: Inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway
References: PMID: 38237527 DOI: 10.1016/j.jneuroim.2024.578288
Contact Info: Shino Shimizu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0165572824000067?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan; Central Research Laboratory, Shiga University of Medical Science, Otsu, Japan.; others
Keywords: SARS-CoV-2, CD38, endothelial cells, lungs, immune response, primates
Summary of Study: Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection
References: PMID: 38507920 DOI: 10.1016/j.virol.2024.110052
Contact Info: Yasushi Itoh: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0042682224000734?via%3Dihub=
NHP Species: cynomolgus macaques
Year Published: 2024
Study Type/Review: pathogenesis
NPRC/Institute: Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan; Central Research Laboratory, Shiga University of Medical Science, Otsu, Japan.; others
Keywords: SARS-CoV-2, CD38, endothelial cells, lungs, immune response, primates
Summary of Study: Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection
References: PMID: 38507920 DOI: 10.1016/j.virol.2024.110052
Contact Info: Yasushi Itoh: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0042682224000734?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxart, Inc., South San Francisco, CA 94080, USA
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity, mucosal, primates
Summary of Study: Adenoviral Vaccine Elicits Mucosal and Systemic Immunogenicity and Reduces Viral Shedding
References: PMID: 38400116 PMCID: PMC10893453 DOI: 10.3390/vaccines12020132
Contact Info: Becca Flitter: [email protected]
URL: https://www.mdpi.com/2076-393X/12/2/132
NHP Species: african green monkeys
Year Published: 2024
Study Type/Review: vaccine
NPRC/Institute: Vaxart, Inc., South San Francisco, CA 94080, USA
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity, mucosal, primates
Summary of Study: Adenoviral Vaccine Elicits Mucosal and Systemic Immunogenicity and Reduces Viral Shedding
References: PMID: 38400116 PMCID: PMC10893453 DOI: 10.3390/vaccines12020132
Contact Info: Becca Flitter: [email protected]
URL: https://www.mdpi.com/2076-393X/12/2/132
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, subunit vaccine, virus strains, primates
Summary of Study: Immunogenicity and protective efficacy of GBP510/AS03 vaccine
References: doi: 10.1038/s41541-023-00622-0
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41541-023-00622-0
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, subunit vaccine, virus strains, primates
Summary of Study: Immunogenicity and protective efficacy of GBP510/AS03 vaccine
References: doi: 10.1038/s41541-023-00622-0
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41541-023-00622-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Consortium on Pathogen Readiness, Boston, MA USA and others
Keywords: SARS-CoV-2, omicron spike protein encoding vaccine, boosters, immune response, primates
Summary of Study: Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy
References: PMID: 37029141 / 10.1038/s41467-023-37715-2
Contact Info: Frank Wegmann: [email protected]
URL: https://www.nature.com/articles/s41467-023-37715-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Consortium on Pathogen Readiness, Boston, MA USA and others
Keywords: SARS-CoV-2, omicron spike protein encoding vaccine, boosters, immune response, primates
Summary of Study: Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy
References: PMID: 37029141 / 10.1038/s41467-023-37715-2
Contact Info: Frank Wegmann: [email protected]
URL: https://www.nature.com/articles/s41467-023-37715-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi, Vaccines R&D, Marcy l'Etoile, France, and others
Keywords: SARS-CoV-2, bivalent vaccine, virus variants, immune response, primates
Summary of Study: Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization
References: doi: 10.1038/s43856-023-00302-z
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212738/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi, Vaccines R&D, Marcy l'Etoile, France, and others
Keywords: SARS-CoV-2, bivalent vaccine, virus variants, immune response, primates
Summary of Study: Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization
References: doi: 10.1038/s43856-023-00302-z
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212738/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany; Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany; others
Keywords: SARS-CoV-2, review, tuberculosis, pathogenesis, several species, primates
Summary of Study: Animal models for COVID-19 and tuberculosis
References: DOI: 10.3389/fimmu.2023.1223260
Contact Info: Björn Corleis: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223260/full
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany; Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany; others
Keywords: SARS-CoV-2, review, tuberculosis, pathogenesis, several species, primates
Summary of Study: Animal models for COVID-19 and tuberculosis
References: DOI: 10.3389/fimmu.2023.1223260
Contact Info: Björn Corleis: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223260/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: West China Hospital Sichuan University Chengdu China; Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan China; others
Keywords: SARS-CoV-2, spheroid-embryonoid stem cells, viral variants, immune response, primates
Summary of Study: 3D-engineered multifunctional biologics to reverse immune system evasion
References: DOI: 10.1002/btm2.10554
Contact Info: Xiancheng Chen: [email protected]
URL: https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10554
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: West China Hospital Sichuan University Chengdu China; Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan China; others
Keywords: SARS-CoV-2, spheroid-embryonoid stem cells, viral variants, immune response, primates
Summary of Study: 3D-engineered multifunctional biologics to reverse immune system evasion
References: DOI: 10.1002/btm2.10554
Contact Info: Xiancheng Chen: [email protected]
URL: https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10554
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Frederick National Laboratory for Cancer Research, Frederick, MD, USA; others
Keywords: SARS-CoV-2, machine-learning, radiomics, biomarkers, immune response, disease progression, primates
Summary of Study: Novel machine-learning analysis of infection using radiomics and blood biomarkers
References: PMID: 37950044 PMCID: PMC10638262 DOI: 10.1038/s41598-023-46694-9
Contact Info: Jeffrey Solomon: [email protected]
URL: https://www.nature.com/articles/s41598-023-46694-9
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Frederick National Laboratory for Cancer Research, Frederick, MD, USA; others
Keywords: SARS-CoV-2, machine-learning, radiomics, biomarkers, immune response, disease progression, primates
Summary of Study: Novel machine-learning analysis of infection using radiomics and blood biomarkers
References: PMID: 37950044 PMCID: PMC10638262 DOI: 10.1038/s41598-023-46694-9
Contact Info: Jeffrey Solomon: [email protected]
URL: https://www.nature.com/articles/s41598-023-46694-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Bremen, Bremen, Germany and others
Keywords: SARS-CoV-2, mRNA vaccination, elderly animals, immune response, primates
Summary of Study: Monitoring vaccination in laboratory rhesus monkeys
References: doi: 10.1038/s41598-023-30473-7
Contact Info: Detlef Wegener: [email protected]
URL: https://www.nature.com/articles/s41598-023-30473-7
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Bremen, Bremen, Germany and others
Keywords: SARS-CoV-2, mRNA vaccination, elderly animals, immune response, primates
Summary of Study: Monitoring vaccination in laboratory rhesus monkeys
References: doi: 10.1038/s41598-023-30473-7
Contact Info: Detlef Wegener: [email protected]
URL: https://www.nature.com/articles/s41598-023-30473-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chan Zuckerberg Biohub, Stanford University, others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, virus variants, primates
Summary of Study: Ferritin-based nanoparticle vaccine
References: PMID: 37069151 / doi: 10.1038/s41467-023-37417-9
Contact Info: Peter S Kim: [email protected]
URL: https://www.nature.com/articles/s41467-023-37417-9
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chan Zuckerberg Biohub, Stanford University, others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, virus variants, primates
Summary of Study: Ferritin-based nanoparticle vaccine
References: PMID: 37069151 / doi: 10.1038/s41467-023-37417-9
Contact Info: Peter S Kim: [email protected]
URL: https://www.nature.com/articles/s41467-023-37417-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
Keywords: SARS-CoV-2, vaccine, immune response, primates
Summary of Study: Humoral immunogenicity of DNA vaccine delivered using needle-free jet injection
References: Doi: 10.1371/journal.pone.0275082
Contact Info: Jay Hooper: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0275082
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
Keywords: SARS-CoV-2, vaccine, immune response, primates
Summary of Study: Humoral immunogenicity of DNA vaccine delivered using needle-free jet injection
References: Doi: 10.1371/journal.pone.0275082
Contact Info: Jay Hooper: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0275082
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: SingHealth Duke-NUS Global Health Institute, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; others
Keywords: SARS-CoV-2, mast cells, lungs, pathology, mice, primates, humans.
Summary of Study: Mast cell activation in lungs and severe COVID-19
References: DOI: 10.1172/JCI149834
Contact Info: Ashley L. St. John: [email protected]
URL: https://www.jci.org/articles/view/149834
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: SingHealth Duke-NUS Global Health Institute, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; others
Keywords: SARS-CoV-2, mast cells, lungs, pathology, mice, primates, humans.
Summary of Study: Mast cell activation in lungs and severe COVID-19
References: DOI: 10.1172/JCI149834
Contact Info: Ashley L. St. John: [email protected]
URL: https://www.jci.org/articles/view/149834
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Intelligence & Technology Lab, Inc., Kaizu, Japan; Innovation Research Center, EPS Holdings, Inc., Tokyo, Japan.
Keywords: SARS-CoV-2, sublingual vaccine, receptor binding domain, immune response, primates
Summary of Study: sublingual vaccine with RBD antigen and poly(I:C) adjuvant
References: DOI: 10.1093/biomethods/bpad017
Contact Info: Shin Nakamura: [email protected]
URL: https://academic.oup.com/biomethods/article/8/1/bpad017/7266774
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Intelligence & Technology Lab, Inc., Kaizu, Japan; Innovation Research Center, EPS Holdings, Inc., Tokyo, Japan.
Keywords: SARS-CoV-2, sublingual vaccine, receptor binding domain, immune response, primates
Summary of Study: sublingual vaccine with RBD antigen and poly(I:C) adjuvant
References: DOI: 10.1093/biomethods/bpad017
Contact Info: Shin Nakamura: [email protected]
URL: https://academic.oup.com/biomethods/article/8/1/bpad017/7266774
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China; Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200438, China; Zhangjiang mRNA Innovation and Translation Center, Fudan University, Shanghai 200438, China; others
Keywords: SARS-CoV-2, mRNA vaccine, chimeric spike protein, immunogenicity, primates
Summary of Study: RQ3013, a broad-spectrum mRNA vaccine against variants
References: PMID: 37993332 DOI: 10.1016/j.scib.2023.11.024
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2095927323007788?via%3Dihub=
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China; Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200438, China; Zhangjiang mRNA Innovation and Translation Center, Fudan University, Shanghai 200438, China; others
Keywords: SARS-CoV-2, mRNA vaccine, chimeric spike protein, immunogenicity, primates
Summary of Study: RQ3013, a broad-spectrum mRNA vaccine against variants
References: PMID: 37993332 DOI: 10.1016/j.scib.2023.11.024
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2095927323007788?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD, others
Keywords: SARS-CoV-2, recombinant vaccine, immune response, virus variants, mice, primates
Summary of Study: Recombinant prefusion-stabilized spike (rS) protein vaccine based on Beta/B.1.351 (rS-Beta) produces robust anamnestic response
References: doi: 10.1038/s41467-022-35606-6
Contact Info: Matthew Freiman: [email protected]
URL: https://www.nature.com/articles/s41467-022-35606-6
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD, others
Keywords: SARS-CoV-2, recombinant vaccine, immune response, virus variants, mice, primates
Summary of Study: Recombinant prefusion-stabilized spike (rS) protein vaccine based on Beta/B.1.351 (rS-Beta) produces robust anamnestic response
References: doi: 10.1038/s41467-022-35606-6
Contact Info: Matthew Freiman: [email protected]
URL: https://www.nature.com/articles/s41467-022-35606-6
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine, Tulane National Primate Research Center, others
Keywords: SARS-CoV-2, CSF, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates.
References: DOI: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine, Tulane National Primate Research Center, others
Keywords: SARS-CoV-2, CSF, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates.
References: DOI: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Vaccine Research Institute, Créteil, France; Université Paris Cité, IAME, Inserm, Paris, France; others
Keywords: SARS-CoV-2, mathematical model, viral dynamic, primates
Summary of Study: Impact of variants of concern on SARS-CoV-2 viral dynamics
References: DOI: 10.1371/journal.pcbi.1010721
Contact Info: Aurélien Marc: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010721
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Vaccine Research Institute, Créteil, France; Université Paris Cité, IAME, Inserm, Paris, France; others
Keywords: SARS-CoV-2, mathematical model, viral dynamic, primates
Summary of Study: Impact of variants of concern on SARS-CoV-2 viral dynamics
References: DOI: 10.1371/journal.pcbi.1010721
Contact Info: Aurélien Marc: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010721
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
Keywords: SARS-CoV-2, attenuated murine pneumonia virus vector, vaccine immune response, primates
Summary of Study: Mucosal prime-boost immunization with live murine pneumonia virus-vectored vaccine
References: DOI: 10.21203/rs.3.rs-3278289/v1
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.researchsquare.com/article/rs-3278289/v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
Keywords: SARS-CoV-2, attenuated murine pneumonia virus vector, vaccine immune response, primates
Summary of Study: Mucosal prime-boost immunization with live murine pneumonia virus-vectored vaccine
References: DOI: 10.21203/rs.3.rs-3278289/v1
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.researchsquare.com/article/rs-3278289/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center, Covington, Louisiana; others
Keywords: SARS-CoV-2, SIV-Induced Immunodeficiency, immune response, coinfection, primates
Summary of Study: Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection
References: bioRxiv.2023 Nov 16:2023.11.15.567132. doi: 10.1101/2023.11.15.567132. Preprint. PMID: 38014096 PMCID: PMC10680717 DOI: 10.1101/2023.11.15.567132
Contact Info: Nicholas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.15.567132v1
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center, Covington, Louisiana; others
Keywords: SARS-CoV-2, SIV-Induced Immunodeficiency, immune response, coinfection, primates
Summary of Study: Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection
References: bioRxiv.2023 Nov 16:2023.11.15.567132. doi: 10.1101/2023.11.15.567132. Preprint. PMID: 38014096 PMCID: PMC10680717 DOI: 10.1101/2023.11.15.567132
Contact Info: Nicholas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.15.567132v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing, China; Cell Culture Engineering Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Keywords: SARS-CoV-2, nanoparticle vaccine, immunogenicity, toxicity, primates
Summary of Study: COVID-19 vaccine showed high immunogenicity and low toxicity in animal models
References: doi: 10.3390/vaccines11030526
Contact Info: Liangzhi Xie: [email protected]
URL: https://www.mdpi.com/2076-393X/11/3/526
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing, China; Cell Culture Engineering Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Keywords: SARS-CoV-2, nanoparticle vaccine, immunogenicity, toxicity, primates
Summary of Study: COVID-19 vaccine showed high immunogenicity and low toxicity in animal models
References: doi: 10.3390/vaccines11030526
Contact Info: Liangzhi Xie: [email protected]
URL: https://www.mdpi.com/2076-393X/11/3/526
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Seattle, Washington USA; HDT Bio, Washington National Primate Research Center, others
Keywords: SARS-CoV-2, replicon RNA vaccine, immune response and protection, primates
Summary of Study: Replicon RNA vaccine for durable protective immunity
References: PMID: 37075079 / doi: 10.1371/journal.ppat.1011298
Contact Info: Jesse Erasmus: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011298
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Seattle, Washington USA; HDT Bio, Washington National Primate Research Center, others
Keywords: SARS-CoV-2, replicon RNA vaccine, immune response and protection, primates
Summary of Study: Replicon RNA vaccine for durable protective immunity
References: PMID: 37075079 / doi: 10.1371/journal.ppat.1011298
Contact Info: Jesse Erasmus: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011298
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China; others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Preclinical safety evaluation of intradermal SARS-CoV-2 inactivated vaccine (Vero cells) administration in macaques.
References: DOI: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China; others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Preclinical safety evaluation of intradermal SARS-CoV-2 inactivated vaccine (Vero cells) administration in macaques.
References: DOI: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Molecular Genetics, University of Toronto; Toronto, Canada; Icosagen Cell Factory OÜ; Tartu, Estonia; others
Keywords: SARS-CoV-2, humanized antibodies, immune response, vaccine, primates
Summary of Study: bnAb protection through inhalation-based delivery
References: DOI: 10.1371/journal.ppat.1011532
Contact Info: Mart Ustav, Jr.: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011532
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Molecular Genetics, University of Toronto; Toronto, Canada; Icosagen Cell Factory OÜ; Tartu, Estonia; others
Keywords: SARS-CoV-2, humanized antibodies, immune response, vaccine, primates
Summary of Study: bnAb protection through inhalation-based delivery
References: DOI: 10.1371/journal.ppat.1011532
Contact Info: Mart Ustav, Jr.: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011532
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, Production Division, Havana, Cuba
Keywords: SARS-CoV-2, chimeric antigen, vaccine, immune response, mice, primates
Summary of Study: chimeric antigen, based on nucleocapsid of SARS-CoV-2 fused to the extracellular domain of human CD154 in HEK-293 cells
References: DOI: 10.1371/journal.pone.0288006
Contact Info: Mario Pablo Estrada: [email protected]; Yamila Carpio: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288006
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, Production Division, Havana, Cuba
Keywords: SARS-CoV-2, chimeric antigen, vaccine, immune response, mice, primates
Summary of Study: chimeric antigen, based on nucleocapsid of SARS-CoV-2 fused to the extracellular domain of human CD154 in HEK-293 cells
References: DOI: 10.1371/journal.pone.0288006
Contact Info: Mario Pablo Estrada: [email protected]; Yamila Carpio: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288006
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Republic of Korea; others
Keywords: SARS-CoV-2, pulmonary lesions, histopathology, primates
Summary of Study: Histopathological pulmonary lesions in SARS-CoV-2
References: PMID: 38007889 DOI: 10.1016/j.jcpa.2023.10.008
Contact Info: Jae-Hak Park: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021997523002967?via%3Dihub=
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Republic of Korea; others
Keywords: SARS-CoV-2, pulmonary lesions, histopathology, primates
Summary of Study: Histopathological pulmonary lesions in SARS-CoV-2
References: PMID: 38007889 DOI: 10.1016/j.jcpa.2023.10.008
Contact Info: Jae-Hak Park: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021997523002967?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, Durham, NC; others
Keywords: SARS-CoV-2, spike protein, mRNA vaccine, immune response, virus variants, conserved epitopes, primates
Summary of Study: Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination
References: bioRxiv PMID: 38187726 PMCID: PMC10769253 DOI: 10.1101/2023.12.18.572191
Contact Info: Kevin O. Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.12.18.572191v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, Durham, NC; others
Keywords: SARS-CoV-2, spike protein, mRNA vaccine, immune response, virus variants, conserved epitopes, primates
Summary of Study: Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination
References: bioRxiv PMID: 38187726 PMCID: PMC10769253 DOI: 10.1101/2023.12.18.572191
Contact Info: Kevin O. Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.12.18.572191v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland; Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Mary
Keywords: SARS-CoV-2, deep learning, computerized tomography, lung lesions, primates
Summary of Study: Modeling whole lung and lung lesions to detect and quantify disease
References: doi: 10.1016/j.acra.2023.02.027
Contact Info: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/36966070/
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland; Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Mary
Keywords: SARS-CoV-2, deep learning, computerized tomography, lung lesions, primates
Summary of Study: Modeling whole lung and lung lesions to detect and quantify disease
References: doi: 10.1016/j.acra.2023.02.027
Contact Info: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/36966070/