Coronavirus Studies in Nonhuman Primate Models

 

This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.

Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven Belgium
Keywords: SARS-CoV-2, review, vaccine development, mice, hamsters, primates
Summary of Study: Do we need nasal vaccines against COVID 19
References: doi: 10.1111/1751-7915.14181
Contact Info: Harald Brüssow: haraldbruessow@yahoo.com
URL: https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14181
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX; Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX; others
Keywords: SARS-CoV-2, Molnupiravir, efficacy, oral administration, primates
Summary of Study: Evaluation of the drug molnupiravir (EIDD-2801) for mild to moderate COVID-19
References: doi: 10.1016/j.antiviral.2022.105492
Contact Info: Jason Comer: jscomer@utmb.edu
URL: https://www.sciencedirect.com/science/article/pii/S0166354222002613?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland; Adimab LLC, Lebanon, New Hampshire; Invivyd, Inc., Waltham, Massachusetts; others
Keywords: SARS-CoV-2, Adintrevimab, prophylactics, viral load, pathology, hamsters, primates
Summary of Study: Monoclonal Antibody Adintrevimab Protects against COVID-19
References: doi: 10.1128/aac.01353-22
Contact Info: Kristin Narayan: knarayan@invivyd.com
URL: https://journals.asm.org/doi/10.1128/aac.01353-22
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Texas Biomedical Research Institute, Institute of Science and Technology on Biomodels, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Keywords: SARS-CoV-2, review, coinfections, primate models, housing, screening
Summary of Study: Eliminating Potential Effects of Other Infections During Selection of Nonhuman Primates for COVID-19 Research
References: doi: 10.30802/AALAS-CM-21-000086
Contact Info: Marcia Andrade: marcia.andrade@fiocruz.br
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00003;…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: kelsey.carpenter2@wayne.edu
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00006
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill & Raleigh, NC
Keywords: SARS-CoV-2, an inhalable bioadhesive hydrogel, physical barrier, virus protection, mice, primates
Summary of Study: Inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection
References: doi: 10.1038/s41563-023-01475-7
Contact Info: Ke Cheng: ke_cheng@ncsu.edu
URL: https://www.nature.com/articles/s41563-023-01475-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven Belgium
Keywords: SARS-CoV-2, review, vaccine development, mice, hamsters, primates
Summary of Study: Do we need nasal vaccines against COVID 19
References: doi: 10.1111/1751-7915.14181
Contact Info: Harald Brüssow: haraldbruessow@yahoo.com
URL: https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14181
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX; Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX; others
Keywords: SARS-CoV-2, Molnupiravir, efficacy, oral administration, primates
Summary of Study: Evaluation of the drug molnupiravir (EIDD-2801) for mild to moderate COVID-19
References: doi: 10.1016/j.antiviral.2022.105492
Contact Info: Jason Comer: jscomer@utmb.edu
URL: https://www.sciencedirect.com/science/article/pii/S0166354222002613?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland; Adimab LLC, Lebanon, New Hampshire; Invivyd, Inc., Waltham, Massachusetts; others
Keywords: SARS-CoV-2, Adintrevimab, prophylactics, viral load, pathology, hamsters, primates
Summary of Study: Monoclonal Antibody Adintrevimab Protects against COVID-19
References: doi: 10.1128/aac.01353-22
Contact Info: Kristin Narayan: knarayan@invivyd.com
URL: https://journals.asm.org/doi/10.1128/aac.01353-22
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Texas Biomedical Research Institute, Institute of Science and Technology on Biomodels, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Keywords: SARS-CoV-2, review, coinfections, primate models, housing, screening
Summary of Study: Eliminating Potential Effects of Other Infections During Selection of Nonhuman Primates for COVID-19 Research
References: doi: 10.30802/AALAS-CM-21-000086
Contact Info: Marcia Andrade: marcia.andrade@fiocruz.br
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00003;…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: kelsey.carpenter2@wayne.edu
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00006
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill & Raleigh, NC
Keywords: SARS-CoV-2, an inhalable bioadhesive hydrogel, physical barrier, virus protection, mice, primates
Summary of Study: Inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection
References: doi: 10.1038/s41563-023-01475-7
Contact Info: Ke Cheng: ke_cheng@ncsu.edu
URL: https://www.nature.com/articles/s41563-023-01475-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: Tulane NPRC; Duke University Medical Center
Keywords: SARS-CoV-2, prophylactic administration, convalescent plasma, disease progression and severity, primates
Summary of Study: Convalescent plasma administration results in suboptimal prophylaxis against SARS-CoV-2 infection
References: doi: 10.3389/fimmu.2023.1085883
Contact Info: Chad Roy: croy@tulane.edu
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1085883/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, subunit vaccine, virus strains, primates
Summary of Study: Immunogenicity and protective efficacy of GBP510/AS03 vaccine
References: doi: 10.1038/s41541-023-00622-0
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.nature.com/articles/s41541-023-00622-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Bremen, Bremen, Germany and others
Keywords: SARS-CoV-2, mRNA vaccination, elderly animals, immune response, primates
Summary of Study: Monitoring vaccination in laboratory rhesus monkeys
References: doi: 10.1038/s41598-023-30473-7
Contact Info: Detlef Wegener: dwegener@uni-bremen.de
URL: https://www.nature.com/articles/s41598-023-30473-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: baboons
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD, others
Keywords: SARS-CoV-2, recombinant vaccine, immune response, virus variants, mice, primates
Summary of Study: Recombinant prefusion-stabilized spike (rS) protein vaccine based on Beta/B.1.351 (rS-Beta) produces robust anamnestic response
References: doi: 10.1038/s41467-022-35606-6
Contact Info: Matthew Freiman: mfrieman@som.umaryland.edu
URL: https://www.nature.com/articles/s41467-022-35606-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing, China; Cell Culture Engineering Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Keywords: SARS-CoV-2, nanoparticle vaccine, immunogenicity, toxicity, primates
Summary of Study: COVID-19 vaccine showed high immunogenicity and low toxicity in animal models
References: doi: 10.3390/vaccines11030526
Contact Info: Liangzhi Xie: LX@sinocelltech.com
URL: https://www.mdpi.com/2076-393X/11/3/526
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland; Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Mary
Keywords: SARS-CoV-2, deep learning, computerized tomography, lung lesions, primates
Summary of Study: Modeling whole lung and lung lesions to detect and quantify disease
References: doi: 10.1016/j.acra.2023.02.027
Contact Info: Jeffrey.solomon@nih.gov
URL: https://pubmed.ncbi.nlm.nih.gov/36966070/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Veterinary Research Institute, Lahore, Pakistan; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan; others
Keywords: SARS-CoV-2, inactivated vaccine, efficacy, immunogenicity, virus variant, rabbits, primates
Summary of Study: Molecular characterization and selection of delta variant for vaccine
References: doi: 10.3390/vaccines11030607
Contact Info: Tahir Yaqub: tahiryaqub@uvas.edu.pk
URL: https://www.mdpi.com/2076-393X/11/3/607
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi and GSK
Keywords: SARS-CoV-2, booster vaccine candidates, immune response, virus variants, primates
Summary of Study: Beta variant COVID-19 protein booster vaccine elicits durable cross-neutralization against SARS-CoV-2 variants
References: doi: 10.1038/s41467-023-36908-z
Contact Info: Valerie Lecouturier: valerie.lecouturier@sanofi.com
URL: https://www.nature.com/articles/s41467-023-36908-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai , China; Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease and Biosecurity, others.
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus protection, primates
Summary of Study: Pan-sarbecovirus vaccines against sarbecoviruses, including SARS-CoV-2 and its variants
References: doi: 10.1073/pnas.2221713120
Contact Info: LuLu: lul@fudan.edu.cn (and other authors
URL: https://www.pnas.org/doi/10.1073/pnas.2221713120
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA; others
Keywords: SARS-CoV-2, tetravalent S1 subunit protein vaccine, immune response, virus variants, primates
Summary of Study: Tetravalent S1 subunit protein vaccination elicits robust humoral and cellular immune responses
References: doi: 10.1101/2023.03.15.532808. Preprint
Contact Info: Christian Apetrei: apetreic@pitt.edu
URL: https://www.biorxiv.org/content/10.1101/2023.03.15.532808v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Mymetics SA, Epalinges, Switzerland; Department of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, influenza virosomes, vaccine, immune response, primates
Summary of Study: Low dose RBD and TLR7/8 agonist displayed on influenza virosome particles is protective
References: doi: 10.1038/s41598-023-31818-y
Contact Info: Sylvain Fleury: sylvain.fleury@mymetics.com
URL: https://pubmed.ncbi.nlm.nih.gov/36977691/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Center for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, Louisiana; Tulane National Primate Research Center, Covington, Louisiana, others
Keywords: SARS-CoV-2, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal fluid protein markers indicate neuro-damage
References: doi: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: jfan5@tulane.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Social and Administrative Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Center of Excellence in Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok, Thailand; others.
Keywords: SARS-CoV-2, plant-produced subunit vaccine, receptor binding domain, neutralizing antibody, primates
Summary of Study: Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based vaccine
References: doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: Waranyoo.P@chula.ac.th
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: baboons
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: University of Oklahoma Health Sciences Center, Oklahoma City, OK USA and others.
Keywords: SARS-CoV-2, air–liquid interface, airway epithelium, immune response, innate immunity, inflammation, primates
Summary of Study: Isolation and in vitro differentiation of primary fetal baboon tracheal epithelial cells for studying host-virus Interactions
References: PMID: 37112842 / doi: 10.3390/v15040862
Contact Info: Matthew Walters: Matthew-S-Walters@ouhsc.edu
URL: https://www.mdpi.com/1999-4915/15/4/862
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA USA
Keywords: SARS-CoV-2, favipiravir, biodistribution and pharmacokinetics, positron emission tomography, mice, primates
Summary of Study: Evaluating Favipiravir in rodents and nonhuman primates (NHP) with positron emission tomography
References: PMID: 37111280 / doi: 10.3390/ph16040524
Contact Info: Steven Liang: steven.liang@emory.edu
URL: https://www.mdpi.com/1424-8247/16/4/524
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Massachusetts General Hospital, Charlestown, Massachusetts USA; Brigham and Women's Hospital, Boston, Massachusetts, and others
Keywords: SARS-CoV-2, review, brain autopsies, neuropathological findings, humans, animal models, primates
Summary of Study: Review: What Can We Still Learn from Brain Autopsies in COVID-19?
References: PMID: 37023787 / doi: 10.1055/s-0043-1767716
Contact Info: Shibani Mukerji: smukerji@partners.org
URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-176771…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Emory University, Emory National Primate Research Center, others
Keywords: SARS-CoV-2, innate immune system, airway inflammation, humans, primates
Summary of Study: TREM2+ and interstitial-like macrophages orchestrate airway inflammation
References: PMID: 37024448 / doi: 10.1038/s41467-023-37425-9
Contact Info: Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.nature.com/articles/s41467-023-37425-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Consortium on Pathogen Readiness, Boston, MA USA and others
Keywords: SARS-CoV-2, omicron spike protein encoding vaccine, boosters, immune response, primates
Summary of Study: Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy
References: PMID: 37029141 / 10.1038/s41467-023-37715-2
Contact Info: Frank Wegmann: fwegmann@its.jnj.com
URL: https://www.nature.com/articles/s41467-023-37715-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chan Zuckerberg Biohub, Stanford University, others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, virus variants, primates
Summary of Study: Ferritin-based nanoparticle vaccine
References: PMID: 37069151 / doi: 10.1038/s41467-023-37417-9
Contact Info: Peter S Kim: kimpeter@stanford.edu
URL: https://www.nature.com/articles/s41467-023-37417-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Seattle, Washington USA; HDT Bio, Washington National Primate Research Center, others
Keywords: SARS-CoV-2, replicon RNA vaccine, immune response and protection, primates
Summary of Study: Replicon RNA vaccine for durable protective immunity
References: PMID: 37075079 / doi: 10.1371/journal.ppat.1011298
Contact Info: Jesse Erasmus: jesse.erasmus@hdt.bio
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011298
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia and others
Keywords: SARS-CoV-2, nucleocapsid (N) protein, vaccine, immune response, pathology, mice, hamsters, primates
Summary of Study: Recombinant nucleocapsid-based vaccine Convacell®.
References: PMID: 37112786 / doi: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: sevastyan@rabdano.ru
URL: https://www.mdpi.com/2076-393X/11/4/874
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand and others
Keywords: SARS-CoV-2, recombinant plant-based RBD vaccine, immunogenicity, efficacy, safety, mice, primates
Summary of Study: Recombinant plant based RBD vaccine formulated with 3M-052-Alum adjuvant
References: PMID: 36963999 / doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: Waranyoo.P@chula.ac.th
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China and others
Keywords: SARS-CoV-2, intradermal inactivated vaccine, immune response, virus variants, primates
Summary of Study: Preclinical safety evaluation of Intradermal inactivated vaccine (vero cells) administration
References: PMID: 37003910 / doi: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: liqihan@imbcams.com.cn
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, others
Keywords: SARS-CoV-2, nelfinavir, prophylactics, virus protection, humans, primates
Summary of Study: Nelfinavir preventive and therapeutic effects
References: PMID: 37095086 / doi: 10.1038/s41392-023-01429-0
Contact Info: Weiliang Zhu: wlzhu@simm.ac.cn
URL: https://www.nature.com/articles/s41392-023-01429-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Patronus Biotech Co. Ltd., Yantai, China
Keywords: SARS-CoV-2, RBD virus-like particle vaccine, immune response, virus infection, mice, primates
Summary of Study: RBD virus-like particle vaccine induces cross-variant antibody responses
References: PMID: 37120453 / doi: 10.1038/s41392-023-01425-4
Contact Info: Yuanyuan Li: liyuanyuan@luye.com
URL: https://www.nature.com/articles/s41392-023-01425-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand; Baiya Phytopharm Co., Ltd., Bangkok, Thailand; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; National Primate Research Center of Thailand-Chulalongkorn University, Saraburi, Thailand.
Keywords: SARS-CoV-2, recombinant subunit vaccine, plants, immune response, mice, primates
Summary of Study: Three-dose regimen of Baiya SARS-CoV-2 Vax 1 vaccine elicits neutralizing immune response against SARS-CoV-2 variants.
References: doi: 10.3389/fpls.2022.901978
Contact Info: Waranyoo Phoolcharoen: ht.ca.aluhc@P.ooynaraW
URL: https://www.frontiersin.org/articles/10.3389/fpls.2022.901978/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccines
NPRC/Institute: Merck & Co., Inc., Rahway, NJ, USA; Certara, Princeton, NJ, USA
Keywords: SARS-CoV-2, vaccine, meta-analysis, preclinical and clinical data, immunogenicity, primates
Summary of Study: Development and application of a model-based meta-analysis (MBMA) approach integrating non-clinical and clinical immunogenicity and protection data.
References: doi: 10.1016/j.ebiom.2022.104264
Contact Info: Bhargava Kandala: moc.kcrem@aladnak.avagrahb
URL: https://www.sciencedirect.com/science/article/pii/S2352396422004467?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: various
Year Published: 2022
Study Type/Review: review
NPRC/Institute: Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China; National Center of Technology Innovation for Animal Model, Beijing, China.
Keywords: SARS-CoV-2, review, animal model resources, comparative analysis, several animal species, primates
Summary of Study: Characterizaton of animal model resources
References: doi: 10.1002/ame2.12278
Contact Info: Chuan Qin: nc.ude.cmup@nauhcniq
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/ame2.12278
Coronavirus Investigated: SARS-CoV-2
NHP Species: various
Year Published: 2022
Study Type/Review: review
NPRC/Institute: University of Milan, Milan, Italy
Keywords: SARS-CoV-2, review, natural and experimental infection, several animal species, primates
Summary of Study: Review updating information on natural and experimental SARS-CoV-2 infections in animals.
References: doi: 10.1007/s00705-022-05609-1
Contact Info: Lauretta Turin: ti.iminu@nirut.atterual
URL: https://link.springer.com/article/10.1007/s00705-022-05609-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Respiratory Disease, China; Guanzhou Laboratory, China; University of Science and Technology Hong Kong, numerous others
Keywords: SARS-CoV-2, spike protein vaccine, immune response, virus variants, mice, primates
Summary of Study: RBMRNA-176 is a vaccine candidate for prevention of COVID-19
References: doi: 10.3390/vaccines10101698
Contact Info: Wei Yang: yangwei@lewwin.com.cn
URL: https://www.mdpi.com/2076-393X/10/10/1698
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Chinese Academy of Sciences; State Key Laboratory of Respiratory Disease; Guangzhou Laboratory & Bioland Laboratory; Gangzhou nBiomed
Keywords: SARS-CoV-2, Ad5-vectored vaccine, SIV, immune response, primates
Summary of Study: Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques
References: doi: 10.1080/22221751.2022.2136538
Contact Info: Ling Chen: chen_ling@gibh.ac.cn
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2136538
Coronavirus Investigated: SARS-CoV-2
NHP Species: NHP - didn't specify
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital; National Kunming High-level Biosafety Primate Research Center; Nagasaki University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, self-assembled trimeric protein vaccine, virus variants, mice, primates
Summary of Study: A self-assembled trimeric protein made from linking a sequence from the Delta variant and a subunit in SARS-CoV-2 shows a strong immune response against Omicron variants.
References: PMID: 36115859 / doi: 10.1038/s41467-022-33209-9
Contact Info: Xiangrong Song: songxr@scu.edu.cn; Shuaiyao Lu: lushuaiyao-km@163.com; Xiaozhong Peng: pengxiaozhong@pumc.edu.cn; Guangwen Lu: lugw@scu.edu.cn; Xiawei Wei: xiaweiwei@scu.edu.cn
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482656/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai East Hospital, Tongji University School of Medicine; Renji Hospital, Shanghai Jiao Tong University School of Medicine; National Kunming High-level Biosafety Primate Research Center; Naval Medical University; China Pharmaceutical University
Keywords: SARS-CoV-2, vaccine, single-cell transcriptome, immune response, primates
Summary of Study: A lipopolyplex-based mRNA vaccine provides a strong immune response by inhibiting the recruitment of proinflammatory macrophages and by providing lung protecting through inhbiting the apoptotic processes in long epithelial and endothelial cells.
References: PMID: 36124363 / doi: 10.1002/jmv.28161
Contact Info: Ang Lin: anglin@cpu.edu.cn; Zhenzhen Zhan: zhanzz@tongji.edu.cn; Xingguang Liu: liuxg@immunol.org
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28161
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: ReNAP Therapeutics; Mashhad Medical Technologies Science Park; Mashhad University of Medical Sciences; Alzahra University; Tehran University of Medical Sciences; Shahid Beheshti University of Medical Sciences;
Keywords: SARS-CoV-2, mRNA-vaccine, COReNAPCIN®, immune response, mice, primates
Summary of Study: COReNAPCIN is a nucleoside modified mRNA-based vaccine that creates a strong humoral response and protects from symptomatic SARS-CoV-2 infection and clinical damage, thus making it a potent vaccine candidate.
References: PMID: 36056015 / doi: 10.1038/s41541-022-00528-3
Contact Info: Somaye Dehghanizadeh: s.dehghanizadeh@renap.ir
URL: https://www.nature.com/articles/s41541-022-00528-3
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: North Carolina State University; University of North Carolina at Chapel Hill
Keywords: SARS-CoV-2, dry powder mRNA vaccine, tissue distribution, mice, primates
Summary of Study: Room-temperature stable inhalable lung-derived exosomes have been developed as mRNA and protein drug carriers, and they are deliverable to the lungs by dry powder inhalation and result in a greater immunoglobulin responsecompared to the standard.
References: PMID: 35847197 / doi: 10.1016/j.matt.2022.06.012
Contact Info: Ke Cheng: ke_cheng@ncsu.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272513/
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Research Centre for Epidemiology and Microbiology; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; Sechenov First Moscow State Medical University
Keywords: SARS-CoV-2, vector-based heterologous vaccine, immune response, mice, primates
Summary of Study: Intranasal Sputnik V vaccine is a novel mucosal vaccine with immunogenic and protective properties identified by immunoglobin and neutralizing antibody production, antigen-specific T-cell response, and cytokine release.
References: PMID: 36031930 / doi: 10.1080/22221751.2022.2119169
Contact Info: Amir I. Tukhvatulin: amir_tukhvatulin@gamaleya.org
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2119169
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: California National Primate Research Center; University of California, Davis
Keywords: SARS-CoV-2, surveillance, diagnostics, multi-antigen assays , RT-PCR, primates
Summary of Study: Colony management practices including restricted access, PPE, personnel vaccination and testing requirements have been adequate to prevent the spread of COVID-19 within the CNPRC NHP colony along with developing multi-antigen assays to survey the population.
References: PMID: 35794847 / doi: 10.1111/jmp.12604
Contact Info: JoAnn Yee: joyee@ucdavis.edu
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12604
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; AstraZeneca; Vanderbilt University Medical Center; Ragon Institute of MGH, MIT, and Harvard, Cambridge
Keywords: SARS-CoV-2, vaccine, bivalent monoclonal antibody, immune response, primates
Summary of Study: Using human monoclonal antibodies that target the spike glycoprotein can be administered along with viral vector-based SARS-CoV-2 vaccines without losing any effectiveness of either product.
References: PMID: 35857623 / doi: 10.1126/scitranslmed.abo6160
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abo6160?rfr_dat=cr_pub%20%…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd
Keywords: SARS-CoV-2, nebulized neutralizing antibody, inhalation, mice, primates
Summary of Study: Feasibility of nebulized antibodies inhalation delivery
References: doi: 10.1007/s11095-022-03340-9
Contact Info: LX@sinocelltech.com
URL: https://link.springer.com/article/10.1007/s11095-022-03340-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology; Civilian Defense Scienti?c Research Center, Carretera de Jamaica y Autopista Nacional; Biotechnology and Pharmaceutical Industries Group, BioCubaFarma, Ave; Latin American School of Medicine
Keywords: SARS-CoV-2, vaccine, yeast, manufacturing, mice, primates
Summary of Study: The COVID-19 receptor-binding domain produced in yeast cells can be modified by adding amino acids in order to create a possible vaccine candidate due to its ability to stimulate anti-inflammatory cells and inhibit binding to ACE2.
References: PMID: 35953030 / doi: 10.1016/j.nbt.2022.08.002
Contact Info: Gerardo Guillén-Nieto: Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 E/ 158 y 190, La Habana 10600, Cuba
URL: https://www.sciencedirect.com/science/article/pii/S1871678422000462?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub%20%20…
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Biomedical Primate Research Centre; Consejo Superior de Investigaciones Cientificas (CSIC); Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC); Erasmus Medical Center; Instituto de Investigacion Hospital Universitario 12 de Octubre (imas12); Universidad Complutense School of Medicine, Biofabri
Keywords: SARS-CoV-2, vaccine, modified vaccinia virus Ankara vector, immune response, primates
Summary of Study: The MVA-S vaccine is safe and well tolerated in rhesus macaques, being highly immunogenic with the induction of potent levels of binding and neutralizing antibodies against several SARS-CoV-2 VOC, as well as Th1-skewed cell responses.
References: PMID: 35371043 / doi: 10.3389/fimmu.2022.845887
Contact Info: Petra Mooij: mooij@bprc.nl; Juan Garcia-Arriaza: jfgarcia@cnb.csic.ed; Gerrit Koopman: koopman@bprc.nl; Mariano Esteban: mesteban@cnb.csic.es
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: jean.haensler@sanofi.com;
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington
Keywords: SARS-CoV-2, remdesivir, math modeling, antiviral potency, nasal passages, lungs, primates
Summary of Study: In rhesus macaques, the nonlinear forces governing SARS-CoV-2 viral load trajectories in the lung and nasal passages differ substantially in the presence of a partially effective antiviral therapy. To the extent that the rhesus macaque model approximates human infection, nasal viral load remains a promising surrogate endpoint marker but perhaps only in the context of a highly potent antiviral therapy.
References: PMID: 35634576 / doi: 10.1016/j.isci.2022.104448
Contact Info: Joshua Schiffer: jschiffe@fredhutch.org
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00719-2?_returnURL=https%3A…
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: rseder@mail.nih.gov
URL: https://insight.jci.org/articles/view/160039
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Guangzhou Medical University; Macau University of Science and Technology; St. Januario Central Hospital Macau
Keywords: SARS-CoV-2, homologous or heterogenous vaccination boosters, virus variants, primates
Summary of Study: The Omicron BA.1 variant showed little sensitivity to all of the neutralizing antibodies evalueted in this study, adding to the emerging body of evidence that the resistance to neutralizing antibodies is conferred largely by the mutations in the RBD, since pseudovirus harboring additional spike protein mutations did not significantly change the resistance to neutralizing activity. A recombinant RBD protein vaccine may be a promising approach for future vaccine development.
References: PMID: 35592756 / doi: 10.1002/mco2.143
Contact Info: Kang Zhang: kang.zhang@gmail.com; Gen Li: superleegen@hotmail.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095991/
Coronavirus Investigated: SARS-CoV2
NHP Species: marmoset
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Universidade Federal Rural do Rio de Janiero; Universidade Federal do Mato Grosso; Universidade Federal do Parana
Keywords: SARS-CoV-2, natural infections, free-ranging animals, pathology, primates
Summary of Study: Free-ranging non-human primates are potential hosts for natural SARS-CoV-2 infection.
References: PMID: 35577455 / doi: 10.1016/j.jcpa.2022.03.005
Contact Info: Valeria Dutra: valeriadutra.dutra@gmail.com
URL: https://www.sciencedirect.com/science/article/pii/S0021997522000433?via%3Dihub
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Unioin Medical College
Keywords: SARS-CoV-2, longitudinal analyses, lungs, intestines, immune response, primates
Summary of Study: Findings indicate an imbalance of immune dynamic in intestinal mucosa during SARS-CoV-2 infection, which may underlie ongoing rectal viral shedding and mild tissue damage.
References: PMID: 35594870 / doi: 10.1016/j.celrep.2022.110864
Contact Info: Zhanlong He: hzl@imbcams.com.cn; Haijing Shi: haijingshi@hotmail.com; Qihan Li: liqihan@imbcams.com.cn; Longing Liu: longdingl@gmail.com
URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00637-4?_returnURL=http…
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; The First Affiliated Hospital of Guangzhou Medical University; Southern University of Science and Technology; The First Affiliated Hospital of Sun Yat-sen University; Guangdong Provincial Center for Disease Control and Prevention; Guangdong-Hong Kong Joint Laboratory for RNA Medicine
Keywords: SARS-CoV-2, quadrivalent mosaic HexaPro-bearing nanoparticle vaccine, virus variants, mice and primates
Summary of Study: A quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and 3 different VOCs elicits equivalent or superior neutralizing antibodies against variant strains in mice and non-human primates with only small reduction in neutralization titers against the ancestral strain.
References: PMID: 35562337 / doi: 10.1038/s41467-022-30222-w
Contact Info: Jin-Cun Zhao: zhaojincun@gird.cn; Run-Yu Yuan: cecilia_yry@hotmail.com; Mu-Sheng Zeng: aengmsh@sysucc.org.cn
URL: https://www.nature.com/articles/s41467-022-30222-w
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: USAMRIID
Keywords: SARS-CoV-2, routes of exposure, pathology, primates
Summary of Study: Cynomolgus macaques may be the better model for SARS-CoV-2 than RM, as these animals had the most severe and consistent disease presentation.
References: PMID: 35632755 / doi: 10.3390/v14051013
Contact Info: Jay Hooper: jay.w.hooper.civ@mail.mil; Jeffrey Koehler: jeffrey.w.koehler4.civ@mail.mil; Charles Shoemaker: Charles.j.shoemaker.civ@mail.mil; Tamara Clements: tamara.l.clements.civ@mail.mil; Alexandra Jay: alexandra.n.jay.civ@mail.mil
URL: https://www.mdpi.com/1999-4915/14/5/1013
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Broad Institute of Harvard and MIT; Harvard University; Universite Paris-Saclay, Inserm, CEA; Genethon INTEGRARE UMR; Rega Institute; University of Siena; University of Pennsylvania
Keywords: SARS-CoV-2, AAV-based vaccine, virus variants, immune response, mice, primates
Summary of Study: AAV-based vaccines for COVID-19 can be effective from a single, low dose and lead to durable humoral and strong T cell immunogenicity.
References: PMID: 35546782 / doi: 10.1016/j.ymthe.2022.05.007
Contact Info: Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu
URL: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0…
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: USAMRIID; Henry M. Jackson Foundation for the Advancement of Military Medicine; Walter Reed Army Institute of Research
Keywords: SARS-CoV-2, spike ferritin nanoparticle vaccine, immune response, primates
Summary of Study: Two adjuvants were compared (ALFQ and AIOH3): Robust humoral and cellular immunological responses were observed for vaccinated animals, with the ALFQ-adjuvanted group generating a significantly higher response compared ot the AIOH3 group. Vaccination with either adjuvant resulted in fewer clinical signs of disease compared to controls, including a significant reduction in lesions and virus replication in the lungs.
References: PMID: 35632473 / doi: 10.3390/vaccines10050717
Contact Info: Jeffrey Smith: jeffrey.smith@fda.hhs.gov; Jay Hooper: jay.w.hooper.civ@mail.mil; Keersten Ricks: keersten.m.ricks.civ@mail.mil; Hannah King: hanna.king@nih.gov; Kristina Peachman: kpeachman@hivresearch.org; Alexandra Jay: alexandra.n.jay.civ@mail.mil
URL: https://www.mdpi.com/2076-393X/10/5/717
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: nabila.seddiki@cea.fr
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Cellid Co., Ltd; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology; International Vaccine Institute; Seoul National University
Keywords: SARS-CoV-2, adenovirus, AdCLD-CoV19 vaccine, immune response, virus variants, primates
Summary of Study: AdCLD-CoV19 can prevent SARS-CoV-2 with a single vaccination, and the new vaccine administration strategy that responds to various variants can maintain the efficacy of the vaccine.
References: PMID: 35632468 / doi: 10.3390/vaccines10050712
Contact Info: Chang-Yuil Kang: cykang@snu.ac.kr
URL: https://www.mdpi.com/2076-393X/10/5/712
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Institute Pasteur; Universite Paris Saclay-INSERM; Beth Israel Deaconess Medical Center
Keywords: SARS-CoV-2, NK cells, macrophages, blood and bronchoalveolar lavage, immune response, primates
Summary of Study: Viral antigen is found in alveolar macrophages up to at least 18 months after SARS-CoV-2 infection in macaques. Additionally, an association was revealed between lower level of persisting viral antigenin alveolar macrophages and the activity of Spike-specific adaptive NH cells in the lung.
References: PMID: 35547853 / doi: 12.21203/rs.3.rs-1561222/v1
Contact Info: Nicolas Huot: nicolas.huot@pasteur.fr
URL: https://www.researchsquare.com/article/rs-1561222/v1
Coronavirus Investigated: SARS-CoV2
NHP Species: multiple species
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Southwest National Primate Research Center; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, protocols, animal models, immunology, primates
Summary of Study: This book describes the different aspects of modelling the SARS-CoV-2 infection in NHPs along with the associated methods used in immunology.
References: PMID: 35554911 / doi. 10.1007/978-1-2111-0_15
Contact Info: Deepak Kaushal: dkaushal@txbiomed.org
URL: https://link.springer.com/protocol/10.1007/978-1-0716-2111-0_15
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands; Department of Radiology and Nuclear Medicine, Tracer Center Amsterdam (TCA), Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands
Keywords: SARS-CoV-2, PET-CT imaging, lungs, inflammation, primates
Summary of Study: Vaccine candiate involving a valuable radiotracer to visualize SARS-CoV-2-associated pulmonary inflammation
References: PMID: 35660200 PMCID: PMC9148436 DOI: 10.1016/j.nucmedbio.2022.05.002
Contact Info: Marieke A Stammes: stammes@bprc.nl
URL: https://www.sciencedirect.com/science/article/pii/S0969805122020509?via%3Dihub
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, CIGB, Ave. 31 E/158 y 190, Havana 10600, Cuba
Keywords: SARS-CoV-2, chimeric antigen vaccine, immune response, mice, primates
Summary of Study: Fusion of SARS-CoV-2 receptor binding domain with the extracellular domain of human CD154 is a promising vaccine candidate
References: PMID: 35746505 PMCID: PMC9228316 DOI: 10.3390/vaccines10060897
Contact Info: Yamila Carpio and Mario Pablo Estrada: yamila.carpio@cigb.edu.cu; mario.pablo@cigb.edu.cu
URL: https://www.mdpi.com/2076-393X/10/6/897
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Université Paris-Saclay; Assistance Publique-Hôpitaux de Paris; Obesity Center, Department of Digestive, Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Paris
Keywords: SARS-CoV-2, fat tissue, diagnostics, immunity, primates
Summary of Study: Subcutaneous adipose tissue (SCAT) is selectively infected by SARS-CoV-2 although changes in the immune properties of adispose tissue are observed in both SCAT and visceral adipose tissue
References: PMID: 35661814 PMCID: PMC9166782 DOI: 10.1038/s42003-022-03503-9
Contact Info: Christine Bourgeois: christine.bourgeois@universite-paris-saclay.fr
URL: https://www.nature.com/articles/s42003-022-03503-9
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Gritstone bio, Inc.; Battelle Biomedical Research Center
Keywords: SARS-CoV-2, self-amplifying mRNA vaccine, immune response, primates
Summary of Study: Report of the preclinical development of a strong self-amplifying mRNA (SAM) vaccine being evaluated in clinical trials as both a homologous prime-boost regimen at low doses and as a boost following heterologous prime
References: PMID: 35672369 PMCID: PMC9173840 DOI: 10.1038/s41467-022-31005-z
Contact Info: Karin Jooss: kjooss@gritstone.com
URL: https://www.nature.com/articles/s41467-022-31005-z
Coronavirus Investigated: SARS-CoV2
NHP Species: multiple species
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Departments of Biochemistry and Pathology & Laboratory Medicine, Bhopal, India
Keywords: SARS-CoV-2, review, animal models, infection, pathology, primates
Summary of Study: Review of the immunological and clinical manifestations observed in various natural and genetically-modified animal models of numerous COVID-19 studies. The authors also summarize up-to-date laboratory findings on available and significant COVID-19 animal models, and put forth their perspective for the objective dependent usage of animal models.
References: PMID: 35757923 DOI: 10.1080/08830185.2022.2089666
Contact Info: Ashok Kumar: ashok.biochemistry@aiimsbhopal.edu.in
URL: https://www.tandfonline.com/doi/abs/10.1080/08830185.2022.2089666?journalCode=ii…
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd.; Department of Pathology and Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, recombinant S-protein vaccine S-268019-b, immune response, primates
Summary of Study: Immunogenicity and protective efficacy of SARS-CoV-2 recombinant S-protein vaccine S-268019-b in cynomolgus monkeys
References: PMID: 35691872 PMCID: PMC9167832 DOI: 10.1016/j.vaccine.22.05.081
Contact Info: Hideki Hasegawa: hasegawa@niid.go.jp
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22007186?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: baboons
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: CAS Key Laboratory of Computational Biology; Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences; Chinese Academy of Sciences; Max Planck Institute of Psychiatry, Proteomics and Biomarkers
Keywords: SARS-CoV-2, circadian gene networks, transcriptome, primates
Summary of Study: Many mammalian genes are controlled by a central clock under circadian control, resulting in a rhythmic expression of genes involved in homeostasis. SARS-CoV-2 related genes are also rhythmically expressed, suggesting close interactions with circadian regulators.
References: PMID: 35906476 / doi: 10.1038/s42003-022-03722-0
Contact Info: Guang-Zhong Wang: guangzhong.wang@picb.ac.cn
URL: https://www.nature.com/articles/s42003-022-03722-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Affinivax; Ragon Institute of MGH, MIT, and Harvard; Boston Children's Hospital
Keywords: SARS-CoV-2, multiple antigen-presenting system vaccine, pathology, primates
Summary of Study: Multiple Antigen-Presenting System is a novel way to create a vaccine presenting proteins on a polymer and is able to induce antibody formation and reduce viral load in NHPS.
References: PMID: 35891233 / doi: 10.3390/vaccines10071069
Contact Info: Gilles Besin: gilles.besin@affinivax.com
URL: https://www.mdpi.com/2076-393X/10/7/1069
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC; Duke University Medical Center, Duke Human Vaccine Institute;
Keywords: SARS-CoV-2, viral kinetics, immune response, primates
Summary of Study: Pulmonary outcome of COVID-19 is not influenced by route of infection even though clinical onset shows differences.
References: PMID: 35789343 / doi: 10.1371/journal.ppat.1010618
Contact Info: Chad Roy: croy@tulane.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010618
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: GigaGen, Inc.; Alira Health, Inc.; Grifols S.A.; Vitalant Research Institute; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, drugs, GMP, clinical manufacturing, therapy, mice, primates
Summary of Study: A novel class of drugs, recombinant hyperimmune globulins are a safe and protective possible treatment to COVID-19 that could be made through large-scale production.
References: PMID: 35890050 / doi: 10.3390/pathogens11070806
Contact Info: Adam Adler: aadler@gigagen.com
URL: https://www.mdpi.com/2076-0817/11/7/806
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses; Jilin University First Hospital; Beijing Institute of Biotechnology; College of Basic Medical Sciences; Zhongshan Hospital Fudan University; Beijing Institute of Microbiology and Epidemiology; Shaanxi Normal University
Keywords: SARS-CoV-2, proteomics, metabolomics, pathology, immune response, primates
Summary of Study: An established COVID-19 model demonstrates that the innate immune response, neutrophil and platelet activation were dysregulated in infected NHPs, and these were greatly weakened in the most infected NHPs, which models moderately infected humans.
References: PMID: 35903092 / doi: 10.3389/fimmu.2022.954121
Contact Info: Yuwei Gao: yuwei0901@outlook.com; Yan Liu: liu820512@163.com; Xiaochang Xue: xuexch@snnu.edu.cn; Hui Wang: geno0109@vip.sina.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.954121/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane University School of Medicine; Beijing Forestry University; Beijing Institute of Lifeomics; Ochsner Clinic Foundation; University of Texas Southwestern Medical Center; Tulane National Primate Research Center
Keywords: SARS-CoV-2, peptide microarrays, neutralizing antibodies, vaccine, primates
Summary of Study: Linear peptide epitopes detected by immunoglobulins after infection have been localized to functionally important virus regions, which can be used to inform vaccine evaluation and targets for site-specific therapy.
References: PMID: 35928300 / doi: 10.34133/2022/9769803
Contact Info: Xiaobo Yu: yuxiaobo@mail.ncpsb.org; Tony Hu: tonyhu@tulane.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297724/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Bordeaux; Université Paris-Saclay; Vaccine Research Institute Créteil; Inserm U955 Créteil; Baylor Scott and White Research Institute; Institut Pasteur Paris; CNRS UMR 3569; University of Amsterdam Amsterdam Infection & Immunity Institute Amsterdam; Hôpital Henri-Mondor Albert-Chenevier; CHU Bordeaux
Keywords: SARS-CoV-2, mathematical modelling, vaccine, viral dynamics, primates
Summary of Study: A model-based approach can identify mechanistic correlates of protection that vaccines provide against infection, such that inhibition of the receptor-binding domain to ACE2 represents a strong mechanism of protection.
References: PMID: 35801637 / doi: 10.7554/eLife.75427
Contact Info: Rodolphe Thiébaut: rodolphe.thiebaut@u-bordeaux.fr
URL: https://elifesciences.org/articles/75427
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: National Rodent Laboratory Animal Resources Center; School of Basic Medical Sciences, Peking University Health Science Center; Northwest University; National Institutes for Food and Drug Control
Keywords: SARS-CoV-2, review, preclinical models, several animal species, primates
Summary of Study: Current animal models for COVID-19 have limitations, and novel models must be developed to truly evaluate the virulence of varients and comorbidities. Proposed model improvements include the use of transgenes or knock-ins to create multiple gene combinations, or reselecting receptor genes.
References: PMID: 35798699 / doi: 10.1038/s41392-022-01087-8
Contact Info: Youchun Wang: wangyc@nifdc.org.cn
URL: https://www.nature.com/articles/s41392-022-01087-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Institute of Zoonosis, and College of Veterinary Medicine, Jilin University; Chinese Academy of Medicine Sciences & Peking Union Medical College; Walvax Biotechnology Co., Ltd; Inner Mongolia University for Nationalities; Chinese Academy of Agricultural Sciences; Yuxi JOZO Biotechnology co., LTD; ongji Medical College, Huazhong University of Science and Technology
Keywords: SARS-CoV-2, equine immunoglobulin, anti virus efficacy, histopathology, immune response, primates
Summary of Study: Therapeutic-grade equine immunoglobins are effective at improving the clinical symptoms of those hospitalized with SARS-CoV-2 and can be rapidly developed.
References: PMID: 35798694 / doi: 10.1038/s41392-022-01095-8
Contact Info: Zhongping Xie: xzp218@hotmail.com; Ningyi Jin: ningyik@126.com; Mingyuan Liu: liumy36@162.com
URL: https://www.nature.com/articles/s41392-022-01095-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Institute of Technology; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University; Scripps Research Institute; University of Louisiana at Lafayette; Beth Israel Deaconess Medical Center, Harvard Medical School; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, lipid-conjugated immunogen, intranasal vaccination, mice, primates
Summary of Study: To combat the problem of poor vaccine uptake across mucus and epithelial linings, intranasal immunization with amphilic albumin binding components was created with the ability to be delivered across the mucosal epithelium and generate an antigen-specific response.
References: PMID: 35857825 / doi: 10.1126/scitranslmed.abn1413
Contact Info: Darrell Irvine: djirvine@mit.edu
URL: https://www.science.org/doi/10.1126/scitranslmed.abn1413?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Defence Science and Technology Laboratory; United Kingdom Health and Security Agency
Keywords: SARS-CoV-2, aerosolized virus, pathology, immune response, primates
Summary of Study: Following COVID-19 exposure, marmosets did not develop clinical signs other than a disruption to the diurnal temperature rhythm. This may be due to an innate immunological response, which included an increase in neutrophils and monocytes and a reduction in T-cells.
References: PMID: 35891560 / doi: 10.3390/v14071580
Contact Info: Rachel Ireland: reireland@dstl.gov.uk
URL: https://www.mdpi.com/1999-4915/14/7/1580
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines Inc; Bill & Melinda Gates Foundation; BIOQUAL Inc; Butler University; Vanderbilt University School of Medicine; University of Texas Medical Branch
Keywords: SARS-CoV-2, attenuated recombinant vaccine, immune response, primates
Summary of Study: A live, attenuated, recombinant human respiratory virus that expresses a chimeric SARS-CoV-2 spike protected against challenge and induced immunoglobulin and neutralizing antibodies.
References: PMID: 35906244 / doi: 10.1038/s41541-022-00509-6
Contact Info: Mariana F. Tioni: mariana.tioni@meissavaccines.com
URL: https://www.nature.com/articles/s41541-022-00509-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heeterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: wenbo_xu1@aliyun.com; Qihan Li: liqihan@imbcams.com.cn
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.life-science-alliance.org/content/5/4/e202101314
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2022
Study Type/Review: prevention, therapeutics
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both rpevention and treatment settings of SARS-CoV-2 infectoin in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: mark.esser@astrazeneca.com
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eigth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell resposnes, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: wangyc@nifdc.org.cn; Yilong Zhang: yilongzhang@fulgentpharma.com; Jincun Zhao: zhaojincun@gird.cn
URL: https://www.nature.com/articles/s41422-022-00612-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: natalie.anosova@sanofi.com
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: wangjz@nifdc.org.cn; Zhenglun Liang: lzhenglun@126.com; Miao Xu: xumiao@nifdc.org.cn
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Stanford University School of Medicine; University of Louisiana at Lafayette; Washington University School of Medicine
Keywords: SARS-CoV-2, vaccine, immune response, mice, primates
Summary of Study: Non-human primates and humans are better models than mice when looking at the potency of neutralizing antibody responses from vaccine as their immune and caution should be used when generalizing data from mouse models.
References: PMID: 35988541 / doi: 10.1016/j.celrep.2022.111299
Contact Info: David Veesler: dveesler@uw.edu
URL: https://www.sciencedirect.com/science/article/pii/S2211124722011196?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Stanford University; University of Washington; Emory National Primate Research Center, and Emory University School of Medicine; Tulane National Primate Research Center; University of Louisiana at Lafayette; University of Maryland School of Medicine; University of California, San Diego; La Jolla Institute for Immunology; GSK; Bill and Melinda Gates Foundation; Tulane University School of Medicine;
Keywords: SARS-CoV-2, adjuvanted subunit vaccine, immune response, primates
Summary of Study: An adjuvanted subunit vaccine rsults in significant and durable memory T- and B-cell responses to Beta and Omicron variants and was found to suppress viral load and protect lungs after Omicron infection.
References: PMID: 35976993 / doi: 10.1126/scitranslmed.abq4130
Contact Info: Bali Pulendran: bpulend@stanford.edu
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abq4130?rfr_dat=cr_pub%20%…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: abai.zhandos15@gmail.com
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
Coronavirus Investigated: SARS-CoV-2; SARS-CoV-1
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Scripps Research Institute; Massachusetts Institute of Technology; Alpha Genesis; University of California, San Diego; La Jolla Institute for Immunology; Howard Hughes Medical Institute; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
Keywords: SARS-CoV-2, SARS-CoV-1, comparative studies, immune response, primates
Summary of Study: Using a two-shot protocol immunization with SARS-CoV-2 spike protein created strong serum receptor binding domain neutralizing antibody responses to both SARS-CoV-1 and SARS-CoV-2.
References: PMID: 35947674 / doi: 10.1126/scitranslmed.abl9605
Contact Info: Ian Wilson: wilson@scripps.edu; Dennis Burton: burton@scripps.edu; Raiees Andrabi: andrabi@scripps.edu
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abl9605?rfr_dat=cr_pub%20%…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Betuvax LLC; Lomonosov Moscow State University; Clinical Excellence Group LLC; I.I. Mechnikov North-Western State Medical University; PJSC Human Stem Cells Institute; Center of Genetics and Reproductive Medicine; Sechenov First Moscow State Medical University; Biotechnology Developments LLC; Ministry of Health of the Russian Federation
Keywords: SARS-CoV-2, subunit vaccine, “Betuvax-CoV-2”, preclinical studies, several animal species, primates
Summary of Study: A vaccine developed as a subunit that contains a recombinant receptor-binding domain fusion protein and virus-like nanoparticles demonstrates effective protection through COVID-19 neutralizing antibody production and conferring infection and lung damage protection.
References: PMID: 36016181 / doi: 10.3390/vaccines10081290
Contact Info: Anna Vakrusheva: vakhrusheva@betuvax.ru
URL: https://www.mdpi.com/2076-393X/10/8/1290
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaque
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University hopsital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral acitivty that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: roger.le-grand@cea.fr; Jeremie Guedj: jeremie.guedj@inserm.fr
URL: https://www.nature.com/articles/s41467-022-32565-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Chinese Academy of Medicine Sciences & Peking Union Medical College; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, virus variants, virulence, pathogenesis, immune response, primates
Summary of Study: Pathogenic differences of ancestral SARS-CoV-2 strain and a beta variant found the variant resulted in more severe lung injury and an elevated level of inflammatory cytokines, but a lower transmission ability.
References: PMID: 36069561 / doi: 10.1128/spectrum.02263-22
Contact Info: Junzhi Wang: wangjz@nifdc.org.cn; Miao Xu: xumiao@nifdc.org.cn
URL: https://journals.asm.org/doi/full/10.1128/spectrum.02263-22?rfr_dat=cr_pub%20%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: University of Saskatchewan; Dalhousie University; University of Pittsburgh
Keywords: SARS-CoV-2, review, post-acute sequelae, pathology, immune response, several animal species, primates
Summary of Study: Analysis of work done in different animal models in order to understand the mechanisms of Long COVID that could help identify treatments.
References: PMID: 36070309 / doi: 10.1371/journal.ppat.1010741
Contact Info: Alyson A. Kelvin: alyson.kelvin@usask.ca
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010741
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: sunming@imbcams.com.cn
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: China Biotechnology Co.LTD; Beijing Chaoyang Hospital, Capital Medical University; Laboratory Animal Center, Academy of Military Medical Sciences
Keywords: SARS-CoV-2, angiotensin-converting enzyme 2, gene sequences, primates
Summary of Study: Angiotensin-converting enzyme (ACE2) binds to the SARS-CoV2 virus as a receptor, and variation of the ACE2 sequence and binding affinity may account for differences in susceptibility and responses to infection
References: PMID: 36105891 / doi: 10.1016/j.bsheal.2022.09.001
Contact Info: Xiaojun Zhou, Jingjing Zhao, Yefeng Qiu, Rui Jia
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461283/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: tahiryaqub@uvas.edu.pk
URL: https://www.mdpi.com/2075-1729/12/9/1424
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus and cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Vaxxiniy, Inc., Dallas, Texas; United Biomedical, Inc. (Taiwan and USA); Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, USA; others.
Keywords: SARS-CoV-2, subunit protein-peptide vaccine, immunogenicity, rat, mice, primates
Summary of Study: RBD-Protein/Peptide Vaccine Elicits Broadly Neutralizing Antibodies
References: doi: 10.1080/22221751.2022.2140608
Contact Info: Farshad Guirakhoo: farshad@vaxxinity.com
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2140608
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Elicio Therapeutics; New Iberia Research Center, Lousiana
Keywords: SARS-CoV-2, vaccine, amphiphile adjuvant, immune response, mice, primates
Summary of Study: Lymph-node adjuvant-targeting to coordinate innate immunity and generate robust adaptive responses critical for vaccine efficacy.
References: doi: 10.1038/s41541-022-00560-3
Contact Info: Peter DeMuth: pete.demuth@elicio.com
URL: https://www.nature.com/articles/s41541-022-00560-3
Coronavirus Investigated: SARS-CoV-2
NHP Species: green monkey
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi India
Keywords: SARS-CoV-2, virus variants, geographical distribution, genome sequencing, several animal species, primates
Summary of Study: Mutations and evolution of seven distinct clades in non?human hosts
References: doi: 10.1111/zph.12971
Contact Info: Thenmalarchelvi Rathinavelan: tr@bt.iith.ac.in
URL: https://onlinelibrary.wiley.com/doi/full/10.1111/zph.12971
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: neural infections and inflammation
NPRC/Institute: California National Primate Research Center; University of California, Davis
Keywords: SARS-CoV-2, neurotropism, microglia, astrocytes, inflammation, aging, primates
Summary of Study: SARS-CoV-2 infects neurons and induces neuroinflammation
References: doi: 10.1016/j.celrep.2022.111573
Contact Info: John H. Morrison: jhmorrison@ucdavis.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554328/#:~:text=Seven%20days%20aft…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: National Biodefense Analysis and Countermeasures Center; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health; Censeo Insight, Seattle, Washington, USA.
Keywords: SARS-CoV-2, dose–response relationships, aerosol, virus isolates, primates
Summary of Study: Provides dose response data important to inform disease transmission and hazard modeling
References: doi: 10.1089/jamp.2022.0043
Contact Info: Paul Dabisch: paul.dabisch@nbacc.dhs.gov
URL: https://www.liebertpub.com/doi/10.1089/jamp.2022.0043
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; CureVac AG, Tübingen, Germany
Keywords: SARS-CoV-2, unmodified mRNA vaccine, CVnCoV, immune response, primates
Summary of Study: A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.
References: doi: 10.1016/j.omtm.2022.10.001
Contact Info: Karin Loré: karin.lore@ki.se
URL: https://www.sciencedirect.com/science/article/pii/S2329050122001437?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: hhc Data Creation Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Drug Discovery Platform, KAN Research Institute, Inc., 6-8-2 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Medicine Development Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Keywords: SARS-CoV-2, lipid nanoparticles, encapsulated mRNA, immunogenicity, mice, primates
Summary of Study:
References: doi: 10.1016/j.omtn.2022.09.017
Contact Info: Yuta Suzuki: y14-suzuki@hhc.eisai.co.jp
URL: https://www.sciencedirect.com/science/article/pii/S2162253122002608?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Gujarat Biotechnology Research Centre (GBRC), India; Kamdhenu University, Gujarat, India; University of California Santa Barbara, Santa Barbara, CA.
Keywords: SARS-CoV-2, surveillance, RT-PCR, several animal species, primates
Summary of Study: Highlights transmission of SARS-CoV-2 infection from human to animals and suggests being watchful for zoonosis.
References: doi: 10.3390/ijerph192114391
Contact Info: Arunkumar Patel: viroarun@gmail.com
URL: https://www.mdpi.com/1660-4601/19/21/14391
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Wuhan Institute of Virology; Chinese Academy of Science; Wuhan National Biosafety Library, others
Keywords: SARS-CoV-2, testicular pathological damage, inflammation, primates
Summary of Study: SARS-CoV-2 infection induces testicular injury in Rhesus macaque
References: 10.1016/j.virs.2022.10.008
Contact Info: Z. Wuan: yzm@wh.iov.cn
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22001833?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: NIBSC Division of Infectious Disease Diagnostics, Division of Virology, Division of Analytical and Biological Sciences, other, Hertfordshire, UK
Keywords: SARS-CoV-2, virology, molecular and pathological outcomes, several animal species, primates
Summary of Study: Viral outcomes in multiple species
References: doi: 10.1038/s41598-022-23339-x
Contact Info: Neil Berry: neil.berry@nibsc.org
URL: https://www.nature.com/articles/s41598-022-23339-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID RNA Viruses Section, Laboratory of Infectious Diseases, numerous others
Keywords: SARS-CoV-2, pediatric vaccine, live-attenuated parainfluenza-virus-vectored vaccine, immunogenicity, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
References: doi: 10.1016/j.cell.2022.11.006
Contact Info: Ursula Buchholz: ubuchholz@niaid.nih.gov
URL: https://www.sciencedirect.com/science/article/pii/S0092867422014180?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotech Co., Ltd.; numerous others
Keywords: SARS-CoV-2, recombinant vaccine, immunogenicity, virus variants, hamster, primates
Summary of Study: A potent, broadly protective vaccine against SARS-CoV-2 variants of concern.
References: doi: 10.1038/s41541-022-00571-0
Contact Info: Chenliang Zhou: zhouchenliang@wallvax.com
URL: https://www.nature.com/articles/s41541-022-00571-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane University, Memorial Sloan Kettering Cancer Ctr, Weill Cornell Medical College, Instuto de Química Pontificia Universidad Católica de Valparaíso
Keywords: SARS-CoV-2, urokinase plasminogen activator receptor, renal dysfunction, pathology, primates
Summary of Study: Elevated soluble urokinase plasminogen activator receptor
References: doi: 10.1111/jmp.12626
Contact Info: Minolfa Prieto: mprieto@tulane.edu
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12626
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: NIAID Laboratory of Virology and NIAID Rocky Mountain Veterinary Branch, Hamilton, MT
Keywords: SARS-CoV-2, pathology, virus variants, primates
Summary of Study: Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
References: doi: 10.1126/sciadv.ade1860
Contact Info: Kyle Rosenke: kyle.rosenke@nih.gov
URL: https://www.science.org/doi/10.1126/sciadv.ade1860
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Beijing Institute for Brain Disorders, Capital Medical University, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing , numerous others.
Keywords: SARS-CoV-2, single-nucleus transcriptomics, pathology, immune response, primates
Summary of Study: Single-nucleus transcriptomic profiling of multiple organs
References: doi: 10.24272/j.issn.2095-8137.2022.443
Contact Info: Xiaoqun Wang: nc.ude.unb@gnawnuqoaix
URL: https://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2022.443
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, vaccine, Ad26.COV2.S, spike ferritin nanoparticles, immune response, primates
Summary of Study: Protection against SARS-CoV-2 Omicron BA.1 variant challenge
References: doi: 10.1126/sciadv.ade4433
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/10.1126/sciadv.ade4433
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, numerous others
Keywords: SARS-CoV-2, vaccine, BNT162b2, mRNA-1273, infants, immune response, primates
Summary of Study: Protection in immunized infant macaques
References: doi: 10.1126/scitranslmed.add6383
Contact Info: Kristina de Paris: abelk@med.unc.edu
URL: https://www.science.org/doi/10.1126/scitranslmed.add6383
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd., Biopharmaceutical Research Division, Osaka, Japan
Keywords: SARS-CoV-2, recombinant spike protein vaccine, virus variants, immune response
Summary of Study: Homologous and heterologous booster vaccinations of S-268019-b, a recombinant S protein-based vaccine
References: doi: 10.1016/j.vaccine.2022.10.092
Contact Info: Shinya Omoto: shinya.oomoto@shionogi.co.jp
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22013792?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Keio University School of Medicine, Tokyo, Japan; RIKEN Center for Integrative Medical Sciences, Infectious Diseases Research unit, Kanagawa, Japan, numerous others.
Keywords: SARS-CoV-2, therapeutic neutralizing antibodies, virus variants, immune response, hamsters, primates
Summary of Study: Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects
References: doi: 10.1016/j.isci.2022.105596
Contact Info: Masaru Takeshita: takeshita@a5.keio.jp
URL: https://www.sciencedirect.com/science/article/pii/S2589004222018685?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, UK; Ifakara Health Institute, Bagamoyo, Tanzania
Keywords: SARS-CoV-2, review, long-lived plasma cells, lymph node germinal centers, humans, primates
Summary of Study: Human lymphoid tissue sampling for vaccinology
References: doi: 10.3389/fimmu.2022.1045529
Contact Info: Carolyn M. Nielsen: carolyn.nielsen@bioch.ox.ac.uk
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1045529/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Shiga University of Medical Science, Otsu, Japan; others
Keywords: SARS-CoV-2, vaccine development, attenuated vaccinia virus, immune response, proteomics, virus variants, mice, primates
Summary of Study: Vaccine protects monkeys and transgenic mice from SARS-CoV-2 and variants
References: doi: 10.3389/fmicb.2022.967019
Contact Info: Michinori Kohara: koharamc@igakuken.or.jp
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.967019/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Chin Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
Keywords: SARS-CoV-2, review, traditional Chinese medicine, mice, hamsters, primates
Summary of Study: Model exploration for discovering COVID-19 targeted traditional Chinese medicine
References: doi: 10.1016/j.heliyon.2022.e12333
Contact Info: Fengmei Lian: lfm565@sohu.com
URL: https://www.sciencedirect.com/science/article/pii/S2405844022036210?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Duke University School of Medicine, Durham, NC; California National Primate Research Center; others.
Keywords: SARS-CoV-2, age-dependent responses, immune response, pathology, primates
Summary of Study: Age-dependent responses to SARS-CoV-2 in dam/infant pairs
References: doi: 10.4049/immunohorizons.2200075
Contact Info: Maria Blasi: maria.blasi@duke.edu
URL: https://journals.aai.org/immunohorizons/article/6/12/851/237621/Dam-Infant-Rhesu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, aerosol or intra-tracheal/intra-nasal infection, viral load, inflammation, primates
Summary of Study: Cellular mechanisms underlying acute respiratory distress syndrome
References: doi: 10.1038/s42003-022-04310-y
Contact Info: Namita Rout: nrout@tulane.edu
URL: https://www.nature.com/articles/s42003-022-04310-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus and cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Praesidium Bioscience, Inc., New York, NY; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Intima Bioscience, Inc., New York, NY; Ragon Institute of Massachusetts General Hospital, Massac
Keywords: SARS-CoV-2, CRISPR, stem cell, iPSC, vaccine, universal cell, primates
Summary of Study: A genetically engineered, stem-cell-derived cellular vaccine
References: doi: 10.1016/j.xcrm.2022.100843
Contact Info: Tom Henley: tom@intimabioscience.com; Dan H. Barouch: dbarouch@bidmc@harvard.edu
URL: https://www.sciencedirect.com/science/article/pii/S2666379122004074?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: martyomov@wustl.edu
URL: https://www.nature.com/articles/s41467-022-28315-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Fudan University; Shanghai King-Cell Biotechnology Co., Ltd.; Mabwell Bioscience Co., Ltd.; Shenzhen University; University of Chinese Academy of Sciences
Keywords: SARS-CoV-2, self-adjuvating peptide vaccine, CoVac501, immune response, virus variants, primates
Summary of Study: CoVac501, a novel SARS-CoV-2 vaccine that is fully chemically synthesized and self-adjuvanting, provided potent protecton for cynomolgus macaques against challenges from very high doses of SARS-CoV-2.
References: PMID: 35102138 / doi: 10.1038/s41421-021-00370-2
Contact Info: Qiuping Qin: pqqin@cdser.simm.ac.cn
URL: https://www.nature.com/articles/s41421-021-00370-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Medicago Inc.; Stanford University School of Medicine; Tulane National Primate Research Center; Tulane University School of Medicine; Research Institute of the McGill University Health Centre
Keywords: SARS-CoV-2, unadjuvanted and adjuvanted formulations, recombinant plant-derived virus-like particle vaccine, safety, immune response, primates
Summary of Study: A VLP bearing a SARS-CoV-2 spike protein vaccine candidate formulated with Adjuvant System 03 (AS03) was shown to be safe and effective and was therefore selected for vaccine development and clinical trials.
References: PMID: 34983950 / doi: 10.1038/s41423-021-00809-2
Contact Info: Brian Ward: wardb@medicago.com
URL: https://www.nature.com/articles/s41423-021-00809-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, lung and liver pathology, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS-CoV-2-infected lung and liver tissues showed potentially active protein synthesis and processing, and dysregulated ECM, cell-to-cell junction, and cytoskeleton but no fibrosis in both the infected lung and liver.
References: PMID: 35091530 / doi: 10.1038/s41392-022-00882-7
Contact Info: Shaui-Yao Lu: lushuaiyao-km@163.com
URL: https://www.nature.com/articles/s41392-022-00882-70pubmed&url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: MIT; Broad Institute of MIT and Harvard; Ragan Institute of MGH, MIT, and Harvard; University of Duisburg-Essen; Space Exploration Technologies Corp.; Harvard University; Vanderbilt University Medical Center; Northwestern University Feinberg School of Medicine; University of Bonn; Howard Hughes Medical Institute; Massachusetts Consortium on Pathogen Readiness; Harvard Medical School; Brigham and Womoen's Hospital; Harvard Humanitarian Initiative
Keywords: SARS-CoV-2, immune biomarkers, reinfection, immune response, primates
Summary of Study: A specific set of SARS-CoV-2-specific humoral features, including spike RBD-specific IgG1 titers, nucleocapsid-specific IgG3 titers, and anti-spike RBD FcyR2A binding activity, were identified as robust biomarkers of reinfection that translate across species. When reinfection cannot be confirmed by viral sequence, changes in SARS-CoV-2 humoral immune responses may offer inexpensive, reliable, and effective measures to track reinfection.
References: PMID: 35073738 / doi: 10.1128/mbio.02141-21
Contact Info: Douglas Lauffenburger: lauffen@mit.edu; Galit Alter: galter@mgh.harvard.edu
URL: https://journals.asm.org/doi/full/10.1128/mbio.02141-21?rfr_dat=cr_pub%20%200pub…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center
Keywords: SARS-CoV-2, synthetic multiantigen modified vaccine, COH04S1, immune response, hamsters, primates
Summary of Study: Vaccine candidate C0H04S1 stimulates protective immunity against SARS-CoV-2 in Syrian hamsters by intramuscular and intranasal vaccination and in non-human primates through two-dose and single-dose regimens.
References: PMID: 35064109 / doi: 10.1038/s41541-022-00436-6
Contact Info: Felix Wussow: fwussow@coh.org
URL: https://www.nature.com/articles/s41541-022-00436-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention, therapeutics
NPRC/Institute: University of Washington; Washington National Primate Research Center; Institute of Biomedical Sciences, Taipei; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, helper-dependent adenovirus (HDAd5/35++), HSC gene therapy, safety, virus protection, mice, primates
Summary of Study: Pilot studies of a simple and portable in vivo hematopoietic HSC transduction approach that involves HSC mobilization from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating, helper-dependent adenovirus vector system demonstrated safety and efficacy in mice and a rhesus macaque.
References: PMID: 35057635 / doi: 10.1089/hum.2021.295
Contact Info: Andre Lieber: lieber00@uw.edu; Steve Roffler: sroff@ibms.sinica.edu.tw; Hans-Peter Kiem: hkiem@fredhutch.org; Deborah Fuller: fullerdh@uw.edu
URL: https://www.liebertpub.com/doi/10.1089/hum.2021.295?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: zhangyw57@mail.sysu.edu.cn; Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; University of California, Irvine
Keywords: SARS-CoV-2, Vesicular Stomatitis Virus-Based Vaccine, route of administration, immune response, primates
Summary of Study: The VSV-SARS2-EBOV vaccine presents a vaccine with a high potential as a boosting option after the already-approved mRNA-based vaccine, because VSV-SARS2-EBOV elicits primarily a humoral response, in contrast to the predominantly T cell-driven immune response after mRNA vaccination.
References: PMID: 35012339 / doi: 10.1128/mbio.03379-21
Contact Info: Andrea Marzi: marzia@niaid.nih.gov
URL: https://journals.asm.org/doi/full/10.1128/mbio.03379-21?rfr_dat=cr_pub%20%200pub…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: nmaness@tulane.edu
URL: https://www.mdpi.com/1999-4915/14/1/77
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Paris-East Creteil University; Universite Paris-Saclay Fontenay-aux-Roses; CEA-INSERM, University of Lille; Universite de Lyon; Centre de Recherche en Cancerologie de Lyon; Institut Curie; Justus Liebig University
Keywords: SARS-CoV-2, lung cell senescence, RNA analysis, pathology, humans, primates
Summary of Study: Cell senescence was monitored in cynomologus macaques to evaluate potential links between SARS-CoV-2 infection and aging. Data constitute the first evidence of temporal and topographic relations between senescent cell accumulation and pulmonary lesions induced by SARS-CoV-2.
References: PMID: 34648725 / doi: 10.1165/rcmb.2021-0205LE
Contact Info: Serge Adnot: serge.adnot@inserm.fr
URL: https://www.atsjournals.org/doi/10.1165/rcmb.2021-0205LE?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Northwestern University; Tulane National Primate Research Center; NIAID; Sanford Burnham Prebys Medical Discovery Institute; Bioqual; New Iberia Research Center
Keywords: SARS-CoV-2, antibody-based in vivo probe system, lungs, primates
Summary of Study: Results provide proof of concept for the use of in vivo antibody-based probes to study SARS-CoV-2 infection dynamics in rhesus macaques.
References: PMID: 35003140 / doi: 10.3389/fimmu.2021.810047
Contact Info: Thomas Hope: thope@northwestern.edu
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.810047/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Washington National Primate Research Center; HDT Bio
Keywords: SARS-CoV-2, immunocompromised animals, SIV, RNA vaccine, immunogenicity, primates
Summary of Study: SARS-CoV-2 alphavirus-derived replicon RNA vaccine formulated with a novel Lipid InOrganic Nanoparticle (LION) emulsion (repRNA-CoV2S) induced robust cellular and humoral immune responses after a single immunization in immunocompromised SIV-infected animals as a highly relevant model of untreated HIV infection in humans.
References: PMID: 34992610 / doi: 10.3389/fimmu.2021.800723
Contact Info: Deborah Fuller: fullerdh@uw.edu
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.800723/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: China Pharmaceutical University; Yunnan Walvax Biotech
Keywords: SARS-CoV-2, chimpanzee adenovirus-based vaccine, immunogenicity, toxicology, rats, primates
Summary of Study: AdC68-19S, a recombinant chimpanzee adenovirus serotype 68 vector-based vaccine encoding the full-length spike protein of SARS-CoV-2, induced an effective immune response with a good safety profile in rhesus macaques.
References: PMID: 35226134 / doi: 10.1007/s00204-021-03221-x
Contact Info: Zhen Huang: hz@walvax.com
URL: https://link.springer.com/article/10.1007/s00204-021-03221-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fudan University; The University of Hong Kong; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park; Graduate School of Peking Union Medical College; Natinal Institute for Food and Drug Control, Beijing, China; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus variants, primates
Summary of Study: A pan-sarbecovirus vaccine consisting of human IgG Fc fragment-conjugated RBC of the original SARS-CoV-2 WA1 strain as the immunogen and a novel small-molecule non-nucleotide STING agonist as the adjuvant could be used to prevent infection by the current SARS-CoV-2 variants, including Omicron, and future emerging sarbecoviruses.
References: PMID: 35210607 / doi: 10. 1038/s41422-022-00631-z
Contact Info: Youchun Wang: wangyc@nifdc.org.cn
URL: https://www.nature.com/articles/s41422-022-00631-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; Guangdong Academy of Medical Sciences; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccine, virus variants, hACE2 mice, primates
Summary of Study: RBD-based monovalent or multivalent nanoparticle vaccines provide a promising second-generation vaccine strategy for SARS-CoV-2 variants.
References: PMID: 35142444 / doi: 10.1002/advs.202105378
Contact Info: Ting Pan: pant8@gmail.sysu.edu.cn; Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008796/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Pfizer; Icahn School of Medicine at Mount Sinai; Texas Biomedical Research Institute; New Iberia Research Center
Keywords: SARS-CoV-2, pathology, inflammation, Golden Syrian Hamster, primates
Summary of Study: Macaques may be appropriate for mechanistic studies of mild asymptomatic COVID-19 pneumonia and COVID-19-associated encephalitis, whereas Syrian hamsters may be more suited to study severe COVID-19 pneumonia.
References: PMID: 35128980 / doi: 10.1177/01926233211072767
Contact Info: Shambhunath Choudhary: shambhunath.choudhary@pfizer.com
URL: https://journals.sagepub.com/doi/full/10.1177/01926233211072767?rfr_dat=cr_pub%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines and Prevention; Ragon Institute of MGH, MIT and Harvard; BIOQUAL; Amsterdam University Medical Center
Keywords: SARS-CoV-2, homologous or variant booster vaccine, humoral and cellular immune responses, primates
Summary of Study: A late boost with Ad26.COV2.S or Ad26.COV2.S.351 resulted in a marked increase in humoral and cellular immune responses that were highly cross-reactive across multiple SARS-CoV-2 variants in rhesus macaques.
References: PMID: 35191769 / doi: 10.1126/scitranslmed.bm4996
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abm4996?rfr_dat=cr_pub%20%…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A//lin…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute of Biological Products; Chinese Academy of Medicine Sciences & Peking Union Medical College
Keywords: SARS-CoV-2, recombinant protein subunit vaccine and an inactivated vaccine, virus variants, primates
Summary of Study: Both vaccines evaluated in this study significantly reduced the viral load in the respiratory tract, alleviated pathological changes, and relieved lung inflammation in vaccinated macaques. The possible contribution of antibodies possessing neutralizing reactivity or cell-mediated cytotoxicity and immune memory to vaccine induced protection was also highlighted.
References: PMID: 35241645 / doi: 10.1038/s41392-022-00926-y
Contact Info: Junzhi Wang: wangjz@nifdc.org.cn
URL: https://www.nature.com/articles/s41392-022-00926-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Chinese Academy of Sciences; China Agricultural University; Capital Medical University; University of Science & Technology of China; Chinese Academy of Medical Sciences and Peking Union Medical College; Chinese Center for Disease Control and Prevention
Keywords: SARS-CoV-2, human neutralizing antibodies, virus variants, mice, primates
Summary of Study: bsAB15 was developed and shown to efficiently neutralize all single-mAb escape mutants. This bsAb is a feasible and effective strategy to treat and prevent severe COVID-19.
References: PMID: 35228696 / doi: 10.1038/s41590-022-01138-w
Contact Info: Yan Wu: wuyan@ccmu.edu.cn; Feng Gao: gaofeng@tib.cas.cn
URL: https://www.nature.com/articles/s41590-022-01138-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, inactivated vaccine, pathology, virus variants, primates
Summary of Study: Three doses of a prototypic SARS-CoV-2 inactivated vaccine reduced viral loads in nasal, throat and anal swabs and pulmonary tissues and improved the pathological changes lungs of animals infected by variants of Alpha, Beta and Delta.
References: PMID: 35217639 / doi: 10.1038/s41392-022-00920-4
Contact Info: Zhongping Xie: szp@imbcams.com.cn; Wenjie Tan: tanwj@ivdc.chinacdc.cn
URL: https://www.nature.com/articles/s41392-022-00920-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; Bioqual; Oak Ridge Institute of Science and Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, nanoparticle vaccine, cellular and humoral immune responses, primates
Summary of Study: Nonhuman primates vaccinated with two doses of SpFN (a SARS-CoV-2 spike protein ferritin nanoparticle vaccine) were protected against SARS-CoV-2 challenge. SErum isolated from vaccinated animals neutralized several variants of concern, including the delta variant.
References: PMID: 39414540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: M. Gordon Joyce: gjoyce@eidresearch.org; Kayvon Modjarrad: kayvon.modjarrad.civ@mail.mil
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: winfried.weissenhorn@ibs.fr; Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retur…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: tmatano@nih.go.jp
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retur…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune reponse, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: lei.han@jechobio.com
URL: https://www.nature.com/articles/s41421-022-00381-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: University of Central Florida; Tulane National Primate Research Center
Keywords: SARS-CoV-2, pathology, heart, immune response, primates
Summary of Study: SARS-CoV-2 infection is characterized by an exaggerated inflammatory immune response in the heart, which possibly contributes to myocardial remodeling and subsequent fibrosis.
References: PMID: 35203260 / doi: 10.3390/cells11040611
Contact Info: Manish Kumar Gupta: manish.gupta@ucf.edu
URL: https://www.mdpi.com/2073-4409/11/4/611
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institution of MGH, MIT, and Harvard; Bioqual; Washington University School of Medicine; Emory School of Medicine, Tufts University Cummings School of Veterinary Medicine
Keywords: SARS-CoV-2, mRNA-based BNT162b2 vaccine, virus variants, immune response, primates
Summary of Study: BNT162b2 and Ad26.COV2.S provided robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in macaques. Protection against this highly mutated SARS-CoV-2 variant correlated with both humoral and cellular immune responses.
References: PMID: 35169798 / doi: 10.1101/2022.02.06.479285
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2022.02.06.479285v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: Diagnostics
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; Sorbonne Universite; BioPredictive; Institut Pasteur
Keywords: SARS-CoV-2, blood test, diagnostics, primates
Summary of Study: Results validate the diagnostic and prognostic performances of A1HPV6 in patients infected by SARS-CoV-2, not hospitalized in ICU. These rsults are reinforced by similar kinetics of A1, HP, and A2M observed in the macaque model.
References: PMID: 35174366 / doi: 10.1016/j.gastha.2021.12.009
Contact Info: Thierry Poynard: thierry@poynard.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818442/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology and Epidemiology; Sinocelltech, Ltd.; Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, polysaccharide–protein-conjugated nanoparticle vaccine, virus variants, mice, rats, primates
Summary of Study: A novel nanoparticle vaccine was designed and prepared by chemically conjugating recombinant SARD-CoV-2 RBD and PPS14. Studies have demonstrated that SCTV01B vaccination induced potent and broad neutralizing antibodies and cellular immune responses against SARS-CoV-2 in mice, rats, and nonhuman primates, as well as high OPA against S. pneumoniae serotype 14.
References: PMID: 35332581 / doi: 10.1002/adma.202200443
Contact Info: Liangzhi Xie: liangzhi@yahoo.com
URL: https://onlinelibrary.wiley.com/doi/10.1002/adma.202200443
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tsinghua University; Chongqing Medical University; Boston University School of Medicine; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenshen Graduate School; Fudan University
Keywords: SARS-CoV-2, pathogenesis, neutralization antibodies, primates
Summary of Study: Kappa, Delta, or B.1.618 spike uses human angiotensin-converting enzyme 2 (ACE2) with no or slightly increased efficiency, while it gains a significantly increased binding affinity with mouse, marmoset, and koala ACE2 orthologs, which exhibit limited binding with wild-type (WT) spike. Collectively, this study revealed that enhanced human and mouse ASE receptor engagement, increased spike cleavage, and reduced sensitivity to neutralization antibodies of Kapa, Delta and B.1.618 may contribute to the rapid spread of these variants.
References: PMID: 35266815 / doi: 10.1128/mbio.00099-22
Contact Info: Qiang Ding: qding@tsinghua.edu.cn
URL: https://journals.asm.org/doi/full/10.1128/mbio.00099-22?rfr_dat=cr_pub%20%200pub…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to moitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: thibaut.naninck@cea.fr
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3A…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: yzm@wh.iov.cn; Chao Shan: shanchao@wh.iov.cn
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: treatment
NPRC/Institute: Lovelace Biomedical; Gilead Sciences; Inspired - Pulmonary Solutions
Keywords: SARS-CoV-2, remdesivir, inhalation, viral load, pharmacokinetics, primates
Summary of Study: Inhaled remdesivir reduced viral load as compared with placebo in African green monkeys infected with SARS-CoV-2.
References: PMID: 34968150 / doi: 10.1126/scitranslmed.abl8282
Contact Info: Danielle Porter: danielle.porter@gilead.com
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8282?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: kayvon.modjarrad.civ@mail.mil
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis, review
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: stammes@bprc.nl
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emory University; University of Sao Paulo School of Medicine; Butantan Institute; La Jolla Institute for Immunology
Keywords: SARS-CoV-2, DNA vaccine HIVBr18, HLA class II vaccine epitopes, immunity, humans and primates
Summary of Study: Results provide preliminary proof of concept that immunization with a vaccine encoding epitopes with high and redundant coverage of the human population can elicit potent T cell responses to multiple epitopes, across species and MHC barriers.
References: PMID: 34961636 / doi: 10.1016/j.vaccine.2021.11.076
Contact Info: Edecio Cunha-Neto: edecunha@usp.br
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21015504?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: rseder@mail.nih.gov; Daniel Douek: ddouek@mail.nih.gov
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center
Keywords: SARS-CoV-2, noncompeting antibody cocktail, vaccine, immune response, primates
Summary of Study: A neutralizing mAB cocktail with extended half-life can be delivered intramuscularly to provide prophylactic protection against infection in rhesus macaques.
References: PMID: 35291730 / doi: 10.1016/j.medj.2022.02.004
Contact Info: Jay Rappaport: jrappaport@tulane.edu
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00087-3?_returnURL=https%3A//lin…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: barberd@niaid.nih.gov
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center; Michigan Technological University; Tulane University
Keywords: SARS-CoV-2, renin-angiotensin system, HIV co-infection, gene expression, primates
Summary of Study: Findings suggest a possible impact of SIV/HIV infection on expression of ACE2 and RAS-associated proteins resulting in the loss of gut homeostasis.
References: PMID: 35281029 / doi: 10.3389/fimmu.2022.835686
Contact Info: Bapi Pahar: bpahar@trudeauinstitute.org
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.835686/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: djirvine@mit.edu; Shane Crotty: shane@lji.org
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_i…
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature atth early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: yingyang@big.ac.cn; Yun-Gui Yang: ygyang@big.ac.cn; Chuan Qin: qinchuan@pumc.edu.cn; Wei-Min Tong: wmtong@ibms.pumc.edu.cn
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
Coronavirus Investigated: SARS-CoV2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: University of Illinois College of Medicine
Keywords: SARS-CoV-2, transcriptomic profiling, lung endothelial cells, primates
Summary of Study: The specific genes that distinguished immuneEC and devEC populations in the NHP lungs after SARS-CoV-2 infection were different from the endotoxemic mouse lung. This may reflect either species differences or different injury-specific responses (bacterial endotoxin vs. SARS-CoV-2).
References: PMID: 35511435 / doi: 10.1172/jci.insight.158079
Contact Info: Lianghui Zhang: lhzhang@uic.edu; Jalees Rehman: jalees@uic.edu
URL: https://insight.jci.org/articles/view/158079
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: wswei@pku.edu.cn
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A//li…
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: kate.broderick@inovio.com
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory School of Medicine; Bioqual; Modernal; Harvard T.H. Chan School of Public Health
Keywords: SARS-CoV-2, vaccination, mRNA-1273 or mRNA-Omicron boost, pathology, primates
Summary of Study: Boosting with homologous mRNA-1273 or mRNA-Omicron leads to comparable and significant increases in neutralizing antibody responses against all VOC, including Omicron.
References: PMID: 35447072 / doi: 10.1016/j.cell.2022.03.038
Contact Info: Daniel Douek: ddouek@mail.nih.gov; Robert Seder: rseder@mail.nih.gov
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00388-9?_returnURL=https%3A//li…
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; University of California, San Francisco
Keywords: SARS-CoV-2, human convalescent plasma, inflammation, primates
Summary of Study: Administration of CCP had minimal effects on reducing virus replication in the respiratory tract, but it significantly reduced lung inflammation. These data, combined with the results of monoclonal antibody studies, emphasize the need to use products with high titers of neutralizing antibodies, and guide the future development of antibody-based therapies.
References: PMID: 35443018 / doi: 10.1371/journal.ppat.1009925
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Michael Busch: mbusch@vitalant.org; Rachel Reader: rreader@ucdavis.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009925
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking Union Medical College; National Center of Technology Innovation for Animal Model; Chinese Academy of Sciences; Capital Medical University
Keywords: SARS-CoV-2, inactivated vaccine, booster, immune response, virus variants, primates
Summary of Study: Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron.
References: PMID: 35436986 / doi: 10.1038/s41392-022-00979-z
Contact Info: Chuan Qin: qinchuan@pumc.edu.cn;
URL: https://www.nature.com/articles/s41392-022-00979-z
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: croy@tulane.edu
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: sdandekar@ucdavis.edu
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; HDT Bio; NIAID; Washington National Primate Research Center
Keywords: SARS-CoV-2, phage-based deep mutational scanning, immune response, vaccination, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 35404959 / doi: 10.1371/journal.ppat.1010155
Contact Info: Julie Overbaugh: joverbau@fredhutch.org
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010155
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: verschoor@bprc.nl
URL: https://www.mdpi.com/1999-4915/14/4/776
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Tufts University Cummings School of Veterinary Medicine; Vaccine & Gene Therapy Institute/OHSU; University of Montreal; Oregon National Primate Research Center; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, Ad26.COV2.S vaccine, transcriptional and proteomic profiling, primates
Summary of Study: Study showed that vaccination with Ad26.COV2.S protected hamsters and rhesus macaques challenged with SARS-CoV-2 from developing excessive proinflammatory responses mediated by IL-6 and IL-1, macrophages, and neutrophil activation.
References: PMID: 35395058 / doi: 10.1371/journal.ppat.1009990
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009990
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Bavarian Nordic GmbH; Biomedical Primate Research Centre; Aarhus University; University of Copenhagen; AdaptVac Aps
Keywords: SARS-CoV-2, capsid virus-like particle-based vaccine ABNCoV2, immunogenicity, primates
Summary of Study: ABNCoV2 induced strong and long-lasting neutralizing antibody responses and efficacy against SARS-CoV-2 in NHP.
References: PMID: 35479095 / doi: 10.3389/fimmu.2022.857440
Contact Info: Ariane Volkmann: ariane.volkmann@bavarian-nordic.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.857440/full
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center
Keywords: SARS-CoV-2, neuropathogenesis, primates
Summary of Study: Substantial pathological changes in brains of SARS-CoV-2 infected NHPs are compatible with autopsy and imaging reports of infected human subjects.
References: PMID: 35365631 / doi: 10.1038/s41467-022-29440-z
Contact Info: Tracy Fischer: tfischer1@tulane.edu
URL: https://www.nature.com/articles/s41467-022-29440-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology; Civilian Defense Scienti?c Research Center, Carretera de Jamaica y Autopista Nacional; Biotechnology and Pharmaceutical Industries Group, BioCubaFarma, Ave; Latin American School of Medicine
Keywords: SARS-CoV-2, vaccine, yeast, manufacturing, mice, primates
Summary of Study: The COVID-19 receptor-binding domain produced in yeast cells can be modified by adding amino acids in order to create a possible vaccine candidate due to its ability to stimulate anti-inflammatory cells and inhibit binding to ACE2.
References: PMID: 35953030 / doi: 10.1016/j.nbt.2022.08.002
Contact Info: Gerardo Guillén-Nieto: Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 E/ 158 y 190, La Habana 10600, Cuba
URL: https://www.sciencedirect.com/science/article/pii/S1871678422000462?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub%20%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: wangjz@nifdc.org.cn; Zhenglun Liang: lzhenglun@126.com; Miao Xu: xumiao@nifdc.org.cn
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Stanford University School of Medicine; University of Louisiana at Lafayette; Washington University School of Medicine
Keywords: SARS-CoV-2, vaccine, immune response, mice, primates
Summary of Study: Non-human primates and humans are better models than mice when looking at the potency of neutralizing antibody responses from vaccine as their immune and caution should be used when generalizing data from mouse models.
References: PMID: 35988541 / doi: 10.1016/j.celrep.2022.111299
Contact Info: David Veesler: dveesler@uw.edu
URL: https://www.sciencedirect.com/science/article/pii/S2211124722011196?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Stanford University; University of Washington; Emory National Primate Research Center, and Emory University School of Medicine; Tulane National Primate Research Center; University of Louisiana at Lafayette; University of Maryland School of Medicine; University of California, San Diego; La Jolla Institute for Immunology; GSK; Bill and Melinda Gates Foundation; Tulane University School of Medicine;
Keywords: SARS-CoV-2, adjuvanted subunit vaccine, immune response, primates
Summary of Study: An adjuvanted subunit vaccine rsults in significant and durable memory T- and B-cell responses to Beta and Omicron variants and was found to suppress viral load and protect lungs after Omicron infection.
References: PMID: 35976993 / doi: 10.1126/scitranslmed.abq4130
Contact Info: Bali Pulendran: bpulend@stanford.edu
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abq4130?rfr_dat=cr_pub%20%…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: abai.zhandos15@gmail.com
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
Coronavirus Investigated: SARS-CoV-2; SARS-CoV-1
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Scripps Research Institute; Massachusetts Institute of Technology; Alpha Genesis; University of California, San Diego; La Jolla Institute for Immunology; Howard Hughes Medical Institute; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
Keywords: SARS-CoV-2, SARS-CoV-1, comparative studies, immune response, primates
Summary of Study: Using a two-shot protocol immunization with SARS-CoV-2 spike protein created strong serum receptor binding domain neutralizing antibody responses to both SARS-CoV-1 and SARS-CoV-2.
References: PMID: 35947674 / doi: 10.1126/scitranslmed.abl9605
Contact Info: Ian Wilson: wilson@scripps.edu; Dennis Burton: burton@scripps.edu; Raiees Andrabi: andrabi@scripps.edu
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abl9605?rfr_dat=cr_pub%20%…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Betuvax LLC; Lomonosov Moscow State University; Clinical Excellence Group LLC; I.I. Mechnikov North-Western State Medical University; PJSC Human Stem Cells Institute; Center of Genetics and Reproductive Medicine; Sechenov First Moscow State Medical University; Biotechnology Developments LLC; Ministry of Health of the Russian Federation
Keywords: SARS-CoV-2, subunit vaccine, “Betuvax-CoV-2”, preclinical studies, several animal species, primates
Summary of Study: A vaccine developed as a subunit that contains a recombinant receptor-binding domain fusion protein and virus-like nanoparticles demonstrates effective protection through COVID-19 neutralizing antibody production and conferring infection and lung damage protection.
References: PMID: 36016181 / doi: 10.3390/vaccines10081290
Contact Info: Anna Vakrusheva: vakhrusheva@betuvax.ru
URL: https://www.mdpi.com/2076-393X/10/8/1290
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaque
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University hopsital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral acitivty that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: roger.le-grand@cea.fr; Jeremie Guedj: jeremie.guedj@inserm.fr
URL: https://www.nature.com/articles/s41467-022-32565-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Chinese Academy of Medicine Sciences & Peking Union Medical College; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, virus variants, virulence, pathogenesis, immune response, primates
Summary of Study: Pathogenic differences of ancestral SARS-CoV-2 strain and a beta variant found the variant resulted in more severe lung injury and an elevated level of inflammatory cytokines, but a lower transmission ability.
References: PMID: 36069561 / doi: 10.1128/spectrum.02263-22
Contact Info: Junzhi Wang: wangjz@nifdc.org.cn; Miao Xu: xumiao@nifdc.org.cn
URL: https://journals.asm.org/doi/full/10.1128/spectrum.02263-22?rfr_dat=cr_pub%20%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: University of Saskatchewan; Dalhousie University; University of Pittsburgh
Keywords: SARS-CoV-2, review, post-acute sequelae, pathology, immune response, several animal species, primates
Summary of Study: Analysis of work done in different animal models in order to understand the mechanisms of Long COVID that could help identify treatments.
References: PMID: 36070309 / doi: 10.1371/journal.ppat.1010741
Contact Info: Alyson A. Kelvin: alyson.kelvin@usask.ca
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010741
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: sunming@imbcams.com.cn
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: China Biotechnology Co.LTD; Beijing Chaoyang Hospital, Capital Medical University; Laboratory Animal Center, Academy of Military Medical Sciences
Keywords: SARS-CoV-2, angiotensin-converting enzyme 2, gene sequences, primates
Summary of Study: Angiotensin-converting enzyme (ACE2) binds to the SARS-CoV2 virus as a receptor, and variation of the ACE2 sequence and binding affinity may account for differences in susceptibility and responses to infection
References: PMID: 36105891 / doi: 10.1016/j.bsheal.2022.09.001
Contact Info: Xiaojun Zhou, Jingjing Zhao, Yefeng Qiu, Rui Jia
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461283/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: tahiryaqub@uvas.edu.pk
URL: https://www.mdpi.com/2075-1729/12/9/1424
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Gujarat Biotechnology Research Centre (GBRC), India; Kamdhenu University, Gujarat, India; University of California Santa Barbara, Santa Barbara, CA.
Keywords: SARS-CoV-2, surveillance, RT-PCR, several animal species, primates
Summary of Study: Highlights transmission of SARS-CoV-2 infection from human to animals and suggests being watchful for zoonosis.
References: doi: 10.3390/ijerph192114391
Contact Info: Arunkumar Patel: viroarun@gmail.com
URL: https://www.mdpi.com/1660-4601/19/21/14391
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Wuhan Institute of Virology; Chinese Academy of Science; Wuhan National Biosafety Library, others
Keywords: SARS-CoV-2, testicular pathological damage, inflammation, primates
Summary of Study: SARS-CoV-2 infection induces testicular injury in Rhesus macaque
References: 10.1016/j.virs.2022.10.008
Contact Info: Z. Wuan: yzm@wh.iov.cn
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22001833?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: NIBSC Division of Infectious Disease Diagnostics, Division of Virology, Division of Analytical and Biological Sciences, other, Hertfordshire, UK
Keywords: SARS-CoV-2, virology, molecular and pathological outcomes, several animal species, primates
Summary of Study: Viral outcomes in multiple species
References: doi: 10.1038/s41598-022-23339-x
Contact Info: Neil Berry: neil.berry@nibsc.org
URL: https://www.nature.com/articles/s41598-022-23339-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID RNA Viruses Section, Laboratory of Infectious Diseases, numerous others
Keywords: SARS-CoV-2, pediatric vaccine, live-attenuated parainfluenza-virus-vectored vaccine, immunogenicity, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
References: doi: 10.1016/j.cell.2022.11.006
Contact Info: Ursula Buchholz: ubuchholz@niaid.nih.gov
URL: https://www.sciencedirect.com/science/article/pii/S0092867422014180?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotech Co., Ltd.; numerous others
Keywords: SARS-CoV-2, recombinant vaccine, immunogenicity, virus variants, hamster, primates
Summary of Study: A potent, broadly protective vaccine against SARS-CoV-2 variants of concern.
References: doi: 10.1038/s41541-022-00571-0
Contact Info: Chenliang Zhou: zhouchenliang@wallvax.com
URL: https://www.nature.com/articles/s41541-022-00571-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane University, Memorial Sloan Kettering Cancer Ctr, Weill Cornell Medical College, Instuto de Química Pontificia Universidad Católica de Valparaíso
Keywords: SARS-CoV-2, urokinase plasminogen activator receptor, renal dysfunction, pathology, primates
Summary of Study: Elevated soluble urokinase plasminogen activator receptor
References: doi: 10.1111/jmp.12626
Contact Info: Minolfa Prieto: mprieto@tulane.edu
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12626
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: NIAID Laboratory of Virology and NIAID Rocky Mountain Veterinary Branch, Hamilton, MT
Keywords: SARS-CoV-2, pathology, virus variants, primates
Summary of Study: Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
References: doi: 10.1126/sciadv.ade1860
Contact Info: Kyle Rosenke: kyle.rosenke@nih.gov
URL: https://www.science.org/doi/10.1126/sciadv.ade1860
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Beijing Institute for Brain Disorders, Capital Medical University, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing , numerous others.
Keywords: SARS-CoV-2, single-nucleus transcriptomics, pathology, immune response, primates
Summary of Study: Single-nucleus transcriptomic profiling of multiple organs
References: doi: 10.24272/j.issn.2095-8137.2022.443
Contact Info: Xiaoqun Wang: nc.ude.unb@gnawnuqoaix
URL: https://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2022.443
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, vaccine, Ad26.COV2.S, spike ferritin nanoparticles, immune response, primates
Summary of Study: Protection against SARS-CoV-2 Omicron BA.1 variant challenge
References: doi: 10.1126/sciadv.ade4433
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/10.1126/sciadv.ade4433
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, numerous others
Keywords: SARS-CoV-2, vaccine, BNT162b2, mRNA-1273, infants, immune response, primates
Summary of Study: Protection in immunized infant macaques
References: doi: 10.1126/scitranslmed.add6383
Contact Info: Kristina de Paris: abelk@med.unc.edu
URL: https://www.science.org/doi/10.1126/scitranslmed.add6383
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd., Biopharmaceutical Research Division, Osaka, Japan
Keywords: SARS-CoV-2, recombinant spike protein vaccine, virus variants, immune response
Summary of Study: Homologous and heterologous booster vaccinations of S-268019-b, a recombinant S protein-based vaccine
References: doi: 10.1016/j.vaccine.2022.10.092
Contact Info: Shinya Omoto: shinya.oomoto@shionogi.co.jp
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22013792?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Keio University School of Medicine, Tokyo, Japan; RIKEN Center for Integrative Medical Sciences, Infectious Diseases Research unit, Kanagawa, Japan, numerous others.
Keywords: SARS-CoV-2, therapeutic neutralizing antibodies, virus variants, immune response, hamsters, primates
Summary of Study: Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects
References: doi: 10.1016/j.isci.2022.105596
Contact Info: Masaru Takeshita: takeshita@a5.keio.jp
URL: https://www.sciencedirect.com/science/article/pii/S2589004222018685?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, UK; Ifakara Health Institute, Bagamoyo, Tanzania
Keywords: SARS-CoV-2, review, long-lived plasma cells, lymph node germinal centers, humans, primates
Summary of Study: Human lymphoid tissue sampling for vaccinology
References: doi: 10.3389/fimmu.2022.1045529
Contact Info: Carolyn M. Nielsen: carolyn.nielsen@bioch.ox.ac.uk
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1045529/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Shiga University of Medical Science, Otsu, Japan; others
Keywords: SARS-CoV-2, vaccine development, attenuated vaccinia virus, immune response, proteomics, virus variants, mice, primates
Summary of Study: Vaccine protects monkeys and transgenic mice from SARS-CoV-2 and variants
References: doi: 10.3389/fmicb.2022.967019
Contact Info: Michinori Kohara: koharamc@igakuken.or.jp
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.967019/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Chin Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
Keywords: SARS-CoV-2, review, traditional Chinese medicine, mice, hamsters, primates
Summary of Study: Model exploration for discovering COVID-19 targeted traditional Chinese medicine
References: doi: 10.1016/j.heliyon.2022.e12333
Contact Info: Fengmei Lian: lfm565@sohu.com
URL: https://www.sciencedirect.com/science/article/pii/S2405844022036210?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Duke University School of Medicine, Durham, NC; California National Primate Research Center; others.
Keywords: SARS-CoV-2, age-dependent responses, immune response, pathology, primates
Summary of Study: Age-dependent responses to SARS-CoV-2 in dam/infant pairs
References: doi: 10.4049/immunohorizons.2200075
Contact Info: Maria Blasi: maria.blasi@duke.edu
URL: https://journals.aai.org/immunohorizons/article/6/12/851/237621/Dam-Infant-Rhesu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, aerosol or intra-tracheal/intra-nasal infection, viral load, inflammation, primates
Summary of Study: Cellular mechanisms underlying acute respiratory distress syndrome
References: doi: 10.1038/s42003-022-04310-y
Contact Info: Namita Rout: nrout@tulane.edu
URL: https://www.nature.com/articles/s42003-022-04310-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus and cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Praesidium Bioscience, Inc., New York, NY; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Intima Bioscience, Inc., New York, NY; Ragon Institute of Massachusetts General Hospital, Massac
Keywords: SARS-CoV-2, CRISPR, stem cell, iPSC, vaccine, universal cell, primates
Summary of Study: A genetically engineered, stem-cell-derived cellular vaccine
References: doi: 10.1016/j.xcrm.2022.100843
Contact Info: Tom Henley: tom@intimabioscience.com; Dan H. Barouch: dbarouch@bidmc@harvard.edu
URL: https://www.sciencedirect.com/science/article/pii/S2666379122004074?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: treatment
NPRC/Institute: Lovelace Biomedical; Gilead Sciences; Inspired - Pulmonary Solutions
Keywords: SARS-CoV-2, remdesivir, inhalation, viral load, pharmacokinetics, primates
Summary of Study: Inhaled remdesivir reduced viral load as compared with placebo in African green monkeys infected with SARS-CoV-2.
References: PMID: 34968150 / doi: 10.1126/scitranslmed.abl8282
Contact Info: Danielle Porter: danielle.porter@gilead.com
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8282?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: kayvon.modjarrad.civ@mail.mil
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis, review
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: stammes@bprc.nl
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emory University; University of Sao Paulo School of Medicine; Butantan Institute; La Jolla Institute for Immunology
Keywords: SARS-CoV-2, DNA vaccine HIVBr18, HLA class II vaccine epitopes, immunity, humans and primates
Summary of Study: Results provide preliminary proof of concept that immunization with a vaccine encoding epitopes with high and redundant coverage of the human population can elicit potent T cell responses to multiple epitopes, across species and MHC barriers.
References: PMID: 34961636 / doi: 10.1016/j.vaccine.2021.11.076
Contact Info: Edecio Cunha-Neto: edecunha@usp.br
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21015504?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: rseder@mail.nih.gov; Daniel Douek: ddouek@mail.nih.gov
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center
Keywords: SARS-CoV-2, noncompeting antibody cocktail, vaccine, immune response, primates
Summary of Study: A neutralizing mAB cocktail with extended half-life can be delivered intramuscularly to provide prophylactic protection against infection in rhesus macaques.
References: PMID: 35291730 / doi: 10.1016/j.medj.2022.02.004
Contact Info: Jay Rappaport: jrappaport@tulane.edu
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00087-3?_returnURL=https%3A//lin…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: barberd@niaid.nih.gov
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center; Michigan Technological University; Tulane University
Keywords: SARS-CoV-2, renin-angiotensin system, HIV co-infection, gene expression, primates
Summary of Study: Findings suggest a possible impact of SIV/HIV infection on expression of ACE2 and RAS-associated proteins resulting in the loss of gut homeostasis.
References: PMID: 35281029 / doi: 10.3389/fimmu.2022.835686
Contact Info: Bapi Pahar: bpahar@trudeauinstitute.org
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.835686/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: djirvine@mit.edu; Shane Crotty: shane@lji.org
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_i…
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature atth early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: yingyang@big.ac.cn; Yun-Gui Yang: ygyang@big.ac.cn; Chuan Qin: qinchuan@pumc.edu.cn; Wei-Min Tong: wmtong@ibms.pumc.edu.cn
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
Coronavirus Investigated: SARS-CoV2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: University of Illinois College of Medicine
Keywords: SARS-CoV-2, transcriptomic profiling, lung endothelial cells, primates
Summary of Study: The specific genes that distinguished immuneEC and devEC populations in the NHP lungs after SARS-CoV-2 infection were different from the endotoxemic mouse lung. This may reflect either species differences or different injury-specific responses (bacterial endotoxin vs. SARS-CoV-2).
References: PMID: 35511435 / doi: 10.1172/jci.insight.158079
Contact Info: Lianghui Zhang: lhzhang@uic.edu; Jalees Rehman: jalees@uic.edu
URL: https://insight.jci.org/articles/view/158079
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: wswei@pku.edu.cn
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A//li…
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: kate.broderick@inovio.com
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory School of Medicine; Bioqual; Modernal; Harvard T.H. Chan School of Public Health
Keywords: SARS-CoV-2, vaccination, mRNA-1273 or mRNA-Omicron boost, pathology, primates
Summary of Study: Boosting with homologous mRNA-1273 or mRNA-Omicron leads to comparable and significant increases in neutralizing antibody responses against all VOC, including Omicron.
References: PMID: 35447072 / doi: 10.1016/j.cell.2022.03.038
Contact Info: Daniel Douek: ddouek@mail.nih.gov; Robert Seder: rseder@mail.nih.gov
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00388-9?_returnURL=https%3A//li…
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; University of California, San Francisco
Keywords: SARS-CoV-2, human convalescent plasma, inflammation, primates
Summary of Study: Administration of CCP had minimal effects on reducing virus replication in the respiratory tract, but it significantly reduced lung inflammation. These data, combined with the results of monoclonal antibody studies, emphasize the need to use products with high titers of neutralizing antibodies, and guide the future development of antibody-based therapies.
References: PMID: 35443018 / doi: 10.1371/journal.ppat.1009925
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Michael Busch: mbusch@vitalant.org; Rachel Reader: rreader@ucdavis.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009925
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking Union Medical College; National Center of Technology Innovation for Animal Model; Chinese Academy of Sciences; Capital Medical University
Keywords: SARS-CoV-2, inactivated vaccine, booster, immune response, virus variants, primates
Summary of Study: Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron.
References: PMID: 35436986 / doi: 10.1038/s41392-022-00979-z
Contact Info: Chuan Qin: qinchuan@pumc.edu.cn;
URL: https://www.nature.com/articles/s41392-022-00979-z
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: croy@tulane.edu
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: sdandekar@ucdavis.edu
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; HDT Bio; NIAID; Washington National Primate Research Center
Keywords: SARS-CoV-2, phage-based deep mutational scanning, immune response, vaccination, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 35404959 / doi: 10.1371/journal.ppat.1010155
Contact Info: Julie Overbaugh: joverbau@fredhutch.org
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010155
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: verschoor@bprc.nl
URL: https://www.mdpi.com/1999-4915/14/4/776
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Tufts University Cummings School of Veterinary Medicine; Vaccine & Gene Therapy Institute/OHSU; University of Montreal; Oregon National Primate Research Center; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, Ad26.COV2.S vaccine, transcriptional and proteomic profiling, primates
Summary of Study: Study showed that vaccination with Ad26.COV2.S protected hamsters and rhesus macaques challenged with SARS-CoV-2 from developing excessive proinflammatory responses mediated by IL-6 and IL-1, macrophages, and neutrophil activation.
References: PMID: 35395058 / doi: 10.1371/journal.ppat.1009990
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009990
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Bavarian Nordic GmbH; Biomedical Primate Research Centre; Aarhus University; University of Copenhagen; AdaptVac Aps
Keywords: SARS-CoV-2, capsid virus-like particle-based vaccine ABNCoV2, immunogenicity, primates
Summary of Study: ABNCoV2 induced strong and long-lasting neutralizing antibody responses and efficacy against SARS-CoV-2 in NHP.
References: PMID: 35479095 / doi: 10.3389/fimmu.2022.857440
Contact Info: Ariane Volkmann: ariane.volkmann@bavarian-nordic.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.857440/full
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center
Keywords: SARS-CoV-2, neuropathogenesis, primates
Summary of Study: Substantial pathological changes in brains of SARS-CoV-2 infected NHPs are compatible with autopsy and imaging reports of infected human subjects.
References: PMID: 35365631 / doi: 10.1038/s41467-022-29440-z
Contact Info: Tracy Fischer: tfischer1@tulane.edu
URL: https://www.nature.com/articles/s41467-022-29440-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heeterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: wenbo_xu1@aliyun.com; Qihan Li: liqihan@imbcams.com.cn
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.life-science-alliance.org/content/5/4/e202101314
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2022
Study Type/Review: prevention, therapeutics
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both rpevention and treatment settings of SARS-CoV-2 infectoin in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: mark.esser@astrazeneca.com
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eigth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell resposnes, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: wangyc@nifdc.org.cn; Yilong Zhang: yilongzhang@fulgentpharma.com; Jincun Zhao: zhaojincun@gird.cn
URL: https://www.nature.com/articles/s41422-022-00612-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: natalie.anosova@sanofi.com
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Biomedical Primate Research Centre; Consejo Superior de Investigaciones Cientificas (CSIC); Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC); Erasmus Medical Center; Instituto de Investigacion Hospital Universitario 12 de Octubre (imas12); Universidad Complutense School of Medicine, Biofabri
Keywords: SARS-CoV-2, vaccine, modified vaccinia virus Ankara vector, immune response, primates
Summary of Study: The MVA-S vaccine is safe and well tolerated in rhesus macaques, being highly immunogenic with the induction of potent levels of binding and neutralizing antibodies against several SARS-CoV-2 VOC, as well as Th1-skewed cell responses.
References: PMID: 35371043 / doi: 10.3389/fimmu.2022.845887
Contact Info: Petra Mooij: mooij@bprc.nl; Juan Garcia-Arriaza: jfgarcia@cnb.csic.ed; Gerrit Koopman: koopman@bprc.nl; Mariano Esteban: mesteban@cnb.csic.es
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: jean.haensler@sanofi.com;
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington
Keywords: SARS-CoV-2, remdesivir, math modeling, antiviral potency, nasal passages, lungs, primates
Summary of Study: In rhesus macaques, the nonlinear forces governing SARS-CoV-2 viral load trajectories in the lung and nasal passages differ substantially in the presence of a partially effective antiviral therapy. To the extent that the rhesus macaque model approximates human infection, nasal viral load remains a promising surrogate endpoint marker but perhaps only in the context of a highly potent antiviral therapy.
References: PMID: 35634576 / doi: 10.1016/j.isci.2022.104448
Contact Info: Joshua Schiffer: jschiffe@fredhutch.org
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00719-2?_returnURL=https%3A…
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: rseder@mail.nih.gov
URL: https://insight.jci.org/articles/view/160039
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Guangzhou Medical University; Macau University of Science and Technology; St. Januario Central Hospital Macau
Keywords: SARS-CoV-2, homologous or heterogenous vaccination boosters, virus variants, primates
Summary of Study: The Omicron BA.1 variant showed little sensitivity to all of the neutralizing antibodies evalueted in this study, adding to the emerging body of evidence that the resistance to neutralizing antibodies is conferred largely by the mutations in the RBD, since pseudovirus harboring additional spike protein mutations did not significantly change the resistance to neutralizing activity. A recombinant RBD protein vaccine may be a promising approach for future vaccine development.
References: PMID: 35592756 / doi: 10.1002/mco2.143
Contact Info: Kang Zhang: kang.zhang@gmail.com; Gen Li: superleegen@hotmail.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095991/
Coronavirus Investigated: SARS-CoV2
NHP Species: marmoset
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Universidade Federal Rural do Rio de Janiero; Universidade Federal do Mato Grosso; Universidade Federal do Parana
Keywords: SARS-CoV-2, natural infections, free-ranging animals, pathology, primates
Summary of Study: Free-ranging non-human primates are potential hosts for natural SARS-CoV-2 infection.
References: PMID: 35577455 / doi: 10.1016/j.jcpa.2022.03.005
Contact Info: Valeria Dutra: valeriadutra.dutra@gmail.com
URL: https://www.sciencedirect.com/science/article/pii/S0021997522000433?via%3Dihub
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Unioin Medical College
Keywords: SARS-CoV-2, longitudinal analyses, lungs, intestines, immune response, primates
Summary of Study: Findings indicate an imbalance of immune dynamic in intestinal mucosa during SARS-CoV-2 infection, which may underlie ongoing rectal viral shedding and mild tissue damage.
References: PMID: 35594870 / doi: 10.1016/j.celrep.2022.110864
Contact Info: Zhanlong He: hzl@imbcams.com.cn; Haijing Shi: haijingshi@hotmail.com; Qihan Li: liqihan@imbcams.com.cn; Longing Liu: longdingl@gmail.com
URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00637-4?_returnURL=http…
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; The First Affiliated Hospital of Guangzhou Medical University; Southern University of Science and Technology; The First Affiliated Hospital of Sun Yat-sen University; Guangdong Provincial Center for Disease Control and Prevention; Guangdong-Hong Kong Joint Laboratory for RNA Medicine
Keywords: SARS-CoV-2, quadrivalent mosaic HexaPro-bearing nanoparticle vaccine, virus variants, mice and primates
Summary of Study: A quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and 3 different VOCs elicits equivalent or superior neutralizing antibodies against variant strains in mice and non-human primates with only small reduction in neutralization titers against the ancestral strain.
References: PMID: 35562337 / doi: 10.1038/s41467-022-30222-w
Contact Info: Jin-Cun Zhao: zhaojincun@gird.cn; Run-Yu Yuan: cecilia_yry@hotmail.com; Mu-Sheng Zeng: aengmsh@sysucc.org.cn
URL: https://www.nature.com/articles/s41467-022-30222-w
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Broad Institute of Harvard and MIT; Harvard University; Universite Paris-Saclay, Inserm, CEA; Genethon INTEGRARE UMR; Rega Institute; University of Siena; University of Pennsylvania
Keywords: SARS-CoV-2, AAV-based vaccine, virus variants, immune response, mice, primates
Summary of Study: AAV-based vaccines for COVID-19 can be effective from a single, low dose and lead to durable humoral and strong T cell immunogenicity.
References: PMID: 35546782 / doi: 10.1016/j.ymthe.2022.05.007
Contact Info: Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu
URL: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0…
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: nabila.seddiki@cea.fr
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Cellid Co., Ltd; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology; International Vaccine Institute; Seoul National University
Keywords: SARS-CoV-2, adenovirus, AdCLD-CoV19 vaccine, immune response, virus variants, primates
Summary of Study: AdCLD-CoV19 can prevent SARS-CoV-2 with a single vaccination, and the new vaccine administration strategy that responds to various variants can maintain the efficacy of the vaccine.
References: PMID: 35632468 / doi: 10.3390/vaccines10050712
Contact Info: Chang-Yuil Kang: cykang@snu.ac.kr
URL: https://www.mdpi.com/2076-393X/10/5/712
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Institute Pasteur; Universite Paris Saclay-INSERM; Beth Israel Deaconess Medical Center
Keywords: SARS-CoV-2, NK cells, macrophages, blood and bronchoalveolar lavage, immune response, primates
Summary of Study: Viral antigen is found in alveolar macrophages up to at least 18 months after SARS-CoV-2 infection in macaques. Additionally, an association was revealed between lower level of persisting viral antigenin alveolar macrophages and the activity of Spike-specific adaptive NH cells in the lung.
References: PMID: 35547853 / doi: 12.21203/rs.3.rs-1561222/v1
Contact Info: Nicolas Huot: nicolas.huot@pasteur.fr
URL: https://www.researchsquare.com/article/rs-1561222/v1
Coronavirus Investigated: SARS-CoV2
NHP Species: multiple species
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Southwest National Primate Research Center; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, protocols, animal models, immunology, primates
Summary of Study: This book describes the different aspects of modelling the SARS-CoV-2 infection in NHPs along with the associated methods used in immunology.
References: PMID: 35554911 / doi. 10.1007/978-1-2111-0_15
Contact Info: Deepak Kaushal: dkaushal@txbiomed.org
URL: https://link.springer.com/protocol/10.1007/978-1-0716-2111-0_15
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands; Department of Radiology and Nuclear Medicine, Tracer Center Amsterdam (TCA), Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands
Keywords: SARS-CoV-2, PET-CT imaging, lungs, inflammation, primates
Summary of Study: Vaccine candiate involving a valuable radiotracer to visualize SARS-CoV-2-associated pulmonary inflammation
References: PMID: 35660200 PMCID: PMC9148436 DOI: 10.1016/j.nucmedbio.2022.05.002
Contact Info: Marieke A Stammes: stammes@bprc.nl
URL: https://www.sciencedirect.com/science/article/pii/S0969805122020509?via%3Dihub
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, CIGB, Ave. 31 E/158 y 190, Havana 10600, Cuba
Keywords: SARS-CoV-2, chimeric antigen vaccine, immune response, mice, primates
Summary of Study: Fusion of SARS-CoV-2 receptor binding domain with the extracellular domain of human CD154 is a promising vaccine candidate
References: PMID: 35746505 PMCID: PMC9228316 DOI: 10.3390/vaccines10060897
Contact Info: Yamila Carpio and Mario Pablo Estrada: yamila.carpio@cigb.edu.cu; mario.pablo@cigb.edu.cu
URL: https://www.mdpi.com/2076-393X/10/6/897
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Université Paris-Saclay; Assistance Publique-Hôpitaux de Paris; Obesity Center, Department of Digestive, Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Paris
Keywords: SARS-CoV-2, fat tissue, diagnostics, immunity, primates
Summary of Study: Subcutaneous adipose tissue (SCAT) is selectively infected by SARS-CoV-2 although changes in the immune properties of adispose tissue are observed in both SCAT and visceral adipose tissue
References: PMID: 35661814 PMCID: PMC9166782 DOI: 10.1038/s42003-022-03503-9
Contact Info: Christine Bourgeois: christine.bourgeois@universite-paris-saclay.fr
URL: https://www.nature.com/articles/s42003-022-03503-9
Coronavirus Investigated: SARS-CoV2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Gritstone bio, Inc.; Battelle Biomedical Research Center
Keywords: SARS-CoV-2, self-amplifying mRNA vaccine, immune response, primates
Summary of Study: Report of the preclinical development of a strong self-amplifying mRNA (SAM) vaccine being evaluated in clinical trials as both a homologous prime-boost regimen at low doses and as a boost following heterologous prime
References: PMID: 35672369 PMCID: PMC9173840 DOI: 10.1038/s41467-022-31005-z
Contact Info: Karin Jooss: kjooss@gritstone.com
URL: https://www.nature.com/articles/s41467-022-31005-z
Coronavirus Investigated: SARS-CoV2
NHP Species: multiple species
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Departments of Biochemistry and Pathology & Laboratory Medicine, Bhopal, India
Keywords: SARS-CoV-2, review, animal models, infection, pathology, primates
Summary of Study: Review of the immunological and clinical manifestations observed in various natural and genetically-modified animal models of numerous COVID-19 studies. The authors also summarize up-to-date laboratory findings on available and significant COVID-19 animal models, and put forth their perspective for the objective dependent usage of animal models.
References: PMID: 35757923 DOI: 10.1080/08830185.2022.2089666
Contact Info: Ashok Kumar: ashok.biochemistry@aiimsbhopal.edu.in
URL: https://www.tandfonline.com/doi/abs/10.1080/08830185.2022.2089666?journalCode=ii…
Coronavirus Investigated: SARS-CoV2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd.; Department of Pathology and Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, recombinant S-protein vaccine S-268019-b, immune response, primates
Summary of Study: Immunogenicity and protective efficacy of SARS-CoV-2 recombinant S-protein vaccine S-268019-b in cynomolgus monkeys
References: PMID: 35691872 PMCID: PMC9167832 DOI: 10.1016/j.vaccine.22.05.081
Contact Info: Hideki Hasegawa: hasegawa@niid.go.jp
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22007186?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: baboons
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: CAS Key Laboratory of Computational Biology; Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences; Chinese Academy of Sciences; Max Planck Institute of Psychiatry, Proteomics and Biomarkers
Keywords: SARS-CoV-2, circadian gene networks, transcriptome, primates
Summary of Study: Many mammalian genes are controlled by a central clock under circadian control, resulting in a rhythmic expression of genes involved in homeostasis. SARS-CoV-2 related genes are also rhythmically expressed, suggesting close interactions with circadian regulators.
References: PMID: 35906476 / doi: 10.1038/s42003-022-03722-0
Contact Info: Guang-Zhong Wang: guangzhong.wang@picb.ac.cn
URL: https://www.nature.com/articles/s42003-022-03722-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Affinivax; Ragon Institute of MGH, MIT, and Harvard; Boston Children's Hospital
Keywords: SARS-CoV-2, multiple antigen-presenting system vaccine, pathology, primates
Summary of Study: Multiple Antigen-Presenting System is a novel way to create a vaccine presenting proteins on a polymer and is able to induce antibody formation and reduce viral load in NHPS.
References: PMID: 35891233 / doi: 10.3390/vaccines10071069
Contact Info: Gilles Besin: gilles.besin@affinivax.com
URL: https://www.mdpi.com/2076-393X/10/7/1069
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC; Duke University Medical Center, Duke Human Vaccine Institute;
Keywords: SARS-CoV-2, viral kinetics, immune response, primates
Summary of Study: Pulmonary outcome of COVID-19 is not influenced by route of infection even though clinical onset shows differences.
References: PMID: 35789343 / doi: 10.1371/journal.ppat.1010618
Contact Info: Chad Roy: croy@tulane.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010618
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: GigaGen, Inc.; Alira Health, Inc.; Grifols S.A.; Vitalant Research Institute; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, drugs, GMP, clinical manufacturing, therapy, mice, primates
Summary of Study: A novel class of drugs, recombinant hyperimmune globulins are a safe and protective possible treatment to COVID-19 that could be made through large-scale production.
References: PMID: 35890050 / doi: 10.3390/pathogens11070806
Contact Info: Adam Adler: aadler@gigagen.com
URL: https://www.mdpi.com/2076-0817/11/7/806
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses; Jilin University First Hospital; Beijing Institute of Biotechnology; College of Basic Medical Sciences; Zhongshan Hospital Fudan University; Beijing Institute of Microbiology and Epidemiology; Shaanxi Normal University
Keywords: SARS-CoV-2, proteomics, metabolomics, pathology, immune response, primates
Summary of Study: An established COVID-19 model demonstrates that the innate immune response, neutrophil and platelet activation were dysregulated in infected NHPs, and these were greatly weakened in the most infected NHPs, which models moderately infected humans.
References: PMID: 35903092 / doi: 10.3389/fimmu.2022.954121
Contact Info: Yuwei Gao: yuwei0901@outlook.com; Yan Liu: liu820512@163.com; Xiaochang Xue: xuexch@snnu.edu.cn; Hui Wang: geno0109@vip.sina.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.954121/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane University School of Medicine; Beijing Forestry University; Beijing Institute of Lifeomics; Ochsner Clinic Foundation; University of Texas Southwestern Medical Center; Tulane National Primate Research Center
Keywords: SARS-CoV-2, peptide microarrays, neutralizing antibodies, vaccine, primates
Summary of Study: Linear peptide epitopes detected by immunoglobulins after infection have been localized to functionally important virus regions, which can be used to inform vaccine evaluation and targets for site-specific therapy.
References: PMID: 35928300 / doi: 10.34133/2022/9769803
Contact Info: Xiaobo Yu: yuxiaobo@mail.ncpsb.org; Tony Hu: tonyhu@tulane.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297724/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Bordeaux; Université Paris-Saclay; Vaccine Research Institute Créteil; Inserm U955 Créteil; Baylor Scott and White Research Institute; Institut Pasteur Paris; CNRS UMR 3569; University of Amsterdam Amsterdam Infection & Immunity Institute Amsterdam; Hôpital Henri-Mondor Albert-Chenevier; CHU Bordeaux
Keywords: SARS-CoV-2, mathematical modelling, vaccine, viral dynamics, primates
Summary of Study: A model-based approach can identify mechanistic correlates of protection that vaccines provide against infection, such that inhibition of the receptor-binding domain to ACE2 represents a strong mechanism of protection.
References: PMID: 35801637 / doi: 10.7554/eLife.75427
Contact Info: Rodolphe Thiébaut: rodolphe.thiebaut@u-bordeaux.fr
URL: https://elifesciences.org/articles/75427
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: National Rodent Laboratory Animal Resources Center; School of Basic Medical Sciences, Peking University Health Science Center; Northwest University; National Institutes for Food and Drug Control
Keywords: SARS-CoV-2, review, preclinical models, several animal species, primates
Summary of Study: Current animal models for COVID-19 have limitations, and novel models must be developed to truly evaluate the virulence of varients and comorbidities. Proposed model improvements include the use of transgenes or knock-ins to create multiple gene combinations, or reselecting receptor genes.
References: PMID: 35798699 / doi: 10.1038/s41392-022-01087-8
Contact Info: Youchun Wang: wangyc@nifdc.org.cn
URL: https://www.nature.com/articles/s41392-022-01087-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Institute of Zoonosis, and College of Veterinary Medicine, Jilin University; Chinese Academy of Medicine Sciences & Peking Union Medical College; Walvax Biotechnology Co., Ltd; Inner Mongolia University for Nationalities; Chinese Academy of Agricultural Sciences; Yuxi JOZO Biotechnology co., LTD; ongji Medical College, Huazhong University of Science and Technology
Keywords: SARS-CoV-2, equine immunoglobulin, anti virus efficacy, histopathology, immune response, primates
Summary of Study: Therapeutic-grade equine immunoglobins are effective at improving the clinical symptoms of those hospitalized with SARS-CoV-2 and can be rapidly developed.
References: PMID: 35798694 / doi: 10.1038/s41392-022-01095-8
Contact Info: Zhongping Xie: xzp218@hotmail.com; Ningyi Jin: ningyik@126.com; Mingyuan Liu: liumy36@162.com
URL: https://www.nature.com/articles/s41392-022-01095-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Institute of Technology; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University; Scripps Research Institute; University of Louisiana at Lafayette; Beth Israel Deaconess Medical Center, Harvard Medical School; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, lipid-conjugated immunogen, intranasal vaccination, mice, primates
Summary of Study: To combat the problem of poor vaccine uptake across mucus and epithelial linings, intranasal immunization with amphilic albumin binding components was created with the ability to be delivered across the mucosal epithelium and generate an antigen-specific response.
References: PMID: 35857825 / doi: 10.1126/scitranslmed.abn1413
Contact Info: Darrell Irvine: djirvine@mit.edu
URL: https://www.science.org/doi/10.1126/scitranslmed.abn1413?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Defence Science and Technology Laboratory; United Kingdom Health and Security Agency
Keywords: SARS-CoV-2, aerosolized virus, pathology, immune response, primates
Summary of Study: Following COVID-19 exposure, marmosets did not develop clinical signs other than a disruption to the diurnal temperature rhythm. This may be due to an innate immunological response, which included an increase in neutrophils and monocytes and a reduction in T-cells.
References: PMID: 35891560 / doi: 10.3390/v14071580
Contact Info: Rachel Ireland: reireland@dstl.gov.uk
URL: https://www.mdpi.com/1999-4915/14/7/1580
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines Inc; Bill & Melinda Gates Foundation; BIOQUAL Inc; Butler University; Vanderbilt University School of Medicine; University of Texas Medical Branch
Keywords: SARS-CoV-2, attenuated recombinant vaccine, immune response, primates
Summary of Study: A live, attenuated, recombinant human respiratory virus that expresses a chimeric SARS-CoV-2 spike protected against challenge and induced immunoglobulin and neutralizing antibodies.
References: PMID: 35906244 / doi: 10.1038/s41541-022-00509-6
Contact Info: Mariana F. Tioni: mariana.tioni@meissavaccines.com
URL: https://www.nature.com/articles/s41541-022-00509-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: martyomov@wustl.edu
URL: https://www.nature.com/articles/s41467-022-28315-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Fudan University; Shanghai King-Cell Biotechnology Co., Ltd.; Mabwell Bioscience Co., Ltd.; Shenzhen University; University of Chinese Academy of Sciences
Keywords: SARS-CoV-2, self-adjuvating peptide vaccine, CoVac501, immune response, virus variants, primates
Summary of Study: CoVac501, a novel SARS-CoV-2 vaccine that is fully chemically synthesized and self-adjuvanting, provided potent protecton for cynomolgus macaques against challenges from very high doses of SARS-CoV-2.
References: PMID: 35102138 / doi: 10.1038/s41421-021-00370-2
Contact Info: Qiuping Qin: pqqin@cdser.simm.ac.cn
URL: https://www.nature.com/articles/s41421-021-00370-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Medicago Inc.; Stanford University School of Medicine; Tulane National Primate Research Center; Tulane University School of Medicine; Research Institute of the McGill University Health Centre
Keywords: SARS-CoV-2, unadjuvanted and adjuvanted formulations, recombinant plant-derived virus-like particle vaccine, safety, immune response, primates
Summary of Study: A VLP bearing a SARS-CoV-2 spike protein vaccine candidate formulated with Adjuvant System 03 (AS03) was shown to be safe and effective and was therefore selected for vaccine development and clinical trials.
References: PMID: 34983950 / doi: 10.1038/s41423-021-00809-2
Contact Info: Brian Ward: wardb@medicago.com
URL: https://www.nature.com/articles/s41423-021-00809-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, lung and liver pathology, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS-CoV-2-infected lung and liver tissues showed potentially active protein synthesis and processing, and dysregulated ECM, cell-to-cell junction, and cytoskeleton but no fibrosis in both the infected lung and liver.
References: PMID: 35091530 / doi: 10.1038/s41392-022-00882-7
Contact Info: Shaui-Yao Lu: lushuaiyao-km@163.com
URL: https://www.nature.com/articles/s41392-022-00882-70pubmed&url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: MIT; Broad Institute of MIT and Harvard; Ragan Institute of MGH, MIT, and Harvard; University of Duisburg-Essen; Space Exploration Technologies Corp.; Harvard University; Vanderbilt University Medical Center; Northwestern University Feinberg School of Medicine; University of Bonn; Howard Hughes Medical Institute; Massachusetts Consortium on Pathogen Readiness; Harvard Medical School; Brigham and Womoen's Hospital; Harvard Humanitarian Initiative
Keywords: SARS-CoV-2, immune biomarkers, reinfection, immune response, primates
Summary of Study: A specific set of SARS-CoV-2-specific humoral features, including spike RBD-specific IgG1 titers, nucleocapsid-specific IgG3 titers, and anti-spike RBD FcyR2A binding activity, were identified as robust biomarkers of reinfection that translate across species. When reinfection cannot be confirmed by viral sequence, changes in SARS-CoV-2 humoral immune responses may offer inexpensive, reliable, and effective measures to track reinfection.
References: PMID: 35073738 / doi: 10.1128/mbio.02141-21
Contact Info: Douglas Lauffenburger: lauffen@mit.edu; Galit Alter: galter@mgh.harvard.edu
URL: https://journals.asm.org/doi/full/10.1128/mbio.02141-21?rfr_dat=cr_pub%20%200pub…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center
Keywords: SARS-CoV-2, synthetic multiantigen modified vaccine, COH04S1, immune response, hamsters, primates
Summary of Study: Vaccine candidate C0H04S1 stimulates protective immunity against SARS-CoV-2 in Syrian hamsters by intramuscular and intranasal vaccination and in non-human primates through two-dose and single-dose regimens.
References: PMID: 35064109 / doi: 10.1038/s41541-022-00436-6
Contact Info: Felix Wussow: fwussow@coh.org
URL: https://www.nature.com/articles/s41541-022-00436-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention, therapeutics
NPRC/Institute: University of Washington; Washington National Primate Research Center; Institute of Biomedical Sciences, Taipei; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, helper-dependent adenovirus (HDAd5/35++), HSC gene therapy, safety, virus protection, mice, primates
Summary of Study: Pilot studies of a simple and portable in vivo hematopoietic HSC transduction approach that involves HSC mobilization from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating, helper-dependent adenovirus vector system demonstrated safety and efficacy in mice and a rhesus macaque.
References: PMID: 35057635 / doi: 10.1089/hum.2021.295
Contact Info: Andre Lieber: lieber00@uw.edu; Steve Roffler: sroff@ibms.sinica.edu.tw; Hans-Peter Kiem: hkiem@fredhutch.org; Deborah Fuller: fullerdh@uw.edu
URL: https://www.liebertpub.com/doi/10.1089/hum.2021.295?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: zhangyw57@mail.sysu.edu.cn; Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; University of California, Irvine
Keywords: SARS-CoV-2, Vesicular Stomatitis Virus-Based Vaccine, route of administration, immune response, primates
Summary of Study: The VSV-SARS2-EBOV vaccine presents a vaccine with a high potential as a boosting option after the already-approved mRNA-based vaccine, because VSV-SARS2-EBOV elicits primarily a humoral response, in contrast to the predominantly T cell-driven immune response after mRNA vaccination.
References: PMID: 35012339 / doi: 10.1128/mbio.03379-21
Contact Info: Andrea Marzi: marzia@niaid.nih.gov
URL: https://journals.asm.org/doi/full/10.1128/mbio.03379-21?rfr_dat=cr_pub%20%200pub…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: nmaness@tulane.edu
URL: https://www.mdpi.com/1999-4915/14/1/77
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Paris-East Creteil University; Universite Paris-Saclay Fontenay-aux-Roses; CEA-INSERM, University of Lille; Universite de Lyon; Centre de Recherche en Cancerologie de Lyon; Institut Curie; Justus Liebig University
Keywords: SARS-CoV-2, lung cell senescence, RNA analysis, pathology, humans, primates
Summary of Study: Cell senescence was monitored in cynomologus macaques to evaluate potential links between SARS-CoV-2 infection and aging. Data constitute the first evidence of temporal and topographic relations between senescent cell accumulation and pulmonary lesions induced by SARS-CoV-2.
References: PMID: 34648725 / doi: 10.1165/rcmb.2021-0205LE
Contact Info: Serge Adnot: serge.adnot@inserm.fr
URL: https://www.atsjournals.org/doi/10.1165/rcmb.2021-0205LE?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Northwestern University; Tulane National Primate Research Center; NIAID; Sanford Burnham Prebys Medical Discovery Institute; Bioqual; New Iberia Research Center
Keywords: SARS-CoV-2, antibody-based in vivo probe system, lungs, primates
Summary of Study: Results provide proof of concept for the use of in vivo antibody-based probes to study SARS-CoV-2 infection dynamics in rhesus macaques.
References: PMID: 35003140 / doi: 10.3389/fimmu.2021.810047
Contact Info: Thomas Hope: thope@northwestern.edu
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.810047/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Washington National Primate Research Center; HDT Bio
Keywords: SARS-CoV-2, immunocompromised animals, SIV, RNA vaccine, immunogenicity, primates
Summary of Study: SARS-CoV-2 alphavirus-derived replicon RNA vaccine formulated with a novel Lipid InOrganic Nanoparticle (LION) emulsion (repRNA-CoV2S) induced robust cellular and humoral immune responses after a single immunization in immunocompromised SIV-infected animals as a highly relevant model of untreated HIV infection in humans.
References: PMID: 34992610 / doi: 10.3389/fimmu.2021.800723
Contact Info: Deborah Fuller: fullerdh@uw.edu
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.800723/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: China Pharmaceutical University; Yunnan Walvax Biotech
Keywords: SARS-CoV-2, chimpanzee adenovirus-based vaccine, immunogenicity, toxicology, rats, primates
Summary of Study: AdC68-19S, a recombinant chimpanzee adenovirus serotype 68 vector-based vaccine encoding the full-length spike protein of SARS-CoV-2, induced an effective immune response with a good safety profile in rhesus macaques.
References: PMID: 35226134 / doi: 10.1007/s00204-021-03221-x
Contact Info: Zhen Huang: hz@walvax.com
URL: https://link.springer.com/article/10.1007/s00204-021-03221-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fudan University; The University of Hong Kong; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park; Graduate School of Peking Union Medical College; Natinal Institute for Food and Drug Control, Beijing, China; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus variants, primates
Summary of Study: A pan-sarbecovirus vaccine consisting of human IgG Fc fragment-conjugated RBC of the original SARS-CoV-2 WA1 strain as the immunogen and a novel small-molecule non-nucleotide STING agonist as the adjuvant could be used to prevent infection by the current SARS-CoV-2 variants, including Omicron, and future emerging sarbecoviruses.
References: PMID: 35210607 / doi: 10. 1038/s41422-022-00631-z
Contact Info: Youchun Wang: wangyc@nifdc.org.cn
URL: https://www.nature.com/articles/s41422-022-00631-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; Guangdong Academy of Medical Sciences; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccine, virus variants, hACE2 mice, primates
Summary of Study: RBD-based monovalent or multivalent nanoparticle vaccines provide a promising second-generation vaccine strategy for SARS-CoV-2 variants.
References: PMID: 35142444 / doi: 10.1002/advs.202105378
Contact Info: Ting Pan: pant8@gmail.sysu.edu.cn; Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008796/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Pfizer; Icahn School of Medicine at Mount Sinai; Texas Biomedical Research Institute; New Iberia Research Center
Keywords: SARS-CoV-2, pathology, inflammation, Golden Syrian Hamster, primates
Summary of Study: Macaques may be appropriate for mechanistic studies of mild asymptomatic COVID-19 pneumonia and COVID-19-associated encephalitis, whereas Syrian hamsters may be more suited to study severe COVID-19 pneumonia.
References: PMID: 35128980 / doi: 10.1177/01926233211072767
Contact Info: Shambhunath Choudhary: shambhunath.choudhary@pfizer.com
URL: https://journals.sagepub.com/doi/full/10.1177/01926233211072767?rfr_dat=cr_pub%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines and Prevention; Ragon Institute of MGH, MIT and Harvard; BIOQUAL; Amsterdam University Medical Center
Keywords: SARS-CoV-2, homologous or variant booster vaccine, humoral and cellular immune responses, primates
Summary of Study: A late boost with Ad26.COV2.S or Ad26.COV2.S.351 resulted in a marked increase in humoral and cellular immune responses that were highly cross-reactive across multiple SARS-CoV-2 variants in rhesus macaques.
References: PMID: 35191769 / doi: 10.1126/scitranslmed.bm4996
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abm4996?rfr_dat=cr_pub%20%…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A//lin…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute of Biological Products; Chinese Academy of Medicine Sciences & Peking Union Medical College
Keywords: SARS-CoV-2, recombinant protein subunit vaccine and an inactivated vaccine, virus variants, primates
Summary of Study: Both vaccines evaluated in this study significantly reduced the viral load in the respiratory tract, alleviated pathological changes, and relieved lung inflammation in vaccinated macaques. The possible contribution of antibodies possessing neutralizing reactivity or cell-mediated cytotoxicity and immune memory to vaccine induced protection was also highlighted.
References: PMID: 35241645 / doi: 10.1038/s41392-022-00926-y
Contact Info: Junzhi Wang: wangjz@nifdc.org.cn
URL: https://www.nature.com/articles/s41392-022-00926-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Chinese Academy of Sciences; China Agricultural University; Capital Medical University; University of Science & Technology of China; Chinese Academy of Medical Sciences and Peking Union Medical College; Chinese Center for Disease Control and Prevention
Keywords: SARS-CoV-2, human neutralizing antibodies, virus variants, mice, primates
Summary of Study: bsAB15 was developed and shown to efficiently neutralize all single-mAb escape mutants. This bsAb is a feasible and effective strategy to treat and prevent severe COVID-19.
References: PMID: 35228696 / doi: 10.1038/s41590-022-01138-w
Contact Info: Yan Wu: wuyan@ccmu.edu.cn; Feng Gao: gaofeng@tib.cas.cn
URL: https://www.nature.com/articles/s41590-022-01138-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, inactivated vaccine, pathology, virus variants, primates
Summary of Study: Three doses of a prototypic SARS-CoV-2 inactivated vaccine reduced viral loads in nasal, throat and anal swabs and pulmonary tissues and improved the pathological changes lungs of animals infected by variants of Alpha, Beta and Delta.
References: PMID: 35217639 / doi: 10.1038/s41392-022-00920-4
Contact Info: Zhongping Xie: szp@imbcams.com.cn; Wenjie Tan: tanwj@ivdc.chinacdc.cn
URL: https://www.nature.com/articles/s41392-022-00920-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; Bioqual; Oak Ridge Institute of Science and Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, nanoparticle vaccine, cellular and humoral immune responses, primates
Summary of Study: Nonhuman primates vaccinated with two doses of SpFN (a SARS-CoV-2 spike protein ferritin nanoparticle vaccine) were protected against SARS-CoV-2 challenge. SErum isolated from vaccinated animals neutralized several variants of concern, including the delta variant.
References: PMID: 39414540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: M. Gordon Joyce: gjoyce@eidresearch.org; Kayvon Modjarrad: kayvon.modjarrad.civ@mail.mil
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: winfried.weissenhorn@ibs.fr; Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retur…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: tmatano@nih.go.jp
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retur…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune reponse, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: lei.han@jechobio.com
URL: https://www.nature.com/articles/s41421-022-00381-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: University of Central Florida; Tulane National Primate Research Center
Keywords: SARS-CoV-2, pathology, heart, immune response, primates
Summary of Study: SARS-CoV-2 infection is characterized by an exaggerated inflammatory immune response in the heart, which possibly contributes to myocardial remodeling and subsequent fibrosis.
References: PMID: 35203260 / doi: 10.3390/cells11040611
Contact Info: Manish Kumar Gupta: manish.gupta@ucf.edu
URL: https://www.mdpi.com/2073-4409/11/4/611
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institution of MGH, MIT, and Harvard; Bioqual; Washington University School of Medicine; Emory School of Medicine, Tufts University Cummings School of Veterinary Medicine
Keywords: SARS-CoV-2, mRNA-based BNT162b2 vaccine, virus variants, immune response, primates
Summary of Study: BNT162b2 and Ad26.COV2.S provided robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in macaques. Protection against this highly mutated SARS-CoV-2 variant correlated with both humoral and cellular immune responses.
References: PMID: 35169798 / doi: 10.1101/2022.02.06.479285
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2022.02.06.479285v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review: Diagnostics
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; Sorbonne Universite; BioPredictive; Institut Pasteur
Keywords: SARS-CoV-2, blood test, diagnostics, primates
Summary of Study: Results validate the diagnostic and prognostic performances of A1HPV6 in patients infected by SARS-CoV-2, not hospitalized in ICU. These rsults are reinforced by similar kinetics of A1, HP, and A2M observed in the macaque model.
References: PMID: 35174366 / doi: 10.1016/j.gastha.2021.12.009
Contact Info: Thierry Poynard: thierry@poynard.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818442/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology and Epidemiology; Sinocelltech, Ltd.; Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, polysaccharide–protein-conjugated nanoparticle vaccine, virus variants, mice, rats, primates
Summary of Study: A novel nanoparticle vaccine was designed and prepared by chemically conjugating recombinant SARD-CoV-2 RBD and PPS14. Studies have demonstrated that SCTV01B vaccination induced potent and broad neutralizing antibodies and cellular immune responses against SARS-CoV-2 in mice, rats, and nonhuman primates, as well as high OPA against S. pneumoniae serotype 14.
References: PMID: 35332581 / doi: 10.1002/adma.202200443
Contact Info: Liangzhi Xie: liangzhi@yahoo.com
URL: https://onlinelibrary.wiley.com/doi/10.1002/adma.202200443
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Tsinghua University; Chongqing Medical University; Boston University School of Medicine; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenshen Graduate School; Fudan University
Keywords: SARS-CoV-2, pathogenesis, neutralization antibodies, primates
Summary of Study: Kappa, Delta, or B.1.618 spike uses human angiotensin-converting enzyme 2 (ACE2) with no or slightly increased efficiency, while it gains a significantly increased binding affinity with mouse, marmoset, and koala ACE2 orthologs, which exhibit limited binding with wild-type (WT) spike. Collectively, this study revealed that enhanced human and mouse ASE receptor engagement, increased spike cleavage, and reduced sensitivity to neutralization antibodies of Kapa, Delta and B.1.618 may contribute to the rapid spread of these variants.
References: PMID: 35266815 / doi: 10.1128/mbio.00099-22
Contact Info: Qiang Ding: qding@tsinghua.edu.cn
URL: https://journals.asm.org/doi/full/10.1128/mbio.00099-22?rfr_dat=cr_pub%20%200pub…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to moitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: thibaut.naninck@cea.fr
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3A…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: yzm@wh.iov.cn; Chao Shan: shanchao@wh.iov.cn
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, baboons, marmosets
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Southwest NPRC
Keywords: SARS-CoV-2, young and old animals, Acute respiratory distress, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034/doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: dkaushal@txbiomed.org
URL: https://www.nature.com/articles/s41564-020-00841-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: review
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, cryopreservation, resources, genetic diversity, primates
Summary of Study: The importance of rhesus macaques as a preclinical model for human diseases and treatment outcomes supports the development of improved cryopreservation methods and routine storage of gametes and embryos.
References: PMID: 34031599 / doi: 10.1038/s41684-021-00792-1
Contact Info: Matthew Arnegard: matthew.arnegard@nih.gov
URL: https://www.nature.com/articles/s41684-021-00792-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, resources, pathology, primates
Summary of Study: Because the SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques biomedical researchers will need to consider alternative NHP models for COVID-19 research and for other biomedical research studies. The authors suggest alternatives.
References: PMID: 33785923 / doi: 10.1038/s41684-021-00755-6
Contact Info: Michael Chang: chang,mic@mail.nih.gov
URL: https://www.nature.com/articles/s41684-021-00755-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: ORIP, NIH
Keywords: SARS-CoV-2, the use of primates for COVID research, animal resources
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SFP) NHPs for development of vaccines and therapeutics. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: doi: 10.1038/s41684-021-00810-2
Contact Info: Miguel Contreras: miguel.contreras
URL: https://www.nature.com/articles/s41684-021-00810-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: review
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, primates, animal resources, biosafety
Summary of Study: Sustaining and increasing NHP research capacity will require careful preparation and collaborations to improve existing infrastructure and expand established facilities, expertise, and programs.
References: PMID: 33927412 / doi: 10.1038/s41684-021-00760-9
Contact Info: Sheri Ann Hild: sheri.hild@nih.gov
URL: https://www.nature.com/articles/s41684-021-00760-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, animal models, viruses, resources, primates
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SPF) nonhuman primates (NHPs) for development of vaccines and therapeutics, thus straining the supply of these animals for biomedical research studies. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: PMID: 34163043 / doi: 10.1038/s41684-021-008102
Contact Info: Miguel Contreras: miguel.contreras@nih.gov
URL: https://www.nature.com/articles/s41684-021-00810-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: NCI/NIH
Keywords: SARS-CoV-2, ACE2, type I interferon, pathology, primates
Summary of Study: Type I interferon mediates an important innate immune response against viral infection by directly inhibiting viral replication. It also bridges innate to adaptive immunity for long-term protection against viral reinfections.
References: PMID: 34149696 / doi: 10.3389/fimmu.2021.658428
Contact Info: Yongjun Sui: suiy@mail.nih.gov; Jay Berzofsky: berzofsj@mail.nih.gov
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.658428/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Perelman School of Medicine (UPenn),
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: wilsonjm@upenn.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Copycat Sciences; Sporos Bioventures
Keywords: SARS-CoV-2, redelivery, analysis of the preclinical data and clinical efficacy, primates
Summary of Study: The gap between the strong preclinical data with remdesivir (RDV) across many virus models and its questionable clinical activitiy suggests that assumptions are being made at the preclinical level that do not reflect the conditions observed in patients.
References: PMID: 34252308 / doi: 10.1128/AAC.01117-21
Contact Info: Victoria Yan: victoria.yan@copycatsciences.com
URL: https://journals.asm.org/doi/10.1128/AAC.01117-21?url_ver=Z39.88-2003&rfr_id=ori…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, african green monkeys
Year Published: 2021
Study Type/Review: therapeutics, vaccine, review
NPRC/Institute: Emory University School of Medicine
Keywords: SARS-CoV-2, several animal species, anti-viral therapeutic, vaccine development, primates
Summary of Study: Summarizing key features, strengths and weaknesses of animal models for SARS-CoV-2, focusing on their application in anti-viral therapeutic and vaccine development.
References: PMID: 33906125 / doi: 10.1016/j.coviro.2021.03.009
Contact Info: Anice Lowen: anice.lowen@emory.edu
URL: https://www.sciencedirect.com/science/article/pii/S1879625721000316?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, neurotropism, central neural system, virus transduction, primates
Summary of Study: The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys.
References: PMID: 33895780 / doi: 10.1038/s41392-021-00591-7
Contact Info: Xiaozhong Peng: pengxiaozhong@pumc.edu.cn; Shuaiyao Lu: lushuaiyao-km@163.com; Hongqi Liu: lhq@imbcams.com.cn
URL: https://www.nature.com/articles/s41392-021-00591-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Wheaten College, Cornell University
Keywords: SARS-CoV-2, virus susceptibility, animal welfare, hamsters, ferrets, primates
Summary of Study: Paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility.
References: PMID: 34359172 / doi: 10.3390/ani11072044
Contact Info: Kathleen Morgan: kmorgan@wheatoncollege.edu
URL: https://www.mdpi.com/2076-2615/11/7/2044
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: liqihan@imbcams.com.cn; Longding Liu: longdingliu@imbcams.com.cn; Cunbao Liu: cunbao_liu@163.com
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates
Summary of Study: Convalescent plasma therapy in humans may be an effective strategy provided that donor sera contain high anti-SARS-CoV-2 neutralizing titers given in early states of the disease.
References: PMID: 33662255 / doi: 10.1016/j.celrep.2021.108837
Contact Info: Thomas W. Geisbert:
URL: https://www.sciencedirect.com/science/article/pii/S2211124721001510?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, apoptosis, lung tissues, pathology, primates
Summary of Study: Significant increases in apoptotic signals in postmortem lung sections from COVID-19 patients and lungs of NHPs infected with SARS-CoV-2 on day 21 p.i.
References: PMID: 33922476 / doi: 10.3390/pathogens10050509
Contact Info: Paul Boor: pboor@utmb.edu; Jason Comer: jscomer@utmb.edu; Bin Gong: bigong@utmb.edu
URL: https://www.mdpi.com/2076-0817/10/5/509
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: USC, , UCLA, City of Hope, Bioqual
Keywords: SARS-CoV-2, pancreatic beta cells, toxicity, metabolism, primates
Summary of Study: SARS-CoV-2 infection enhances beta cell stress that may compromise beta-cell function beyond the duration of the disease course, raising the possibility that the beta cell stress and injury may have clinical implications to the long-term future health of patients that have recovered from COVID19.
References: PMID: 34312617 / doi: 10.21203/rs.3.rs-592374/v1
Contact Info: Senta Georgia: sgeorgia@chla.usc.edu
URL: https://www.researchsquare.com/article/rs-592374/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaque, african green monkeys, cynomolgus macaques, marmosets
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Fudan University, Shanghai, China
Keywords: SARS-CoV-2, review, transmission, pathogenicity, therapeutics, ferrets, minks, tree shrews, primates
Summary of Study: Animal models of SARS-CoV-2 are reviewed and compared.
References: PMID: 34531831 / doi: 10.3389/fmicb.2021.626553
Contact Info: Youhua Xie: yhxie@fudan.edu.cn
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.626553/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: janet_xu_zhang@singlomics.com
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, vaccines, antibody and T cell immunogenicity, review, primates
Summary of Study: This review article looks at what is known of the antibody and T cell immunogenicity of vaccines that have advanced to human clinical trials. Includes summary of press releases on the outcomes of vaccine efficacy trials.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John P. Moore: jpm2003@med.cornell.edu
URL: https://advances.sciencemag.org/content/7/12/eabe8065
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine, review
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, antibody and T cell immunogenicity, testing vaccines in humans and primates, review
Summary of Study: This review article summaries what is known of the antibody and T cell immunogenicity of multiple preventive vaccines in NHPs and humans.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John Moore: jpm2003@med.cornell.edu
URL: https://advances.sciencemag.org/content/7/12/eabe8065
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: Chungbuk National University
Keywords: SARS-CoV-2, several animal species, transduction, pathology, primates
Summary of Study: Review of various animal models employed for SARS-CoV-2 infection studies that outlines their individual strengths and limitations for use in studies aimed at increasing understanding of coronavirus pathogenesis.
References: PMID: 33996168 / doi: 10.4110/in.2021.21.e12
Contact Info: Young Ki Choi: choiki55@CHUNGBUK.AC.KR
URL: https://immunenetwork.org/DOIx.php?id=10.4110/in.2021.21.e12
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, primates
Summary of Study: The severity of respiratory tract infection enhanced air transmission and induced wide and severe SARS-CoV-2 infection in the lungs, suggesting the occurrence of more severe infectiousness and lung injury in SARS-CoV-2 patients with nasal infection.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, virus load, primates
Summary of Study: Nasal infection may be regarded as an important index to assess the severity of COVID-19. Furthermore, treatments focused on nasal infection, like hypertonic saline nasal irrigation and gargling, should be considered as a therapeutic option for COVID-19.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Texas Christian University
Keywords: SARS-CoV-2, young and aged animals, viral dynamics, antiviral treatment, primates
Summary of Study: This study finds the viral dynamics of SARS-CoV-2 between young and aged animals and has shown that these differrences should be considered when considering antiviral treatment.
References: PMID: 34804559 / doi: 10.1098/rsos.202345
Contact Info: Hana Dobrovolny: h.dobrovolny@tcu.edu
URL: https://royalsocietypublishing.org/doi/full/10.1098/rsos.202345?rfr_dat=cr_pub%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Washington Univ SOM, NIAID
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, immunogenicity and protective efficacy, primates
Summary of Study: A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge in rhesus macaques.
References: PMID: 33754147 / doi: 10.1016/j.xcrm.2021.100230
Contact Info: Heinz Feldmann: feldmannh@niaid.nih.gov; Michael Diamond: diamond@wusm.wustl.edu
URL: https://www.sciencedirect.com/science/article/pii/S266637912100046X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: Prime boost vaccination of rhesus macaques with 4 ug of CV07050101 elicited neither a uniform nor a robust immune response. However, vaccination using 8 ug of the same vaccine was protective in an NHP challenge study.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.mdpi.com/1999-4915/13/8/1645
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA-vaccine, spike protein, humoral and cellular immune responses, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited mimmune responses in four out of six non-human primates.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.mdpi.com/1999-4915/13/8/1645
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, virus genomic variants, virus replication, immune response, pathology, primates
Summary of Study: A study of pathogenesis of B.1.1.7 and B.1.351 compared to a SARS-CoV-2 isolate containing the D614G spike substitution showed that B.1.351 was slightly less pathogenic than the other two variants, but there were no differences in virus shedding between the variants that could explain increased transmissibility.
References: PMID: 34678071 / doi: 10.1126/sciadv.abj3627
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.science.org/doi/10.1126/sciadv.abj3627?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques, african green monkeys, squirrel monkeys
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, pulmonary histopathologic characteristics, immunohistochemistry, species comparison, primates
Summary of Study: Histopathology does not appear to be a superior readout for interpretation of vaccine and therapeutic evaluations in the NHPs studied. The recommendation of which NHP is a superior model should be based on virology data as well as further work on genetic factors that contribute to significant disease.
References: PMID: 34963391 / doi: 10.1177/03009858211067468
Contact Info: Chad Clancy: chad.clancy@nih.gov
URL: https://journals.sagepub.com/doi/10.1177/03009858211067468?url_ver=Z39.88-2003&r…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Statens Serum Institute; Robert Koch Institute; BIOQUAL; University of Southern Denmark
Keywords: SARS-CoV-2, DNA plasmid vaccine, immune response, primates
Summary of Study: The candidate plasmid DNA vaccine encoding the SARS-CoV-2 spike protein is immunogenic in different models and confers protection against lung infection in nonhuman primates. Further evaluation of this DNA vaccine candidate in clinical trials is warranted.
References: PMID: 34930909 / doi: 10.1038/s41541-021-00419-z
Contact Info: Anders Fomsgaard: afo@ssi.dk
URL: https://www.nature.com/articles/s41541-021-00419-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: nmaness@tulane.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University Vaccine Center; BIOQUAL; Moderna; Johns Hopkins University
Keywords: SARS-CoV-2, variants of concern, booster, immune response, primates
Summary of Study: An additional, delayed boost with mRNA vaccines matched to either the original vaccine strain or to the heterologous challenge strain can have a marked and sustained effect on increaseing the breadth of neutralization against all VOCs tested and protection in both the lower and upper airways against the beta variant.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: rseder@mail.nih.gov; Barney Graham: bgraham@nih.gov
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nanogen Pharmaceutical Biotechnology Joint Stock Company; National Institute of Hygiene and Epidemiology (Hanoi, Vietnam)
Keywords: SARS-CoV-2, protein subunit vaccine, Nanocovax, pathogenesis, mice, hamsters, primates
Summary of Study: Nanocovax, a SARS-CoV-2 vaccine candidates based on recombinant protein production of the extracellular portion of the spike protein, was shown to be safe and effective in three animal models.
References: PMID: 34938290 / doi: 10.3389/fimmu.2021.766112
Contact Info: Min Si Do: minhsi@nanogenpharma.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.766112/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: treatment
NPRC/Institute: Chinese Academy of Medical Science and Peking Union Medical College; Genuine Biotech, Inc.; Wuhan Research Center for Infectious Diseases and Cancer; The First Affiliated Hospital of Henan University of Chinese Medicine; Henan Provincial Peoples Hospital; Henan Normal University; Zhengzhou University
Keywords: SARS-CoV-2, Azvudine, preclinical studies, Phase III trial, humans, primates
Summary of Study: Treating SARS-CoV-2 infected rhesus macaques with FNC reduced viral load, recuperated the thymus, improved lymphocyte profiles, alleviated inflammation and organ damage, and lessened ground-glass opacities in chest X-ray.
References: PMID: 34873151 / doi: 10.1038/s41392-021-00835-6
Contact Info: Zhenshun Cheng: chzs1990@163.com; Jun-Biao Chang: changjunbiao@zzu.edu.cn; Jian-Dong Jiang: jiang.jdong@163.com
URL: https://www.nature.com/articles/s41392-021-00835-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning, epitope targets, spike protein, humans, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 34909774 / doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: joverbau@fredhutch.org
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; University Paris-Saclay, Inserm, CEA; AIMM Therapeutics BV; J&S Preclinical Solutions; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, variants of concern, third vaccination, mice, rabbits, primates
Summary of Study: A third immunization improves neutralizing antibody titers against the variants-of-concern (Alpha, Beta, Gamma, and Delta).
References: PMID: 34862406 / doi: 10.1038/s41541-021-00411-7
Contact Info: Rogier Sanders: r.w.sanders@amsterdamumc.nl
URL: https://www.nature.com/articles/s41541-021-00411-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Tulane National primate Research Center; Tulane School of Medicine; Duke University Medical Center
Keywords: SARS-CoV-2, anti-SARS-CoV-2 monoclonal antibodies, pharmacokinetics, immune response, primates
Summary of Study: A combination of two high-affinity anti-SARS-CoV-2 monoclonal antibodies (mAbs; C144-LS and C135-LS) effectively blocks development of COVID-19 in the rhesus disease model and accelerates the prospect of clinical studies with this effective antibody combination.
References: PMID: 34869063 / doi: 10.3389/fcimb.2021.753444
Contact Info: Chad Roy: croy@tulane.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637877/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys, cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: Sichuan University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, review of the current animal models, pathology, immune response, use for the testing therapeutics and vaccines, mice, hamsters, nonhuman primates, and ferrets
Summary of Study: A variety of animal models have been developed to demonstrate the transmission, pathogenesis, and immunology induced by SARS-CoV-2 and to evaluate the immunomodulatory and antiviral drugs and vaccines against COVID-19. None of these models can completely recapitulate the changes seein in COVID-19 patients. It may be beneficial for investigators to apply appropriate options of animal models depending on the scientific goals.
References: PMID: 34909757 / doi: 10.1002/mco2.98
Contact Info: Shuaiyao Lu: lushuaiyao-km@163.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662225/pdf/MCO2-2-548.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: drpramodr@gmail.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: dewit@nih.gov
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
Coronavirus Investigated: SARS-CoV-2
NHP Species: baboons
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: NIH
Keywords: SARS-CoV-2, review, different primate species
Summary of Study: The authors advocate for baboons as a viable alternative to rhesus macaques in SARS-CoV-2 research.
References: PMID: 33785923 / doi:10.1038/s41684-021-00755-6
Contact Info: Michael Chang: changmic@mail.nih.gov
URL: https://www.nature.com/articles/s41684-021-00755-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases; University of Amsterdam; Universite de Paris, INSERM, IAME; University of Texas Medical Branch at Galveston; Galveston National Laboratory; Icahn School of Medicine at Mount Sinai; The Scripps Research Institute; Duke Human Vaccine Institute & Department of Surgery; Nexelis; The University of Maryland School of Medicine; Institut Pasteur; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, neutralizing antibody, prophylactic, pathology, mice, hamsters, primates
Summary of Study: COVA1-18, a neutralizing antibody highly potent against the B.1.1.7 isolate, has a strong antiviral activity in three preclinical models and could be a valuable candidate for further clinical evaluation.
References: PMID: 34671037 / doi: 10.1038/s41467-021-26354-0
Contact Info: Rogier Sanders: r.w.sanders@amsterdamumc.nl; Marit van Gils: m.j.vangils@amsterdamumc.nl; Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.nature.com/articles/s41467-021-26354-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: tamarins, marmosets, howler monkeys, titi monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Faculdade de Medicina de Sao Jose do Rio Preto, Brazil; Fundacao de Medicina Tropical Doutor Heitor Vieria Dourado, Brazil; Universidade do Estado do Amazonas, Brazil; Universidade Federal do Amazonas, Brazil; Universidade de Sao Paulo, Brazil; Hospital Israelita Albert Einstein; Instituto Butanta; Departamento de Vigilancia Epidemiologica de Sao Jose do Rio Preto; New Mexico State University; The University of Texas Medical Branch, Galveston; Instituto Leonidas e Maria Deane, Brazil
Keywords: SARS-CoV-2, wild animals, molecular and serological tests, primates
Summary of Study: Although no evidence of SARS-CoV-2 infection was detected, continued surveillance of NHPs in this region is warranted and may identify geographic areas or particular NHP species prone to spillover.
References: PMID: 34696363 / doi: 10.3390/v13101933
Contact Info: Marcus Vinicius Guimaraes de Lacerda: marcuslacerda.br@gmail.com; Mauricio Lacerda Nogueira: mnogueira@famerp.br
URL: https://www.mdpi.com/1999-4915/13/10/1933
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Washington; University of North Carolina at Chapel Hil; Fred Hutchinson Cancer Research Center; Stanford University School of Medicine; Institut Pasteur and CNRS UMR 3569; New Iberia Research Center and Department of Biology; Washington National Primate Research Center; University of Texas at Austin; GSK; Humabs Biomed SA; Bill & Melinda Gates Foundation\
Keywords: SARS-CoV-2, vaccine design, spike glycoprotein, receptor-binding domain, self-assembling nanoparticle, sarbecovirus, primates
Summary of Study: This study provides proof of the principle that multivalent sarbecovirus RBD-NPs induce heterotypic protection and motivates advancing such broadly protective sarbecovirus vaccines to the clinic.
References: PMID: 34619077 / doi: 10.1016/j.cell.2021.09.015
Contact Info: Neil King: neil@ipd.uw.edu; David Veesler: dveesler@uw.edu
URL: https://www.sciencedirect.com/science/article/pii/S009286742101062X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; INSERM, CEA; National Institute for Public Health and the Environment, RIVM; Public Health Service of Amsterdam; Tergooi Hospital; Amsterdam Neuroscience, AMC; Amsterdam Infectoin & Immunity, AMC; Amsterdam Infection & Immunity, VUmc; The University of Melbourne; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, cross-reactive antibodies, human coronaviruses, primates
Summary of Study: The results from this study on the presence and specificity of cross-reactive antibodies to other hCoVs after SARS-CoV-2 infection and vaccination emphasize the feasibility of broad coronavirus vaccines and may guide future vaccine designs.
References: PMID: 34812143 / doi: 10.7554/eLife.70330
Contact Info: Marit J van Gils: m.j.vangils@amsterdamumc.nl
URL: https://elifesciences.org/articles/70330
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets, howler monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade Federal dos Vales do Jequitinhonha e Mucuri, Brazil; Centro Estadual de Vigilancia em Saude; Universidade de Brasilia; Universidade Federal de Minas Gerais; State University of Santa Cruz; Universidade Federal de Tocantins
Keywords: SARS-CoV-2, wild animals, RT-qPCR, primates
Summary of Study: 51 NHPs were examined for signs of SARS-CoV-2; 89 samples of various tissues were analyzed, with no SARS-CoV-2 positive samples detected, regardless of NHP species, tissue, habitat, municipalities or state/biome tested.
References: PMID: 34843021 / doi: 10.1007/s10393-021-01569-1
Contact Info: Danilo Bretas de Oliveira: danilo.bretas@ufvjm.edu.br
URL: https://link.springer.com/article/10.1007%2Fs10393-021-01569-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: National Primate Research Centre, Republic of Korea; Chonnam National University; Korea Cancer Center Hospital; University of Ulsan College of Medicine; Futuristic Animal Resource Centre; Seoul National University; Korea University of Science & Technology; and others.
Keywords: SARS-CoV-2, germinal centers, viral reinfection, lung damage, primates
Summary of Study: The seroconversion observed in macaques, which recapitulates the course of COVID-19 disese in human survivors with mild or moderate symptoms, was consistent with the response of GCs in lymphoid tissues and blood of the human subjects tested.
References: PMID: 34718664 / doi: 10.1093/infdis/jiab535
Contact Info: Jung Joo Hong: hong75@kribb.re.kr
URL: https://academic.oup.com/jid/article/224/11/1861/6413652
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: University of California-Davis; California National Primate Research Center, UC Davis; Chan Zuckerberg Biohub; Vitalant Research Institute; University of Wisconsin-Madison; Wisconsin National Primate Research Center/UW Madison; University of California-San Francisco
Keywords: SARS-CoV-2, convalescent plasma, viral shedding, treatment efficiency, primates
Summary of Study: Passive immunization with convalescent plasma (CP), even during early infection, provided no significant benefit in a nonhuman primate model of SARS-CoV-2 infection.
References: PMID: 34817208 / doi: 10.1128/Spectrum.01397-21
Contact Info: Jesse Deere: jddeere@ucdavis.edu
URL: https://journals.asm.org/doi/10.1128/Spectrum.01397-21
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; CureVac AG; Tufts University Cummings School of Veterinary Medicine; University of North Carolina at Chapel Hill; Beth Israel Deaconess Medical Center; Bioqual; Washington University School of Medicine; Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity, protective efficacy, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in nonhuman primates.
References: PMID: 34794169 / doi: 10.1038/s41586-021-04231-6
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu; Susanne Rauch: Susanne.rauch@curevac.com
URL: https://www.nature.com/articles/s41586-021-04231-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotechnology Co., Ltd.; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; Shanghai Medical College, Fudan University; Wuhan University; National Institute for Food and Drug Control (NIFDC)
Keywords: SARS-CoV-2, recombinant vaccine, spike trimer, immunogenicity, mice, hamsters, primates
Summary of Study: A recombinant spike protein vaccine adjuvanted with aluminium hydroxide and CpG 7909 showed high immunogenicity and good protective efficacy in preclinical studies, supporting further clinical trials.
References: PMID: 34750014 / doi: 10.1016/j.vaccine.2021.10.066
Contact Info: Ge Liu: liuge@walvax.com; Jiangning Liu: liujn@cnilas.org.cn; Youhua Xie: yhxie@fudan.edu.cn; Zhongyu Hu: huzy67@163.com
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21013992?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; BIOQUAL; Texas Biomedical Research Institute; Columbia University Vagelos College of Physicians and Surgeons.
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, virus variants, primates
Summary of Study: A ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein adjuvanted with Army Liposomal Formulation QS-21 induces robust and broad antibody and T cell responses, as well as protection against viral replication and lung pathology following high-dose respiratory tract challenge with SARS-CoV-2.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: kmodjarrad@eidresearch.org; Diane Bolton: dbolton@hivresearch.org
URL: https://www.pnas.org/content/118/38/e2106433118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Chinese Academy of Sciences; State Key Laboratory of Pathogen an dBiosecutiry, Academy of Military Medical Sciences, Beijing; Sinocelltech Ltd., National Institutes for Food and Drug Control, Beijing; Institute for Biological Product Control, Beijing
Keywords: SARS-CoV-2, monoclonal antibody, preclinical safety evaluation, cryo-EM structure, mice, primates
Summary of Study: Increasing access to panels of authentic neutralizing monoclonal antibodies will facilitate structure-function studies to unpick the underlying biological processes of virus-host interactions, and provide molecular basis for applying HB27 for potential COVID-19 treatment.
References: PMID: 34676096 / doi: 10.1093/nsr/nwaa297
Contact Info: Cheng-Feng Qin: qincf@bmi.ac.cn; Xiangxi Wang: xiangxi@ibp.ac.cn; Youchun Wang: wangyc@nifdc.org.cn; Zihe Rao: raozh@tsinghua.edu.cn; Liangzhi Xie: liangzhi@yahoo.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798916/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; Amirabad Virology Laboratory; Tarbiat Modares University; University of Tehran; Islamic Azad University; Hamadan University of Medical Sciences; Darou Pakhsh Pharmaceutical; Arena Diagnostic; and others.
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, safety, immune response, guinea pig, rabbit, mice, primates
Summary of Study: Rhesus macaques were immunised with the two-dose schedule of 5 or 3 ug of the B1V1-CovIran vaccine and showed highly efficient protection against 10^4 TCID50 of SARS-CoV-2 intratracheal challenge compared with the control group.
References: PMID: 34699647 / doi: 10.1002/rmv.2305
Contact Info: Reza Aalizadeh: aalizadehreza19@gmail.com; Hasan Jalili: hjalili@ut.ac.ir
URL: https://onlinelibrary.wiley.com/doi/10.1002/rmv.2305
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: jkolls1@tulane.edu; Fengming Liu: fliu6@tulane.edu; Jay Rappaport: jrappaport@tulane.edu
URL: https://www.thno.org/v11p8076.htm
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, endotheliopathy, inflammation, primates, mice
Summary of Study: In addition to pneumocytes, SARS-CoV-2 also directly infects mature vascular endothelial cells in vivo and ex vivo which may contribute to cardiovascular complications in SARS-CoV-2 infection, including multipleorgan failure.
References: PMID: 34307198 / doi: 10.3389/fcimb.2021.701278
Contact Info: Xuebin Qin: xqin2@tulane.edu; Suleyman Ergun: sueleyman.erguen@uni-wuerzburg.de
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292147/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences, National Institute of Food and Drug Control (Beijing, China), Yunnan Provincial Infectious Disease Hospital, Yunnan Center for Disease Control and Prevention, Kunming Third People's Hospital
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine, produced by sequential inactivation with formaldehyde followed by propiolactone, was shown to be effective against SARS-Co-V 2 challenge in rhesus macaques.
References: PMID: 34462721 / doi: 10.1016/j.omtm.2021.08.005
Contact Info: Changgui Li: changguili@aliyun.com; Qihan Li: liqihan@imbcams.com.cn; Longding Liu: liuld@imbcams.com.cn
URL: https://www.sciencedirect.com/science/article/pii/S2329050121001315?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: skastur@emory.edu; Maria Elena Bottazzi: bottazzi@bcm.edu
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_i…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center/Emory University; Emory School of Medicine; Ragon Institute of MGH, MIT and Harvard; The University of Texas Medical Branch; 3M Corporate Research Materials Laboratory; and others.
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, neutralizing antibody, immune response, primates
Summary of Study: This study demonstrated the potential benefits of RBD trimer as an immunogen for COVID-19 vaccine using mice and macaque models. Future studies will investigate the durability of the vaccine-induced immune responses and what parameters lead to protection.
References: PMID: 34117252 / doi: 10.1038/s41467-021-23942-y
Contact Info: Rama Rao Amara: ramara@emory.edu
URL: https://www.nature.com/articles/s41467-021-23942-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Qassim University, Buraydah, Saudi Aribia; Imam Abdulrahman Bin Faisal University, MGM Dental College and Hospital, Baba Farid University of Health Sciences, Himachal Institute of Dental Sciences, Panineeya Mahavidyalaya
Keywords: SARS-CoV-2, immune response, animal models, meta analysis, mice, hamsters, ferrets, cats, dogs, primates
Summary of Study: This systematic review found that animal models only mimic limited signs and symptoms experienced in COVID infection as compared to infections in humans, yet are still essential to understand the pathogenesis, transmissibility or viral particles, and vaccine testing.
References: PMID: 34447038 / doi: 10.4103/jpbs.JPBS_749_20
Contact Info: Muhamood Moothedath: drmuhamoodmoothedath@gmail.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375911/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan; Osaka University; Gunma University; The University of Tokyo; University of Wisconsin-Madison; Mie University Graduate School of Medicine
Keywords: SARS-CoV-2, pathogenicity, old animals, pathology, immune response, primates
Summary of Study: The COVID-19 cynomolgus monkey model reflects the pathophysiology of humans and would be useful for elucidating the pathophysiology and developing therapeutic agents and vaccines.
References: PMID: 34625475 / doi: 10.1073/pnas.2104847118
Contact Info: Yasuhiro Yasutomi: yasutomi@nibiohn.go.jp
URL: https://www.pnas.org/content/118/43/e2104847118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard; Novavax; University of Duisburg-Essen; MIT; Texas Biomedical Research Institute; University of Maryland School of Medicine; Duke University Medical Center; La Jolla Institute for Immunology; and others
Keywords: SARS-CoV-2, humoral immune response, vaccine-induced antibody fingerprint, protection, primates
Summary of Study: Data presented suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging varriants.
References: PMID: 34485950 / doi: 10.1016/j.xcrm.2021.100405
Contact Info: Gale Smith: gsmith@novavax.com; Galit Alter: galter@mgh.harvard.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Akston Biosciences Corp.; Biomere Biomedical Research Models; Feigin ABSL-3 Facility, Baylor College of Medicine; BIOQUAL; California National Primate Research Center; Sinclair Research Center; Pharmaceutical Research Associates Group B.V.
Keywords: SARS-CoV-2, viral spike protein, immunogenicity, prophylaxis, Fc-fusion, mice, primates
Summary of Study: Preclinical studies support the initiation of Phase I clinical studies with adjuvanted AKS-452 with the expectation that this room-temperature stable, Fc-fusion subunit vaccine can be rapidly and inexpensively manufactured to provide billions of doses per year especially in regions where the cold-chain is difficult to maintain.
References: PMID: 34642088 / doi: 10.1016/j.vaccine.2021.09.077
Contact Info: Todd Zion: todd.zion@akstonbio.com
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21012949?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Institute for Basic Science (IBS) (Repblic of Kores), Eulji University School of Medicine, Seol National University Hospital, Jeonbuk National University Medical School, Sungkyunkwan University School of Medicine
Keywords: SARS-CoV-2, nasal ciliated cells, virus tropism, primates
Summary of Study: Nasal multiciliated epithelial cells are th emain target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19, implying that targeting nasal ciliated cells could be an ideal strategy to prevent SARS-CoV-2 propagation.
References: PMID: 34003804 / doi: 10.1172/JCI148517
Contact Info: Ji Hoon Ahn: ahnadun@kaist.ac.kr; JungMo Kim: jmkim@ibs.re.kr; Seon Pyo Hong: sp_hong@kaist.ac.kr; Young Tae Kim: ytkim@snu.ac.kr, Chang-Seop Lee: lcsmd@jbnu.ac.kr
URL: https://www.jci.org/articles/view/148517
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite Paris-Saclay, Inserm; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Institute Pasteur; Mass General Brigham Innovation; Albamunity
Keywords: SARS-CoV-2, AAV-based vaccine, immunogenicity, thermostability, mice, primates
Summary of Study: AAVrh32.33 technology demonstrated its utilitiy as a preventative vaccine for COVID19, and its unique attributes may be applicable to other pathogens or immunization targets.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu; Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: National Health Commission of the People's Republic of China; Chinese Academy of Sciences; Nanjing Medical University; Beijing Institute of Microbiology and Epidemiology; Jiangsu Rec-biotechnology Col Ltd.
Keywords: SARS-CoV-2, neutralizing antibodies, immunization, spike protein, immunogenicity, rabbits, primates
Summary of Study: The immunogenic data derived from immunization with a combination of SARS-CoV-2 RBD and NTD demonstrate the feasility of eliciting robust targeted immune profiles by using antibody-guided vaccine design.
References: PMID: 34676098 / doi: 10.1093/nsr/nwab053
Contact Info: Xiangxi Wang: xiangxi@ibp.ac.cn; Cheng-Feng Qin: qincf@bmi.ac.cn; Feng-Cai Zhu: jszfc@vip.sina.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083607/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite paris-Saclay/Inserm/Cea; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Ragon Institute of MGH, MIT, and Harvard; and others
Keywords: SARS-CoV-2, AAV-vaccine candidates, immune response, mice, primates
Summary of Study: Studies of the AAV-based vaccine candidate AC1 support its potential to protect from COVID-19 disease and infection from a single-dose immunization; may lead to highly durable immunogenicity; and is stable at ambient temperature for storage for several weeks. The combination of these WHO-specific key attributes have not been met by any of the currently approved vaccines. Continued development of second-generation vaccine candidates such at AC1 is needed.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Roger LeGrand: roger.le-grand@cea.fr; Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Kangtai Biotechnology Co., Ltd.; Academy of Military Medical Sciences; Zhenzhou University; National Institutes for Food and Drug Control; Henan Normal University
Keywords: SARS-CoV-2, chimeric spike protein, humoral immune response, pathology, mice, primates
Summary of Study: The strategy of chimerica expression SARS-CoV-2 S RBD in SARS-CoV represents a new design for other vaccine platforms.
References: PMID: 34759261 / doi: 10.1038/s41392-021-00797-9
Contact Info: Shuguang Duo: duoshuguang@ioz.ac.cn
URL: https://www.nature.com/articles/s41392-021-00797-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: University of Tehran, Tabriz University of Medical Sciences, Karolinska Institute, University of Rochester Medical Center, Toyko University of Science, University of Veterinary Medicine (Vienna)
Keywords: SARS-CoV-2, immune response, reinfection, recovery, primates
Summary of Study: Review paper proposing a new strategy to predict the potential of reinfection in each identified category. This classification may help to distribute resources more meticulously to determine: Who needs to be serologically tested for SARS-CoV-2 neutralizing antibodies, what percentage of the population is immune to the virus, and who needs to be vaccinated.
References: PMID: 33520309 / doi: 10.1016/jare.2020.12.013
Contact Info: Younes Aftabi: aftably@tbzmed.ac.ir; Sasan Fereidouni: sasan.fereidouni@vetmeduni.ac.at
URL: https://www.sciencedirect.com/science/article/pii/S2090123220302630?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: California National Primate Research Center, UC Davis School of Medicine, The Rockefeller University, UC Davis School of Veterinary Medicine, DMID/NIAID/NIH, Howard Hughes Medical Institute
Keywords: SARS-CoV-2, therapeutic interventions, neutralizing monoclonal antibodies, pathology, primates
Summary of Study: Study provides proof-of-concept in support of further clinical development of monoclonal antibodies C135-LS and C144-LS against COVID-19 during early infection.
References: PMID: 34228761 / doi: 10.1371/journal.ppat.1009688
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Michel Nussenzweig: nussen@rockefeller.edu; J. Rachel Reader: rreader@ucdavis.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009688
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: EcoHealth Alliance; Deakin University; Institute of Epidemiology, Disease Control and Research (Dhaka, Bangladesh); University of Dhaka; Chattogram Veterinary and Animal Sciences University
Keywords: SARS-CoV-2, meta analysis, virus transmission, public health, susceptible animal species, primates
Summary of Study: The continuing spillover and spillback of SARS-CoV-2 in a wide range of animals in farming, captive and free-ranging interfaces make inferences for human and animal health, welfare and conservation. Pets, farmed and captive wild animals should be vaccinated in accordance with vaccination in humans.
References: PMID: 34694705 / doi: 10.111/tbed.14356
Contact Info: Ariful Islam: arif@ecohealthalliance.org
URL: https://onlinelibrary.wiley.com/doi/10.1111/tbed.14356
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets, howler monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade Federal dos Vales do Jequitinhonha e Mucuri, Brazil; Centro Estadual de Vigilancia em Saude; Universidade de Brasilia; Universidade Federal de Minas Gerais; State University of Santa Cruz; Universidade Federal de Tocantins
Keywords: SARS-CoV-2, wild animals, RT-qPCR, primates
Summary of Study: 51 NHPs were examined for signs of SARS-CoV-2; 89 samples of various tissues were analyzed, with no SARS-CoV-2 positive samples detected, regardless of NHP species, tissue, habitat, municipalities or state/biome tested.
References: PMID: 34843021 / doi: 10.1007/s10393-021-01569-1
Contact Info: Danilo Bretas de Oliveira: danilo.bretas@ufvjm.edu.br
URL: https://link.springer.com/article/10.1007%2Fs10393-021-01569-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: National Primate Research Centre, Republic of Korea; Chonnam National University; Korea Cancer Center Hospital; University of Ulsan College of Medicine; Futuristic Animal Resource Centre; Seoul National University; Korea University of Science & Technology; and others.
Keywords: SARS-CoV-2, germinal centers, viral reinfection, lung damage, primates
Summary of Study: The seroconversion observed in macaques, which recapitulates the course of COVID-19 disese in human survivors with mild or moderate symptoms, was consistent with the response of GCs in lymphoid tissues and blood of the human subjects tested.
References: PMID: 34718664 / doi: 10.1093/infdis/jiab535
Contact Info: Jung Joo Hong: hong75@kribb.re.kr
URL: https://academic.oup.com/jid/article/224/11/1861/6413652
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: University of California-Davis; California National Primate Research Center, UC Davis; Chan Zuckerberg Biohub; Vitalant Research Institute; University of Wisconsin-Madison; Wisconsin National Primate Research Center/UW Madison; University of California-San Francisco
Keywords: SARS-CoV-2, convalescent plasma, viral shedding, treatment efficiency, primates
Summary of Study: Passive immunization with convalescent plasma (CP), even during early infection, provided no significant benefit in a nonhuman primate model of SARS-CoV-2 infection.
References: PMID: 34817208 / doi: 10.1128/Spectrum.01397-21
Contact Info: Jesse Deere: jddeere@ucdavis.edu
URL: https://journals.asm.org/doi/10.1128/Spectrum.01397-21
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; CureVac AG; Tufts University Cummings School of Veterinary Medicine; University of North Carolina at Chapel Hill; Beth Israel Deaconess Medical Center; Bioqual; Washington University School of Medicine; Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity, protective efficacy, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in nonhuman primates.
References: PMID: 34794169 / doi: 10.1038/s41586-021-04231-6
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu; Susanne Rauch: Susanne.rauch@curevac.com
URL: https://www.nature.com/articles/s41586-021-04231-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotechnology Co., Ltd.; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; Shanghai Medical College, Fudan University; Wuhan University; National Institute for Food and Drug Control (NIFDC)
Keywords: SARS-CoV-2, recombinant vaccine, spike trimer, immunogenicity, mice, hamsters, primates
Summary of Study: A recombinant spike protein vaccine adjuvanted with aluminium hydroxide and CpG 7909 showed high immunogenicity and good protective efficacy in preclinical studies, supporting further clinical trials.
References: PMID: 34750014 / doi: 10.1016/j.vaccine.2021.10.066
Contact Info: Ge Liu: liuge@walvax.com; Jiangning Liu: liujn@cnilas.org.cn; Youhua Xie: yhxie@fudan.edu.cn; Zhongyu Hu: huzy67@163.com
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21013992?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; BIOQUAL; Texas Biomedical Research Institute; Columbia University Vagelos College of Physicians and Surgeons.
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, virus variants, primates
Summary of Study: A ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein adjuvanted with Army Liposomal Formulation QS-21 induces robust and broad antibody and T cell responses, as well as protection against viral replication and lung pathology following high-dose respiratory tract challenge with SARS-CoV-2.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: kmodjarrad@eidresearch.org; Diane Bolton: dbolton@hivresearch.org
URL: https://www.pnas.org/content/118/38/e2106433118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Chinese Academy of Sciences; State Key Laboratory of Pathogen an dBiosecutiry, Academy of Military Medical Sciences, Beijing; Sinocelltech Ltd., National Institutes for Food and Drug Control, Beijing; Institute for Biological Product Control, Beijing
Keywords: SARS-CoV-2, monoclonal antibody, preclinical safety evaluation, cryo-EM structure, mice, primates
Summary of Study: Increasing access to panels of authentic neutralizing monoclonal antibodies will facilitate structure-function studies to unpick the underlying biological processes of virus-host interactions, and provide molecular basis for applying HB27 for potential COVID-19 treatment.
References: PMID: 34676096 / doi: 10.1093/nsr/nwaa297
Contact Info: Cheng-Feng Qin: qincf@bmi.ac.cn; Xiangxi Wang: xiangxi@ibp.ac.cn; Youchun Wang: wangyc@nifdc.org.cn; Zihe Rao: raozh@tsinghua.edu.cn; Liangzhi Xie: liangzhi@yahoo.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798916/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases; University of Amsterdam; Universite de Paris, INSERM, IAME; University of Texas Medical Branch at Galveston; Galveston National Laboratory; Icahn School of Medicine at Mount Sinai; The Scripps Research Institute; Duke Human Vaccine Institute & Department of Surgery; Nexelis; The University of Maryland School of Medicine; Institut Pasteur; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, neutralizing antibody, prophylactic, pathology, mice, hamsters, primates
Summary of Study: COVA1-18, a neutralizing antibody highly potent against the B.1.1.7 isolate, has a strong antiviral activity in three preclinical models and could be a valuable candidate for further clinical evaluation.
References: PMID: 34671037 / doi: 10.1038/s41467-021-26354-0
Contact Info: Rogier Sanders: r.w.sanders@amsterdamumc.nl; Marit van Gils: m.j.vangils@amsterdamumc.nl; Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.nature.com/articles/s41467-021-26354-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: tamarins, marmosets, howler monkeys, titi monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Faculdade de Medicina de Sao Jose do Rio Preto, Brazil; Fundacao de Medicina Tropical Doutor Heitor Vieria Dourado, Brazil; Universidade do Estado do Amazonas, Brazil; Universidade Federal do Amazonas, Brazil; Universidade de Sao Paulo, Brazil; Hospital Israelita Albert Einstein; Instituto Butanta; Departamento de Vigilancia Epidemiologica de Sao Jose do Rio Preto; New Mexico State University; The University of Texas Medical Branch, Galveston; Instituto Leonidas e Maria Deane, Brazil
Keywords: SARS-CoV-2, wild animals, molecular and serological tests, primates
Summary of Study: Although no evidence of SARS-CoV-2 infection was detected, continued surveillance of NHPs in this region is warranted and may identify geographic areas or particular NHP species prone to spillover.
References: PMID: 34696363 / doi: 10.3390/v13101933
Contact Info: Marcus Vinicius Guimaraes de Lacerda: marcuslacerda.br@gmail.com; Mauricio Lacerda Nogueira: mnogueira@famerp.br
URL: https://www.mdpi.com/1999-4915/13/10/1933
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Washington; University of North Carolina at Chapel Hil; Fred Hutchinson Cancer Research Center; Stanford University School of Medicine; Institut Pasteur and CNRS UMR 3569; New Iberia Research Center and Department of Biology; Washington National Primate Research Center; University of Texas at Austin; GSK; Humabs Biomed SA; Bill & Melinda Gates Foundation\
Keywords: SARS-CoV-2, vaccine design, spike glycoprotein, receptor-binding domain, self-assembling nanoparticle, sarbecovirus, primates
Summary of Study: This study provides proof of the principle that multivalent sarbecovirus RBD-NPs induce heterotypic protection and motivates advancing such broadly protective sarbecovirus vaccines to the clinic.
References: PMID: 34619077 / doi: 10.1016/j.cell.2021.09.015
Contact Info: Neil King: neil@ipd.uw.edu; David Veesler: dveesler@uw.edu
URL: https://www.sciencedirect.com/science/article/pii/S009286742101062X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; INSERM, CEA; National Institute for Public Health and the Environment, RIVM; Public Health Service of Amsterdam; Tergooi Hospital; Amsterdam Neuroscience, AMC; Amsterdam Infectoin & Immunity, AMC; Amsterdam Infection & Immunity, VUmc; The University of Melbourne; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, cross-reactive antibodies, human coronaviruses, primates
Summary of Study: The results from this study on the presence and specificity of cross-reactive antibodies to other hCoVs after SARS-CoV-2 infection and vaccination emphasize the feasibility of broad coronavirus vaccines and may guide future vaccine designs.
References: PMID: 34812143 / doi: 10.7554/eLife.70330
Contact Info: Marit J van Gils: m.j.vangils@amsterdamumc.nl
URL: https://elifesciences.org/articles/70330
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; Amirabad Virology Laboratory; Tarbiat Modares University; University of Tehran; Islamic Azad University; Hamadan University of Medical Sciences; Darou Pakhsh Pharmaceutical; Arena Diagnostic; and others.
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, safety, immune response, guinea pig, rabbit, mice, primates
Summary of Study: Rhesus macaques were immunised with the two-dose schedule of 5 or 3 ug of the B1V1-CovIran vaccine and showed highly efficient protection against 10^4 TCID50 of SARS-CoV-2 intratracheal challenge compared with the control group.
References: PMID: 34699647 / doi: 10.1002/rmv.2305
Contact Info: Reza Aalizadeh: aalizadehreza19@gmail.com; Hasan Jalili: hjalili@ut.ac.ir
URL: https://onlinelibrary.wiley.com/doi/10.1002/rmv.2305
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: jkolls1@tulane.edu; Fengming Liu: fliu6@tulane.edu; Jay Rappaport: jrappaport@tulane.edu
URL: https://www.thno.org/v11p8076.htm
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, endotheliopathy, inflammation, primates, mice
Summary of Study: In addition to pneumocytes, SARS-CoV-2 also directly infects mature vascular endothelial cells in vivo and ex vivo which may contribute to cardiovascular complications in SARS-CoV-2 infection, including multipleorgan failure.
References: PMID: 34307198 / doi: 10.3389/fcimb.2021.701278
Contact Info: Xuebin Qin: xqin2@tulane.edu; Suleyman Ergun: sueleyman.erguen@uni-wuerzburg.de
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292147/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences, National Institute of Food and Drug Control (Beijing, China), Yunnan Provincial Infectious Disease Hospital, Yunnan Center for Disease Control and Prevention, Kunming Third People's Hospital
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine, produced by sequential inactivation with formaldehyde followed by propiolactone, was shown to be effective against SARS-Co-V 2 challenge in rhesus macaques.
References: PMID: 34462721 / doi: 10.1016/j.omtm.2021.08.005
Contact Info: Changgui Li: changguili@aliyun.com; Qihan Li: liqihan@imbcams.com.cn; Longding Liu: liuld@imbcams.com.cn
URL: https://www.sciencedirect.com/science/article/pii/S2329050121001315?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: skastur@emory.edu; Maria Elena Bottazzi: bottazzi@bcm.edu
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_i…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center/Emory University; Emory School of Medicine; Ragon Institute of MGH, MIT and Harvard; The University of Texas Medical Branch; 3M Corporate Research Materials Laboratory; and others.
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, neutralizing antibody, immune response, primates
Summary of Study: This study demonstrated the potential benefits of RBD trimer as an immunogen for COVID-19 vaccine using mice and macaque models. Future studies will investigate the durability of the vaccine-induced immune responses and what parameters lead to protection.
References: PMID: 34117252 / doi: 10.1038/s41467-021-23942-y
Contact Info: Rama Rao Amara: ramara@emory.edu
URL: https://www.nature.com/articles/s41467-021-23942-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Qassim University, Buraydah, Saudi Aribia; Imam Abdulrahman Bin Faisal University, MGM Dental College and Hospital, Baba Farid University of Health Sciences, Himachal Institute of Dental Sciences, Panineeya Mahavidyalaya
Keywords: SARS-CoV-2, immune response, animal models, meta analysis, mice, hamsters, ferrets, cats, dogs, primates
Summary of Study: This systematic review found that animal models only mimic limited signs and symptoms experienced in COVID infection as compared to infections in humans, yet are still essential to understand the pathogenesis, transmissibility or viral particles, and vaccine testing.
References: PMID: 34447038 / doi: 10.4103/jpbs.JPBS_749_20
Contact Info: Muhamood Moothedath: drmuhamoodmoothedath@gmail.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375911/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan; Osaka University; Gunma University; The University of Tokyo; University of Wisconsin-Madison; Mie University Graduate School of Medicine
Keywords: SARS-CoV-2, pathogenicity, old animals, pathology, immune response, primates
Summary of Study: The COVID-19 cynomolgus monkey model reflects the pathophysiology of humans and would be useful for elucidating the pathophysiology and developing therapeutic agents and vaccines.
References: PMID: 34625475 / doi: 10.1073/pnas.2104847118
Contact Info: Yasuhiro Yasutomi: yasutomi@nibiohn.go.jp
URL: https://www.pnas.org/content/118/43/e2104847118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard; Novavax; University of Duisburg-Essen; MIT; Texas Biomedical Research Institute; University of Maryland School of Medicine; Duke University Medical Center; La Jolla Institute for Immunology; and others
Keywords: SARS-CoV-2, humoral immune response, vaccine-induced antibody fingerprint, protection, primates
Summary of Study: Data presented suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging varriants.
References: PMID: 34485950 / doi: 10.1016/j.xcrm.2021.100405
Contact Info: Gale Smith: gsmith@novavax.com; Galit Alter: galter@mgh.harvard.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Akston Biosciences Corp.; Biomere Biomedical Research Models; Feigin ABSL-3 Facility, Baylor College of Medicine; BIOQUAL; California National Primate Research Center; Sinclair Research Center; Pharmaceutical Research Associates Group B.V.
Keywords: SARS-CoV-2, viral spike protein, immunogenicity, prophylaxis, Fc-fusion, mice, primates
Summary of Study: Preclinical studies support the initiation of Phase I clinical studies with adjuvanted AKS-452 with the expectation that this room-temperature stable, Fc-fusion subunit vaccine can be rapidly and inexpensively manufactured to provide billions of doses per year especially in regions where the cold-chain is difficult to maintain.
References: PMID: 34642088 / doi: 10.1016/j.vaccine.2021.09.077
Contact Info: Todd Zion: todd.zion@akstonbio.com
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21012949?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Institute for Basic Science (IBS) (Repblic of Kores), Eulji University School of Medicine, Seol National University Hospital, Jeonbuk National University Medical School, Sungkyunkwan University School of Medicine
Keywords: SARS-CoV-2, nasal ciliated cells, virus tropism, primates
Summary of Study: Nasal multiciliated epithelial cells are th emain target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19, implying that targeting nasal ciliated cells could be an ideal strategy to prevent SARS-CoV-2 propagation.
References: PMID: 34003804 / doi: 10.1172/JCI148517
Contact Info: Ji Hoon Ahn: ahnadun@kaist.ac.kr; JungMo Kim: jmkim@ibs.re.kr; Seon Pyo Hong: sp_hong@kaist.ac.kr; Young Tae Kim: ytkim@snu.ac.kr, Chang-Seop Lee: lcsmd@jbnu.ac.kr
URL: https://www.jci.org/articles/view/148517
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: National Health Commission of the People's Republic of China; Chinese Academy of Sciences; Nanjing Medical University; Beijing Institute of Microbiology and Epidemiology; Jiangsu Rec-biotechnology Col Ltd.
Keywords: SARS-CoV-2, neutralizing antibodies, immunization, spike protein, immunogenicity, rabbits, primates
Summary of Study: The immunogenic data derived from immunization with a combination of SARS-CoV-2 RBD and NTD demonstrate the feasility of eliciting robust targeted immune profiles by using antibody-guided vaccine design.
References: PMID: 34676098 / doi: 10.1093/nsr/nwab053
Contact Info: Xiangxi Wang: xiangxi@ibp.ac.cn; Cheng-Feng Qin: qincf@bmi.ac.cn; Feng-Cai Zhu: jszfc@vip.sina.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083607/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite paris-Saclay/Inserm/Cea; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Ragon Institute of MGH, MIT, and Harvard; and others
Keywords: SARS-CoV-2, AAV-vaccine candidates, immune response, mice, primates
Summary of Study: Studies of the AAV-based vaccine candidate AC1 support its potential to protect from COVID-19 disease and infection from a single-dose immunization; may lead to highly durable immunogenicity; and is stable at ambient temperature for storage for several weeks. The combination of these WHO-specific key attributes have not been met by any of the currently approved vaccines. Continued development of second-generation vaccine candidates such at AC1 is needed.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Roger LeGrand: roger.le-grand@cea.fr; Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Kangtai Biotechnology Co., Ltd.; Academy of Military Medical Sciences; Zhenzhou University; National Institutes for Food and Drug Control; Henan Normal University
Keywords: SARS-CoV-2, chimeric spike protein, humoral immune response, pathology, mice, primates
Summary of Study: The strategy of chimerica expression SARS-CoV-2 S RBD in SARS-CoV represents a new design for other vaccine platforms.
References: PMID: 34759261 / doi: 10.1038/s41392-021-00797-9
Contact Info: Shuguang Duo: duoshuguang@ioz.ac.cn
URL: https://www.nature.com/articles/s41392-021-00797-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite Paris-Saclay, Inserm; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Institute Pasteur; Mass General Brigham Innovation; Albamunity
Keywords: SARS-CoV-2, AAV-based vaccine, immunogenicity, thermostability, mice, primates
Summary of Study: AAVrh32.33 technology demonstrated its utilitiy as a preventative vaccine for COVID19, and its unique attributes may be applicable to other pathogens or immunization targets.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu; Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: University of Tehran, Tabriz University of Medical Sciences, Karolinska Institute, University of Rochester Medical Center, Toyko University of Science, University of Veterinary Medicine (Vienna)
Keywords: SARS-CoV-2, immune response, reinfection, recovery, primates
Summary of Study: Review paper proposing a new strategy to predict the potential of reinfection in each identified category. This classification may help to distribute resources more meticulously to determine: Who needs to be serologically tested for SARS-CoV-2 neutralizing antibodies, what percentage of the population is immune to the virus, and who needs to be vaccinated.
References: PMID: 33520309 / doi: 10.1016/jare.2020.12.013
Contact Info: Younes Aftabi: aftably@tbzmed.ac.ir; Sasan Fereidouni: sasan.fereidouni@vetmeduni.ac.at
URL: https://www.sciencedirect.com/science/article/pii/S2090123220302630?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: California National Primate Research Center, UC Davis School of Medicine, The Rockefeller University, UC Davis School of Veterinary Medicine, DMID/NIAID/NIH, Howard Hughes Medical Institute
Keywords: SARS-CoV-2, therapeutic interventions, neutralizing monoclonal antibodies, pathology, primates
Summary of Study: Study provides proof-of-concept in support of further clinical development of monoclonal antibodies C135-LS and C144-LS against COVID-19 during early infection.
References: PMID: 34228761 / doi: 10.1371/journal.ppat.1009688
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Michel Nussenzweig: nussen@rockefeller.edu; J. Rachel Reader: rreader@ucdavis.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009688
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: EcoHealth Alliance; Deakin University; Institute of Epidemiology, Disease Control and Research (Dhaka, Bangladesh); University of Dhaka; Chattogram Veterinary and Animal Sciences University
Keywords: SARS-CoV-2, meta analysis, virus transmission, public health, susceptible animal species, primates
Summary of Study: The continuing spillover and spillback of SARS-CoV-2 in a wide range of animals in farming, captive and free-ranging interfaces make inferences for human and animal health, welfare and conservation. Pets, farmed and captive wild animals should be vaccinated in accordance with vaccination in humans.
References: PMID: 34694705 / doi: 10.111/tbed.14356
Contact Info: Ariful Islam: arif@ecohealthalliance.org
URL: https://onlinelibrary.wiley.com/doi/10.1111/tbed.14356
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; National Cancer Institute/NIH; BIOQUAL; and others
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, primates
Summary of Study: Findings support the continued development of SARS-CoV-2 RBD ferritin nanoparticle vaccines (RFN) for managing COVID-19 and related SARS-CoV-like virus outbreaks.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: kmodjarrad@eidresearch.org; Diane Bolton: dbolton@hivresearch.org
URL: https://www.pnas.org/content/118/38/e2106433118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Universite Paris-Saclay/Inserm/CEA; Vaccine Research INstitute, Creteil, France; Inserm; Baylor Scott and White Research Institute; Institut Pasteur; Karolinska Institutet; and others
Keywords: SARS-CoV-2, subunit vaccine, receptor-binding domain, immune response, humanized mice, primates
Summary of Study: A single dose of the alphaCD40.RBD (a vaccine that targets the receptor-binding domain of the SARS-CoV-2 spike antigen to the CD40 receptor) administered without adjuvant boosts the protective response in COVID-10 convalescent NHPs.
References: PMID: 34471122 / doi: 10.1038/s41467-021-25382-0
Contact Info: Yves Levy: yves.levy@inserm.fr
URL: https://www.nature.com/articles/s41467-021-25382-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University; UNC Chapel Hill; 3M Corporate Research Materials Laboratory; Infectious Disease Research Institute; California National Primate Research Center; and others
Keywords: SARS-CoV-2, mRNA vaccine, infants, immune response, primates
Summary of Study: Infant rhesus macaques were vaccinated with an mRNA-based SARS-CoV-2 vaccine, similar to the Moderna vaccine, or an S protein plus TLR7/8 agonist-based vaccine. Both vaccines induced profound induction of neutralizing antibody titers, memory B cells responses, and SARS-CV-2 specific CD4+ T cell responses that were long-lasting, all while limiting vaccine related toxicity.
References: PMID: 34131024 / doi: 10.1126/sciimmunol.abj3684
Contact Info: Kristina De Paris: abelk@med.unc.edu
URL: https://www.science.org/doi/10.1126/sciimmunol.abj3684?url_ver=Z39.88-2003&rfr_i…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID, Ragon Institute of MGH, MIT< and Harvard, University of Duisburg-Essen, Harvard University, Emory Vaccine Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, protein subunit vaccine, soluble prefusion-stabilized spike trimers, immune response, primates
Summary of Study: Soluble prefusion-stablized spike protein trimers (preS DTM) from SARS-CoV-2 were formulated with the adjuvant AS03 and administered twice to NHPs. Two days after challenge, vaccinated NHPs showed rapid control of viral replication in both the upper and lower airways. These data indicate that antibodies induced by the AS03-adjuvanted preS dTM vaccine were sufficient to mediate protection against SARS-CoV-2 in NHPs and that rapid anamnestic antibody responses in the lung may be a key mechanism for protection.
References: PMID: 34315825 / doi: 10.1126/scitranslmed.abi4547
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://www.science.org/doi/10.1126/scitranslmed.abi4547?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Celltech Pharmed Co.; Iran University of Medical Sciences; University of Iran; Tarbiat Modares University; Royan Institute for Stem Cell Biology and Technology; and others
Keywords: SARS-CoV-2, mRNA-vaccine, lipid nanoparticle, spike protein, immune response, primates
Summary of Study: A novel mRNA-LNP vaccine against SARS-CoV-2 was developed and preclinically evaluated, revealing that it was efficient enough to induce hgih level production of neutralizing antibodies against SARS-CoV-2 in mice and rhesus macaque monkeys.
References: PMID: 34579244 / doi: 10.3390/vaccines9091007
Contact Info: Alireza Sohi: nanosohi@strc.ac.ir; Jafar Kiani: kiani.ja@iums.ac.ir; Ehsan Arefian: arefian@ut.ac.ir; Arezou Khosrojerdi: arezou.khosrojerdi@modares.ac.ir; Mohammad Zim: mk.zim73@ut.ac.ir
URL: https://www.mdpi.com/2076-393X/9/9/1007
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Brigham and Women's Hospital and Harvard Medical School, The Affiliated Hospital of Youjiang Medical Univ. for Nationalities (China), and the University of Alabama
Keywords: SARS-CoV-2, ACE2 protein expression, lung injury, mice and primates
Summary of Study: Data from this study unequivocally support the key role of ACE2 in the sinonasal mucosa as a functional reARS-CoV-2; however, the restricted baseline expression pattern of ACE1 in the lung presents a conundrum as it raises questions about alternative viral receptors or additional mechanisms of lung injury in COVID-19 pneumonia.
References: PMID: 33626084 / doi: 10.1371/journal.pone.0247510
Contact Info: Sule Cataltepe: scataltepe@bwh.harvard.edu
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247510
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines & Prevention; Tufts University Cummings School of Veterinary Medicine; Bioqual; Ragon Institute of MGH, MIT, and Harvard.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, virus transduction, primates
Summary of Study: A single immunization with relatively low dose of Ad26.COV2.S effectively protected against SARS-CV-2 challenge in rhesus macaques, although a higher vaccine dose may be required for protection in the upper respiratory tract.
References: PMID: 34133941 / doi: 10.1016/j.cell.2021.05.040
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.cell.com/cell/fulltext/S0092-8674(21)00693-0?_returnURL=https%3A//li…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Kunming Institute of Zoology; Institute of Infectious Diseases, Shenzhen Bay Laboratory; School of Medicine, Tsinghua University
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, humoral and cellular immune responses, pathology, primates
Summary of Study: A trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine that stimulates the natural structure of the spike (S) trimer glycoprotein is highly immunogenic and safe, providing long-lasting, broad, and significant immunity protection in NHPs. The vaccine-induced antibodies can effectively neutralize the SARS-CoV-2 501Y.V2 variant. A booster vaccination can quickly activate the memory immune response to avoid re-infection.
References: PMID: 34179862 / doi: 10.1016/j.xinn.2021.100140
Contact Info: Limin Yang: lmyang@im.ac.cn; Yong-tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214323/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, University of North Carolina at Chapel Hill, Ragon Institute of MGH, MIT, and Harvard, Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity and protective efficacy, mice
Summary of Study: RhAd52 vaccines elicit robust SARS-CoV-2 specific antibody responses and protect against clinical disease and viral replication in the lungs. These data validate the MA10 mouse model as a useful tool to screen and study novel vaccine candidates, as well as the development of RhAd52 vaccines for COVID-19.
References: PMID: 34523968 / doi: 10.1128/JVI.00974-21
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://journals.asm.org/doi/10.1128/JVI.00974-21?url_ver=Z39.88-2003&rfr_id=ori…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: California National Primate Research Center; University of California, Davis; Louisiana State University Health Sciences Center; The Rockefeller University.
Keywords: SARS-CoV-2, neuroinflammation, effector CD4 T cells, inflammation, cerebrospinal fluid, pneumonia, primates
Summary of Study: Neutralizing mABs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
References: PMID: 34706272 / doi: 10.1016/j.celrep.2021.109942
Contact Info: Smita Iyer: smiyer@ucdavis.edu
URL: https://www.sciencedirect.com/science/article/pii/S2211124721014157?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines & Prevention B.V.; Harvard Medical School; Lucidity Biomedical Consulting; Ragon Institute of MGH, MIT and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vector, immunogenicity, protective efficacy, immune response, primates
Summary of Study: Ad26.COV2.S vaccine confers durable protection against replication of SARS-CoV-2 in the lungs that is predicted by the levels of Spike-binding and neutralizing antibodies, indicating that Ad26.COV2.S could confer durable protection in humans and immunological correlates of protection may enable the prediction of durability of protection.
References: PMID: 34620860 / doi: 10.1038/s41467-021-26117-x
Contact Info: Roland Zahn: RZahn@its.jnj.com
URL: https://www.nature.com/articles/s41467-021-26117-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Center for Disease Control and Prevention; Chinese Academy of Medical Sciences & Peking Union Medical College; Chinese Academy of Sciences
Keywords: SARS-CoV-2, mRNA vaccine, nanoparticles, immune response, pathology, mice and primates
Summary of Study: Using both mouse and rhesus macaque SARS-CoV-2 challenge models, this study demonstrates strong immunogenicity, protective ability and high safety profiles of SW0123 (an LPP-based mRA vaccine), and supports this promising candidate for future clinical evaluation.
References: PMID: 34059617 / doi: 10.1038/s41392-021-00634-z
Contact Info: Wenjie Tan: tanwj@ivdc.chinacdc.cn; Xiaozhong Peng: pengxiaozhong@pumc.edu.cn
URL: https://www.nature.com/articles/s41392-021-00634-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Catholic University of Korea, Korea Research Institute of Bioscience and Biotechnology, SK Science, Jeonbuk National University, and others
Keywords: SARS-CoV-2, receptor-binding domain of SARS-CoV-2, immune response, mice and primates
Summary of Study: RBD-P2 + alum immunization elicits a robust neutralizing antibody response and provides complete or near-complete elimination of live SARS-CoV-2 virus particles. Additionally, findings provide insight into the potential use of the N protein in the development of SARS-CoV-2 vaccines.
References: PMID: 34049881 / doi: 10.1126/sciadv.abg7156
Contact Info: Jae-Hwan Nam: jhnam@catholic.ac.kr; Sang-Myeong Lee: smlee@chungbuk.ac.kr; Jung Joo Hong: hong75@kribb.re.kr
URL: https://www.science.org/doi/10.1126/sciadv.abg7156?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs, lorises
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: University of Calgary; Institut de Biologia Evolutiva, Universitat Pompeu Fabra; North Carolina Central University, Duke University and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Study suggests that lemurs of the families Indriidae, Daubentonlidae, and Lemuridae are likely to be particularly vulnerable to SARS-CoV-2 infection.
References: PMID: 33792947 / doi: 10.1002/ajp.23255
Contact Info: James Higham: jhigham@nyu.edu
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23255
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Huazhong University of Science & Technology; Chinese Academy of Sciences; Peking University; Shanghai Junshi Biosciences Co., Ltd.; and others
Keywords: SARS-CoV-2, ACE2-blocking monoclonal antibody, receptor-binding domain, pathology, primates
Summary of Study: The ACE2-blocking MAb represents a broadly promising therapeutic candidate against emergence, re-emergence, and future zoonotic transmission events from SARSr-CoVs and variants.
References: PMID: 34404805 / doi: 10.1038/s41467-021-25331-x
Contact Info: Wenjie Tan: tanwj@ivdc.chinacdc.cn
URL: https://www.nature.com/articles/s41467-021-25331-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Shanghai Jemincare Pharmaceuticals Co.; Chinese Academy of Sciences; tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: Two potent nABs against SARS-CoV-2 from naive phage-displayed human B cell single-chain variable fragment libraries were identified. One, JMB2002) not only showed potent in vitro blocking activity against a broad-spectrum of SARS-CoV-2 variants including the B.1.351 lineage, but also potent therapeutic efficacy and complete prophylactic protection against SARS-CoV-2 in a rhesus macaque infection model. Prophylactic and therapeutic countermeasure intervention of SARS-CoV-2 using antibody JMB2002 would likely slow down the transmission of currently emerged SARS-CoV-2 variants and result in more efficient control of the COVID-19 pandemic.
References: PMID: 34097570 / doi: 10.1080/19420862.2021.1930636
Contact Info: Su-Jun Deng: dengsujun@jemincare.com; Wuxiang Guan: guanwx@wh.iov.cn; Zhiming Yuan: yzm@wh.iov.cn
URL: https://www.tandfonline.com/doi/full/10.1080/19420862.2021.1930636
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Tongji Medical College, University of Chinese Academy of Sciences, Wuhan Institute of Biological Products Co.
Keywords: SARS-CoV-2, inactivated vaccine, mice and primates, immune response
Summary of Study: The authors tested the safety, immunogenicity and efficacy of an inactivated vaccine based on on the whole viral particles in human ACE2 transgenic mouse and in NHPs. This inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in both models.
References: PMID: 33835391 / doi: 10.1007/s12250-021-00376-w
Contact Info: Xing-Lou Yang: yangsx@wh.iov.cn; Shuo Shen: shenshuo1@sinopharm.com; Zhi-Ming Yuan: yzm@wh.iov.cn
URL: https://link.springer.com/article/10.1007%2Fs12250-021-00376-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Agricultural Sciences; National Research Center for Exotic Animal Diseases, China Animal Health and Epidemiology Center
Keywords: SARS-CoV-2, meta analysis, review of the animal models, vaccination, mice, hamsters, ferrets, primates
Summary of Study: This review summarizes the landscape of animal models for COVID-19 vaccine evaluation and advanced vaccines with an efficacy range from about 50% to more than 95%.
References: PMID: 34696190 / doi: 10.3390/vaccines9101082
Contact Info: Yuwei Gao: yuwei0901@outlook.com; Feihu Yan: yanfh1990@163.com; Songtao Yang: yst62041@163.com
URL: https://www.mdpi.com/2076-393X/9/10/1082
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Wisconsin National Primate Research Center, Harvard Medical School, Tufts University, BIOQUAL, Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, prior infection, vaccination, virus variants, protection, hamsters, primates
Summary of Study: Data suggest partial but reduced short-term protective efficacy of WA1/2020 natural immunity against SARS-CoV-2 variants of concern. More research is needed to define protective efficacy against other SARS-CoV-2 variants and the immunologic mechanisms of protection against these variants.
References: PMID: 34546094 / doi: 10.1126/scitranslmed.abj2641
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/10.1126/scitranslmed.abj2641?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Chinese Academy of Sciences; University of the Chinese Academy of Sciences; Wuhan YZY Biopharma Co., Ltd.
Keywords: SARS-CoV-2, subunit vaccine, immunity, virus load, pathology, primates
Summary of Study: The RBD-homodimer vaccine candidate studied can induce both humoral and cellular response in vivo and prevent SARS-CoV-2 infection in both rodents and non-human primates. Production of this RBD vaccine candidate can be performed in large scale, which will enhance the vaccine supply and warrants future clinical trials.
References: PMID: 34493710 / doi: 10.1038/s41421-021-00320-y
Contact Info: Zhiming Yuan: yzm@wh.iov.cn; Chao Shan: shanchao@wh.iov.cn; Genfu Xiao: xiaogf@wh.iov.cn
URL: https://www.nature.com/articles/s41421-021-00320-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Stanford Univ. SOM, Univ. of Washington, Tulane National Primate Research Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, subunit vaccine, immune response, primates
Summary of Study: Data highlighted the efficacy of the adjuvanted RBD-NP vaccine in promoting protective immunity against SARS-Cov-2 and have led to phase I/II clinical trials of this vaccine.
References: PMID: 33873199 / doi: 10.1038/s41586-021-03530-2
Contact Info: Bali Pulendran: bpulend@stanford.edu;
URL: https://www.nature.com/articles/s41586-021-03530-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: SW National Primate Research Center, Washington University School of Medicine, Texas Biomedical Research Institute, Tulane University
Keywords: SARS-CoV-2, single-cell RNA sequencing. Immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Deepak Kaushal: dkaushal@txbiomed.org
URL: https://www.researchsquare.com/article/rs-664507/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: UC Davis, National Institutes of Health (Pakistan), California National Primate Research Center, New York State Department of Health
Keywords: SARS-CoV-2, multiplex test, immune response, primates
Summary of Study: The authors report the development and validation of a multiplex bead assay to simultaneously and specifically detect antibodies to the SARS-CoV-2, SARS-CoV, MERS-CoV and common human coronavirus strains (229E, NL63, OC43, HKU1). Multiplex serological assays enabled the investigation of the dynamics of immune responses in COVID-19 patients.
References: PMID: 34242356 / doi: 10.1371/journal.pone.0254367
Contact Info: Imran Khan: ihkhan@ucdavis.edu
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254367
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center; SE LA Veterans Affairs Healthcare System, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome and diabetes, chronic pancreatic dysfunction, primates
Summary of Study: SARS-CoV-2 infects pancreatic islet, ductal, and endothelial cells in male and female NHPs and humans with COVID-19. The long-term consequences of a fibrotic/thrombotic pancreas, such as chronic pancreatic exocrine dysfunction and late-onset diabetes, should be investigated as postacute sequelae of COVID-19.
References: PMID: 34241597 / doi: 10.1172/jci.insight.151551
Contact Info: Mirza Muhammad Fahd Qadir: mqadir@tulane.edu; Rudolf Bohm: bohm@tulane.edu
URL: https://insight.jci.org/articles/view/151551
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: State Key Laboratory of Veterinary Biotechnologi, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences
Keywords: SARS-CoV-2, virus entry mediated by ACE2, several species
Summary of Study: A natural isoform of the rhesus macaque ACE2 protein with the Y217N mutation was resistant to SARS-CoV-2 infection, highlighting the possible impact of this ACE2 mutation on SARS-CoV-2 studies in rhesus macaques. The authors also demonstrated that the Y217 residue of ACE2 is a critical determinant for the ability of ACE2 to mediate SARS-CoV-2 entry. The results of this study clarify that SARS-CoV-2 can use the ACE2 receptors of multiple animal species and show that tracking the natural reservoirs and intermediate hosts of SARS-CoV-2 is complex.
References: PMID: 33610551 / doi: 10.1016/j.jbc.2021.100435
Contact Info: Yan-Dong Tang: tangyandong2008@163.com
URL: https://www.sciencedirect.com/science/article/pii/S0021925821002088?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Ragon Institute of MGH, MIT and Harvard; UNC Chapel Hill; Tufts University; Janssen Vaccines & Prevention.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, humoral and cellular immune responses, genome variants, primates
Summary of Study: The Ad26.COV2.S vaccine provided robust protection against both WA1/2020 and B.1.351 variants.
References: PMID: 34161961 / doi: 10.1038/s41586-021-03732-8
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.nature.com/articles/s41586-021-03732-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NCI, Frederick National Laboratory for Cancer Research, BIOQUAL, University of Athens School of Medicine, University of Washington
Keywords: SARS-CoV-2, DNA-based vaccine, immune response, primates
Summary of Study: A vaccine regimen comprising simultaneous co-immunization of DNA and Protein at the same anatomical site showed best neutralizing abilities and was more effective than DNA alone in inducing protective immune responses and controlling SARS-CoV-2 infection. An expansion of the DNA vaccine regimen to include co-immunization with Spike protein may be of advantage for SARS-CoV-2.
References: PMID: 34551020 / doi: 10.1371/journal.ppat.1009701
Contact Info: Barbara Felber: barbara.felber@nih.gov
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Tsinghua University School of Medicine; Chinese Academy of Sciences; Peking Union Medical College, The University of Hong Kong, and more
Keywords: SARS-CoV-2, adenovirus vector, vaccine candidate, immune response, hamsters, mice, primates
Summary of Study: ADC68, a rare chimpanzee adenovirus serotype, was used as a vector for vaccine and induced potent and protective immune responses against SARS-CoV-2 in experimental animals, providing scientific rationale for further developing ADC68-19S as a clinical vaccine against SARS-CoV-2 infection in humans.
References: PMID: 34262569 / doi: 10.3389/fimmu.2021.697074
Contact Info: Zhiwei Chen: zchenai@hku.hk; Xioxhong Peng: pengxiaozhong@pumc.edu.cn; Dongming Zhou: zhoudongming@tmu.edu.cn
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.697074/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Third People's Hospital; Guangzhou Medical University; UT Southwestern Medical Center; and others
Keywords: SARS-CoV-2, fusion protein vaccine, immune response, rodents and primates
Summary of Study: the pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-C0V-2 challenge in rhesus macaques.
References: PMID: 34267349 / doi: 10.1038/s41422-021-00531-8
Contact Info: Yang-Xin Fu: Yang-Xin.Fu@UTSouthwestern.edu
URL: https://www.nature.com/articles/s41422-021-00531-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Advanced Study in Science and Technology (India), Biodiversity Research Center, Academic Sinica (Taipei) and others
Keywords: SARS-CoV-2, ACE2 variants, binding affinity of ACE2 to S-protein, multiple species, humans and primates
Summary of Study: Binding affinity of ACE2 to S-protein was studied in various NHP species. Based on findings, the authors propose that the common ancestor of primates was strongly resistant to and that of New World monkeys was completely resistant to SARS-CoV-2; whereas apes and Old World monkeys, like most humans, are susceptible. This study increases our understanding of the differences in susceptibility to SARS-CV-2 infection among primates.
References: PMID: 33674876 / doi: 10.1093/molbev/msab060
Contact Info: Yan Yuan Tseng: ytseng@wayne.edu; Lily Hui-Ching Wang: lilywang@life.nthu.edu.tw
URL: https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msab060/6154855
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chulalongkorn University, Mahidol University, Baiya Phytopharm Co., National Center for Genetic Engineering and Biotechnology
Keywords: SARS-CoV-2, plant-produced receptor-binding domain, immune response, primates
Summary of Study: The plant-based protein RBD-Fc was shown to be immunogenic and significantly boosted a humoral and cell-mediated immune response in both mice and cynomolgus macaques. This protein has the potential for use as a vaccine candidate against SARS-CoV-2.
References: PMID: 34054909 / doi: 10.3389/fpls.2021.682953
Contact Info: Waranyoo Phoolcharoen: waranyoo.p@chula.ac.th
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158422/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England; University of Oxford; Oxford University Hospitals NHS Foundation Trust; Quadram Institute Bioscience
Keywords: SARS-CoV-2, inactivated vaccine, vaccine-enhanced disease, pathology, ferrets, primates
Summary of Study: Studies assessed the potential for VED (vaccine-enhanced disease) in animals faccinated with formaldehyde-inactivated SARS-CoV-2 forumlated with Alhydrogel, compared to a negative control vaccine. No evidence of enhanced disease was shown in ferrets of rhrsus macaques except for mild transient enhanced disease seen 7 days after infection in ferrets. This was resolved by day 15.
References: PMID: 34516768 / doi: 10.1126/sciadv.abg7996
Contact Info: Miles Carol: miles.carrol@phe.gov.uk; Andrew Gorringe: andrew.gorringe@phe.gov.uk
URL: https://www.science.org/doi/10.1126/sciadv.abg7996?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences, Hynnan Key Laboratory of Vaccine Research, University of Massachusetts Medical School
Keywords: SARS-CoV-2, T cells, immune response, primates
Summary of Study: Six peptides were defined as the most frequently recognized T cell epitopes, and overlapped to produce three main long epitopes. This finding may provide a convenient pattern in the detection of T cell responses for the development of new vaccines and provides a novel target in the diagnosis of patients with COVID-19.
References: PMID: 33980582 / doi: 10.4049/jimmunol.2000922
Contact Info: Wei Cun: cunwei@foxmail.com
URL: https://www.jimmunol.org/content/206/11/2527.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Erasmus Medical Center, Biomedical Primate Research Centre, Utrecht University, Friedrich-Loeffler-Institute, and others
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: The surrogate virus-neutralization test (sVNT) detects high titers of RBD-binding antibodies and thus is potentially useful as an assay for large seroprevalence studies that aim at detecting high titers (vaccination trials or large-scale initial testing of potential animal reservoirs.)
References: PMID: 34458548 / doi: 10.1016/j.onehlt.2021.100313
Contact Info: Carmen Embregts: c.embregts@erasmusmc.nl; Corine GeurtsvanKessel: c. geurtsvankessel@erasmusmc.nl
URL: https://www.sciencedirect.com/science/article/pii/S2352771421001038?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology & Immunology; Institute of Military Veterinary, Academic of Military Medical Sciences
Keywords: SARS-CoV-2, recombinant vaccine, efficacy of RBD-Fc Vacc, mice and primates
Summary of Study: A new recombinant vaccine made by fusing the SARS-CoV-2 RBD with the Fc fragment of human IgG1induced a potent immune response, protecting cynomolgus macaques against SARS-CoV-2 infection.
References: PMID: 33731916 / doi: 10.1038/s41423-021-00658-z
Contact Info: Yansong Sun: yansongsunamms@126.com; Yuwei Gao: gaoyuwei@gmail.com
URL: https://www.nature.com/articles/s41423-021-00658-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Tulane University Information Technology
Keywords: SARS-CoV-2, whole-blood transcriptome profiling, primates
Summary of Study: Hallmark similarities and differences in the RM and AGM accute response to SARS-CoV-2 infection were discovered and may help guide the selection of particular NHP species in modeling aspects of COVID-19 disease outcome.
References: PMID: 34691074 / doi: 10.3389/fimmu.2021.754642
Contact Info: Joseph Mudd: jmudd1@tulane.edu
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.754642/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Milad Daro Noor Pharmaceutical (MDNP) Co., Iran; Stem Cell Technology Research Center (STRC); Imam Hussein University
Keywords: SARS-CoV-2, inactivated vaccine candidate, immunization, immune response, mice, guinea pigs, rabbits, primates
Summary of Study: FAKHRAVAC, a purified inactivated SARS-CoV-2 virus vaccine candidate induced neutralizing antibodies in Balb/c mice, guinea pigs, rabbits, and rhesus macaques.
References: PMID: 34835202 / doi: 10.3390/vaccines9111271
Contact Info: Ahmad Karimi Rahjerdi: A-Karimi@mdnp.ir or rahjerdi@strc.ac.ir
URL: https://www.mdpi.com/2076-393X/9/11/1271
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Eurofins-INGENASA; Erasmus University Medical Center; Utrecht University
Keywords: SARS-CoV-2, post-acute phase, immune response, tomography, virus replication, primates
Summary of Study: NHPs infected with SARS-CoV-2 were followed for up to 6 weeks and monitored for COVID-19-like disease symptoms. Data indicate widespread tissue dissemination of SARS-CoV-2 in individual monkeys and provide evidence for continuing virus replication in lungs and surrounding lymph nodes after alleged convalescence of infection.
References: PMID: 34452537 / doi: 10.3390/v13081673
Contact Info: Ernst Verschoor: verschoor@bprc.nl
URL: https://www.mdpi.com/1999-4915/13/8/1673
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Korea Research Institute of Bioscience & Biotechnology, Chonnam National University, Chungbuk National University
Keywords: SARS-CoV-2, virus variants, microevolution, species specific variations, primates
Summary of Study: The genomes of SARS-CoV-2 differ according to individuals and species despite infection of the identical virus in NHPs. These results are important for the interprretation of longitudinal studies evaluating the evolution of the SARS-CoV-2 in humans and development of new diagnostics, vaccine, and therapeutics targeting SARS-CoV-2.
References: PMID: 34305860 / doi: 10.3389/fmicb.2021.694897
Contact Info: Jungjoo Hong: hong75@kribb.re.kr; Bon-Sang Koo: porco9@kribb.re.kr
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.694897/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Sciences, Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
Keywords: SARS-CoV-2, immunopathology, young and old animals, primates
Summary of Study: Results showed that the age-related immune microenvironment in the lungs, spleens, PBMCs , and CD8+ cells significantly affected the immunopathology of SARS-CoV-2 infection, whereas the increase in inflammatory factor-secreting cells in the lungs and systemic accumulation of CXCR3+ cells are associated with necrosis and inflammatory activation of ACE2+ lung cells.
References: PMID: 34471088 / doi: 10.1038/s41392-021-00734-w
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://www.nature.com/articles/s41392-021-00734-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Ottawa; Ottawa Hospital Research Institute; Institut du Cancer de Montreal; University of Calgary
Keywords: SARS-CoV-2, attenuated vaccinia virus vector, spike receptor binding domain, immune response, mice, primates
Summary of Study: Robust immune responses and protective immunity against SARS-CoV-2 variants were demonstrated after only a single dose of a temperature stable vaccine candidate (TOH-Vac1) that uses a replication-competent, attenuated vaccinia virus as a vector to express a membrane-tethered spike receptor binding domain antigen.
References: PMID: 34687845 / doi: 10.1016/j.ymthe.2021.10.008
Contact Info: John Bell: jbell@ohri.ca; Carolina Ilkow: cilkow@uottawa.ca
URL: https://www.sciencedirect.com/science/article/pii/S1525001621005153?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: YishengBio Co., Ltd.; Chinese Academy of Sciences; National Health Commission of the People's Republic of China
Keywords: SARS-CoV-2, S-trimer, PIKA, vaccine, virus genomic variants, primates
Summary of Study: In this study of non-human primates, PIKA adjuvanted S-trimer induced high SARS-CoV-2 neutralization titers and protected from virus replication in the lung following SARS-CoV-2 challenge.
References: PMID: 34766005 / doi: 10.1186/s43556-021-00054-z
Contact Info: Yi Zhang: zhang@yishengbio.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475395/
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences, Sechenov First Moscow State Medical University, Lomonosov Moscow State University
Keywords: SARS-CoV-2, serology, neutralizing antibodies, immunogenicity, inactivated vaccine, primates
Summary of Study: A B-propiolactone-inactivated whole virion vaccine CoviVac was developed and assessed. The vaccine produced stable and robust humoral immune response in mice, Syrian hamsters and common marmosets.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: lubov_i_k@mail.ru
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences; Sechenov First Moscow State Medical Univeristy; Lomonosov Moscow State University
Keywords: SARS-CoV-2, inactivated vaccine, long-term humoral immunogenicity, toxicity, mice, hamsters, primates
Summary of Study: A beta-propiolactone-inactivated whole virion vaccine (CoviVac) was asses and showed no signs of acute/chronic, reproductive, embryo- and fetotoxicity or teratogenic effects, as well as no allergenic properties in the animal species studied.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: lubov_i_k@mail.ru
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: King Mongkut's University of Technology; Chulalongkorn University; Mahidol University; B.F. Feed Company, Ltd.
Keywords: SARS-CoV-2, spike receptor-binding domain, immunization, convalescent sera, B-cell epitopes, primates
Summary of Study: The immunoinformatics method described could be a useful tool for identification of antibody epitopes in new virus variants and also other target proteins.
References: PMID: 34650130 / doi: 10.1038/s41598-021-99642-w
Contact Info: Yaowaluck Mapring Roshorm: yaowaluck.ros@kmutt.ac.th
URL: https://www.nature.com/articles/s41598-021-99642-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Columbia University, University of Texas Medical Branch, Case Western Reserve School of Medicine, and others
Keywords: SARS-CoV-2, peptide-based vaccine targeting MHC class I epitopes, immune response, pathology, primates
Summary of Study: A room temperature stable peptide vaccine based on known immunogenic HLA class I bound CTL epitopes from the nucleocapsid protein can provide protection against SARS-CoV-2 infection in nonhuman primates.
References: PMID: 34070152 / doi: 10.3390/vaccines9050520
Contact Info: Jason Comer: jscomer@utmb.edu; Reid Rubsamen: reid.rubsamen@UHHospitals.org
URL: https://www.mdpi.com/2076-393X/9/5/520
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: DSO National Laboratories, Singapore; University of Texas Medical Branch; Hummingbird Bioscience; and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, hamsters and primates
Summary of Study: SC31, a potent SARS-CoV-2 neutralizing antibody isolated from a convalescent patient, demonstrated therapeutic efficacy in three different models.
References: PMID: 34161386 / doi: 10.1371/journal.pone.0253487
Contact Info: Brendon John Hanson: hbrendon@dso.org.sg; Trevor Brasel: tbrasel@utmb.edu; Piers J. Ingram: p.ingram@hummingbirdbio.com
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253487
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Eli Lilly and Co., AbCellera Biologics, UNC - Chapel Hill, University of Texas Medical Branch, and others.
Keywords: SARS-CoV-2, monoclonal antibodies, immune response, primates
Summary of Study: LY-CoV555 (aka bamlanivimab), a potent anti-spike neutralizing antibody from a hospitalized, convalescent patient with COVID-19 was followed in a pharmacokinetic study in cynomolgus monkeys and in a challenge model in rhesus macaques, where it showed impressive results. Currently in clinical testing.
References: PMID: 33820835 / doi: 10.1126/scitranslmed.abf1906
Contact Info: Bryan Jones: jones_bryan_edward@lilly.com; Ester Falconer: ester.falconer@abcellera.com
URL: https://www.science.org/doi/10.1126/scitranslmed.abf1906?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC, Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, infection route, virus detection, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: paul.dabisch@nbacc.dhs.gov
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC; Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, seroconversion, fever, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: paul.dabisch@nbacc.dhs.gov
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Laboratory of Virology, Hamilton, MT; NIAID; University of Plymouth, Plymouth, UK; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, virus genomic variants, pathology, virus replication, shedding, primates
Summary of Study: Results from the intranasal AGM COVID-19 surrogate model support the most recent data from B.1.1.7 in humans, providing direct empirical data for increased replication in the respiratory tissue, but with no enhancement of disease.
References: PMID: 34724885 / doi: 10.1080/22221751.2021.1997074
Contact Info: Heinz Feldmann: feldmannh@niaid.nih.gov
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1997074
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ReiThera Srl, University of Nottingham, National Institute for Infectious Diseases "Lazzaro Spallanzani"
Keywords: SARS-CoV-2, replication-defective gorilla adenovirus-vectored vaccine, immune response, mice and primates
Summary of Study: Pre-fusion stabilized Spike antigen is superior to the wild type in inducing ACE2-interfering, SARS-CoV-2-neutralizing antibodies.
References: PMID: 33895322 / doi: 10.1016/j.ymthe.2021.04.022
Contact Info: Alessandra Vitelli: alessandra.vitelli@reithera.com
URL: https://www.sciencedirect.com/science/article/pii/S1525001621002100?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Shandong Boan Biotech Co., National Institutes for Food and Drug Control, Shuimu Biosciences, and others
Keywords: SARS-CoV-2, neutralizing antibodies, structural analysis, primates
Summary of Study: CA521^FALA is a promising antibody that reacts with SARS-CoV-2 Spike protein to strongly neutralize its activity.
References: PMID: 33893388 / doi: 10.1038/s42003-021-02029-w
Contact Info: Lan Wang: wanglan@nifdc.org.cn; Yong-Qiang Deng: dengyq1977@126.com; Changlin Dou: douchanglin@luye.com
URL: https://www.nature.com/articles/s42003-021-02029-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, hamadryas baboons, marmosets
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute, Regeneron, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome, young and old animals, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034 / doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: dkaushal@txbiomed.org, Luis Giavedoni: lgiavedoni@txbiomed.org
URL: https://www.nature.com/articles/s41564-020-00841-4#Sec9
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: National Institute of Infectious Diseases, Japan; University of Tokyo; Kumamoto University, and others
Keywords: SARS-CoV-2, virus-specific CD8+ T-cell responses, virus replication, immune response, primates
Summary of Study: The effect of CD8+ cell depletion on SARS-CoV-2 replication when monoclonal anti-CD8 antibody is administered in the subacute phase was studied in cynomolgus macaques. Analysis revealed no significant impact of CD8+ cell depletion on viral replication, indicating the subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells.
References: PMID: 34280241 / doi: 10.1371/journal.ppat.1009668
Contact Info: Tetsuro Matano: tmatano@nih.go.jp; Takushi Nomura: nomutaku@nih.go.jp
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009668
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Xiamen University, The University of HongKong, Shantou University, Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, review of the primate models, clinical symptoms, pathogenesis, applications
Summary of Study: Review summarizes the benefits and caveats of NHP models currently available for SARS-CoV-2 and discusses key topics including model optimization, extended application, and clinical translation.
References: PMID: 34490832 / doi: 10.1080/22221751.2021.1976598
Contact Info: Tong Cheng: tcheng@xmu.edu.cn; Ningshao Xia: nsxia@xmu.edu.cn
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1976598
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Institut Pasteur; Sorbonne Universite; Ecole normale superieure Paris-Saclay; Universite de Paris
Keywords: SARS-CoV-2, therapeutics, vaccine, pathogenesis, drug discovery, animal model, primates
Summary of Study: This review discusses the use of NHPs as models for COVID-19 research, with focus on the pathogenesis of SARS-CoV-2 infection, drug discovery and pre-clinical evaluation of vaccine candidates.
References: PMID: 34452011 / doi: 10.3390/vaccines9080886
Contact Info: Caroline Passaes: caroline.pereira-bittencourt@pasteur.fr
URL: https://www.mdpi.com/2076-393X/9/8/886
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, University of North Carolina at Chapel Hill, FDA, and others
Keywords: SARS-CoV-2, nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: The immunization of macaques with nanoparticles conjugated with the receptor-binding domain of SARS-CoV-2, and adjuvanted with 3M-052 and alum, elicits cross-neutralizing antibody responses against bat coronaviruses, SARS-CoV and SARS-CoV-2. Nucleoside-modified mRNAs that encode a stabilized transmembrane spike or monomeric receptor-binding domain also induced cross-neutralizing antibody responses against SARS-CoV and bat coronaviruses.
References: PMID: 33971664 / doi: 10.1038/s41586-021-03594-0
Contact Info: Kevin Saunders: kevin.saunders@duke.edu; Barton Haynes: barton.haynes@duke.edu
URL: https://www.nature.com/articles/s41586-021-03594-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences; Tsinghua University; Advaccine Biopharmaceuticals (Suzhou)
Keywords: SARS-CoV-2, B cells, Toll-like receptor, preclinical study, virus-like particle, pathogen-like antigen, primates
Summary of Study: A PLA-based COVID-19 vaccine candidate could potentially serve as an alternative option for coping with the SARS-CoV-2 pandemic.
References: PMID: 34723223 / doi: 10.1016/j.xcrm.2021.100448
Contact Info: Zhaolin Hua: zlhua@moon.ibp.ac.cn; Hongyu Deng: hydeng@ibp.ac.cn; Baidong Hou: baidong_hou@ibp.ac.cn
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003165?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Nagoya University; Kyushu University; Akita University Graduate School of Medicine; and others
Keywords: SARS-CoV-2, mathematical model, infection dynamics, kinetics of viral shedding, primates
Summary of Study: The authors used a simple mathematical model to quantify SARS-CoV-2 infection dynamics in rhesus macaques. When antiviral treatments are initiated early (i.e. 0.5 d after virus inoculation), viral shedding is (paradoxically) prolonged by about 6.0 days compared with no treatment.
References: PMID: 34344719 / doi: 10.26508/lsa.202101049
Contact Info: Keisuke Ejima: kejima@iu.edu; Shingo Iwami: iwami.iblab@bio.nagoya-u.ac.jp
URL: https://www.life-science-alliance.org/content/4/10/e202101049
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Duke University School of Medicine, UNC Chapel Hill, NIAID, Harvard Medical School, and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: In vitro infection-enhancing RBC and NTD ABs controlled virus in vito and was rarely associated with enhanced lung pathology.
References: PMID: 34242577 / doi: 10.1016/j.cell.2021.06.021
Contact Info: Barton Haynes (Duke University School of Medicine); Kevin Saunders (Duke University School of Medicine)
URL: https://www.sciencedirect.com/science/article/pii/S009286742100756X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences; Peking Union Medical College; Capital Medical University
Keywords: SARS-CoV-2, pathology, myocardial injury, differential expression, primates
Summary of Study: SARS-CoV-2 infected rhesus macaques showed viral myocarditis, where inflammation and endothelial injury jointly resulted in cardiac damage.
References: PMID: 34489396 / doi: 10.1038/s413392-021-00747-5
Contact Info: Jiangning Liu: liujn@cnilas.org; Jing Wang: wangjing@ibms.pumc.edu.cn
URL: https://www.nature.com/articles/s41392-021-00747-5
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Southern Medical University, Shenzhen; Guangzhou Center for Disease Control and Prevention
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: Prime-boost immunization with Sad23L-nCoV-S and Ad49L-nCoV-S (both carrying the full-length of SARS-CoV-2 spike protein gene) can safely elicit strong immunity in animals.
References: PMID: 33993845 / doi: 10.1080/22221751.2021.1931466
Contact Info: Yuming Zhang: yumingzhang1966@hotmail.com; Tingting Li: apple-ting-007@163.com
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1931466
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Washington Univ, SW National Primate Research Center, Texas Biomedical Research Institute
Keywords: SARS-CoV-2, transcriptional signatures, juvenile and old animals, lungs, primates
Summary of Study: Transcriptional profiles of lungs from juvenile and old macaques infected with SARS-CoV-2 were interrogated, providing fundamentally new information on the host response in young and old macaques. This model provides relevant insights necessary for further vaccine and therapeutic development for COVID-19.
References: PMID: 33674719 / doi: 10.1038/s42003-021-01829-4
Contact Info: Makedonka Mitreva: mmitreva@wustl.edu; Deepak Kaushal: dkaushal@txbiomed.org
URL: https://www.nature.com/articles/s42003-021-01829-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Harvard T.H. Chan School of Public Health; Emory University; Moderna, Bioqual
Keywords: SARS-CoV-2, RNA-vaccine, immune response, virus replication, protection, primates
Summary of Study: Data establish that a two-dose regimen of mRNA-1273 (Moderna vaccine) will be critical for providing upper and lower airway protection against major varriants of concern.
References: PMID: 34417590 / doi: 10.1038/s41590-021-02021-0
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov
URL: https://www.nature.com/articles/s41590-021-01021-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam, Universite Paris-Saclay, University of Southampton, and others
Keywords: SARS-CoV-2, two-component protein nanoparticle vaccine, primates
Summary of Study: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate.
References: PMID: 33577765 / doi: 10.1016/j.cell.2021.01.035
Contact Info: Roger Le Grand: roger.le-grand@cea.fr; Rogier Sanders: r.w.sanders@amsterdamumc.nl
URL: https://www.sciencedirect.com/science/article/pii/S0092867421000787?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: Sabzevar University of Medical Sciences, University of Edinburgh, Nagasaki University
Keywords: SARS-CoV-2, infective dose, several animal species, pathogenesis, primates
Summary of Study: This review focused on comparative infective dose studies for SARS-CoV-2, SARS-CoV-1, and MERS. The review suggests that the infective dose in humans is small, perhaps about 100 particles. Further work is required to understand the relationship between routes of transmission, infective dose, co-infection and outcomes.
References: PMID: 33849679 / doi: 10.1017/S0950268821000790
Contact Info: Sedighe Karimzadeh: sedigekarimsadeh@gmail.com; Raj Bhopal: Raj.Bhopal@ed.ac.uk
URL: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/revie…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: North Carolina State University; UNC-Chapel Hill; BreStem Therapeutics, Bioqual, Inc.
Keywords: SARS-CoV-2, ACE2 nanodecoys, inhalation therapy, mice and primates
Summary of Study: ACE2 nanodecoys derived from human lung spheroid cells (LSCs) can bind and neutralize SARS-CoV-2. In cynomolgus macaques challenged with live SARS-CoV-2, four doses of these nanodecoys delivered by inhalation promoted viral clearance and reduced lung injury. these results suggest that LSC-nanodecoys can serve as a potential therapeutic agent for treating COVID-19.
References: PMID: 34140674 / doi: 10.1038/s41565-021-00923-2
Contact Info: Ke Cheng: ke_cheng@ncsu.edu
URL: https://www.nature.com/articles/s41565-021-00923-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Kazan State Medical Academy; Kazan State Medical University; Kazan Federal University
Keywords: SARS-CoV-2, infection, pathogenicity, eye surface, literature meta analysis, primates
Summary of Study: There is a possibility of COVID-19 transmission through the eye surface. Eye protection measures should be undertaken when working with potentially infected patients.
References: PMID: 34410064 / doi: 10.17116/oftalma2021137041104
Contact Info: not provided
URL: https://pubmed.ncbi.nlm.nih.gov/34410064/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Duke University School of Medicine, Harvard
Keywords: SARS-CoV-2, modified vaccinia Ankara vector-based vaccine, immune response, pathology, primates
Summary of Study: MVA/S vaccination can provide protection from intranasal and intratracheal SARS-CoV-2 challenge and support further development of this vaccine to test immunogenicity and efficacy in humans.
References: PMID: 33631118 / doi: 10.1016/j.immuni.2021.02.001
Contact Info: Rama Rao Amara: ramara@emory.edu
URL: https://www.sciencedirect.com/science/article/pii/S107476132100042X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: VaxiGen, Inc., Genexine, Inc., Korea National Primate Research Centre, and others
Keywords: SARS-CoV-2, DNA-based vaccine, mice and primates, immune response
Summary of Study: A synthetic soluble SARS-CoV-2 spike (S) DNA-based vaccine candidate, GX-19, provides a durable protective immune response in rhesus macaques, supporting further development of GX-19 as a vaccine candidate for SARS-CoV-2.
References: PMID: 33804981 / doi: 10.3390/vaccines9040307
Contact Info: Yong Bok Seo: ybseo@slvaxigen.com; You Suk Suh: yssuh@genexine.com; Jung Joo Hong: hong75@kribb.re.kr
URL: https://www.mdpi.com/2076-393X/9/4/307
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University; BIOQUAL, Inc.; Moderna, Inc.; Johns Hopkins University
Keywords: SARS-CoV-2, virus genomic variants, boost, immune response, primates
Summary of Study: Homologous mRNA-1273 boost can significantly improve both the breadth and potency of neutralizing antibody responses and confer protection against upper and lower airway infection to a heterologous challenge virus, which is relatively resistant to in vitro neutralization.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: rseder@mail.nih.gov; Barney Graham: bgraham@nih.gov
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, Inc.; IosBio; Battelle Biomedical Research Center; NantKwest, Inc.
Keywords: SARS-CoV-2, dual-antigen vaccine, adenovirus vector, immune response, virus replication, primates
Summary of Study: In the rhesus macaque model, SC prime vaccination with two oral boosts with the dual-antigen hAd5 S-Fusion + N-ETSD vaccine provides protection from SARS-CoV-2 infection for both nasal and lung airways.
References: PMID: 34603305 / doi: 10.3389/fimmu.2021.729837
Contact Info: Patrick Soon-Shiong: patrick@nantworks.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.729837/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Emory University; Duke University Medical Center; Moderna; BIOQUAL
Keywords: SARS-CoV-2, mRNA-vaccine, immune response, hamsters, primates
Summary of Study: mRNA-1273 vaccine-induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP.
References: PMID: 34529476 / doi: 10.1126/science.abj0299
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov
URL: https://www.science.org/doi/10.1126/science.abj0299?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & U. Mass.
Keywords: SARS-CoV-2, DNA and protein vaccine combination, primates
Summary of Study: The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine elicited full protection against the challenge of SARS-CoV-2 in an NHP model.
References: PMID: 33555988 / doi: 10.1080/22221751.2021.1887767
Contact Info: Wei Cun: cun@imbcams.com.cn / Shan Lu: shan.lu@umassmed.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1887767
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines, Leiden University Medical Center, Harvard Medical School
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: The immunogenicity, protective efficacy, and SARS-CoV-2 spike variant neutralizing data presented in this manuscript further support the decision to evaluate a single 5 x 10^10-vp dose of Ad26.COV2.S in Phase 3 trials.
References: PMID: 33909009 / doi: 10.1084/jem.20202756
Contact Info: Roland Zahn: rzahn@its.jnj.com
URL: https://rupress.org/jem/article/218/7/e20202756/212032/Immunogenicity-and-effica…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Biomedical Primate Research Centre (BPRC, Netherlands), Utrecht University
Keywords: SARS-CoV-2, computed tomography, bronchoalveolar lavage, test interference, primates
Summary of Study: Thorax CTs were evaluated for alteractions in lung density in health and experimentally SARS-CoV-infected female rhesus macaques before and after brochoalveolar lavage (BAL). An increase in the lung density was observed on the post-BAL CT but resolved within 24 hours in the healthy animals; a significant difference in both the lung density and CT score was still found 24 hours post BAL in the infected animals.
References: PMID: 34242213 / doi: 10.1371/journal.pone.0252941
Contact Info: Marieke Stammes: stammes@bprc.nl
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252941
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIH, University of Oxford, NIAID, Icahn School of Medicine at Mount Sinai
Keywords: SARS-CoV-2, adenovirus-based vaccine, intranasal administration, hamsters, primates
Summary of Study: Intranasal vaccination with ChAdOx1 nCoV-19/AZD1222 reduced virus concentrations in nasal swabs in two different SARS-CoV-2 animal models, warranting further investigation as a potential vaccination route for COVID-19 vaccines.
References: PMID: 34315826 / doi: 10.1126/scitranslmed.abh0755
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.science.org/doi/10.1126/scitranslmed.abh0755?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, Yoh Services, Global Discovery Pathology, Translate Bio
Keywords: SARS-CoV-2, multiple animal species, mRNA vaccine, immune response, pathology, primates
Summary of Study: Several mRNA vaccine candidates were assessed; the lead 2P/GSAS vaccine formulation (designated MRT550) elicited potent nAbs as well as TH1-biased responses in NHPs, thus alleviating a hypothetical concern of potential vaccine-associated enhanced respiratory diseases known associated with TH2-biased responses. These data position MRT5500 as a viable vaccine candidate for entering clinical development.
References: PMID: 33875658 / doi: 10.1038/s41541-021-00324-5
Contact Info: Kirill Kalnin: kkirill45us@gmail.com
URL: https://www.nature.com/articles/s41541-021-00324-5
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Fudan University, Second Military Medical University, Peking University
Keywords: SARS-CoV-2, cell-based vaccine, neutralizing antibodies, immune response, pathology, mice, primates
Summary of Study: The data present strong evidence supporting the promise of K562-S (a novel cell-based vaccine candidate that uses human cell K562 as a cellular carrier to display Spike (S) protein on the membrane) as a new effective vaccine for the prevention of COVID-19.
References: PMID: 34304724 / doi: 10.1080/22221751.2021.1957400
Contact Info: Jianqing Xu: xujianqing@shphc.org.cn; Xiaoyan Zhang: zhangxiaoyan@shphc.org.cn; Chen Zhao: chen_zhao72@163.com; Ping Zhao: pnzhao@163.com
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1957400
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Hebei Agricultural University; Military Veterinary Research Institute
Keywords: SARS-CoV-2, aerosol particles, viruse transduction, primates
Summary of Study: Most SARS-CoV-2 aerosol particles exhaled by the cynomolgus monkeys in this study were smaller (<4.7 um), suggesting that aerosols might be a route for SARS-CoV-2 transmission.
References: PMID: 34152969 / doi: 10.3201/eid2707.203948
Contact Info: Yuwei Gao: gaoyuwei@gmail.com
URL: https://wwwnc.cdc.gov/eid/article/27/7/20-3948_article
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute, Perelman School of Medicine, NIAID, and others
Keywords: MERS-CoV, intradermal and intramuscular delivery, synthetic DNA vaccine, primates
Summary of Study: Results illustrate that a MERS spike antigen synthetic DNA vaccine administered in a 2-dose i.d. EP regimen can have positive impact in an important NHP challenge model protecting against symptoms and pathology.
References: PMID: 33886507 / doi: 10.1172/jci.insight.146082
Contact Info: David Weiner: dweiner@wistar.org
URL: https://insight.jci.org/articles/view/146082
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases
Keywords: SARS-CoV-2, comparative evaluation of disease progression in three primate species
Summary of Study: In addition to African green monkeys, macaques can be successfully infected by airborne SARS-CoV-2, providing viable macaque natural transmission models for medical countermeasure evaluation.
References: PMID: 33529233 / doi: 10.1371/journal.pone.0246366
Contact Info: Sara Johnston: sara.c.johnston2.civ@mail.mil; Aysegul Nalca: aysegul.nalca.civ@mail.mil
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246366
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, ACE2 expression, transcription factor AhR, pathology, primates
Summary of Study: Data in this study show that the transcription factor AhR is able to bind the promoter of the ACE2 gene, thus promoting ACE2 expression and augmenting the subsequent pathology in SARS-CoV-2-infected lungs.
References: PMID: 33795851 / doi: 10.1038/s41423-021-00672-1
Contact Info: Chuan Qin: qinchuan@pumc.edu.cn; Bo Huang: tjhuangbo@hotmail.com
URL: https://www.nature.com/articles/s41423-021-00672-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: Johns Hopkins School of Medicine; Yale University School of Medicine
Keywords: SARS-CoV-2, several animal species, immunological response, primates
Summary of Study: This review discusses small and large animal model studies previously used in SARS-CoV-2 research that may be useful in elucidating the immunological contributions to hallmark syndromes observed with COVID-19.
References: PMID: 33914873 / doi: 10.1093/ilar/ilab010
Contact Info: Rebecca Veenhuis: rterill1@jhmi.edu
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab010/62…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, Public Health England, The Pirbright Institute
Keywords: SARS-CoV-2, vaccine, immune response, pathology, primates
Summary of Study: Lung pathology caused by SARS-CoV-2 meiated pneumonia is reduced in rhesus macaques by prior vaccination with ChAdOx1 nCoV-19, which induced neutralising antibody responses after a single intramuscular administration.
References: PMID: 34312487 / doi: 10.1038/s42003-021-02443-0
Contact Info: Sarah Gilbert: sarah.gilbert@ndm.ox.ac.uk
URL: https://www.nature.com/articles/s42003-021-02443-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Korea Advanced Institute of Science & Technology, GENOME INSIGHT, INC.
Keywords: SARS-CoV-2, infection models, organoids, primates
Summary of Study: Review of in vitro and in vivo models for SARS-CoV-2 infection.
References: PMID: 34187969 / doi: 10.14348/molcells.2021.0094
Contact Info: Young Seok Ju: ysju@kaist.ac.kr
URL: https://www.molcells.org/journal/view.html?doi=10.14348/molcells.2021.0094
Coronavirus Investigated: SARS-CoV-2
NHP Species: olive baboons
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Novavax, University of Maryland, University of Oklahoma, and others
Keywords: SARS-CoV-2, subunit vaccine (NVX-CoV2373), mice and primates
Summary of Study: Administering a subunit vaccine (NVX-CoV2373) constructed from the full-length S-protein, with Matrix-M adjuvant in a nonhuman primate model induces B- and T-cell responses, hACE2-receptor-blocking antibodies, and SARS-CoV-2 neutralizing antibodies. These results support the clinical development of the NVX-C0V2373 vaccine for prevention of COVID-19.
References: PMID: 33446655 / doi: 10.1038/s41467-020-20653-8
Contact Info: Gale Smith: gsmith@novavax.com
URL: https://www.nature.com/articles/s41467-020-20653-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology
Keywords: SARS-CoV-2, inactivated SARS-CoV-2 vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: A two-dose regimen of vaccine candidate BBV152 with adjuvant B induces a significant immune response and provides effective protection in rhesus macaques challenged with SARS-CoV-2.
References: PMID: 33654090 / doi: 10.1038/s41467-021-21639-w
Contact Info: Balram Bhargava: balrambhargava@yahoo.com
URL: https://www.nature.com/articles/s41467-021-21639-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England, Inovio Pharmaceuticals, Oxford University
Keywords: SARS-CoV-2, synthetic DNA vaccine candidate, immune response, primates
Summary of Study: The results in a stringent preclinical SARS-CoV-2 animal model provide further support for the efficacy and safety of the synthetic DNA vaccine INO-4800 as a prophylatic countermeasure against COVID-19.
References: PMID: 34253420 / doi: 10.1016/j.vaccine.2021.06.057
Contact Info: Kate Broderick (Inovio Pharmaceuticals, Inc.; Miles Carroll (Public Health England)
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21008070?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Public Health England & Welcome Trust Centre for Human Genetics
Keywords: SARS-CoV-2, pathogenicity, comparative studies, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. This provides convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human populations and both species can e used to evaluate the safety and efficacy of interventions proposed against SARS-CoV-2. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks.
References: PMID: 33627662 / doi: 10.1038/s41467-021-21389-9
Contact Info: Miles Carroll: miles.carroll@phe.gov.uk
URL: https://www.nature.com/articles/s41467-021-21389-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Utrecht University
Keywords: SARS-CoV-2, chest CT, ultrasound, pulmonary lesions, primates
Summary of Study: As has been observed in humans, the sensitivity of lung ultrasound (LUS) is high though the diagnostic efficacy or mild-to-moderate disease is relatively low. The low efficacy outweighs the advantages of LUS over CT (i.e. no need to transport the animals and the absence of ionizing radiation). For this reason, CT is still the imaging modality of choice for diagnosis, monitoring, and longitudinal assessment of a SARS-CoV-2 infection in NHPs.
References: PMID: 34778433 / doi: 10.3389/fvets.2021.748635
Contact Info: Marieke Stammes: stammes@bprc.nl
URL: https://www.frontiersin.org/articles/10.3389/fvets.2021.748635/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Harvard Univ., MIT, Tulane National Primate Research Center
Keywords: SARS-CoV-2, respiratory droplet generation and exhalation, primates
Summary of Study: The proportion of small respiratory droplets (the majority of particles exhaled in all subjects) increased at the peak of COVID-19 infection in NHPs. This confirms a previously published observation from the exhaled aerosol profile of a single COVID-19 positive human subject, and suggests that, at peak infection, there may be an elevated risk of the airborne transmission of SARS-CoV-2 by way of the very small droplets that transmit through conventional masks and travers distances far exceeding the conventional social distance of 2 m.
References: PMID: 33563754 / doi: 10.1073/pnas.2021830118
Contact Info: David Edwards: dedwards@seas.harvard.edu; Chad Roy: croy@tulane.edu
URL: https://www.pnas.org/content/118/8/e2021830118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NCI/NIH; University of Maryland, BIOQUAL, NIAID and others
Keywords: SARS-CoV-2, adjuvanted subunit vaccines, immune response, primates
Summary of Study: Mucosal vaccine efficiently cleared virus in the nasal cavity and may act as a potent complementary reinforcing boost for conventional systemic vaccines to provide overall better protection.
References: PMID: 33908897 / doi: 10.1172/jci.insight.148494
Contact Info: Yongjun Sui: suiy@mail.nih.gov; Jay Berzofsky: berzofsj@mail.nih.gov
URL: https://insight.jci.org/articles/view/148494
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nankai University, Chinese Academy of Sciences, and others
Keywords: SARS-CoV-2, monoclonal antibodies, structure analysis, immune response, primates
Summary of Study: The engineered antibody P4A1 (originally identified from COVID-19 convalescent patients) exhibits an optimized pharmacokinetic and safety profile, and results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection.
References: PMID: 33976198 / doi: 10.1038/s41467-021-22926-2
Contact Info: Yu Guo: guoyu@nankai.edu.cn; Hongkai Zhang: hongkai@nankai.edu.cn
URL: https://www.nature.com/articles/s41467-021-22926-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Zhongshan School of Medicine
Keywords: SARS-CoV-2, convalescent sera, receptor-binding domain based nanoparticles, virus variants, primates
Summary of Study: Results show that as mutations accumulate in the RBD, spike proteins may acquire an antigenic shift that enable SARS-CoV-2 variants to eventually resist the current vaccines. Intensive monitoring of virus mutations and timely adjustment of the designed vaccines are required to control the viral pandemic.
References: PMID: 33580167 / doi: 10.1038/s41423-021-00641-8
Contact Info: Xin He: hexin59@mail.sysu.edu.cn
URL: https://www.nature.com/articles/s41423-021-00641-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: Department of Virology, Aggeu Magalhaes Institute, Brazil
Keywords: SARS-CoV-2, in vitro and in vivo models, several animal species, including primates, review
Summary of Study: This review article summarizes the main models of SARS-CoV-2 infection developed so far and discusses their advantages, drawbacks and main uses.
References: PMID: 33673614 / doi: 10.3390/v13030379
Contact Info: Lindomar Pena: lindomar.pena@cpqam.fiocruz.br
URL: https://www.mdpi.com/1999-4915/13/3/379/htm
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Yale School of Medicine, Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, ACE2, several animal species, immine response, pathology, primates
Summary of Study: This review summarized key clinical, radiologic, and pathologic features of human COVID-19, followed by a comparison with spontaneous and genetically altered animal models of SARS-CoV-2 infection.
References: PMID: 33836527 / doi: 10.1093/ilar/ilab0071
Contact Info: Caroline Zeiss: caroline.zeiss@yale.edu
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab007/62…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Science, Trinomab Biotech Co.
Keywords: SARS-CoV-2, ferritin nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: Self-assembling nanoparticle vaccines displaying the RBD of SARS-CoV-2 were prepared, and the vaccine candidate elicited obust humoral and T cell responses and protected the rhesus monkeys from infection with short-term shedding and only minor pathological damage.
References: PMID: 33951913 / doi: 10.1021/acs.bioconjchem.1c00208
Contact Info: Longding Liu: longdingl@gmail.com; Qihan Li: liqihan@imbcams.com.cn; Zhanlong He: hzl@imbcams.com.cn
URL: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00208
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Kunming Institute of Zoology
Keywords: SARS-CoV-2, S-Trimer, subunit vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: PMID: 33649323 / doi: 10.1038/s41467-021-21634-1
Contact Info: Peng Liang: liang.peng@cloverbiopharma.com
URL: https://www.nature.com/articles/s41467-021-21634-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute; Inovio Pharmaceuticals; Bioqual
Keywords: SARS-CoV-2, DNA vaccine, immunogenicity, immune response, adaptive immune response, primates
Summary of Study: INO-4800, an intradermal-delivered SARS-CoV-2 spike DNA vaccine, induced both humoral and cellular arms of the adaptive immune system.
References: PMID: 34604818 / doi: 10.1016/j.xcrm.2021.100420
Contact Info: Kate Broderick: kate.broderick@inovio.com; David Weiner: dweiner@wistar.org
URL: https://www.sciencedirect.com/science/article/pii/S2666379121002822?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: California National Primate Research Center, UC Davis
Keywords: SARS-CoV-2, CD4 T follicular helper (Tfh) cells, primates
Summary of Study: SARC-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion showed induction of germinal center (GC) responses.
References: PMID: 33483492 / doi: 10.1038/s41467-020-20642-x
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Smita Iyer: smiyer@ucdavis.edu
URL: https://www.nature.com/articles/s41467-020-20642-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Beth Israel Deaconess Medical Center, MIT, Harvard
Keywords: SARS-CoV-2, DNA- and Ad26-based vaccines, serum profiles, primates
Summary of Study: Data highlight the similarities between infection and vaccine induced humoral immunity for SARS-Cov-2 and cross-reactivity of these responses to other CoVs.
References: PMID: 33692201 / doi: 10.1128/JVI.00117-21
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://journals.asm.org/doi/10.1128/JVI.00117-21?url_ver=Z39.88-2003&rfr_id=ori…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, severe acute respiratory syndrome, immune response, primates
Summary of Study: Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. Because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
References: PMID: 33412411/doi: 10.1016/j.virol.2020.12.013
Contact Info: Yasushi Itoh (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S0042682220302609?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: antonio.goncalves@inserm.fr
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: NIAID; University of Colorado School of Medicine
Keywords: SARS-CoV-2, role of T cells in recovery, immune response, primates
Summary of Study: Results suggest that T cells are not critical for recovery from acute SARS-CoV-2 infections in the rhesus macaque nodel (which develop only mild COVID-19, similar to most humans), pointing toward B cell responses and antibodies as the essential mediators of protection from re-exposure.
References: PMID: 34311582 / doi: 10.1128/mBio.01503-21
Contact Info: Kim Hasenkrug: khasenkrug@nih.gov
URL: https://journals.asm.org/doi/10.1128/mBio.01503-21
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: sharunkhansk@gmail.com; Kuldeep Dhama: kdhama@rediffmail.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Sciences, Nanjing University
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2-infected northern pig-tailed macaques could be considered as a critically ill animal model in COVID-19 research.
References: PMID: 33998182 / doi: 10.24272/j.issn.2095-8137.2020.334
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: http://www.zoores.ac.cn/article/doi/10.24272/j.issn.2095-8137.2020.334
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet; University of Cape Town
Keywords: SARS-CoV-2, virus genomic variants, antigenic sin, boost, passive immunization, mice, primates
Summary of Study: A single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs.
References: PMID: 34723224 / doi: 10.1016/j.xcrm.2021.100450
Contact Info: Daniel Sheward: daniel.sheward@ki.se; Gunilla Karlsson Hedestam: gunilla.karlsson.hedestam@ki.se; Ben Murrell: benjamin.murrell@ki.se
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003189?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: benjamin.murrell@ki.se; Daniel Sheward: daniel.sheward@ki.se, Gunilla Karlsson Hedestam: gunilla.karlsson.hedestam@ki.se
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Tulane NPRC, North Carolina State University
Keywords: SARS-CoV-2, portable, ultrasensitive saliva-based virus assay, primates
Summary of Study: CRISPR-FDS determined that mean SARS-Cov-2 RNA levels were 3.6 fold to 124-fold higher, and more stable, in oropharyngeal versus nasal swab samples from nonhuman primates at all time points after infection, suggesting that saliva may represent a more robust diagnostic sample than nasal swabs both early and later in infection.
References: PMID: 33310733 / doi: 10.1126/sciadv.abe3703
Contact Info: Tony Hu: tonyhu@tulane.edu
URL: https://advances.sciencemag.org/content/7/2/eabe3703
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Dalhousie University; University of Calgary
Keywords: SARS-CoV-2, anthropozoonosis, virus transmission between the sanimal species, primates
Summary of Study: While the risk of transmission of SARS-CoV-2 via wastewater is low, tracing of viral RNA in wastewater does provide a unique testing approach to help protect NHPs at zoos and wildlife sanctuaries.
References: PMID: 34662463 / doi: 10.1002/ajp.23340
Contact Info: Graham Dellaire: dellaire@dal.ca
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23340
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: skent@unimelb.edu.au
URL: https://www.nature.com/articles/s41467-021-21665-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,dormitzer@pfizer.com
URL: https://www.nature.com/articles/s41541-021-00313-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: University of Iowa; University of Florida
Keywords: SARS-CoV-2, meta analysis, airway mucus, mucin glycoproteins, inflammation, primates
Summary of Study: Ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
References: PMID: 34794359 / doi: 10.1177/03009858211058837
Contact Info: not available
URL: https://journals.sagepub.com/doi/10.1177/03009858211058837?url_ver=Z39.88-2003&r…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques, african green monkeys, squirrel monkeys
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, pulmonary histopathologic characteristics, immunohistochemistry, species comparison, primates
Summary of Study: Histopathology does not appear to be a superior readout for interpretation of vaccine and therapeutic evaluations in the NHPs studied. The recommendation of which NHP is a superior model should be based on virology data as well as further work on genetic factors that contribute to significant disease.
References: PMID: 34963391 / doi: 10.1177/03009858211067468
Contact Info: Chad Clancy: chad.clancy@nih.gov
URL: https://journals.sagepub.com/doi/10.1177/03009858211067468?url_ver=Z39.88-2003&r…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Statens Serum Institute; Robert Koch Institute; BIOQUAL; University of Southern Denmark
Keywords: SARS-CoV-2, DNA plasmid vaccine, immune response, primates
Summary of Study: The candidate plasmid DNA vaccine encoding the SARS-CoV-2 spike protein is immunogenic in different models and confers protection against lung infection in nonhuman primates. Further evaluation of this DNA vaccine candidate in clinical trials is warranted.
References: PMID: 34930909 / doi: 10.1038/s41541-021-00419-z
Contact Info: Anders Fomsgaard: afo@ssi.dk
URL: https://www.nature.com/articles/s41541-021-00419-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: nmaness@tulane.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University Vaccine Center; BIOQUAL; Moderna; Johns Hopkins University
Keywords: SARS-CoV-2, variants of concern, booster, immune response, primates
Summary of Study: An additional, delayed boost with mRNA vaccines matched to either the original vaccine strain or to the heterologous challenge strain can have a marked and sustained effect on increaseing the breadth of neutralization against all VOCs tested and protection in both the lower and upper airways against the beta variant.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: rseder@mail.nih.gov; Barney Graham: bgraham@nih.gov
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nanogen Pharmaceutical Biotechnology Joint Stock Company; National Institute of Hygiene and Epidemiology (Hanoi, Vietnam)
Keywords: SARS-CoV-2, protein subunit vaccine, Nanocovax, pathogenesis, mice, hamsters, primates
Summary of Study: Nanocovax, a SARS-CoV-2 vaccine candidates based on recombinant protein production of the extracellular portion of the spike protein, was shown to be safe and effective in three animal models.
References: PMID: 34938290 / doi: 10.3389/fimmu.2021.766112
Contact Info: Min Si Do: minhsi@nanogenpharma.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.766112/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: treatment
NPRC/Institute: Chinese Academy of Medical Science and Peking Union Medical College; Genuine Biotech, Inc.; Wuhan Research Center for Infectious Diseases and Cancer; The First Affiliated Hospital of Henan University of Chinese Medicine; Henan Provincial Peoples Hospital; Henan Normal University; Zhengzhou University
Keywords: SARS-CoV-2, Azvudine, preclinical studies, Phase III trial, humans, primates
Summary of Study: Treating SARS-CoV-2 infected rhesus macaques with FNC reduced viral load, recuperated the thymus, improved lymphocyte profiles, alleviated inflammation and organ damage, and lessened ground-glass opacities in chest X-ray.
References: PMID: 34873151 / doi: 10.1038/s41392-021-00835-6
Contact Info: Zhenshun Cheng: chzs1990@163.com; Jun-Biao Chang: changjunbiao@zzu.edu.cn; Jian-Dong Jiang: jiang.jdong@163.com
URL: https://www.nature.com/articles/s41392-021-00835-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning, epitope targets, spike protein, humans, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 34909774 / doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: joverbau@fredhutch.org
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; University Paris-Saclay, Inserm, CEA; AIMM Therapeutics BV; J&S Preclinical Solutions; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, variants of concern, third vaccination, mice, rabbits, primates
Summary of Study: A third immunization improves neutralizing antibody titers against the variants-of-concern (Alpha, Beta, Gamma, and Delta).
References: PMID: 34862406 / doi: 10.1038/s41541-021-00411-7
Contact Info: Rogier Sanders: r.w.sanders@amsterdamumc.nl
URL: https://www.nature.com/articles/s41541-021-00411-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Tulane National primate Research Center; Tulane School of Medicine; Duke University Medical Center
Keywords: SARS-CoV-2, anti-SARS-CoV-2 monoclonal antibodies, pharmacokinetics, immune response, primates
Summary of Study: A combination of two high-affinity anti-SARS-CoV-2 monoclonal antibodies (mAbs; C144-LS and C135-LS) effectively blocks development of COVID-19 in the rhesus disease model and accelerates the prospect of clinical studies with this effective antibody combination.
References: PMID: 34869063 / doi: 10.3389/fcimb.2021.753444
Contact Info: Chad Roy: croy@tulane.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637877/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys, cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: Sichuan University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, review of the current animal models, pathology, immune response, use for the testing therapeutics and vaccines, mice, hamsters, nonhuman primates, and ferrets
Summary of Study: A variety of animal models have been developed to demonstrate the transmission, pathogenesis, and immunology induced by SARS-CoV-2 and to evaluate the immunomodulatory and antiviral drugs and vaccines against COVID-19. None of these models can completely recapitulate the changes seein in COVID-19 patients. It may be beneficial for investigators to apply appropriate options of animal models depending on the scientific goals.
References: PMID: 34909757 / doi: 10.1002/mco2.98
Contact Info: Shuaiyao Lu: lushuaiyao-km@163.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662225/pdf/MCO2-2-548.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: drpramodr@gmail.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, vaccines, antibody and T cell immunogenicity, review, primates
Summary of Study: This review article looks at what is known of the antibody and T cell immunogenicity of vaccines that have advanced to human clinical trials. Includes summary of press releases on the outcomes of vaccine efficacy trials.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John P. Moore: jpm2003@med.cornell.edu
URL: https://advances.sciencemag.org/content/7/12/eabe8065
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine, review
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, antibody and T cell immunogenicity, testing vaccines in humans and primates, review
Summary of Study: This review article summaries what is known of the antibody and T cell immunogenicity of multiple preventive vaccines in NHPs and humans.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John Moore: jpm2003@med.cornell.edu
URL: https://advances.sciencemag.org/content/7/12/eabe8065
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: Chungbuk National University
Keywords: SARS-CoV-2, several animal species, transduction, pathology, primates
Summary of Study: Review of various animal models employed for SARS-CoV-2 infection studies that outlines their individual strengths and limitations for use in studies aimed at increasing understanding of coronavirus pathogenesis.
References: PMID: 33996168 / doi: 10.4110/in.2021.21.e12
Contact Info: Young Ki Choi: choiki55@CHUNGBUK.AC.KR
URL: https://immunenetwork.org/DOIx.php?id=10.4110/in.2021.21.e12
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, primates
Summary of Study: The severity of respiratory tract infection enhanced air transmission and induced wide and severe SARS-CoV-2 infection in the lungs, suggesting the occurrence of more severe infectiousness and lung injury in SARS-CoV-2 patients with nasal infection.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, virus load, primates
Summary of Study: Nasal infection may be regarded as an important index to assess the severity of COVID-19. Furthermore, treatments focused on nasal infection, like hypertonic saline nasal irrigation and gargling, should be considered as a therapeutic option for COVID-19.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Texas Christian University
Keywords: SARS-CoV-2, young and aged animals, viral dynamics, antiviral treatment, primates
Summary of Study: This study finds the viral dynamics of SARS-CoV-2 between young and aged animals and has shown that these differrences should be considered when considering antiviral treatment.
References: PMID: 34804559 / doi: 10.1098/rsos.202345
Contact Info: Hana Dobrovolny: h.dobrovolny@tcu.edu
URL: https://royalsocietypublishing.org/doi/full/10.1098/rsos.202345?rfr_dat=cr_pub%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Washington Univ SOM, NIAID
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, immunogenicity and protective efficacy, primates
Summary of Study: A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge in rhesus macaques.
References: PMID: 33754147 / doi: 10.1016/j.xcrm.2021.100230
Contact Info: Heinz Feldmann: feldmannh@niaid.nih.gov; Michael Diamond: diamond@wusm.wustl.edu
URL: https://www.sciencedirect.com/science/article/pii/S266637912100046X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: Prime boost vaccination of rhesus macaques with 4 ug of CV07050101 elicited neither a uniform nor a robust immune response. However, vaccination using 8 ug of the same vaccine was protective in an NHP challenge study.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.mdpi.com/1999-4915/13/8/1645
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA-vaccine, spike protein, humoral and cellular immune responses, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited mimmune responses in four out of six non-human primates.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.mdpi.com/1999-4915/13/8/1645
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, baboons, marmosets
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Southwest NPRC
Keywords: SARS-CoV-2, young and old animals, Acute respiratory distress, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034/doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: dkaushal@txbiomed.org
URL: https://www.nature.com/articles/s41564-020-00841-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: review
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, cryopreservation, resources, genetic diversity, primates
Summary of Study: The importance of rhesus macaques as a preclinical model for human diseases and treatment outcomes supports the development of improved cryopreservation methods and routine storage of gametes and embryos.
References: PMID: 34031599 / doi: 10.1038/s41684-021-00792-1
Contact Info: Matthew Arnegard: matthew.arnegard@nih.gov
URL: https://www.nature.com/articles/s41684-021-00792-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, resources, pathology, primates
Summary of Study: Because the SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques biomedical researchers will need to consider alternative NHP models for COVID-19 research and for other biomedical research studies. The authors suggest alternatives.
References: PMID: 33785923 / doi: 10.1038/s41684-021-00755-6
Contact Info: Michael Chang: chang,mic@mail.nih.gov
URL: https://www.nature.com/articles/s41684-021-00755-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: ORIP, NIH
Keywords: SARS-CoV-2, the use of primates for COVID research, animal resources
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SFP) NHPs for development of vaccines and therapeutics. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: doi: 10.1038/s41684-021-00810-2
Contact Info: Miguel Contreras: miguel.contreras
URL: https://www.nature.com/articles/s41684-021-00810-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: review
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, primates, animal resources, biosafety
Summary of Study: Sustaining and increasing NHP research capacity will require careful preparation and collaborations to improve existing infrastructure and expand established facilities, expertise, and programs.
References: PMID: 33927412 / doi: 10.1038/s41684-021-00760-9
Contact Info: Sheri Ann Hild: sheri.hild@nih.gov
URL: https://www.nature.com/articles/s41684-021-00760-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, animal models, viruses, resources, primates
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SPF) nonhuman primates (NHPs) for development of vaccines and therapeutics, thus straining the supply of these animals for biomedical research studies. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: PMID: 34163043 / doi: 10.1038/s41684-021-008102
Contact Info: Miguel Contreras: miguel.contreras@nih.gov
URL: https://www.nature.com/articles/s41684-021-00810-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: NCI/NIH
Keywords: SARS-CoV-2, ACE2, type I interferon, pathology, primates
Summary of Study: Type I interferon mediates an important innate immune response against viral infection by directly inhibiting viral replication. It also bridges innate to adaptive immunity for long-term protection against viral reinfections.
References: PMID: 34149696 / doi: 10.3389/fimmu.2021.658428
Contact Info: Yongjun Sui: suiy@mail.nih.gov; Jay Berzofsky: berzofsj@mail.nih.gov
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.658428/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, virus genomic variants, virus replication, immune response, pathology, primates
Summary of Study: A study of pathogenesis of B.1.1.7 and B.1.351 compared to a SARS-CoV-2 isolate containing the D614G spike substitution showed that B.1.351 was slightly less pathogenic than the other two variants, but there were no differences in virus shedding between the variants that could explain increased transmissibility.
References: PMID: 34678071 / doi: 10.1126/sciadv.abj3627
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.science.org/doi/10.1126/sciadv.abj3627?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: dewit@nih.gov
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
Coronavirus Investigated: SARS-CoV-2
NHP Species: baboons
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: NIH
Keywords: SARS-CoV-2, review, different primate species
Summary of Study: The authors advocate for baboons as a viable alternative to rhesus macaques in SARS-CoV-2 research.
References: PMID: 33785923 / doi:10.1038/s41684-021-00755-6
Contact Info: Michael Chang: changmic@mail.nih.gov
URL: https://www.nature.com/articles/s41684-021-00755-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University; UNC Chapel Hill; 3M Corporate Research Materials Laboratory; Infectious Disease Research Institute; California National Primate Research Center; and others
Keywords: SARS-CoV-2, mRNA vaccine, infants, immune response, primates
Summary of Study: Infant rhesus macaques were vaccinated with an mRNA-based SARS-CoV-2 vaccine, similar to the Moderna vaccine, or an S protein plus TLR7/8 agonist-based vaccine. Both vaccines induced profound induction of neutralizing antibody titers, memory B cells responses, and SARS-CV-2 specific CD4+ T cell responses that were long-lasting, all while limiting vaccine related toxicity.
References: PMID: 34131024 / doi: 10.1126/sciimmunol.abj3684
Contact Info: Kristina De Paris: abelk@med.unc.edu
URL: https://www.science.org/doi/10.1126/sciimmunol.abj3684?url_ver=Z39.88-2003&rfr_i…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID, Ragon Institute of MGH, MIT< and Harvard, University of Duisburg-Essen, Harvard University, Emory Vaccine Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, protein subunit vaccine, soluble prefusion-stabilized spike trimers, immune response, primates
Summary of Study: Soluble prefusion-stablized spike protein trimers (preS DTM) from SARS-CoV-2 were formulated with the adjuvant AS03 and administered twice to NHPs. Two days after challenge, vaccinated NHPs showed rapid control of viral replication in both the upper and lower airways. These data indicate that antibodies induced by the AS03-adjuvanted preS dTM vaccine were sufficient to mediate protection against SARS-CoV-2 in NHPs and that rapid anamnestic antibody responses in the lung may be a key mechanism for protection.
References: PMID: 34315825 / doi: 10.1126/scitranslmed.abi4547
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://www.science.org/doi/10.1126/scitranslmed.abi4547?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Celltech Pharmed Co.; Iran University of Medical Sciences; University of Iran; Tarbiat Modares University; Royan Institute for Stem Cell Biology and Technology; and others
Keywords: SARS-CoV-2, mRNA-vaccine, lipid nanoparticle, spike protein, immune response, primates
Summary of Study: A novel mRNA-LNP vaccine against SARS-CoV-2 was developed and preclinically evaluated, revealing that it was efficient enough to induce hgih level production of neutralizing antibodies against SARS-CoV-2 in mice and rhesus macaque monkeys.
References: PMID: 34579244 / doi: 10.3390/vaccines9091007
Contact Info: Alireza Sohi: nanosohi@strc.ac.ir; Jafar Kiani: kiani.ja@iums.ac.ir; Ehsan Arefian: arefian@ut.ac.ir; Arezou Khosrojerdi: arezou.khosrojerdi@modares.ac.ir; Mohammad Zim: mk.zim73@ut.ac.ir
URL: https://www.mdpi.com/2076-393X/9/9/1007
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; National Cancer Institute/NIH; BIOQUAL; and others
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, primates
Summary of Study: Findings support the continued development of SARS-CoV-2 RBD ferritin nanoparticle vaccines (RFN) for managing COVID-19 and related SARS-CoV-like virus outbreaks.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: kmodjarrad@eidresearch.org; Diane Bolton: dbolton@hivresearch.org
URL: https://www.pnas.org/content/118/38/e2106433118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Universite Paris-Saclay/Inserm/CEA; Vaccine Research INstitute, Creteil, France; Inserm; Baylor Scott and White Research Institute; Institut Pasteur; Karolinska Institutet; and others
Keywords: SARS-CoV-2, subunit vaccine, receptor-binding domain, immune response, humanized mice, primates
Summary of Study: A single dose of the alphaCD40.RBD (a vaccine that targets the receptor-binding domain of the SARS-CoV-2 spike antigen to the CD40 receptor) administered without adjuvant boosts the protective response in COVID-10 convalescent NHPs.
References: PMID: 34471122 / doi: 10.1038/s41467-021-25382-0
Contact Info: Yves Levy: yves.levy@inserm.fr
URL: https://www.nature.com/articles/s41467-021-25382-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Brigham and Women's Hospital and Harvard Medical School, The Affiliated Hospital of Youjiang Medical Univ. for Nationalities (China), and the University of Alabama
Keywords: SARS-CoV-2, ACE2 protein expression, lung injury, mice and primates
Summary of Study: Data from this study unequivocally support the key role of ACE2 in the sinonasal mucosa as a functional reARS-CoV-2; however, the restricted baseline expression pattern of ACE1 in the lung presents a conundrum as it raises questions about alternative viral receptors or additional mechanisms of lung injury in COVID-19 pneumonia.
References: PMID: 33626084 / doi: 10.1371/journal.pone.0247510
Contact Info: Sule Cataltepe: scataltepe@bwh.harvard.edu
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247510
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines & Prevention; Tufts University Cummings School of Veterinary Medicine; Bioqual; Ragon Institute of MGH, MIT, and Harvard.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, virus transduction, primates
Summary of Study: A single immunization with relatively low dose of Ad26.COV2.S effectively protected against SARS-CV-2 challenge in rhesus macaques, although a higher vaccine dose may be required for protection in the upper respiratory tract.
References: PMID: 34133941 / doi: 10.1016/j.cell.2021.05.040
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.cell.com/cell/fulltext/S0092-8674(21)00693-0?_returnURL=https%3A//li…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Kunming Institute of Zoology; Institute of Infectious Diseases, Shenzhen Bay Laboratory; School of Medicine, Tsinghua University
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, humoral and cellular immune responses, pathology, primates
Summary of Study: A trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine that stimulates the natural structure of the spike (S) trimer glycoprotein is highly immunogenic and safe, providing long-lasting, broad, and significant immunity protection in NHPs. The vaccine-induced antibodies can effectively neutralize the SARS-CoV-2 501Y.V2 variant. A booster vaccination can quickly activate the memory immune response to avoid re-infection.
References: PMID: 34179862 / doi: 10.1016/j.xinn.2021.100140
Contact Info: Limin Yang: lmyang@im.ac.cn; Yong-tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214323/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, University of North Carolina at Chapel Hill, Ragon Institute of MGH, MIT, and Harvard, Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity and protective efficacy, mice
Summary of Study: RhAd52 vaccines elicit robust SARS-CoV-2 specific antibody responses and protect against clinical disease and viral replication in the lungs. These data validate the MA10 mouse model as a useful tool to screen and study novel vaccine candidates, as well as the development of RhAd52 vaccines for COVID-19.
References: PMID: 34523968 / doi: 10.1128/JVI.00974-21
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://journals.asm.org/doi/10.1128/JVI.00974-21?url_ver=Z39.88-2003&rfr_id=ori…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: California National Primate Research Center; University of California, Davis; Louisiana State University Health Sciences Center; The Rockefeller University.
Keywords: SARS-CoV-2, neuroinflammation, effector CD4 T cells, inflammation, cerebrospinal fluid, pneumonia, primates
Summary of Study: Neutralizing mABs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
References: PMID: 34706272 / doi: 10.1016/j.celrep.2021.109942
Contact Info: Smita Iyer: smiyer@ucdavis.edu
URL: https://www.sciencedirect.com/science/article/pii/S2211124721014157?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Center for Disease Control and Prevention; Chinese Academy of Medical Sciences & Peking Union Medical College; Chinese Academy of Sciences
Keywords: SARS-CoV-2, mRNA vaccine, nanoparticles, immune response, pathology, mice and primates
Summary of Study: Using both mouse and rhesus macaque SARS-CoV-2 challenge models, this study demonstrates strong immunogenicity, protective ability and high safety profiles of SW0123 (an LPP-based mRA vaccine), and supports this promising candidate for future clinical evaluation.
References: PMID: 34059617 / doi: 10.1038/s41392-021-00634-z
Contact Info: Wenjie Tan: tanwj@ivdc.chinacdc.cn; Xiaozhong Peng: pengxiaozhong@pumc.edu.cn
URL: https://www.nature.com/articles/s41392-021-00634-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Catholic University of Korea, Korea Research Institute of Bioscience and Biotechnology, SK Science, Jeonbuk National University, and others
Keywords: SARS-CoV-2, receptor-binding domain of SARS-CoV-2, immune response, mice and primates
Summary of Study: RBD-P2 + alum immunization elicits a robust neutralizing antibody response and provides complete or near-complete elimination of live SARS-CoV-2 virus particles. Additionally, findings provide insight into the potential use of the N protein in the development of SARS-CoV-2 vaccines.
References: PMID: 34049881 / doi: 10.1126/sciadv.abg7156
Contact Info: Jae-Hwan Nam: jhnam@catholic.ac.kr; Sang-Myeong Lee: smlee@chungbuk.ac.kr; Jung Joo Hong: hong75@kribb.re.kr
URL: https://www.science.org/doi/10.1126/sciadv.abg7156?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs, lorises
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: University of Calgary; Institut de Biologia Evolutiva, Universitat Pompeu Fabra; North Carolina Central University, Duke University and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Study suggests that lemurs of the families Indriidae, Daubentonlidae, and Lemuridae are likely to be particularly vulnerable to SARS-CoV-2 infection.
References: PMID: 33792947 / doi: 10.1002/ajp.23255
Contact Info: James Higham: jhigham@nyu.edu
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23255
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Huazhong University of Science & Technology; Chinese Academy of Sciences; Peking University; Shanghai Junshi Biosciences Co., Ltd.; and others
Keywords: SARS-CoV-2, ACE2-blocking monoclonal antibody, receptor-binding domain, pathology, primates
Summary of Study: The ACE2-blocking MAb represents a broadly promising therapeutic candidate against emergence, re-emergence, and future zoonotic transmission events from SARSr-CoVs and variants.
References: PMID: 34404805 / doi: 10.1038/s41467-021-25331-x
Contact Info: Wenjie Tan: tanwj@ivdc.chinacdc.cn
URL: https://www.nature.com/articles/s41467-021-25331-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Shanghai Jemincare Pharmaceuticals Co.; Chinese Academy of Sciences; tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: Two potent nABs against SARS-CoV-2 from naive phage-displayed human B cell single-chain variable fragment libraries were identified. One, JMB2002) not only showed potent in vitro blocking activity against a broad-spectrum of SARS-CoV-2 variants including the B.1.351 lineage, but also potent therapeutic efficacy and complete prophylactic protection against SARS-CoV-2 in a rhesus macaque infection model. Prophylactic and therapeutic countermeasure intervention of SARS-CoV-2 using antibody JMB2002 would likely slow down the transmission of currently emerged SARS-CoV-2 variants and result in more efficient control of the COVID-19 pandemic.
References: PMID: 34097570 / doi: 10.1080/19420862.2021.1930636
Contact Info: Su-Jun Deng: dengsujun@jemincare.com; Wuxiang Guan: guanwx@wh.iov.cn; Zhiming Yuan: yzm@wh.iov.cn
URL: https://www.tandfonline.com/doi/full/10.1080/19420862.2021.1930636
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Tongji Medical College, University of Chinese Academy of Sciences, Wuhan Institute of Biological Products Co.
Keywords: SARS-CoV-2, inactivated vaccine, mice and primates, immune response
Summary of Study: The authors tested the safety, immunogenicity and efficacy of an inactivated vaccine based on on the whole viral particles in human ACE2 transgenic mouse and in NHPs. This inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in both models.
References: PMID: 33835391 / doi: 10.1007/s12250-021-00376-w
Contact Info: Xing-Lou Yang: yangsx@wh.iov.cn; Shuo Shen: shenshuo1@sinopharm.com; Zhi-Ming Yuan: yzm@wh.iov.cn
URL: https://link.springer.com/article/10.1007%2Fs12250-021-00376-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Agricultural Sciences; National Research Center for Exotic Animal Diseases, China Animal Health and Epidemiology Center
Keywords: SARS-CoV-2, meta analysis, review of the animal models, vaccination, mice, hamsters, ferrets, primates
Summary of Study: This review summarizes the landscape of animal models for COVID-19 vaccine evaluation and advanced vaccines with an efficacy range from about 50% to more than 95%.
References: PMID: 34696190 / doi: 10.3390/vaccines9101082
Contact Info: Yuwei Gao: yuwei0901@outlook.com; Feihu Yan: yanfh1990@163.com; Songtao Yang: yst62041@163.com
URL: https://www.mdpi.com/2076-393X/9/10/1082
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines & Prevention B.V.; Harvard Medical School; Lucidity Biomedical Consulting; Ragon Institute of MGH, MIT and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vector, immunogenicity, protective efficacy, immune response, primates
Summary of Study: Ad26.COV2.S vaccine confers durable protection against replication of SARS-CoV-2 in the lungs that is predicted by the levels of Spike-binding and neutralizing antibodies, indicating that Ad26.COV2.S could confer durable protection in humans and immunological correlates of protection may enable the prediction of durability of protection.
References: PMID: 34620860 / doi: 10.1038/s41467-021-26117-x
Contact Info: Roland Zahn: RZahn@its.jnj.com
URL: https://www.nature.com/articles/s41467-021-26117-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Wisconsin National Primate Research Center, Harvard Medical School, Tufts University, BIOQUAL, Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, prior infection, vaccination, virus variants, protection, hamsters, primates
Summary of Study: Data suggest partial but reduced short-term protective efficacy of WA1/2020 natural immunity against SARS-CoV-2 variants of concern. More research is needed to define protective efficacy against other SARS-CoV-2 variants and the immunologic mechanisms of protection against these variants.
References: PMID: 34546094 / doi: 10.1126/scitranslmed.abj2641
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/10.1126/scitranslmed.abj2641?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Chinese Academy of Sciences; University of the Chinese Academy of Sciences; Wuhan YZY Biopharma Co., Ltd.
Keywords: SARS-CoV-2, subunit vaccine, immunity, virus load, pathology, primates
Summary of Study: The RBD-homodimer vaccine candidate studied can induce both humoral and cellular response in vivo and prevent SARS-CoV-2 infection in both rodents and non-human primates. Production of this RBD vaccine candidate can be performed in large scale, which will enhance the vaccine supply and warrants future clinical trials.
References: PMID: 34493710 / doi: 10.1038/s41421-021-00320-y
Contact Info: Zhiming Yuan: yzm@wh.iov.cn; Chao Shan: shanchao@wh.iov.cn; Genfu Xiao: xiaogf@wh.iov.cn
URL: https://www.nature.com/articles/s41421-021-00320-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Stanford Univ. SOM, Univ. of Washington, Tulane National Primate Research Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, subunit vaccine, immune response, primates
Summary of Study: Data highlighted the efficacy of the adjuvanted RBD-NP vaccine in promoting protective immunity against SARS-Cov-2 and have led to phase I/II clinical trials of this vaccine.
References: PMID: 33873199 / doi: 10.1038/s41586-021-03530-2
Contact Info: Bali Pulendran: bpulend@stanford.edu;
URL: https://www.nature.com/articles/s41586-021-03530-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: SW National Primate Research Center, Washington University School of Medicine, Texas Biomedical Research Institute, Tulane University
Keywords: SARS-CoV-2, single-cell RNA sequencing. Immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Deepak Kaushal: dkaushal@txbiomed.org
URL: https://www.researchsquare.com/article/rs-664507/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: UC Davis, National Institutes of Health (Pakistan), California National Primate Research Center, New York State Department of Health
Keywords: SARS-CoV-2, multiplex test, immune response, primates
Summary of Study: The authors report the development and validation of a multiplex bead assay to simultaneously and specifically detect antibodies to the SARS-CoV-2, SARS-CoV, MERS-CoV and common human coronavirus strains (229E, NL63, OC43, HKU1). Multiplex serological assays enabled the investigation of the dynamics of immune responses in COVID-19 patients.
References: PMID: 34242356 / doi: 10.1371/journal.pone.0254367
Contact Info: Imran Khan: ihkhan@ucdavis.edu
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254367
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center; SE LA Veterans Affairs Healthcare System, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome and diabetes, chronic pancreatic dysfunction, primates
Summary of Study: SARS-CoV-2 infects pancreatic islet, ductal, and endothelial cells in male and female NHPs and humans with COVID-19. The long-term consequences of a fibrotic/thrombotic pancreas, such as chronic pancreatic exocrine dysfunction and late-onset diabetes, should be investigated as postacute sequelae of COVID-19.
References: PMID: 34241597 / doi: 10.1172/jci.insight.151551
Contact Info: Mirza Muhammad Fahd Qadir: mqadir@tulane.edu; Rudolf Bohm: bohm@tulane.edu
URL: https://insight.jci.org/articles/view/151551
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: State Key Laboratory of Veterinary Biotechnologi, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences
Keywords: SARS-CoV-2, virus entry mediated by ACE2, several species
Summary of Study: A natural isoform of the rhesus macaque ACE2 protein with the Y217N mutation was resistant to SARS-CoV-2 infection, highlighting the possible impact of this ACE2 mutation on SARS-CoV-2 studies in rhesus macaques. The authors also demonstrated that the Y217 residue of ACE2 is a critical determinant for the ability of ACE2 to mediate SARS-CoV-2 entry. The results of this study clarify that SARS-CoV-2 can use the ACE2 receptors of multiple animal species and show that tracking the natural reservoirs and intermediate hosts of SARS-CoV-2 is complex.
References: PMID: 33610551 / doi: 10.1016/j.jbc.2021.100435
Contact Info: Yan-Dong Tang: tangyandong2008@163.com
URL: https://www.sciencedirect.com/science/article/pii/S0021925821002088?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Ragon Institute of MGH, MIT and Harvard; UNC Chapel Hill; Tufts University; Janssen Vaccines & Prevention.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, humoral and cellular immune responses, genome variants, primates
Summary of Study: The Ad26.COV2.S vaccine provided robust protection against both WA1/2020 and B.1.351 variants.
References: PMID: 34161961 / doi: 10.1038/s41586-021-03732-8
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.nature.com/articles/s41586-021-03732-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NCI, Frederick National Laboratory for Cancer Research, BIOQUAL, University of Athens School of Medicine, University of Washington
Keywords: SARS-CoV-2, DNA-based vaccine, immune response, primates
Summary of Study: A vaccine regimen comprising simultaneous co-immunization of DNA and Protein at the same anatomical site showed best neutralizing abilities and was more effective than DNA alone in inducing protective immune responses and controlling SARS-CoV-2 infection. An expansion of the DNA vaccine regimen to include co-immunization with Spike protein may be of advantage for SARS-CoV-2.
References: PMID: 34551020 / doi: 10.1371/journal.ppat.1009701
Contact Info: Barbara Felber: barbara.felber@nih.gov
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Tsinghua University School of Medicine; Chinese Academy of Sciences; Peking Union Medical College, The University of Hong Kong, and more
Keywords: SARS-CoV-2, adenovirus vector, vaccine candidate, immune response, hamsters, mice, primates
Summary of Study: ADC68, a rare chimpanzee adenovirus serotype, was used as a vector for vaccine and induced potent and protective immune responses against SARS-CoV-2 in experimental animals, providing scientific rationale for further developing ADC68-19S as a clinical vaccine against SARS-CoV-2 infection in humans.
References: PMID: 34262569 / doi: 10.3389/fimmu.2021.697074
Contact Info: Zhiwei Chen: zchenai@hku.hk; Xioxhong Peng: pengxiaozhong@pumc.edu.cn; Dongming Zhou: zhoudongming@tmu.edu.cn
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.697074/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Third People's Hospital; Guangzhou Medical University; UT Southwestern Medical Center; and others
Keywords: SARS-CoV-2, fusion protein vaccine, immune response, rodents and primates
Summary of Study: the pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-C0V-2 challenge in rhesus macaques.
References: PMID: 34267349 / doi: 10.1038/s41422-021-00531-8
Contact Info: Yang-Xin Fu: Yang-Xin.Fu@UTSouthwestern.edu
URL: https://www.nature.com/articles/s41422-021-00531-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Advanced Study in Science and Technology (India), Biodiversity Research Center, Academic Sinica (Taipei) and others
Keywords: SARS-CoV-2, ACE2 variants, binding affinity of ACE2 to S-protein, multiple species, humans and primates
Summary of Study: Binding affinity of ACE2 to S-protein was studied in various NHP species. Based on findings, the authors propose that the common ancestor of primates was strongly resistant to and that of New World monkeys was completely resistant to SARS-CoV-2; whereas apes and Old World monkeys, like most humans, are susceptible. This study increases our understanding of the differences in susceptibility to SARS-CV-2 infection among primates.
References: PMID: 33674876 / doi: 10.1093/molbev/msab060
Contact Info: Yan Yuan Tseng: ytseng@wayne.edu; Lily Hui-Ching Wang: lilywang@life.nthu.edu.tw
URL: https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msab060/6154855
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chulalongkorn University, Mahidol University, Baiya Phytopharm Co., National Center for Genetic Engineering and Biotechnology
Keywords: SARS-CoV-2, plant-produced receptor-binding domain, immune response, primates
Summary of Study: The plant-based protein RBD-Fc was shown to be immunogenic and significantly boosted a humoral and cell-mediated immune response in both mice and cynomolgus macaques. This protein has the potential for use as a vaccine candidate against SARS-CoV-2.
References: PMID: 34054909 / doi: 10.3389/fpls.2021.682953
Contact Info: Waranyoo Phoolcharoen: waranyoo.p@chula.ac.th
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158422/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England; University of Oxford; Oxford University Hospitals NHS Foundation Trust; Quadram Institute Bioscience
Keywords: SARS-CoV-2, inactivated vaccine, vaccine-enhanced disease, pathology, ferrets, primates
Summary of Study: Studies assessed the potential for VED (vaccine-enhanced disease) in animals faccinated with formaldehyde-inactivated SARS-CoV-2 forumlated with Alhydrogel, compared to a negative control vaccine. No evidence of enhanced disease was shown in ferrets of rhrsus macaques except for mild transient enhanced disease seen 7 days after infection in ferrets. This was resolved by day 15.
References: PMID: 34516768 / doi: 10.1126/sciadv.abg7996
Contact Info: Miles Carol: miles.carrol@phe.gov.uk; Andrew Gorringe: andrew.gorringe@phe.gov.uk
URL: https://www.science.org/doi/10.1126/sciadv.abg7996?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences, Hynnan Key Laboratory of Vaccine Research, University of Massachusetts Medical School
Keywords: SARS-CoV-2, T cells, immune response, primates
Summary of Study: Six peptides were defined as the most frequently recognized T cell epitopes, and overlapped to produce three main long epitopes. This finding may provide a convenient pattern in the detection of T cell responses for the development of new vaccines and provides a novel target in the diagnosis of patients with COVID-19.
References: PMID: 33980582 / doi: 10.4049/jimmunol.2000922
Contact Info: Wei Cun: cunwei@foxmail.com
URL: https://www.jimmunol.org/content/206/11/2527.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Erasmus Medical Center, Biomedical Primate Research Centre, Utrecht University, Friedrich-Loeffler-Institute, and others
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: The surrogate virus-neutralization test (sVNT) detects high titers of RBD-binding antibodies and thus is potentially useful as an assay for large seroprevalence studies that aim at detecting high titers (vaccination trials or large-scale initial testing of potential animal reservoirs.)
References: PMID: 34458548 / doi: 10.1016/j.onehlt.2021.100313
Contact Info: Carmen Embregts: c.embregts@erasmusmc.nl; Corine GeurtsvanKessel: c. geurtsvankessel@erasmusmc.nl
URL: https://www.sciencedirect.com/science/article/pii/S2352771421001038?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology & Immunology; Institute of Military Veterinary, Academic of Military Medical Sciences
Keywords: SARS-CoV-2, recombinant vaccine, efficacy of RBD-Fc Vacc, mice and primates
Summary of Study: A new recombinant vaccine made by fusing the SARS-CoV-2 RBD with the Fc fragment of human IgG1induced a potent immune response, protecting cynomolgus macaques against SARS-CoV-2 infection.
References: PMID: 33731916 / doi: 10.1038/s41423-021-00658-z
Contact Info: Yansong Sun: yansongsunamms@126.com; Yuwei Gao: gaoyuwei@gmail.com
URL: https://www.nature.com/articles/s41423-021-00658-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Tulane University Information Technology
Keywords: SARS-CoV-2, whole-blood transcriptome profiling, primates
Summary of Study: Hallmark similarities and differences in the RM and AGM accute response to SARS-CoV-2 infection were discovered and may help guide the selection of particular NHP species in modeling aspects of COVID-19 disease outcome.
References: PMID: 34691074 / doi: 10.3389/fimmu.2021.754642
Contact Info: Joseph Mudd: jmudd1@tulane.edu
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.754642/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Korea Research Institute of Bioscience & Biotechnology, Chonnam National University, Chungbuk National University
Keywords: SARS-CoV-2, virus variants, microevolution, species specific variations, primates
Summary of Study: The genomes of SARS-CoV-2 differ according to individuals and species despite infection of the identical virus in NHPs. These results are important for the interprretation of longitudinal studies evaluating the evolution of the SARS-CoV-2 in humans and development of new diagnostics, vaccine, and therapeutics targeting SARS-CoV-2.
References: PMID: 34305860 / doi: 10.3389/fmicb.2021.694897
Contact Info: Jungjoo Hong: hong75@kribb.re.kr; Bon-Sang Koo: porco9@kribb.re.kr
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.694897/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Sciences, Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
Keywords: SARS-CoV-2, immunopathology, young and old animals, primates
Summary of Study: Results showed that the age-related immune microenvironment in the lungs, spleens, PBMCs , and CD8+ cells significantly affected the immunopathology of SARS-CoV-2 infection, whereas the increase in inflammatory factor-secreting cells in the lungs and systemic accumulation of CXCR3+ cells are associated with necrosis and inflammatory activation of ACE2+ lung cells.
References: PMID: 34471088 / doi: 10.1038/s41392-021-00734-w
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://www.nature.com/articles/s41392-021-00734-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Ottawa; Ottawa Hospital Research Institute; Institut du Cancer de Montreal; University of Calgary
Keywords: SARS-CoV-2, attenuated vaccinia virus vector, spike receptor binding domain, immune response, mice, primates
Summary of Study: Robust immune responses and protective immunity against SARS-CoV-2 variants were demonstrated after only a single dose of a temperature stable vaccine candidate (TOH-Vac1) that uses a replication-competent, attenuated vaccinia virus as a vector to express a membrane-tethered spike receptor binding domain antigen.
References: PMID: 34687845 / doi: 10.1016/j.ymthe.2021.10.008
Contact Info: John Bell: jbell@ohri.ca; Carolina Ilkow: cilkow@uottawa.ca
URL: https://www.sciencedirect.com/science/article/pii/S1525001621005153?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: YishengBio Co., Ltd.; Chinese Academy of Sciences; National Health Commission of the People's Republic of China
Keywords: SARS-CoV-2, S-trimer, PIKA, vaccine, virus genomic variants, primates
Summary of Study: In this study of non-human primates, PIKA adjuvanted S-trimer induced high SARS-CoV-2 neutralization titers and protected from virus replication in the lung following SARS-CoV-2 challenge.
References: PMID: 34766005 / doi: 10.1186/s43556-021-00054-z
Contact Info: Yi Zhang: zhang@yishengbio.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475395/
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences, Sechenov First Moscow State Medical University, Lomonosov Moscow State University
Keywords: SARS-CoV-2, serology, neutralizing antibodies, immunogenicity, inactivated vaccine, primates
Summary of Study: A B-propiolactone-inactivated whole virion vaccine CoviVac was developed and assessed. The vaccine produced stable and robust humoral immune response in mice, Syrian hamsters and common marmosets.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: lubov_i_k@mail.ru
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences; Sechenov First Moscow State Medical Univeristy; Lomonosov Moscow State University
Keywords: SARS-CoV-2, inactivated vaccine, long-term humoral immunogenicity, toxicity, mice, hamsters, primates
Summary of Study: A beta-propiolactone-inactivated whole virion vaccine (CoviVac) was asses and showed no signs of acute/chronic, reproductive, embryo- and fetotoxicity or teratogenic effects, as well as no allergenic properties in the animal species studied.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: lubov_i_k@mail.ru
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: King Mongkut's University of Technology; Chulalongkorn University; Mahidol University; B.F. Feed Company, Ltd.
Keywords: SARS-CoV-2, spike receptor-binding domain, immunization, convalescent sera, B-cell epitopes, primates
Summary of Study: The immunoinformatics method described could be a useful tool for identification of antibody epitopes in new virus variants and also other target proteins.
References: PMID: 34650130 / doi: 10.1038/s41598-021-99642-w
Contact Info: Yaowaluck Mapring Roshorm: yaowaluck.ros@kmutt.ac.th
URL: https://www.nature.com/articles/s41598-021-99642-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Columbia University, University of Texas Medical Branch, Case Western Reserve School of Medicine, and others
Keywords: SARS-CoV-2, peptide-based vaccine targeting MHC class I epitopes, immune response, pathology, primates
Summary of Study: A room temperature stable peptide vaccine based on known immunogenic HLA class I bound CTL epitopes from the nucleocapsid protein can provide protection against SARS-CoV-2 infection in nonhuman primates.
References: PMID: 34070152 / doi: 10.3390/vaccines9050520
Contact Info: Jason Comer: jscomer@utmb.edu; Reid Rubsamen: reid.rubsamen@UHHospitals.org
URL: https://www.mdpi.com/2076-393X/9/5/520
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: DSO National Laboratories, Singapore; University of Texas Medical Branch; Hummingbird Bioscience; and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, hamsters and primates
Summary of Study: SC31, a potent SARS-CoV-2 neutralizing antibody isolated from a convalescent patient, demonstrated therapeutic efficacy in three different models.
References: PMID: 34161386 / doi: 10.1371/journal.pone.0253487
Contact Info: Brendon John Hanson: hbrendon@dso.org.sg; Trevor Brasel: tbrasel@utmb.edu; Piers J. Ingram: p.ingram@hummingbirdbio.com
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253487
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Eli Lilly and Co., AbCellera Biologics, UNC - Chapel Hill, University of Texas Medical Branch, and others.
Keywords: SARS-CoV-2, monoclonal antibodies, immune response, primates
Summary of Study: LY-CoV555 (aka bamlanivimab), a potent anti-spike neutralizing antibody from a hospitalized, convalescent patient with COVID-19 was followed in a pharmacokinetic study in cynomolgus monkeys and in a challenge model in rhesus macaques, where it showed impressive results. Currently in clinical testing.
References: PMID: 33820835 / doi: 10.1126/scitranslmed.abf1906
Contact Info: Bryan Jones: jones_bryan_edward@lilly.com; Ester Falconer: ester.falconer@abcellera.com
URL: https://www.science.org/doi/10.1126/scitranslmed.abf1906?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC, Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, infection route, virus detection, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: paul.dabisch@nbacc.dhs.gov
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC; Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, seroconversion, fever, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: paul.dabisch@nbacc.dhs.gov
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Laboratory of Virology, Hamilton, MT; NIAID; University of Plymouth, Plymouth, UK; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, virus genomic variants, pathology, virus replication, shedding, primates
Summary of Study: Results from the intranasal AGM COVID-19 surrogate model support the most recent data from B.1.1.7 in humans, providing direct empirical data for increased replication in the respiratory tissue, but with no enhancement of disease.
References: PMID: 34724885 / doi: 10.1080/22221751.2021.1997074
Contact Info: Heinz Feldmann: feldmannh@niaid.nih.gov
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1997074
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Milad Daro Noor Pharmaceutical (MDNP) Co., Iran; Stem Cell Technology Research Center (STRC); Imam Hussein University
Keywords: SARS-CoV-2, inactivated vaccine candidate, immunization, immune response, mice, guinea pigs, rabbits, primates
Summary of Study: FAKHRAVAC, a purified inactivated SARS-CoV-2 virus vaccine candidate induced neutralizing antibodies in Balb/c mice, guinea pigs, rabbits, and rhesus macaques.
References: PMID: 34835202 / doi: 10.3390/vaccines9111271
Contact Info: Ahmad Karimi Rahjerdi: A-Karimi@mdnp.ir or rahjerdi@strc.ac.ir
URL: https://www.mdpi.com/2076-393X/9/11/1271
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Eurofins-INGENASA; Erasmus University Medical Center; Utrecht University
Keywords: SARS-CoV-2, post-acute phase, immune response, tomography, virus replication, primates
Summary of Study: NHPs infected with SARS-CoV-2 were followed for up to 6 weeks and monitored for COVID-19-like disease symptoms. Data indicate widespread tissue dissemination of SARS-CoV-2 in individual monkeys and provide evidence for continuing virus replication in lungs and surrounding lymph nodes after alleged convalescence of infection.
References: PMID: 34452537 / doi: 10.3390/v13081673
Contact Info: Ernst Verschoor: verschoor@bprc.nl
URL: https://www.mdpi.com/1999-4915/13/8/1673
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ReiThera Srl, University of Nottingham, National Institute for Infectious Diseases "Lazzaro Spallanzani"
Keywords: SARS-CoV-2, replication-defective gorilla adenovirus-vectored vaccine, immune response, mice and primates
Summary of Study: Pre-fusion stabilized Spike antigen is superior to the wild type in inducing ACE2-interfering, SARS-CoV-2-neutralizing antibodies.
References: PMID: 33895322 / doi: 10.1016/j.ymthe.2021.04.022
Contact Info: Alessandra Vitelli: alessandra.vitelli@reithera.com
URL: https://www.sciencedirect.com/science/article/pii/S1525001621002100?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Shandong Boan Biotech Co., National Institutes for Food and Drug Control, Shuimu Biosciences, and others
Keywords: SARS-CoV-2, neutralizing antibodies, structural analysis, primates
Summary of Study: CA521^FALA is a promising antibody that reacts with SARS-CoV-2 Spike protein to strongly neutralize its activity.
References: PMID: 33893388 / doi: 10.1038/s42003-021-02029-w
Contact Info: Lan Wang: wanglan@nifdc.org.cn; Yong-Qiang Deng: dengyq1977@126.com; Changlin Dou: douchanglin@luye.com
URL: https://www.nature.com/articles/s42003-021-02029-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, hamadryas baboons, marmosets
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute, Regeneron, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome, young and old animals, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034 / doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: dkaushal@txbiomed.org, Luis Giavedoni: lgiavedoni@txbiomed.org
URL: https://www.nature.com/articles/s41564-020-00841-4#Sec9
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: National Institute of Infectious Diseases, Japan; University of Tokyo; Kumamoto University, and others
Keywords: SARS-CoV-2, virus-specific CD8+ T-cell responses, virus replication, immune response, primates
Summary of Study: The effect of CD8+ cell depletion on SARS-CoV-2 replication when monoclonal anti-CD8 antibody is administered in the subacute phase was studied in cynomolgus macaques. Analysis revealed no significant impact of CD8+ cell depletion on viral replication, indicating the subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells.
References: PMID: 34280241 / doi: 10.1371/journal.ppat.1009668
Contact Info: Tetsuro Matano: tmatano@nih.go.jp; Takushi Nomura: nomutaku@nih.go.jp
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009668
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Xiamen University, The University of HongKong, Shantou University, Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, review of the primate models, clinical symptoms, pathogenesis, applications
Summary of Study: Review summarizes the benefits and caveats of NHP models currently available for SARS-CoV-2 and discusses key topics including model optimization, extended application, and clinical translation.
References: PMID: 34490832 / doi: 10.1080/22221751.2021.1976598
Contact Info: Tong Cheng: tcheng@xmu.edu.cn; Ningshao Xia: nsxia@xmu.edu.cn
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1976598
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, University of North Carolina at Chapel Hill, FDA, and others
Keywords: SARS-CoV-2, nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: The immunization of macaques with nanoparticles conjugated with the receptor-binding domain of SARS-CoV-2, and adjuvanted with 3M-052 and alum, elicits cross-neutralizing antibody responses against bat coronaviruses, SARS-CoV and SARS-CoV-2. Nucleoside-modified mRNAs that encode a stabilized transmembrane spike or monomeric receptor-binding domain also induced cross-neutralizing antibody responses against SARS-CoV and bat coronaviruses.
References: PMID: 33971664 / doi: 10.1038/s41586-021-03594-0
Contact Info: Kevin Saunders: kevin.saunders@duke.edu; Barton Haynes: barton.haynes@duke.edu
URL: https://www.nature.com/articles/s41586-021-03594-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences; Tsinghua University; Advaccine Biopharmaceuticals (Suzhou)
Keywords: SARS-CoV-2, B cells, Toll-like receptor, preclinical study, virus-like particle, pathogen-like antigen, primates
Summary of Study: A PLA-based COVID-19 vaccine candidate could potentially serve as an alternative option for coping with the SARS-CoV-2 pandemic.
References: PMID: 34723223 / doi: 10.1016/j.xcrm.2021.100448
Contact Info: Zhaolin Hua: zlhua@moon.ibp.ac.cn; Hongyu Deng: hydeng@ibp.ac.cn; Baidong Hou: baidong_hou@ibp.ac.cn
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003165?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Nagoya University; Kyushu University; Akita University Graduate School of Medicine; and others
Keywords: SARS-CoV-2, mathematical model, infection dynamics, kinetics of viral shedding, primates
Summary of Study: The authors used a simple mathematical model to quantify SARS-CoV-2 infection dynamics in rhesus macaques. When antiviral treatments are initiated early (i.e. 0.5 d after virus inoculation), viral shedding is (paradoxically) prolonged by about 6.0 days compared with no treatment.
References: PMID: 34344719 / doi: 10.26508/lsa.202101049
Contact Info: Keisuke Ejima: kejima@iu.edu; Shingo Iwami: iwami.iblab@bio.nagoya-u.ac.jp
URL: https://www.life-science-alliance.org/content/4/10/e202101049
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Duke University School of Medicine, UNC Chapel Hill, NIAID, Harvard Medical School, and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: In vitro infection-enhancing RBC and NTD ABs controlled virus in vito and was rarely associated with enhanced lung pathology.
References: PMID: 34242577 / doi: 10.1016/j.cell.2021.06.021
Contact Info: Barton Haynes (Duke University School of Medicine); Kevin Saunders (Duke University School of Medicine)
URL: https://www.sciencedirect.com/science/article/pii/S009286742100756X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Institut Pasteur; Sorbonne Universite; Ecole normale superieure Paris-Saclay; Universite de Paris
Keywords: SARS-CoV-2, therapeutics, vaccine, pathogenesis, drug discovery, animal model, primates
Summary of Study: This review discusses the use of NHPs as models for COVID-19 research, with focus on the pathogenesis of SARS-CoV-2 infection, drug discovery and pre-clinical evaluation of vaccine candidates.
References: PMID: 34452011 / doi: 10.3390/vaccines9080886
Contact Info: Caroline Passaes: caroline.pereira-bittencourt@pasteur.fr
URL: https://www.mdpi.com/2076-393X/9/8/886
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences; Peking Union Medical College; Capital Medical University
Keywords: SARS-CoV-2, pathology, myocardial injury, differential expression, primates
Summary of Study: SARS-CoV-2 infected rhesus macaques showed viral myocarditis, where inflammation and endothelial injury jointly resulted in cardiac damage.
References: PMID: 34489396 / doi: 10.1038/s413392-021-00747-5
Contact Info: Jiangning Liu: liujn@cnilas.org; Jing Wang: wangjing@ibms.pumc.edu.cn
URL: https://www.nature.com/articles/s41392-021-00747-5
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Southern Medical University, Shenzhen; Guangzhou Center for Disease Control and Prevention
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: Prime-boost immunization with Sad23L-nCoV-S and Ad49L-nCoV-S (both carrying the full-length of SARS-CoV-2 spike protein gene) can safely elicit strong immunity in animals.
References: PMID: 33993845 / doi: 10.1080/22221751.2021.1931466
Contact Info: Yuming Zhang: yumingzhang1966@hotmail.com; Tingting Li: apple-ting-007@163.com
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1931466
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Washington Univ, SW National Primate Research Center, Texas Biomedical Research Institute
Keywords: SARS-CoV-2, transcriptional signatures, juvenile and old animals, lungs, primates
Summary of Study: Transcriptional profiles of lungs from juvenile and old macaques infected with SARS-CoV-2 were interrogated, providing fundamentally new information on the host response in young and old macaques. This model provides relevant insights necessary for further vaccine and therapeutic development for COVID-19.
References: PMID: 33674719 / doi: 10.1038/s42003-021-01829-4
Contact Info: Makedonka Mitreva: mmitreva@wustl.edu; Deepak Kaushal: dkaushal@txbiomed.org
URL: https://www.nature.com/articles/s42003-021-01829-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Harvard T.H. Chan School of Public Health; Emory University; Moderna, Bioqual
Keywords: SARS-CoV-2, RNA-vaccine, immune response, virus replication, protection, primates
Summary of Study: Data establish that a two-dose regimen of mRNA-1273 (Moderna vaccine) will be critical for providing upper and lower airway protection against major varriants of concern.
References: PMID: 34417590 / doi: 10.1038/s41590-021-02021-0
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov
URL: https://www.nature.com/articles/s41590-021-01021-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam, Universite Paris-Saclay, University of Southampton, and others
Keywords: SARS-CoV-2, two-component protein nanoparticle vaccine, primates
Summary of Study: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate.
References: PMID: 33577765 / doi: 10.1016/j.cell.2021.01.035
Contact Info: Roger Le Grand: roger.le-grand@cea.fr; Rogier Sanders: r.w.sanders@amsterdamumc.nl
URL: https://www.sciencedirect.com/science/article/pii/S0092867421000787?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: Sabzevar University of Medical Sciences, University of Edinburgh, Nagasaki University
Keywords: SARS-CoV-2, infective dose, several animal species, pathogenesis, primates
Summary of Study: This review focused on comparative infective dose studies for SARS-CoV-2, SARS-CoV-1, and MERS. The review suggests that the infective dose in humans is small, perhaps about 100 particles. Further work is required to understand the relationship between routes of transmission, infective dose, co-infection and outcomes.
References: PMID: 33849679 / doi: 10.1017/S0950268821000790
Contact Info: Sedighe Karimzadeh: sedigekarimsadeh@gmail.com; Raj Bhopal: Raj.Bhopal@ed.ac.uk
URL: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/revie…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: North Carolina State University; UNC-Chapel Hill; BreStem Therapeutics, Bioqual, Inc.
Keywords: SARS-CoV-2, ACE2 nanodecoys, inhalation therapy, mice and primates
Summary of Study: ACE2 nanodecoys derived from human lung spheroid cells (LSCs) can bind and neutralize SARS-CoV-2. In cynomolgus macaques challenged with live SARS-CoV-2, four doses of these nanodecoys delivered by inhalation promoted viral clearance and reduced lung injury. these results suggest that LSC-nanodecoys can serve as a potential therapeutic agent for treating COVID-19.
References: PMID: 34140674 / doi: 10.1038/s41565-021-00923-2
Contact Info: Ke Cheng: ke_cheng@ncsu.edu
URL: https://www.nature.com/articles/s41565-021-00923-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Kazan State Medical Academy; Kazan State Medical University; Kazan Federal University
Keywords: SARS-CoV-2, infection, pathogenicity, eye surface, literature meta analysis, primates
Summary of Study: There is a possibility of COVID-19 transmission through the eye surface. Eye protection measures should be undertaken when working with potentially infected patients.
References: PMID: 34410064 / doi: 10.17116/oftalma2021137041104
Contact Info: not provided
URL: https://pubmed.ncbi.nlm.nih.gov/34410064/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Duke University School of Medicine, Harvard
Keywords: SARS-CoV-2, modified vaccinia Ankara vector-based vaccine, immune response, pathology, primates
Summary of Study: MVA/S vaccination can provide protection from intranasal and intratracheal SARS-CoV-2 challenge and support further development of this vaccine to test immunogenicity and efficacy in humans.
References: PMID: 33631118 / doi: 10.1016/j.immuni.2021.02.001
Contact Info: Rama Rao Amara: ramara@emory.edu
URL: https://www.sciencedirect.com/science/article/pii/S107476132100042X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: VaxiGen, Inc., Genexine, Inc., Korea National Primate Research Centre, and others
Keywords: SARS-CoV-2, DNA-based vaccine, mice and primates, immune response
Summary of Study: A synthetic soluble SARS-CoV-2 spike (S) DNA-based vaccine candidate, GX-19, provides a durable protective immune response in rhesus macaques, supporting further development of GX-19 as a vaccine candidate for SARS-CoV-2.
References: PMID: 33804981 / doi: 10.3390/vaccines9040307
Contact Info: Yong Bok Seo: ybseo@slvaxigen.com; You Suk Suh: yssuh@genexine.com; Jung Joo Hong: hong75@kribb.re.kr
URL: https://www.mdpi.com/2076-393X/9/4/307
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University; BIOQUAL, Inc.; Moderna, Inc.; Johns Hopkins University
Keywords: SARS-CoV-2, virus genomic variants, boost, immune response, primates
Summary of Study: Homologous mRNA-1273 boost can significantly improve both the breadth and potency of neutralizing antibody responses and confer protection against upper and lower airway infection to a heterologous challenge virus, which is relatively resistant to in vitro neutralization.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: rseder@mail.nih.gov; Barney Graham: bgraham@nih.gov
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, Inc.; IosBio; Battelle Biomedical Research Center; NantKwest, Inc.
Keywords: SARS-CoV-2, dual-antigen vaccine, adenovirus vector, immune response, virus replication, primates
Summary of Study: In the rhesus macaque model, SC prime vaccination with two oral boosts with the dual-antigen hAd5 S-Fusion + N-ETSD vaccine provides protection from SARS-CoV-2 infection for both nasal and lung airways.
References: PMID: 34603305 / doi: 10.3389/fimmu.2021.729837
Contact Info: Patrick Soon-Shiong: patrick@nantworks.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.729837/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Emory University; Duke University Medical Center; Moderna; BIOQUAL
Keywords: SARS-CoV-2, mRNA-vaccine, immune response, hamsters, primates
Summary of Study: mRNA-1273 vaccine-induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP.
References: PMID: 34529476 / doi: 10.1126/science.abj0299
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov
URL: https://www.science.org/doi/10.1126/science.abj0299?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & U. Mass.
Keywords: SARS-CoV-2, DNA and protein vaccine combination, primates
Summary of Study: The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine elicited full protection against the challenge of SARS-CoV-2 in an NHP model.
References: PMID: 33555988 / doi: 10.1080/22221751.2021.1887767
Contact Info: Wei Cun: cun@imbcams.com.cn / Shan Lu: shan.lu@umassmed.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1887767
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines, Leiden University Medical Center, Harvard Medical School
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: The immunogenicity, protective efficacy, and SARS-CoV-2 spike variant neutralizing data presented in this manuscript further support the decision to evaluate a single 5 x 10^10-vp dose of Ad26.COV2.S in Phase 3 trials.
References: PMID: 33909009 / doi: 10.1084/jem.20202756
Contact Info: Roland Zahn: rzahn@its.jnj.com
URL: https://rupress.org/jem/article/218/7/e20202756/212032/Immunogenicity-and-effica…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Biomedical Primate Research Centre (BPRC, Netherlands), Utrecht University
Keywords: SARS-CoV-2, computed tomography, bronchoalveolar lavage, test interference, primates
Summary of Study: Thorax CTs were evaluated for alteractions in lung density in health and experimentally SARS-CoV-infected female rhesus macaques before and after brochoalveolar lavage (BAL). An increase in the lung density was observed on the post-BAL CT but resolved within 24 hours in the healthy animals; a significant difference in both the lung density and CT score was still found 24 hours post BAL in the infected animals.
References: PMID: 34242213 / doi: 10.1371/journal.pone.0252941
Contact Info: Marieke Stammes: stammes@bprc.nl
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252941
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIH, University of Oxford, NIAID, Icahn School of Medicine at Mount Sinai
Keywords: SARS-CoV-2, adenovirus-based vaccine, intranasal administration, hamsters, primates
Summary of Study: Intranasal vaccination with ChAdOx1 nCoV-19/AZD1222 reduced virus concentrations in nasal swabs in two different SARS-CoV-2 animal models, warranting further investigation as a potential vaccination route for COVID-19 vaccines.
References: PMID: 34315826 / doi: 10.1126/scitranslmed.abh0755
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.science.org/doi/10.1126/scitranslmed.abh0755?url_ver=Z39.88-2003&rfr…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, Yoh Services, Global Discovery Pathology, Translate Bio
Keywords: SARS-CoV-2, multiple animal species, mRNA vaccine, immune response, pathology, primates
Summary of Study: Several mRNA vaccine candidates were assessed; the lead 2P/GSAS vaccine formulation (designated MRT550) elicited potent nAbs as well as TH1-biased responses in NHPs, thus alleviating a hypothetical concern of potential vaccine-associated enhanced respiratory diseases known associated with TH2-biased responses. These data position MRT5500 as a viable vaccine candidate for entering clinical development.
References: PMID: 33875658 / doi: 10.1038/s41541-021-00324-5
Contact Info: Kirill Kalnin: kkirill45us@gmail.com
URL: https://www.nature.com/articles/s41541-021-00324-5
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Fudan University, Second Military Medical University, Peking University
Keywords: SARS-CoV-2, cell-based vaccine, neutralizing antibodies, immune response, pathology, mice, primates
Summary of Study: The data present strong evidence supporting the promise of K562-S (a novel cell-based vaccine candidate that uses human cell K562 as a cellular carrier to display Spike (S) protein on the membrane) as a new effective vaccine for the prevention of COVID-19.
References: PMID: 34304724 / doi: 10.1080/22221751.2021.1957400
Contact Info: Jianqing Xu: xujianqing@shphc.org.cn; Xiaoyan Zhang: zhangxiaoyan@shphc.org.cn; Chen Zhao: chen_zhao72@163.com; Ping Zhao: pnzhao@163.com
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1957400
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Hebei Agricultural University; Military Veterinary Research Institute
Keywords: SARS-CoV-2, aerosol particles, viruse transduction, primates
Summary of Study: Most SARS-CoV-2 aerosol particles exhaled by the cynomolgus monkeys in this study were smaller (<4.7 um), suggesting that aerosols might be a route for SARS-CoV-2 transmission.
References: PMID: 34152969 / doi: 10.3201/eid2707.203948
Contact Info: Yuwei Gao: gaoyuwei@gmail.com
URL: https://wwwnc.cdc.gov/eid/article/27/7/20-3948_article
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute, Perelman School of Medicine, NIAID, and others
Keywords: MERS-CoV, intradermal and intramuscular delivery, synthetic DNA vaccine, primates
Summary of Study: Results illustrate that a MERS spike antigen synthetic DNA vaccine administered in a 2-dose i.d. EP regimen can have positive impact in an important NHP challenge model protecting against symptoms and pathology.
References: PMID: 33886507 / doi: 10.1172/jci.insight.146082
Contact Info: David Weiner: dweiner@wistar.org
URL: https://insight.jci.org/articles/view/146082
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases
Keywords: SARS-CoV-2, comparative evaluation of disease progression in three primate species
Summary of Study: In addition to African green monkeys, macaques can be successfully infected by airborne SARS-CoV-2, providing viable macaque natural transmission models for medical countermeasure evaluation.
References: PMID: 33529233 / doi: 10.1371/journal.pone.0246366
Contact Info: Sara Johnston: sara.c.johnston2.civ@mail.mil; Aysegul Nalca: aysegul.nalca.civ@mail.mil
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246366
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, ACE2 expression, transcription factor AhR, pathology, primates
Summary of Study: Data in this study show that the transcription factor AhR is able to bind the promoter of the ACE2 gene, thus promoting ACE2 expression and augmenting the subsequent pathology in SARS-CoV-2-infected lungs.
References: PMID: 33795851 / doi: 10.1038/s41423-021-00672-1
Contact Info: Chuan Qin: qinchuan@pumc.edu.cn; Bo Huang: tjhuangbo@hotmail.com
URL: https://www.nature.com/articles/s41423-021-00672-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: Johns Hopkins School of Medicine; Yale University School of Medicine
Keywords: SARS-CoV-2, several animal species, immunological response, primates
Summary of Study: This review discusses small and large animal model studies previously used in SARS-CoV-2 research that may be useful in elucidating the immunological contributions to hallmark syndromes observed with COVID-19.
References: PMID: 33914873 / doi: 10.1093/ilar/ilab010
Contact Info: Rebecca Veenhuis: rterill1@jhmi.edu
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab010/62…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, Public Health England, The Pirbright Institute
Keywords: SARS-CoV-2, vaccine, immune response, pathology, primates
Summary of Study: Lung pathology caused by SARS-CoV-2 meiated pneumonia is reduced in rhesus macaques by prior vaccination with ChAdOx1 nCoV-19, which induced neutralising antibody responses after a single intramuscular administration.
References: PMID: 34312487 / doi: 10.1038/s42003-021-02443-0
Contact Info: Sarah Gilbert: sarah.gilbert@ndm.ox.ac.uk
URL: https://www.nature.com/articles/s42003-021-02443-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Korea Advanced Institute of Science & Technology, GENOME INSIGHT, INC.
Keywords: SARS-CoV-2, infection models, organoids, primates
Summary of Study: Review of in vitro and in vivo models for SARS-CoV-2 infection.
References: PMID: 34187969 / doi: 10.14348/molcells.2021.0094
Contact Info: Young Seok Ju: ysju@kaist.ac.kr
URL: https://www.molcells.org/journal/view.html?doi=10.14348/molcells.2021.0094
Coronavirus Investigated: SARS-CoV-2
NHP Species: olive baboons
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Novavax, University of Maryland, University of Oklahoma, and others
Keywords: SARS-CoV-2, subunit vaccine (NVX-CoV2373), mice and primates
Summary of Study: Administering a subunit vaccine (NVX-CoV2373) constructed from the full-length S-protein, with Matrix-M adjuvant in a nonhuman primate model induces B- and T-cell responses, hACE2-receptor-blocking antibodies, and SARS-CoV-2 neutralizing antibodies. These results support the clinical development of the NVX-C0V2373 vaccine for prevention of COVID-19.
References: PMID: 33446655 / doi: 10.1038/s41467-020-20653-8
Contact Info: Gale Smith: gsmith@novavax.com
URL: https://www.nature.com/articles/s41467-020-20653-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology
Keywords: SARS-CoV-2, inactivated SARS-CoV-2 vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: A two-dose regimen of vaccine candidate BBV152 with adjuvant B induces a significant immune response and provides effective protection in rhesus macaques challenged with SARS-CoV-2.
References: PMID: 33654090 / doi: 10.1038/s41467-021-21639-w
Contact Info: Balram Bhargava: balrambhargava@yahoo.com
URL: https://www.nature.com/articles/s41467-021-21639-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England, Inovio Pharmaceuticals, Oxford University
Keywords: SARS-CoV-2, synthetic DNA vaccine candidate, immune response, primates
Summary of Study: The results in a stringent preclinical SARS-CoV-2 animal model provide further support for the efficacy and safety of the synthetic DNA vaccine INO-4800 as a prophylatic countermeasure against COVID-19.
References: PMID: 34253420 / doi: 10.1016/j.vaccine.2021.06.057
Contact Info: Kate Broderick (Inovio Pharmaceuticals, Inc.; Miles Carroll (Public Health England)
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21008070?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Public Health England & Welcome Trust Centre for Human Genetics
Keywords: SARS-CoV-2, pathogenicity, comparative studies, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. This provides convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human populations and both species can e used to evaluate the safety and efficacy of interventions proposed against SARS-CoV-2. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks.
References: PMID: 33627662 / doi: 10.1038/s41467-021-21389-9
Contact Info: Miles Carroll: miles.carroll@phe.gov.uk
URL: https://www.nature.com/articles/s41467-021-21389-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Utrecht University
Keywords: SARS-CoV-2, chest CT, ultrasound, pulmonary lesions, primates
Summary of Study: As has been observed in humans, the sensitivity of lung ultrasound (LUS) is high though the diagnostic efficacy or mild-to-moderate disease is relatively low. The low efficacy outweighs the advantages of LUS over CT (i.e. no need to transport the animals and the absence of ionizing radiation). For this reason, CT is still the imaging modality of choice for diagnosis, monitoring, and longitudinal assessment of a SARS-CoV-2 infection in NHPs.
References: PMID: 34778433 / doi: 10.3389/fvets.2021.748635
Contact Info: Marieke Stammes: stammes@bprc.nl
URL: https://www.frontiersin.org/articles/10.3389/fvets.2021.748635/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Harvard Univ., MIT, Tulane National Primate Research Center
Keywords: SARS-CoV-2, respiratory droplet generation and exhalation, primates
Summary of Study: The proportion of small respiratory droplets (the majority of particles exhaled in all subjects) increased at the peak of COVID-19 infection in NHPs. This confirms a previously published observation from the exhaled aerosol profile of a single COVID-19 positive human subject, and suggests that, at peak infection, there may be an elevated risk of the airborne transmission of SARS-CoV-2 by way of the very small droplets that transmit through conventional masks and travers distances far exceeding the conventional social distance of 2 m.
References: PMID: 33563754 / doi: 10.1073/pnas.2021830118
Contact Info: David Edwards: dedwards@seas.harvard.edu; Chad Roy: croy@tulane.edu
URL: https://www.pnas.org/content/118/8/e2021830118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NCI/NIH; University of Maryland, BIOQUAL, NIAID and others
Keywords: SARS-CoV-2, adjuvanted subunit vaccines, immune response, primates
Summary of Study: Mucosal vaccine efficiently cleared virus in the nasal cavity and may act as a potent complementary reinforcing boost for conventional systemic vaccines to provide overall better protection.
References: PMID: 33908897 / doi: 10.1172/jci.insight.148494
Contact Info: Yongjun Sui: suiy@mail.nih.gov; Jay Berzofsky: berzofsj@mail.nih.gov
URL: https://insight.jci.org/articles/view/148494
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Zhongshan School of Medicine
Keywords: SARS-CoV-2, convalescent sera, receptor-binding domain based nanoparticles, virus variants, primates
Summary of Study: Results show that as mutations accumulate in the RBD, spike proteins may acquire an antigenic shift that enable SARS-CoV-2 variants to eventually resist the current vaccines. Intensive monitoring of virus mutations and timely adjustment of the designed vaccines are required to control the viral pandemic.
References: PMID: 33580167 / doi: 10.1038/s41423-021-00641-8
Contact Info: Xin He: hexin59@mail.sysu.edu.cn
URL: https://www.nature.com/articles/s41423-021-00641-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: Department of Virology, Aggeu Magalhaes Institute, Brazil
Keywords: SARS-CoV-2, in vitro and in vivo models, several animal species, including primates, review
Summary of Study: This review article summarizes the main models of SARS-CoV-2 infection developed so far and discusses their advantages, drawbacks and main uses.
References: PMID: 33673614 / doi: 10.3390/v13030379
Contact Info: Lindomar Pena: lindomar.pena@cpqam.fiocruz.br
URL: https://www.mdpi.com/1999-4915/13/3/379/htm
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, african green monkeys
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Yale School of Medicine, Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, ACE2, several animal species, immine response, pathology, primates
Summary of Study: This review summarized key clinical, radiologic, and pathologic features of human COVID-19, followed by a comparison with spontaneous and genetically altered animal models of SARS-CoV-2 infection.
References: PMID: 33836527 / doi: 10.1093/ilar/ilab0071
Contact Info: Caroline Zeiss: caroline.zeiss@yale.edu
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab007/62…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nankai University, Chinese Academy of Sciences, and others
Keywords: SARS-CoV-2, monoclonal antibodies, structure analysis, immune response, primates
Summary of Study: The engineered antibody P4A1 (originally identified from COVID-19 convalescent patients) exhibits an optimized pharmacokinetic and safety profile, and results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection.
References: PMID: 33976198 / doi: 10.1038/s41467-021-22926-2
Contact Info: Yu Guo: guoyu@nankai.edu.cn; Hongkai Zhang: hongkai@nankai.edu.cn
URL: https://www.nature.com/articles/s41467-021-22926-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Science, Trinomab Biotech Co.
Keywords: SARS-CoV-2, ferritin nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: Self-assembling nanoparticle vaccines displaying the RBD of SARS-CoV-2 were prepared, and the vaccine candidate elicited obust humoral and T cell responses and protected the rhesus monkeys from infection with short-term shedding and only minor pathological damage.
References: PMID: 33951913 / doi: 10.1021/acs.bioconjchem.1c00208
Contact Info: Longding Liu: longdingl@gmail.com; Qihan Li: liqihan@imbcams.com.cn; Zhanlong He: hzl@imbcams.com.cn
URL: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00208
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Kunming Institute of Zoology
Keywords: SARS-CoV-2, S-Trimer, subunit vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: PMID: 33649323 / doi: 10.1038/s41467-021-21634-1
Contact Info: Peng Liang: liang.peng@cloverbiopharma.com
URL: https://www.nature.com/articles/s41467-021-21634-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute; Inovio Pharmaceuticals; Bioqual
Keywords: SARS-CoV-2, DNA vaccine, immunogenicity, immune response, adaptive immune response, primates
Summary of Study: INO-4800, an intradermal-delivered SARS-CoV-2 spike DNA vaccine, induced both humoral and cellular arms of the adaptive immune system.
References: PMID: 34604818 / doi: 10.1016/j.xcrm.2021.100420
Contact Info: Kate Broderick: kate.broderick@inovio.com; David Weiner: dweiner@wistar.org
URL: https://www.sciencedirect.com/science/article/pii/S2666379121002822?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: California National Primate Research Center, UC Davis
Keywords: SARS-CoV-2, CD4 T follicular helper (Tfh) cells, primates
Summary of Study: SARC-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion showed induction of germinal center (GC) responses.
References: PMID: 33483492 / doi: 10.1038/s41467-020-20642-x
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Smita Iyer: smiyer@ucdavis.edu
URL: https://www.nature.com/articles/s41467-020-20642-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Beth Israel Deaconess Medical Center, MIT, Harvard
Keywords: SARS-CoV-2, DNA- and Ad26-based vaccines, serum profiles, primates
Summary of Study: Data highlight the similarities between infection and vaccine induced humoral immunity for SARS-Cov-2 and cross-reactivity of these responses to other CoVs.
References: PMID: 33692201 / doi: 10.1128/JVI.00117-21
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://journals.asm.org/doi/10.1128/JVI.00117-21?url_ver=Z39.88-2003&rfr_id=ori…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, severe acute respiratory syndrome, immune response, primates
Summary of Study: Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. Because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
References: PMID: 33412411/doi: 10.1016/j.virol.2020.12.013
Contact Info: Yasushi Itoh (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S0042682220302609?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: antonio.goncalves@inserm.fr
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: NIAID; University of Colorado School of Medicine
Keywords: SARS-CoV-2, role of T cells in recovery, immune response, primates
Summary of Study: Results suggest that T cells are not critical for recovery from acute SARS-CoV-2 infections in the rhesus macaque nodel (which develop only mild COVID-19, similar to most humans), pointing toward B cell responses and antibodies as the essential mediators of protection from re-exposure.
References: PMID: 34311582 / doi: 10.1128/mBio.01503-21
Contact Info: Kim Hasenkrug: khasenkrug@nih.gov
URL: https://journals.asm.org/doi/10.1128/mBio.01503-21
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis, review
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: sharunkhansk@gmail.com; Kuldeep Dhama: kdhama@rediffmail.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Sciences, Nanjing University
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2-infected northern pig-tailed macaques could be considered as a critically ill animal model in COVID-19 research.
References: PMID: 33998182 / doi: 10.24272/j.issn.2095-8137.2020.334
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: http://www.zoores.ac.cn/article/doi/10.24272/j.issn.2095-8137.2020.334
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet; University of Cape Town
Keywords: SARS-CoV-2, virus genomic variants, antigenic sin, boost, passive immunization, mice, primates
Summary of Study: A single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs.
References: PMID: 34723224 / doi: 10.1016/j.xcrm.2021.100450
Contact Info: Daniel Sheward: daniel.sheward@ki.se; Gunilla Karlsson Hedestam: gunilla.karlsson.hedestam@ki.se; Ben Murrell: benjamin.murrell@ki.se
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003189?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: benjamin.murrell@ki.se; Daniel Sheward: daniel.sheward@ki.se, Gunilla Karlsson Hedestam: gunilla.karlsson.hedestam@ki.se
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Tulane NPRC, North Carolina State University
Keywords: SARS-CoV-2, portable, ultrasensitive saliva-based virus assay, primates
Summary of Study: CRISPR-FDS determined that mean SARS-Cov-2 RNA levels were 3.6 fold to 124-fold higher, and more stable, in oropharyngeal versus nasal swab samples from nonhuman primates at all time points after infection, suggesting that saliva may represent a more robust diagnostic sample than nasal swabs both early and later in infection.
References: PMID: 33310733 / doi: 10.1126/sciadv.abe3703
Contact Info: Tony Hu: tonyhu@tulane.edu
URL: https://advances.sciencemag.org/content/7/2/eabe3703
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Dalhousie University; University of Calgary
Keywords: SARS-CoV-2, anthropozoonosis, virus transmission between the sanimal species, primates
Summary of Study: While the risk of transmission of SARS-CoV-2 via wastewater is low, tracing of viral RNA in wastewater does provide a unique testing approach to help protect NHPs at zoos and wildlife sanctuaries.
References: PMID: 34662463 / doi: 10.1002/ajp.23340
Contact Info: Graham Dellaire: dellaire@dal.ca
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23340
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: skent@unimelb.edu.au
URL: https://www.nature.com/articles/s41467-021-21665-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,dormitzer@pfizer.com
URL: https://www.nature.com/articles/s41541-021-00313-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: University of Iowa; University of Florida
Keywords: SARS-CoV-2, meta analysis, airway mucus, mucin glycoproteins, inflammation, primates
Summary of Study: Ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
References: PMID: 34794359 / doi: 10.1177/03009858211058837
Contact Info: not available
URL: https://journals.sagepub.com/doi/10.1177/03009858211058837?url_ver=Z39.88-2003&r…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Copycat Sciences; Sporos Bioventures
Keywords: SARS-CoV-2, redelivery, analysis of the preclinical data and clinical efficacy, primates
Summary of Study: The gap between the strong preclinical data with remdesivir (RDV) across many virus models and its questionable clinical activitiy suggests that assumptions are being made at the preclinical level that do not reflect the conditions observed in patients.
References: PMID: 34252308 / doi: 10.1128/AAC.01117-21
Contact Info: Victoria Yan: victoria.yan@copycatsciences.com
URL: https://journals.asm.org/doi/10.1128/AAC.01117-21?url_ver=Z39.88-2003&rfr_id=ori…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, african green monkeys
Year Published: 2021
Study Type/Review: therapeutics, vaccine, review
NPRC/Institute: Emory University School of Medicine
Keywords: SARS-CoV-2, several animal species, anti-viral therapeutic, vaccine development, primates
Summary of Study: Summarizing key features, strengths and weaknesses of animal models for SARS-CoV-2, focusing on their application in anti-viral therapeutic and vaccine development.
References: PMID: 33906125 / doi: 10.1016/j.coviro.2021.03.009
Contact Info: Anice Lowen: anice.lowen@emory.edu
URL: https://www.sciencedirect.com/science/article/pii/S1879625721000316?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, neurotropism, central neural system, virus transduction, primates
Summary of Study: The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys.
References: PMID: 33895780 / doi: 10.1038/s41392-021-00591-7
Contact Info: Xiaozhong Peng: pengxiaozhong@pumc.edu.cn; Shuaiyao Lu: lushuaiyao-km@163.com; Hongqi Liu: lhq@imbcams.com.cn
URL: https://www.nature.com/articles/s41392-021-00591-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Wheaten College, Cornell University
Keywords: SARS-CoV-2, virus susceptibility, animal welfare, hamsters, ferrets, primates
Summary of Study: Paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility.
References: PMID: 34359172 / doi: 10.3390/ani11072044
Contact Info: Kathleen Morgan: kmorgan@wheatoncollege.edu
URL: https://www.mdpi.com/2076-2615/11/7/2044
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: liqihan@imbcams.com.cn; Longding Liu: longdingliu@imbcams.com.cn; Cunbao Liu: cunbao_liu@163.com
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Perelman School of Medicine (UPenn),
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: wilsonjm@upenn.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates
Summary of Study: Convalescent plasma therapy in humans may be an effective strategy provided that donor sera contain high anti-SARS-CoV-2 neutralizing titers given in early states of the disease.
References: PMID: 33662255 / doi: 10.1016/j.celrep.2021.108837
Contact Info: Thomas W. Geisbert:
URL: https://www.sciencedirect.com/science/article/pii/S2211124721001510?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, apoptosis, lung tissues, pathology, primates
Summary of Study: Significant increases in apoptotic signals in postmortem lung sections from COVID-19 patients and lungs of NHPs infected with SARS-CoV-2 on day 21 p.i.
References: PMID: 33922476 / doi: 10.3390/pathogens10050509
Contact Info: Paul Boor: pboor@utmb.edu; Jason Comer: jscomer@utmb.edu; Bin Gong: bigong@utmb.edu
URL: https://www.mdpi.com/2076-0817/10/5/509
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: USC, , UCLA, City of Hope, Bioqual
Keywords: SARS-CoV-2, pancreatic beta cells, toxicity, metabolism, primates
Summary of Study: SARS-CoV-2 infection enhances beta cell stress that may compromise beta-cell function beyond the duration of the disease course, raising the possibility that the beta cell stress and injury may have clinical implications to the long-term future health of patients that have recovered from COVID19.
References: PMID: 34312617 / doi: 10.21203/rs.3.rs-592374/v1
Contact Info: Senta Georgia: sgeorgia@chla.usc.edu
URL: https://www.researchsquare.com/article/rs-592374/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaque, african green monkeys, cynomolgus macaques, marmosets
Year Published: 2021
Study Type/Review: pathogenesis
NPRC/Institute: Fudan University, Shanghai, China
Keywords: SARS-CoV-2, review, transmission, pathogenicity, therapeutics, ferrets, minks, tree shrews, primates
Summary of Study: Animal models of SARS-CoV-2 are reviewed and compared.
References: PMID: 34531831 / doi: 10.3389/fmicb.2021.626553
Contact Info: Youhua Xie: yhxie@fudan.edu.cn
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.626553/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: janet_xu_zhang@singlomics.com
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Sinovac Biotech, Beijing, China
Keywords: coronavirus, SARS-CoV-2, vaccine, nonhuman primate
Summary of Study: Rhesus macaques were immunized three times via the intramuscular route with medium or high doses of PiCoVacc three weeks before virus challenge. The high dose provided complete protection against SARS-CoV-2 challenge; neither infection enhancement of immunopathological exacerbation was observed.
References: doi: 10.1126/science.abc1932; PMID: 32376603
Contact Info: Gao Q, et al.; correspondence to Chuan Qin (qinchuan@pumc.edu.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/32376603/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis, review
NPRC/Institute: South Valley Univ., Qena, Egypt
Keywords: SARS-CoV-2, many species, review
Summary of Study: This article reviews the possible animal reservoirs of SARS-CoV-2, as well as best suited models for further study.
References: PMID: 33363234/doi: 10.3389/fvets.2020.596391
Contact Info: Mohamed Mahdy: m_mahdi@vet.svu.edu.eg
URL: https://www.frontiersin.org/articles/10.3389/fvets.2020.596391/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet, Stockholm
Keywords: SARS-CoV-2, spike trimers, neutralizing antibodies, mice, primates
Summary of Study: Adjuvanted protein intramuscular immunization with SARS-CoV-2 spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaque.
References: doi:10.1101/2020.07.31.228486
Contact Info: Mandolesi, Marco; daniel.sheward@ki.se, gunilla.karlsson.hedestam@ki.se, benjamin.murrell@ki.se
URL: https://www.biorxiv.org/content/10.1101/2020.07.31.228486v1
Coronavirus Investigated: SARS-CoV-2, MERS-CoV
NHP Species: cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: University of Erasmus, Netherlands
Keywords: coronavirus, MERS-CoV, SARS-CoV-2, animal models
Summary of Study: The authors' study shows that SARS-CoV-2 causes COVID-19-like disease in macaques and provides a new model to test preventive and therapeutic strategies.
References: doi: 10.1126/science.abb7314
Contact Info: Rockx B, et al.; correspondence to Barry Rockx (b.rockx@erasmusmc.nl)
URL: https://pubmed.ncbi.nlm.nih.gov/32303590/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Tongji Medical College, Wuhan, China
Keywords: SARS, ACE2, receptor-binding domain, pneumonia
Summary of Study: The authors analyzed 82 representative ACE2 sequences from the 1000 sequences with the closest homology to the human ACE2 protein to identify potential SARS-CoV-2 natural and intermediate hosts, as well as susceptible animals. Results suggest that several NHPs may be intermediate hosts and most are susceptible to SARS-CoV-2.
References: doi: 10.26434/chemrxiv.12057996.v1; Preprint
Contact Info: Wu C, et al.; correspondence to Hui Li (li_hua@hust.edu.cn)
URL: https://europepmc.org/article/ppr/ppr138914
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Beijing
Keywords: SARS-CoV-2, ACE2, convalescent plasma, neutralizing monoclonal antibodies
Summary of Study: Two neutralizing monoclonal antibodies (CA1 and CB6 MAbs) against SARS-CoV-2 were isolated and tested in vitro. CB6 showed stronger neutralizing activity and was further tested in rhesus macaques at both prophylactic and treatment settings. Treatment reduced virus titers and significant protection was seen in the prophylactic group.
References: doi: 10.1038/s41586-020-2381-y; PMID: 32454512
Contact Info: Shi R, et al.; correspondence to Fu-sheng Wang (fswang302@163.com)
URL: https://pubmed.ncbi.nlm.nih.gov/32454512/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, pathogenesis, primates
Summary of Study: African green monkeys support robust SARS-CoV-2 replication and develop pronounced respiratory disease, which may more accurately reflect human COVID-19 cases than other nonhuman primate species.
References: PMID: 33235385/doi: 10.1038/s41590-020-00835-8
Contact Info: Thomas Geisbert: twgeisbe@utmb.edu
URL: https://www.nature.com/articles/s41590-020-00835-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Solongevity Research, Milan, Italy
Keywords: SARS-CoV-1 and SARS-CoV-2, cross-reactive immunity, pathogenesis, primates
Summary of Study: Review Article discussing the potential of cross-reactive immunity to drive the immunopathogenesis of COVID-19 and its implications for current efforts to develop immune-based therapies and vaccines.
References: PMID: 33178193/doi: 10.3389/fimmu.2020.567710
Contact Info: Alberto Beretta: alterto.beretta@solongevity.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2020.567710/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: therapeutics
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, therapeutics, the lipoglycopeptide antibiotic, primates
Summary of Study: In both mouse and rhesus macaque models, viral replication and histopathological injuries caused by SARS-CoV-2 infection are significantly inhibited by the administration of the lipoglycopeptide antibiotic dalbavancin. These results suggest that dalbavancin is a promising anti-COVID-19 drug candidate.
References: PMID: 33262453/doi: 10.1038/s41422-020-00450-0
Contact Info: Ren Lai: rlai@mail.kiz.ac.cn; Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://www.nature.com/articles/s41422-020-00450-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: therapeutics
NPRC/Institute: Mabwell Bioscience, Shanghai, China
Keywords: SARS-CoV-2, therapeutics, neutralizing antibody, primates
Summary of Study: A single dose of monoclonal antibody MW05 (after introducing mutation to the Fc region) blocks infection of SARS-CoV-2 in prophylactic treatment and clears SARS-CoV-2 in three days in rhesus monkeys.
References: PMID: 33188207/doi: 10.1038/s41467-020-19568-1
Contact Info: Datao Liu: datao.liu@mabwell.com
URL: https://www.nature.com/articles/s41467-020-19568-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: University of California, San Francisco
Keywords: coronavirus, SARS-CoV-2, animal models
Summary of Study: The authors reviewed a variety of animal models, including NHPs. Individual NHP studies are represented elsewhere in this document.
References: doi: 10.1111/bph.15143; PMID: 32462701
Contact Info: Cleary SJ, et al.; correspondence to Clive Page (clive.page@kcl.ac.uk)
URL: https://pubmed.ncbi.nlm.nih.gov/32462701/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Peking Union Medical College, Yunnan, China
Keywords: SARS-CoV-2, Gastrointestinal Tract, primates
Summary of Study: Both intranasal and intragastric inoculation with SARS-CoV-2 caused pneumonia and GI dysfunction in the rhesus macaque model. Inflammatory cytokines are possible connections for the pathogenesis of SARS-CoV-2 between the respiratory and digestive systems.
References: PMID: 33307034/doi: 10.1053/j.gastro.2020.12.001
Contact Info: Xiaozhong Peng: pengxiaozhong@pumc.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S001650852035527X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, olive baboons, marmosets
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Southwest National Primate Research Center
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species
References: doi:10.1101/2020.06.05.136481
Contact Info: Dhiraj Kumar Singh et al; Deepak Kaushal, dkaushal@txbiomed.org
URL: https://www.biorxiv.org/content/10.1101/2020.06.05.136481v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Zongshan School of Medicine, Guangdong, China
Keywords: SARS-CoV-2, Nanoparticle Vaccines, mice and primates
Summary of Study: The nanoparticle vaccination of rhesus macaques induced neutralizing antibodies, and T and B cell responses prior to boost immunization; these responses persisted for more than three months. RBD- and HR-based nanoparticles thus present a promising vaccination approach against SARS-CoV-2 and other coronaviruses.
References: PMID: 33275896/doi: 10.1016/j.immuni.2020.11.015
Contact Info: Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S1074761320305021?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Guangdong, China
Keywords: SARS-CoV-2, nanoparticle vaccine, primates
Summary of Study: Nanoparticle vaccines (developed by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the SARS-CoV-2 spike protein) induced neutralizing antibodies, and T and B cell responses prior to boost immunization in rhesus macaques.
References: PMID: 33275896/doi: 10.1016/j.immuni.2020.11.015
Contact Info: Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S1074761320305021?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis, review
NPRC/Institute: National Institute of Biologicals, Noida, India
Keywords: SARS-CoV-2, many species, review
Summary of Study: This review article finds the rhesus macaque most closely resembles the SARS-CoV-2 infection observed in humans.
References: PMID: 33283030/doi: 10.1007/s13337-020-00637-4
Contact Info: Suresh Kumar: suresh.kumar@nib.gov.in
URL: https://link.springer.com/article/10.1007/s13337-020-00637-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Wistar Institute, Inovio Pharmaceuticals, Bioqual
Keywords: SARS-CoV-2, DNA vaccine, spike protein, primates
Summary of Study: Rhesus macaques were inoculated with an intradermal (ID)- delivered SARS-CoV-2 spike DNA vaccine, INO-4800, inducing a T cell response and neutralizing antibody response. T and B cell responses after challenge with SARS-CoV-2 results in lower viral loads.
References: doi:10.1101/2020.07.28.225649
Contact Info: Ami Patel; kate.brodrick@inovio.com
URL: https://www.biorxiv.org/content/10.1101/2020.07.28.225649v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: The University of Texas Medical Branch, Galveston, TX
Keywords: coronavirus, SARS-CoV-2, animal models
Summary of Study: African green monkeys were infected with a low passage isolate of SARS-CoV-2 (SARS-CoV-2/INMII-Isolate/2020/Italy, the first V clade virus to be experimentally inoculated into NHPs). AGMs mimic several aspects of human disease and should thus be considered to conduct pathogenesis studies and to screen potential vaccines and therapeutics.
References: doi: 10.1101/2020.05.17.100289; PMID: 32511377
Contact Info: Woolsey C, et al.; correspondence to Thomas W. Geisbert (twgeisbe@utmb.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/32511377/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Basic Medical Sciences, Beijing, China
Keywords: SARS-CoV-2, pathogenesis, aryl hydrocarbon receptor (AhR) signaling, mucus, primates
Summary of Study: Findings potentially explain the silent hypoxia formation in COVID-19 patients, and suggest a possible intervention strategy by targeting the aryl hydrocarbon receptor pathway.
References: PMID: 33159154/doi: 10.1038/s41422-020-00435-z
Contact Info: Bo Huang: tjhuangbo@hotmail.com
URL: https://www.nature.com/articles/s41422-020-00435-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Medical Biology, Yunnan Province, China
Keywords: SARS-CoV-2, pathogenesis, nasal route of infection. T cells, primates
Summary of Study: Rhesus macaques were infected with SARS-CoV-2 via the nasal route. Data suggested that T cell response and cytokine/chemokine changes in lungs should be considered as evaluation parameters for COVID-19 treatment and vaccine development (in addition to observation of virus shedding and pathological analysis).
References: PMID: 33180882/doi: 10.1371/journal.ppat.1008949
Contact Info: Zhanlong He: hzl@imbcams.com.cn & Qihan Li: liqihan@imbcams.com.cn
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008949
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Harvard, Massachusetts Institute of Technology, and more
Keywords: scRNA-seq, interferon, ISG, ACE2, SARS-CoV-2, COVID-19, influenza, non-human primate, human, mouse
Summary of Study: The authors analyzed human, macaque, and mouse scRNA-seq data sets across health and disease to uncover putative targets of SARS-CoV-2 among tissue-resident cell subsets. Data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.
References: doi: 10.1016/j.cell.2020.04.035; PMID: 32413319
Contact Info: Ziegler CGK, et al.; correspondence to Jose Ordovas-Montanes (jose.ordovas-montanes@childrens.harvard.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/32413319/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, cynomolgus macaques, rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: US Army Medical Research Institute of Infectious Diseases
Keywords: SARS-CoV-2, pre-screening strategies, primates
Summary of Study: Pre-exposure to SARS-CoV-2 affects biomarker responses in animal models, highlighting a need for robust pre-screening protocols prior to medical countermeasure studies.
References: doi:10.1101/2020.07.06.189803
Contact Info: Keersten M. Ricks;timothy.d.minogue.civ@mail.mil
URL: https://www.biorxiv.org/content/10.1101/2020.07.06.189803v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: National Infection Service, Public Health England (PHE)
Keywords: SARS-CoV-2, virus replication, lung histopathology, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques, resembling the mild clinical cases of COVID-19 in humans.
References: doi:10.1101/2020.09.17.301093
Contact Info: Francisco J. Salguero et al; Miles W. Carroll, miles.carroll@phe.gov.uk
URL: https://www.biorxiv.org/content/10.1101/2020.09.17.301093v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Jiaotong Univ. Health Science Center, Xi'an, Shaanxi, China
Keywords: SARS-CoV-2, phylogeny and expression pattern of ACE2; variety of animals, including primates
Summary of Study: Using bioinformatics tools to screen for the presence of angiotensin converting enzyme 2 (ACE2) in a variety of tissues in various animals, the authors found that the tissue presence of this enzyme marks the tissues vulnerable to SARS-CoV-2 infection. The pattern of infection in cynomolgus macaques was similar to that in humans.
References: PMID: 33364494/doi: 10.1016/j.heliyon.2020.e05725
Contact Info: Enqi Liu: liuenqi@xjtu.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S2405844020325688?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Oregon National Primate Research Center, Harvard, and others
Keywords: coronavirus, SARS-CoV-2, protective immunity
Summary of Study: Rhesus macaques were inoculated intranasally and intratracheally with SARS-CoV-2, which induced humoral and cellular immune responses and provided protective efficacy against SARS-CoV-2 rechallenge. These data raise the possibility that immunologic approaches to the prevention and treatment of SARS-CoV-2 may be effective.
References: doi: 10.1126/science.abc4776; PMID: 32434946
Contact Info: Chandrashekar A, et al.; correspondence to Dan H. Barouch (dbarouch@bidmc.harvard.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/32434946/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Oregon National Primate Research Center, Harvard, and others
Keywords: coronavirus, SARS-CoV-2, vaccine, nonhuman primate
Summary of Study: A series of DNA vaccine candidates expressing different forms of the SARS-CoV-2 Spike (S) protein were evaluated in rhesus macaques. Vaccine-elicited neutralizing antibody titers correlated with protective efficacy, demonstrating vaccine protection against SARS-CoV-2 in NHPs.
References: doi: 10.1126/science.abc6284; PMID: 32434945
Contact Info: Yu, et al.; correspondence to Dan H. Barouch (dbarouch@bidmc.harvard.edu
URL: https://pubmed.ncbi.nlm.nih.gov/32434945/
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Washington National Primate Research Center
Keywords: coronavirus, SARS-CoV-2, vaccine, RNA, replicon, nanoparticle, nonhuman primate
Summary of Study: Single-dose intramuscular vaccination with LION/repRNA-CoV2S elicited antibody responses that potently neutralized SARS-CoV-2 in pigtail macaques.
References: doi: 10.1101/2020.05.28.121640; Preprint
Contact Info: Erasmus JH, et al.; correspondence to Deborah Fuller (fullerdh@uw.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/32511417/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences and Comparative Medicine Center
Keywords: pathogenicity, pneumonia, rhesus macaque model, SARS-CoV-2
Summary of Study: SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection.
References: doi: 10.1002/ame2.12108
Contact Info: Yu P, et al.; correspondence to Chuan Qin (ginchaun@pumc.edu.cn) and Wenjie Tan (tanwj@ivdc.chinacdc.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/32318665/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, marmosets
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: coronavirus, SARS-CoV-2, nonhuman primate, viral shedding, viral genome
Summary of Study: Old world and new world monkeys were inoculated with SARS-CoV-2. Rhesus was most susceptible to infection, followed by cynomolgus and marmoset.
References: doi: 10.1101/2020.04.08.031807; Preprint
Contact Info: Lu S, et al.; correspondence to Xiaozhong Peng (pengxiaozhong@pumc.edu.cn)
URL: https://www.biorxiv.org/content/10.1101/2020.04.08.031807v1.abstract
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Capital Medical University, Beijing, China; Baruch S. Blumberg Institute
Keywords: SARS-CoV-2, animal ACE2, receptor, entry, furin cleavage, animal hosts
Summary of Study: Receptor activity of ACE2 was examined in 14 mammal species, including the rhesus macaque. Rhesus exhibited the highest ACE2 receptor activity.
References: doi: 10.1101/2020.04.19.048710; Preprint
Contact Info: Zhao X, et al.; correspondence to Xuesen Zhao (zhaoxuesen@ccmu.edu.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/32661139/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Department of Molecular Microbiology and Immunology, Saint Louis University
Keywords: SARS-CoV-2, focus forming assay, viral growth kinetics
Summary of Study: Characterization of cells susceptible to SARS-COV-2 and methods for detection of neutralizing antibody by focus forming assay
References: doi: 10.1101/2020.08.20.259838
Contact Info: E. Taylor Stone et al; Amelia K. Pinto, amelia.pinto@health.slu.edu
URL: https://www.biorxiv.org/content/10.1101/2020.08.20.259838v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: MOE Joint International Research Laboratory of Animal Health and Food Safety
Keywords: coronavirus, SARS-CoV-2, receptor sequence binding
Summary of Study: Similarities of receptor sequence binding to 2019-nCoV between humans and animals suggest a low species barrier for transmission of the virus to farm animals. Authors propose, based on the One Health model, that veterinarians and animal specialists should be involved in a cross-disciplinary collaboration in the fight against this epidemic.
References: doi: 10.1016/j.molmed.2020.02.008
Contact Info: Sun J, et al.; correspondence to Jiumeng Sun (shuosu@njau.edu.cn) and Michael Veit (michael.veit@fu-berlin.de)
URL: https://pubmed.ncbi.nlm.nih.gov/32359479/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, crab-eating macaques, marmosets
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Structural and Molecular Biology, University College London, London
Keywords: SARS-CoV-2, receptor binding, 215 vertebrate species
Summary of Study: SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals
References: doi:10.1101/2020.05.01.072371
Contact Info: CA Orengo: c.orengo@ucl.ac.uk
URL: https://www.biorxiv.org/content/10.1101/2020.05.01.072371v6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases
Keywords: coronavirus, SARS-CoV-2, nonhuman primate, neutralizing antibodies
Summary of Study: Rhesus macaques were inoculated intratracheally with SARS-CoV-2/WH-09/human/2020/CHN. Neutralizing antibodies against SARS CoV-2 might protect rhesus macaques which have undergone an initial infection from reinfection during early recovery days.
References: doi: 10.1101/2020.03.13.990226; Preprint
Contact Info: Bao L, et al.; correspondence to Chuan Qin (qinchuan@pumc.edu.cn)
URL: https://www.biorxiv.org/content/10.1101/2020.03.13.990226v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques, cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Virology Division, United States Army Medical Research Institute of Infectious Diseases
Keywords: SARS-CoV-2, airborne transmission, primates
Summary of Study: Development of a Coronavirus Disease 2019 Nonhuman Primate Model Using Airborne Exposure
References: doi:10.1101/2020.06.26.174128
Contact Info: sara.c.johnston2.civ@mail.mil, aysegul.nalca.civ@mail.mil
URL: https://www.biorxiv.org/content/10.1101/2020.06.26.174128v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medicine Science & Peking Union Medical College
Keywords: SARS-CoV-2, SARS-CoV-2 inactivated vaccine, immune response
Summary of Study: Immunization of rhesus macaques with a SARS-CoV-2 inactivated vaccine elicited effective immunity with indexes of humoral and cellular reactions.
References: doi: 10.1101/2020.08.04.235747
Contact Info: Hongbo Chen, et al; correspondence to Quhan Li, liqihan@imbcams.com.cn or Longding Liu, liuld@imgcams.com.cn
URL: https://www.biorxiv.org/content/10.1101/2020.08.04.235747v1
Coronavirus Investigated: SARS-CoV, SARS-CoV-2, MERS-CoV
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: National Institute of Diagnostics and Vaccine Development, School of Public Health, Xiamen University, China
Keywords: coronavirus, infectious disease, respiratory syndrome, animal model, vaccine, drug discovery
Summary of Study: The authors reviewed a variety of animal models, including NHPs. Individual NHP studies are represented elsewhere in this document.
References: doi: 10.1080/22221751.2020.1764871; PMID: 32378471
Contact Info: Yuan L, et al.; correspondence to Ningshao Xia (nsxia@xmu.edu.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/32378471/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
Keywords: coronavirus, SARS-CoV-2, ACE2
Summary of Study: Authors conducted sequence and structural analyses of angiotensin-converting enzyme 2 (ACE2) from different species, which sheds some light on cross-species receptor usage of 2019-nCoV.
References: doi: 10.1016/j.jinf.2020.02.013
Contact Info: Li R, et al.; correspondence to Gaiping Zhang (zhanggaip@126.com)
URL: https://pubmed.ncbi.nlm.nih.gov/32092392/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, pathogenicity, primates
Summary of Study: Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques
References: doi:10.1101/2020.08.18.256446
Contact Info: yasushii@belle.shiga-med.ac.jp
URL: https://www.biorxiv.org/content/10.1101/2020.08.18.256446v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, crab-eating macaques, marmosets
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, pathogenesis, three species of primates comparison
Summary of Study: Three species were inoculated (new world: intratracheally, intranasally, and on conjunctiva; old world: intranasally) and showed varying clinical and pathological signs of the disease. M. mulatta was the most suspectable followed by Callithrix jacchus and Macaca fascicularis.
References: doi:10.1101/2020.04.08.031807
Contact Info: Lu, Shuaiyao; pengxiaozhong@pumc.edu.cn; lhq@imbcams.com.cn; kecw1965@aliyun.com
URL: https://www.biorxiv.org/content/10.1101/2020.04.08.031807v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria
Keywords: SARS-CoV-2, vaccine, receptor binding domain, mice, primates
Summary of Study: Prime-boost protein subunit vaccines against SARS-CoV-2 are highly immunogenic in mice and macaques
References: doi: 10.1101/2020.09.01.278630
Contact Info: Hyon-Xhi Tan et al; Adam K Wheatley, awheatley@unimelb.edu.au
URL: https://www.biorxiv.org/content/10.1101/2020.09.01.278630v1
Coronavirus Investigated: SARS-CoV-2, SARS-CoV
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: NIAID
Keywords: beta coronaviruses, SARS-CoV-2, receptor sequence binding
Summary of Study: Authors show that host protease processing during viral entry is a significant barrier for several lineage B viruses and that bypassing this barrier allows several lineage B viruses to enter human cells through an unknown receptor. They also demonstrate how different lineage B viruses can recombine to gain entry into human cells, and confirm that human ACE2 is the receptor for the recently emerging SARS-CoV-2.
References: doi: 10.1038/s41564-020-0688-y
Contact Info: Letko M, et al.; correspondence to Michael Letko (michael.letko@wsu.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/32094589/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, animal models, viral load, nonhuman primate
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2 (isolate nCoV WA1-2020). Data established that the rhesus macaque recapitulates human disease with respect to virus replication and shedding, the presence of pulmonary infiltrates, histological lesions and seroconversion.
References: doi: 10.1038/s41586-020-2324-7; PMID: 32396922
Contact Info: Munster VJ, et al.; correspondence to Emmie de Wit (emmie.dewit@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/32396922/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, MERS-CoV, vaccine
Summary of Study: Rhesus macaques vaccinated intramuscularly with ChAdOx1 nCoV-19 showed humoral and cellular immune response. The authors observed a significantly reduced viral load in bronchoalveolar lavage fluid and respiratory tract tissues of vaccinated animals challenged with SARS-CoV-2 compared with control animals, and no pneumonia was observed in the vaccinated animals.
References: doi: 10.1101/2020.05.13.093195; Preprint; PMID: 32511340
Contact Info: van Doremalen N, et al.; correspondence to Vincent Munster (vincent.munster@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/32511340/
Coronavirus Investigated: SARS-CoV-2
NHP Species: crab-eating macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, serial computed tomography, positron emission tomography, FDG
Summary of Study: Crab-eating macaques were exposed to SARS-CoV-2 via direct bilateral primary intrabronchial instillation, which resulted in mild-moderate COVID-19 symptoms.
References: doi: 10.1101/2020.05.14.096727; PMID: 32511338
Contact Info: Finch CL, et al.; correspondence to Thomas Friedrich (tfriedrich@wisc.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/32511338/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, animal models
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2 (isolate nCoV-WA1-2020) via a combination of intratracheal, intranasal, ocular, and oral routes. Outcome established that the rhesus macaque recapitulates moderate disease observed in the majority of human cases.
References: doi: 10.1101/2020.03.21.001628; PMID: 32511299
Contact Info: Munster VJ, et al.; correspondence to Emmie de Wit (emmie.dewit@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/32511299/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: NIAID
Keywords: coronavirus, remdesivir, MERS-CoV, SARS-CoV-2, animal models, nonhuman primate
Summary of Study: The authors tested the efficacy of remdesivir treatment in a rhesus macaque model of SARS-CoV-2 infection.
References: doi: 10.1101/2020.04.15.043166
Contact Info: Williamson BN, et al.; correspondence to Emmie de Wit (emmie.dewit@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/32516797/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: TNPRC
Keywords: SARS-CoV-2, acute respiratory distress syndrome, pathology, primates
Summary of Study: Four, aged, AGMs were exposed by two routes to SARS-CoV-2 isolate USA-WA1/2020. The study reports fatal ARDS in two of the infected animals, demonstrating pathological lesions and disease similar to severe COVID-19 in humans. Three of the four infected AGMs showed cytokine storm, and all four animals showed increased levels of IL-6 in plasma. These results suggest the AGM is a useful model to study disease pathogenesis of SARS-CoV-2.
References: doi: 10.1101/2020.06.18.157933
Contact Info: Robert V. Blair, et al; correspondence to Jay Rappaport, jrappaport@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2020.06.18.157933v2
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: therapeutics
NPRC/Institute: NIAID
Keywords: MERS-CoV, animal model, antiviral, remdesivir, therapy.
Summary of Study: The efficacy of prophylactic and therapeutic remdesivir treatment was tested in a rhesus macaque model of MERS-CoV infection. Prophylactic remdesivir treatment completely prevented MERS-CoV-induced clinical disease; therapeutic remdesivir treatment also provided a clear clinical benefit. The data support testing the efficacy of remdesivir treatment in the context of a MERS clinical trial.
References: doi: 10.1073/pnas.1922083117; PMID: 32054787
Contact Info: de Wit E, et al.; Correspondence to Emmie de Wit (emmie.dewit@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/32054787/
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Washington NPRC
Keywords: SARS-CoV-2, two-component nanoparticle vaccine, mice and primates
Summary of Study: The study showed that two-component self-assembling SARS-CoV-2 RBC nanoparticle vaccine candidates elicit potent neutralizing Ab responses targeting multiple distinct RBT epitopes.
References: PMID: 33160446/doi: 10.1016/j.cell.2020.10.043
Contact Info: David Veesler: dveesler@uw.edu
URL: https://www.sciencedirect.com/science/article/pii/S0092867420314501?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, pathogenesis, immune response kinetics, blood and lungs, primates
Summary of Study: Investigation of immune events from the acute state up to four weeks post SARS-CoV-2 infection unravels cellular mechanisms of COVID-19 and suggests that NHPs may be appropriate models to test immune therapies.
References: PMID: 33247138/doi: 10.1038/s41467-020-19967-4
Contact Info: M. Vaccari: mvaccari@tulane.edu
URL: https://www.nature.com/articles/s41467-020-19967-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, pathogenesis, aged animals, primates
Summary of Study: Data indicate that both African green monkeys and Rhesus macaques are capable of modeling SARS-CoV-2 infection and suggest that aged African green monkeys may be useful for modeling severe disease manifestations, including Acute Respiratory Distress Syndrome (ARDS).
References: PMID: 33171111/doi: 10.1016/j.ajpath.2020.10.016
Contact Info: Robert Blair: rblair3@tulane.edu
URL: https://ajp.amjpathol.org/article/S0002-9440(20)30497-1/fulltext
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, from acute state up to four weeks post infection, primates
Summary of Study: This study uncovers critical steps in the immune events of the host response to SARS-CoV-2 and describes the correlates of viral replication and disease progression. The authors show viral driven inflammation/cell recruitment to the lung occurs rapidly, and lasts up to 4 weeks post-infection. Results suggest that NHP may be appropriate models to test immune therapies.
References: PMID: 33247138/doi: 10.1038/s41467-020-19967-4
Contact Info: M. Vaccari: mvaccari@tulane.edu
URL: https://www.nature.com/articles/s41467-020-19967-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Yerkes NPRC
Keywords: SARS-CoV-2, Baricitinib, immunologic and virologic efficacy, primates
Summary of Study: The authors investigated the immunologic and virologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection. Animals treated with baricitinib showed reduced inflammation, decreased lung infiltration of inflammatory cells, reduced NETosis activity, and more limited lung pathology. These data support a beneficial role for the use of baricitinib as a frontline treatment for inflammation induced by SARS-CoV-2 infection.
References: PMID: 33278358/doi: 10.1016/j.cell.2020.11.007
Contact Info: Steven Bosinger: steven.bosinger@emory.edu
URL: https://www.sciencedirect.com/science/article/pii/S0092867420314665?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: review
NPRC/Institute: University of Oxford
Keywords: coronavirus, COVID-19, MERS, SARS, vaccine
Summary of Study: The author reviewed the past and ongoing vaccine development efforts for clinically relevant coronavirus strains with the intention that this information helps in the development of effective and safe vaccines for COVID-19.
References: doi: 10.1007/s40121-020-00300-x
Contact Info: Padron-Regalado E; correspondence to Eriko Padron-Regalado (eriko.padronregalado@gmail.com)
URL: https://pubmed.ncbi.nlm.nih.gov/32328406/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: KU Leuven, Belgium
Keywords: SARS-CoV-2, live virus-vectored vaccine candidate, primates
Summary of Study: Vaccine candidate YF-SO (a live virus-vectored SARS-CoV-2 vaccine candidate using the yellow fever 17D(YF17D) vaccine as a vector to express a non-cleavable prefusion form of the SARS-CoV-2 Spike antigen) prevents infection with SARS-CoV-2 in a stringent hamster model as well as in non-human primates.
References: PMID: 33260195/doi: 10.1038/s41586-020-3035-9
Contact Info: Johan Neyts: johan.neyts@kuleuven.be
URL: https://www.nature.com/articles/s41586-020-3035-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis, therapeutics
NPRC/Institute: SWNPRC/Regeneron
Keywords: SARS-CoV-2, neutralizing antibody therapy, primates
Summary of Study: REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10922) can greatly reduce virus load in lower and upper airway and decrease virus induced pathological sequalae when administered prophylactically or therapeutically.
References: doi: 10.1101/2020.08.02.233320
Contact Info: Baum, A., et al; correspondence to C.A. Kyratsous, christos.kyratsous@regeneron.com
URL: https://www.biorxiv.org/content/10.1101/2020.08.02.233320v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: University of Minnesota
Keywords: 2019-nCoV, SARS coronavirus, ACE2, animal reservoir, cross-species transmission, human-to-human transmission
Summary of Study: The authors' decade-long structural studies on the receptor recognition by SARS-CoV have identified key interactions between SARS-CoV spike protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV.
References: doi: 10.1128/JVI.00127-20
Contact Info: Wan Y, et al.; correspondence to Fang Li (lifang@umn.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/31996437/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: BGi (China) and others
Keywords: single-cell transcriptomics, nonhuman primate, COVID-19, SARS-CoV-2, ACE2, TMPRSS2, kidney, interleukin 6, STAT transcription factors, immune cell exhaustion
Summary of Study: A single-cell transcriptome atlas of nine monkey tissues was used to study COVID-19. ACE2+TMPRSS2+ epithelial cells of lung, kidney and liver were shown to be targets for SARS-CoV-2. ACE2 correlation analysis identifies IDO2 and ANPEP as potential therapeutic opportunities.
References: doi: 10.1101/2020.04.10.022103; Preprint
Contact Info: Han L, et al.; correspondence to Xun Xu (xuxun@genomics.cn)
URL: https://www.biorxiv.org/content/10.1101/2020.04.10.022103v2.abstract
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Harvard Medical School
Keywords: SARS-CoV-2, pathogenesis, purified IgG, primates
Summary of Study: Adoptive transfer of purified IgG from convalescent macaques protects naive recipient rhesus macaques against SARS-CoV-2 challenge in a dose dependent fashion.
References: PMID: 33276369/doi: 10.1038/s41586-020-03041-6
Contact Info: Dan  Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.nature.com/articles/s41586-020-03041-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: University of Calgary
Keywords: coronavirus, SARS-CoV-2, ACE2, nonhuman primate
Summary of Study: Authors conducted a study to show that all NHPs exhibit the same set of twelve key amino acid residues as human ACE2, putting them at danger of infection from humans.
References: doi: 10.1101/2020.04.09.034967
Contact Info: Melin AD, et al.; correspondence to Amanda Melin (amanda.melin@ucalgary.ca)
URL: https://pubmed.ncbi.nlm.nih.gov/32511330/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Ministry of Health
Keywords: coronavirus, SARS-CoV-2, viral transmission, nonhuman primate
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2/WH-09/human/2020/CHN via conjunctival, intratracheal, and intragastric routes. Results suggest that conjunctiva is a potential portal for viral transmission; virus was also detected after IT inoculation. No virus was detected after IG inoculation.
References: doi: 10.1101/2020.03.13.990036; Preprint
Contact Info: Deng W, et al.; correspondence to Chuan Qin (qinchuan@pumc.edu.cn)
URL: https://www.biorxiv.org/content/10.1101/2020.03.13.990036v2.full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Wistar Institute, Inovio Pharmaceuticals, Bioqual
Keywords: SARS-CoV-2, DNA vaccine, spike protein, primates
Summary of Study: Rhesus macaques were inoculated with an intradermal (ID)- delivered SARS-CoV-2 spike DNA vaccine, INO-4800, inducing a T cell response and neutralizing antibody response. T and B cell responses after challenge with SARS-CoV-2 results in lower viral loads.
References: doi:10.1101/2020.07.28.225649
Contact Info: Ami Patel; kate.brodrick@inovio.com
URL: https://www.biorxiv.org/content/10.1101/2020.07.28.225649v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Peking Union Medical College, Yunnan, China
Keywords: SARS-CoV-2, Gastrointestinal Tract, primates
Summary of Study: Both intranasal and intragastric inoculation with SARS-CoV-2 caused pneumonia and GI dysfunction in the rhesus macaque model. Inflammatory cytokines are possible connections for the pathogenesis of SARS-CoV-2 between the respiratory and digestive systems.
References: PMID: 33307034/doi: 10.1053/j.gastro.2020.12.001
Contact Info: Xiaozhong Peng: pengxiaozhong@pumc.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S001650852035527X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Guangdong, China
Keywords: SARS-CoV-2, nanoparticle vaccine, primates
Summary of Study: Nanoparticle vaccines (developed by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the SARS-CoV-2 spike protein) induced neutralizing antibodies, and T and B cell responses prior to boost immunization in rhesus macaques.
References: PMID: 33275896/doi: 10.1016/j.immuni.2020.11.015
Contact Info: Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S1074761320305021?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Zongshan School of Medicine, Guangdong, China
Keywords: SARS-CoV-2, Nanoparticle Vaccines, mice and primates
Summary of Study: The nanoparticle vaccination of rhesus macaques induced neutralizing antibodies, and T and B cell responses prior to boost immunization; these responses persisted for more than three months. RBD- and HR-based nanoparticles thus present a promising vaccination approach against SARS-CoV-2 and other coronaviruses.
References: PMID: 33275896/doi: 10.1016/j.immuni.2020.11.015
Contact Info: Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S1074761320305021?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis, review
NPRC/Institute: National Institute of Biologicals, Noida, India
Keywords: SARS-CoV-2, many species, review
Summary of Study: This review article finds the rhesus macaque most closely resembles the SARS-CoV-2 infection observed in humans.
References: PMID: 33283030/doi: 10.1007/s13337-020-00637-4
Contact Info: Suresh Kumar: suresh.kumar@nib.gov.in
URL: https://link.springer.com/article/10.1007/s13337-020-00637-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Medical Biology, Yunnan Province, China
Keywords: SARS-CoV-2, pathogenesis, nasal route of infection. T cells, primates
Summary of Study: Rhesus macaques were infected with SARS-CoV-2 via the nasal route. Data suggested that T cell response and cytokine/chemokine changes in lungs should be considered as evaluation parameters for COVID-19 treatment and vaccine development (in addition to observation of virus shedding and pathological analysis).
References: PMID: 33180882/doi: 10.1371/journal.ppat.1008949
Contact Info: Zhanlong He: hzl@imbcams.com.cn & Qihan Li: liqihan@imbcams.com.cn
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008949
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Basic Medical Sciences, Beijing, China
Keywords: SARS-CoV-2, pathogenesis, aryl hydrocarbon receptor (AhR) signaling, mucus, primates
Summary of Study: Findings potentially explain the silent hypoxia formation in COVID-19 patients, and suggest a possible intervention strategy by targeting the aryl hydrocarbon receptor pathway.
References: PMID: 33159154/doi: 10.1038/s41422-020-00435-z
Contact Info: Bo Huang: tjhuangbo@hotmail.com
URL: https://www.nature.com/articles/s41422-020-00435-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: The University of Texas Medical Branch, Galveston, TX
Keywords: coronavirus, SARS-CoV-2, animal models
Summary of Study: African green monkeys were infected with a low passage isolate of SARS-CoV-2 (SARS-CoV-2/INMII-Isolate/2020/Italy, the first V clade virus to be experimentally inoculated into NHPs). AGMs mimic several aspects of human disease and should thus be considered to conduct pathogenesis studies and to screen potential vaccines and therapeutics.
References: doi: 10.1101/2020.05.17.100289; PMID: 32511377
Contact Info: Woolsey C, et al.; correspondence to Thomas W. Geisbert (twgeisbe@utmb.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/32511377/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: National Infection Service, Public Health England (PHE)
Keywords: SARS-CoV-2, virus replication, lung histopathology, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques, resembling the mild clinical cases of COVID-19 in humans.
References: doi:10.1101/2020.09.17.301093
Contact Info: Francisco J. Salguero et al; Miles W. Carroll, miles.carroll@phe.gov.uk
URL: https://www.biorxiv.org/content/10.1101/2020.09.17.301093v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Harvard, Massachusetts Institute of Technology, and more
Keywords: scRNA-seq, interferon, ISG, ACE2, SARS-CoV-2, COVID-19, influenza, non-human primate, human, mouse
Summary of Study: The authors analyzed human, macaque, and mouse scRNA-seq data sets across health and disease to uncover putative targets of SARS-CoV-2 among tissue-resident cell subsets. Data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.
References: doi: 10.1016/j.cell.2020.04.035; PMID: 32413319
Contact Info: Ziegler CGK, et al.; correspondence to Jose Ordovas-Montanes (jose.ordovas-montanes@childrens.harvard.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/32413319/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, cynomolgus macaques, rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: US Army Medical Research Institute of Infectious Diseases
Keywords: SARS-CoV-2, pre-screening strategies, primates
Summary of Study: Pre-exposure to SARS-CoV-2 affects biomarker responses in animal models, highlighting a need for robust pre-screening protocols prior to medical countermeasure studies.
References: doi:10.1101/2020.07.06.189803
Contact Info: Keersten M. Ricks;timothy.d.minogue.civ@mail.mil
URL: https://www.biorxiv.org/content/10.1101/2020.07.06.189803v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Jiaotong Univ. Health Science Center, Xi'an, Shaanxi, China
Keywords: SARS-CoV-2, phylogeny and expression pattern of ACE2; variety of animals, including primates
Summary of Study: Using bioinformatics tools to screen for the presence of angiotensin converting enzyme 2 (ACE2) in a variety of tissues in various animals, the authors found that the tissue presence of this enzyme marks the tissues vulnerable to SARS-CoV-2 infection. The pattern of infection in cynomolgus macaques was similar to that in humans.
References: PMID: 33364494/doi: 10.1016/j.heliyon.2020.e05725
Contact Info: Enqi Liu: liuenqi@xjtu.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S2405844020325688?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Oregon National Primate Research Center, Harvard, and others
Keywords: coronavirus, SARS-CoV-2, protective immunity
Summary of Study: Rhesus macaques were inoculated intranasally and intratracheally with SARS-CoV-2, which induced humoral and cellular immune responses and provided protective efficacy against SARS-CoV-2 rechallenge. These data raise the possibility that immunologic approaches to the prevention and treatment of SARS-CoV-2 may be effective.
References: doi: 10.1126/science.abc4776; PMID: 32434946
Contact Info: Chandrashekar A, et al.; correspondence to Dan H. Barouch (dbarouch@bidmc.harvard.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/32434946/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Oregon National Primate Research Center, Harvard, and others
Keywords: coronavirus, SARS-CoV-2, vaccine, nonhuman primate
Summary of Study: A series of DNA vaccine candidates expressing different forms of the SARS-CoV-2 Spike (S) protein were evaluated in rhesus macaques. Vaccine-elicited neutralizing antibody titers correlated with protective efficacy, demonstrating vaccine protection against SARS-CoV-2 in NHPs.
References: doi: 10.1126/science.abc6284; PMID: 32434945
Contact Info: Yu, et al.; correspondence to Dan H. Barouch (dbarouch@bidmc.harvard.edu
URL: https://pubmed.ncbi.nlm.nih.gov/32434945/
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Washington National Primate Research Center
Keywords: coronavirus, SARS-CoV-2, vaccine, RNA, replicon, nanoparticle, nonhuman primate
Summary of Study: Single-dose intramuscular vaccination with LION/repRNA-CoV2S elicited antibody responses that potently neutralized SARS-CoV-2 in pigtail macaques.
References: doi: 10.1101/2020.05.28.121640; Preprint
Contact Info: Erasmus JH, et al.; correspondence to Deborah Fuller (fullerdh@uw.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/32511417/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences and Comparative Medicine Center
Keywords: pathogenicity, pneumonia, rhesus macaque model, SARS-CoV-2
Summary of Study: SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection.
References: doi: 10.1002/ame2.12108
Contact Info: Yu P, et al.; correspondence to Chuan Qin (ginchaun@pumc.edu.cn) and Wenjie Tan (tanwj@ivdc.chinacdc.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/32318665/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques, marmosets
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: coronavirus, SARS-CoV-2, nonhuman primate, viral shedding, viral genome
Summary of Study: Old world and new world monkeys were inoculated with SARS-CoV-2. Rhesus was most susceptible to infection, followed by cynomolgus and marmoset.
References: doi: 10.1101/2020.04.08.031807; Preprint
Contact Info: Lu S, et al.; correspondence to Xiaozhong Peng (pengxiaozhong@pumc.edu.cn)
URL: https://www.biorxiv.org/content/10.1101/2020.04.08.031807v1.abstract
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Capital Medical University, Beijing, China; Baruch S. Blumberg Institute
Keywords: SARS-CoV-2, animal ACE2, receptor, entry, furin cleavage, animal hosts
Summary of Study: Receptor activity of ACE2 was examined in 14 mammal species, including the rhesus macaque. Rhesus exhibited the highest ACE2 receptor activity.
References: doi: 10.1101/2020.04.19.048710; Preprint
Contact Info: Zhao X, et al.; correspondence to Xuesen Zhao (zhaoxuesen@ccmu.edu.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/32661139/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: MOE Joint International Research Laboratory of Animal Health and Food Safety
Keywords: coronavirus, SARS-CoV-2, receptor sequence binding
Summary of Study: Similarities of receptor sequence binding to 2019-nCoV between humans and animals suggest a low species barrier for transmission of the virus to farm animals. Authors propose, based on the One Health model, that veterinarians and animal specialists should be involved in a cross-disciplinary collaboration in the fight against this epidemic.
References: doi: 10.1016/j.molmed.2020.02.008
Contact Info: Sun J, et al.; correspondence to Jiumeng Sun (shuosu@njau.edu.cn) and Michael Veit (michael.veit@fu-berlin.de)
URL: https://pubmed.ncbi.nlm.nih.gov/32359479/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Department of Molecular Microbiology and Immunology, Saint Louis University
Keywords: SARS-CoV-2, focus forming assay, viral growth kinetics
Summary of Study: Characterization of cells susceptible to SARS-COV-2 and methods for detection of neutralizing antibody by focus forming assay
References: doi: 10.1101/2020.08.20.259838
Contact Info: E. Taylor Stone et al; Amelia K. Pinto, amelia.pinto@health.slu.edu
URL: https://www.biorxiv.org/content/10.1101/2020.08.20.259838v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, crab-eating macaques, marmosets
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Institute of Structural and Molecular Biology, University College London, London
Keywords: SARS-CoV-2, receptor binding, 215 vertebrate species
Summary of Study: SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals
References: doi:10.1101/2020.05.01.072371
Contact Info: CA Orengo: c.orengo@ucl.ac.uk
URL: https://www.biorxiv.org/content/10.1101/2020.05.01.072371v6
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques, cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Virology Division, United States Army Medical Research Institute of Infectious Diseases
Keywords: SARS-CoV-2, airborne transmission, primates
Summary of Study: Development of a Coronavirus Disease 2019 Nonhuman Primate Model Using Airborne Exposure
References: doi:10.1101/2020.06.26.174128
Contact Info: sara.c.johnston2.civ@mail.mil, aysegul.nalca.civ@mail.mil
URL: https://www.biorxiv.org/content/10.1101/2020.06.26.174128v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases
Keywords: coronavirus, SARS-CoV-2, nonhuman primate, neutralizing antibodies
Summary of Study: Rhesus macaques were inoculated intratracheally with SARS-CoV-2/WH-09/human/2020/CHN. Neutralizing antibodies against SARS CoV-2 might protect rhesus macaques which have undergone an initial infection from reinfection during early recovery days.
References: doi: 10.1101/2020.03.13.990226; Preprint
Contact Info: Bao L, et al.; correspondence to Chuan Qin (qinchuan@pumc.edu.cn)
URL: https://www.biorxiv.org/content/10.1101/2020.03.13.990226v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medicine Science & Peking Union Medical College
Keywords: SARS-CoV-2, SARS-CoV-2 inactivated vaccine, immune response
Summary of Study: Immunization of rhesus macaques with a SARS-CoV-2 inactivated vaccine elicited effective immunity with indexes of humoral and cellular reactions.
References: doi: 10.1101/2020.08.04.235747
Contact Info: Hongbo Chen, et al; correspondence to Quhan Li, liqihan@imbcams.com.cn or Longding Liu, liuld@imgcams.com.cn
URL: https://www.biorxiv.org/content/10.1101/2020.08.04.235747v1
Coronavirus Investigated: SARS-CoV, SARS-CoV-2, MERS-CoV
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: National Institute of Diagnostics and Vaccine Development, School of Public Health, Xiamen University, China
Keywords: coronavirus, infectious disease, respiratory syndrome, animal model, vaccine, drug discovery
Summary of Study: The authors reviewed a variety of animal models, including NHPs. Individual NHP studies are represented elsewhere in this document.
References: doi: 10.1080/22221751.2020.1764871; PMID: 32378471
Contact Info: Yuan L, et al.; correspondence to Ningshao Xia (nsxia@xmu.edu.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/32378471/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, pathogenicity, primates
Summary of Study: Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques
References: doi:10.1101/2020.08.18.256446
Contact Info: yasushii@belle.shiga-med.ac.jp
URL: https://www.biorxiv.org/content/10.1101/2020.08.18.256446v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, crab-eating macaques, marmosets
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, pathogenesis, three species of primates comparison
Summary of Study: Three species were inoculated (new world: intratracheally, intranasally, and on conjunctiva; old world: intranasally) and showed varying clinical and pathological signs of the disease. M. mulatta was the most suspectable followed by Callithrix jacchus and Macaca fascicularis.
References: doi:10.1101/2020.04.08.031807
Contact Info: Lu, Shuaiyao; pengxiaozhong@pumc.edu.cn; lhq@imbcams.com.cn; kecw1965@aliyun.com
URL: https://www.biorxiv.org/content/10.1101/2020.04.08.031807v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria
Keywords: SARS-CoV-2, vaccine, receptor binding domain, mice, primates
Summary of Study: Prime-boost protein subunit vaccines against SARS-CoV-2 are highly immunogenic in mice and macaques
References: doi: 10.1101/2020.09.01.278630
Contact Info: Hyon-Xhi Tan et al; Adam K Wheatley, awheatley@unimelb.edu.au
URL: https://www.biorxiv.org/content/10.1101/2020.09.01.278630v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
Keywords: coronavirus, SARS-CoV-2, ACE2
Summary of Study: Authors conducted sequence and structural analyses of angiotensin-converting enzyme 2 (ACE2) from different species, which sheds some light on cross-species receptor usage of 2019-nCoV.
References: doi: 10.1016/j.jinf.2020.02.013
Contact Info: Li R, et al.; correspondence to Gaiping Zhang (zhanggaip@126.com)
URL: https://pubmed.ncbi.nlm.nih.gov/32092392/
Coronavirus Investigated: SARS-CoV-2, SARS-CoV
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: NIAID
Keywords: beta coronaviruses, SARS-CoV-2, receptor sequence binding
Summary of Study: Authors show that host protease processing during viral entry is a significant barrier for several lineage B viruses and that bypassing this barrier allows several lineage B viruses to enter human cells through an unknown receptor. They also demonstrate how different lineage B viruses can recombine to gain entry into human cells, and confirm that human ACE2 is the receptor for the recently emerging SARS-CoV-2.
References: doi: 10.1038/s41564-020-0688-y
Contact Info: Letko M, et al.; correspondence to Michael Letko (michael.letko@wsu.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/32094589/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: review
NPRC/Institute: University of Oxford
Keywords: coronavirus, COVID-19, MERS, SARS, vaccine
Summary of Study: The author reviewed the past and ongoing vaccine development efforts for clinically relevant coronavirus strains with the intention that this information helps in the development of effective and safe vaccines for COVID-19.
References: doi: 10.1007/s40121-020-00300-x
Contact Info: Padron-Regalado E; correspondence to Eriko Padron-Regalado (eriko.padronregalado@gmail.com)
URL: https://pubmed.ncbi.nlm.nih.gov/32328406/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Harvard Medical School
Keywords: SARS-CoV-2, pathogenesis, purified IgG, primates
Summary of Study: Adoptive transfer of purified IgG from convalescent macaques protects naive recipient rhesus macaques against SARS-CoV-2 challenge in a dose dependent fashion.
References: PMID: 33276369/doi: 10.1038/s41586-020-03041-6
Contact Info: Dan  Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.nature.com/articles/s41586-020-03041-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: University of Calgary
Keywords: coronavirus, SARS-CoV-2, ACE2, nonhuman primate
Summary of Study: Authors conducted a study to show that all NHPs exhibit the same set of twelve key amino acid residues as human ACE2, putting them at danger of infection from humans.
References: doi: 10.1101/2020.04.09.034967
Contact Info: Melin AD, et al.; correspondence to Amanda Melin (amanda.melin@ucalgary.ca)
URL: https://pubmed.ncbi.nlm.nih.gov/32511330/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: University of Minnesota
Keywords: 2019-nCoV, SARS coronavirus, ACE2, animal reservoir, cross-species transmission, human-to-human transmission
Summary of Study: The authors' decade-long structural studies on the receptor recognition by SARS-CoV have identified key interactions between SARS-CoV spike protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV.
References: doi: 10.1128/JVI.00127-20
Contact Info: Wan Y, et al.; correspondence to Fang Li (lifang@umn.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/31996437/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: BGi (China) and others
Keywords: single-cell transcriptomics, nonhuman primate, COVID-19, SARS-CoV-2, ACE2, TMPRSS2, kidney, interleukin 6, STAT transcription factors, immune cell exhaustion
Summary of Study: A single-cell transcriptome atlas of nine monkey tissues was used to study COVID-19. ACE2+TMPRSS2+ epithelial cells of lung, kidney and liver were shown to be targets for SARS-CoV-2. ACE2 correlation analysis identifies IDO2 and ANPEP as potential therapeutic opportunities.
References: doi: 10.1101/2020.04.10.022103; Preprint
Contact Info: Han L, et al.; correspondence to Xun Xu (xuxun@genomics.cn)
URL: https://www.biorxiv.org/content/10.1101/2020.04.10.022103v2.abstract
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Ministry of Health
Keywords: coronavirus, SARS-CoV-2, viral transmission, nonhuman primate
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2/WH-09/human/2020/CHN via conjunctival, intratracheal, and intragastric routes. Results suggest that conjunctiva is a potential portal for viral transmission; virus was also detected after IT inoculation. No virus was detected after IG inoculation.
References: doi: 10.1101/2020.03.13.990036; Preprint
Contact Info: Deng W, et al.; correspondence to Chuan Qin (qinchuan@pumc.edu.cn)
URL: https://www.biorxiv.org/content/10.1101/2020.03.13.990036v2.full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, olive baboons, marmosets
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Southwest National Primate Research Center
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species
References: doi:10.1101/2020.06.05.136481
Contact Info: Dhiraj Kumar Singh et al; Deepak Kaushal, dkaushal@txbiomed.org
URL: https://www.biorxiv.org/content/10.1101/2020.06.05.136481v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Sinovac Biotech, Beijing, China
Keywords: coronavirus, SARS-CoV-2, vaccine, nonhuman primate
Summary of Study: Rhesus macaques were immunized three times via the intramuscular route with medium or high doses of PiCoVacc three weeks before virus challenge. The high dose provided complete protection against SARS-CoV-2 challenge; neither infection enhancement of immunopathological exacerbation was observed.
References: doi: 10.1126/science.abc1932; PMID: 32376603
Contact Info: Gao Q, et al.; correspondence to Chuan Qin (qinchuan@pumc.edu.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/32376603/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet, Stockholm
Keywords: SARS-CoV-2, spike trimers, neutralizing antibodies, mice, primates
Summary of Study: Adjuvanted protein intramuscular immunization with SARS-CoV-2 spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaque.
References: doi:10.1101/2020.07.31.228486
Contact Info: Mandolesi, Marco; daniel.sheward@ki.se, gunilla.karlsson.hedestam@ki.se, benjamin.murrell@ki.se
URL: https://www.biorxiv.org/content/10.1101/2020.07.31.228486v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis, review
NPRC/Institute: South Valley Univ., Qena, Egypt
Keywords: SARS-CoV-2, many species, review
Summary of Study: This article reviews the possible animal reservoirs of SARS-CoV-2, as well as best suited models for further study.
References: PMID: 33363234/doi: 10.3389/fvets.2020.596391
Contact Info: Mohamed Mahdy: m_mahdi@vet.svu.edu.eg
URL: https://www.frontiersin.org/articles/10.3389/fvets.2020.596391/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, pathogenesis, primates
Summary of Study: African green monkeys support robust SARS-CoV-2 replication and develop pronounced respiratory disease, which may more accurately reflect human COVID-19 cases than other nonhuman primate species.
References: PMID: 33235385/doi: 10.1038/s41590-020-00835-8
Contact Info: Thomas Geisbert: twgeisbe@utmb.edu
URL: https://www.nature.com/articles/s41590-020-00835-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Solongevity Research, Milan, Italy
Keywords: SARS-CoV-1 and SARS-CoV-2, cross-reactive immunity, pathogenesis, primates
Summary of Study: Review Article discussing the potential of cross-reactive immunity to drive the immunopathogenesis of COVID-19 and its implications for current efforts to develop immune-based therapies and vaccines.
References: PMID: 33178193/doi: 10.3389/fimmu.2020.567710
Contact Info: Alberto Beretta: alterto.beretta@solongevity.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2020.567710/full
Coronavirus Investigated: SARS-CoV-2, MERS-CoV
NHP Species: cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: University of Erasmus, Netherlands
Keywords: coronavirus, MERS-CoV, SARS-CoV-2, animal models
Summary of Study: The authors' study shows that SARS-CoV-2 causes COVID-19-like disease in macaques and provides a new model to test preventive and therapeutic strategies.
References: doi: 10.1126/science.abb7314
Contact Info: Rockx B, et al.; correspondence to Barry Rockx (b.rockx@erasmusmc.nl)
URL: https://pubmed.ncbi.nlm.nih.gov/32303590/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: therapeutics
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, therapeutics, the lipoglycopeptide antibiotic, primates
Summary of Study: In both mouse and rhesus macaque models, viral replication and histopathological injuries caused by SARS-CoV-2 infection are significantly inhibited by the administration of the lipoglycopeptide antibiotic dalbavancin. These results suggest that dalbavancin is a promising anti-COVID-19 drug candidate.
References: PMID: 33262453/doi: 10.1038/s41422-020-00450-0
Contact Info: Ren Lai: rlai@mail.kiz.ac.cn; Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://www.nature.com/articles/s41422-020-00450-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: therapeutics
NPRC/Institute: Mabwell Bioscience, Shanghai, China
Keywords: SARS-CoV-2, therapeutics, neutralizing antibody, primates
Summary of Study: A single dose of monoclonal antibody MW05 (after introducing mutation to the Fc region) blocks infection of SARS-CoV-2 in prophylactic treatment and clears SARS-CoV-2 in three days in rhesus monkeys.
References: PMID: 33188207/doi: 10.1038/s41467-020-19568-1
Contact Info: Datao Liu: datao.liu@mabwell.com
URL: https://www.nature.com/articles/s41467-020-19568-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Tongji Medical College, Wuhan, China
Keywords: SARS, ACE2, receptor-binding domain, pneumonia
Summary of Study: The authors analyzed 82 representative ACE2 sequences from the 1000 sequences with the closest homology to the human ACE2 protein to identify potential SARS-CoV-2 natural and intermediate hosts, as well as susceptible animals. Results suggest that several NHPs may be intermediate hosts and most are susceptible to SARS-CoV-2.
References: doi: 10.26434/chemrxiv.12057996.v1; Preprint
Contact Info: Wu C, et al.; correspondence to Hui Li (li_hua@hust.edu.cn)
URL: https://europepmc.org/article/ppr/ppr138914
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Beijing
Keywords: SARS-CoV-2, ACE2, convalescent plasma, neutralizing monoclonal antibodies
Summary of Study: Two neutralizing monoclonal antibodies (CA1 and CB6 MAbs) against SARS-CoV-2 were isolated and tested in vitro. CB6 showed stronger neutralizing activity and was further tested in rhesus macaques at both prophylactic and treatment settings. Treatment reduced virus titers and significant protection was seen in the prophylactic group.
References: doi: 10.1038/s41586-020-2381-y; PMID: 32454512
Contact Info: Shi R, et al.; correspondence to Fu-sheng Wang (fswang302@163.com)
URL: https://pubmed.ncbi.nlm.nih.gov/32454512/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: University of California, San Francisco
Keywords: coronavirus, SARS-CoV-2, animal models
Summary of Study: The authors reviewed a variety of animal models, including NHPs. Individual NHP studies are represented elsewhere in this document.
References: doi: 10.1111/bph.15143; PMID: 32462701
Contact Info: Cleary SJ, et al.; correspondence to Clive Page (clive.page@kcl.ac.uk)
URL: https://pubmed.ncbi.nlm.nih.gov/32462701/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: therapeutics
NPRC/Institute: NIAID
Keywords: MERS-CoV, animal model, antiviral, remdesivir, therapy.
Summary of Study: The efficacy of prophylactic and therapeutic remdesivir treatment was tested in a rhesus macaque model of MERS-CoV infection. Prophylactic remdesivir treatment completely prevented MERS-CoV-induced clinical disease; therapeutic remdesivir treatment also provided a clear clinical benefit. The data support testing the efficacy of remdesivir treatment in the context of a MERS clinical trial.
References: doi: 10.1073/pnas.1922083117; PMID: 32054787
Contact Info: de Wit E, et al.; Correspondence to Emmie de Wit (emmie.dewit@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/32054787/
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Washington NPRC
Keywords: SARS-CoV-2, two-component nanoparticle vaccine, mice and primates
Summary of Study: The study showed that two-component self-assembling SARS-CoV-2 RBC nanoparticle vaccine candidates elicit potent neutralizing Ab responses targeting multiple distinct RBT epitopes.
References: PMID: 33160446/doi: 10.1016/j.cell.2020.10.043
Contact Info: David Veesler: dveesler@uw.edu
URL: https://www.sciencedirect.com/science/article/pii/S0092867420314501?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, animal models, viral load, nonhuman primate
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2 (isolate nCoV WA1-2020). Data established that the rhesus macaque recapitulates human disease with respect to virus replication and shedding, the presence of pulmonary infiltrates, histological lesions and seroconversion.
References: doi: 10.1038/s41586-020-2324-7; PMID: 32396922
Contact Info: Munster VJ, et al.; correspondence to Emmie de Wit (emmie.dewit@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/32396922/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, MERS-CoV, vaccine
Summary of Study: Rhesus macaques vaccinated intramuscularly with ChAdOx1 nCoV-19 showed humoral and cellular immune response. The authors observed a significantly reduced viral load in bronchoalveolar lavage fluid and respiratory tract tissues of vaccinated animals challenged with SARS-CoV-2 compared with control animals, and no pneumonia was observed in the vaccinated animals.
References: doi: 10.1101/2020.05.13.093195; Preprint; PMID: 32511340
Contact Info: van Doremalen N, et al.; correspondence to Vincent Munster (vincent.munster@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/32511340/
Coronavirus Investigated: SARS-CoV-2
NHP Species: crab-eating macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, serial computed tomography, positron emission tomography, FDG
Summary of Study: Crab-eating macaques were exposed to SARS-CoV-2 via direct bilateral primary intrabronchial instillation, which resulted in mild-moderate COVID-19 symptoms.
References: doi: 10.1101/2020.05.14.096727; PMID: 32511338
Contact Info: Finch CL, et al.; correspondence to Thomas Friedrich (tfriedrich@wisc.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/32511338/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, animal models
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2 (isolate nCoV-WA1-2020) via a combination of intratracheal, intranasal, ocular, and oral routes. Outcome established that the rhesus macaque recapitulates moderate disease observed in the majority of human cases.
References: doi: 10.1101/2020.03.21.001628; PMID: 32511299
Contact Info: Munster VJ, et al.; correspondence to Emmie de Wit (emmie.dewit@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/32511299/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: NIAID
Keywords: coronavirus, remdesivir, MERS-CoV, SARS-CoV-2, animal models, nonhuman primate
Summary of Study: The authors tested the efficacy of remdesivir treatment in a rhesus macaque model of SARS-CoV-2 infection.
References: doi: 10.1101/2020.04.15.043166
Contact Info: Williamson BN, et al.; correspondence to Emmie de Wit (emmie.dewit@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/32516797/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: TNPRC
Keywords: SARS-CoV-2, acute respiratory distress syndrome, pathology, primates
Summary of Study: Four, aged, AGMs were exposed by two routes to SARS-CoV-2 isolate USA-WA1/2020. The study reports fatal ARDS in two of the infected animals, demonstrating pathological lesions and disease similar to severe COVID-19 in humans. Three of the four infected AGMs showed cytokine storm, and all four animals showed increased levels of IL-6 in plasma. These results suggest the AGM is a useful model to study disease pathogenesis of SARS-CoV-2.
References: doi: 10.1101/2020.06.18.157933
Contact Info: Robert V. Blair, et al; correspondence to Jay Rappaport, jrappaport@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2020.06.18.157933v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, pathogenesis, immune response kinetics, blood and lungs, primates
Summary of Study: Investigation of immune events from the acute state up to four weeks post SARS-CoV-2 infection unravels cellular mechanisms of COVID-19 and suggests that NHPs may be appropriate models to test immune therapies.
References: PMID: 33247138/doi: 10.1038/s41467-020-19967-4
Contact Info: M. Vaccari: mvaccari@tulane.edu
URL: https://www.nature.com/articles/s41467-020-19967-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, pathogenesis, aged animals, primates
Summary of Study: Data indicate that both African green monkeys and Rhesus macaques are capable of modeling SARS-CoV-2 infection and suggest that aged African green monkeys may be useful for modeling severe disease manifestations, including Acute Respiratory Distress Syndrome (ARDS).
References: PMID: 33171111/doi: 10.1016/j.ajpath.2020.10.016
Contact Info: Robert Blair: rblair3@tulane.edu
URL: https://ajp.amjpathol.org/article/S0002-9440(20)30497-1/fulltext
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, from acute state up to four weeks post infection, primates
Summary of Study: This study uncovers critical steps in the immune events of the host response to SARS-CoV-2 and describes the correlates of viral replication and disease progression. The authors show viral driven inflammation/cell recruitment to the lung occurs rapidly, and lasts up to 4 weeks post-infection. Results suggest that NHP may be appropriate models to test immune therapies.
References: PMID: 33247138/doi: 10.1038/s41467-020-19967-4
Contact Info: M. Vaccari: mvaccari@tulane.edu
URL: https://www.nature.com/articles/s41467-020-19967-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis
NPRC/Institute: Yerkes NPRC
Keywords: SARS-CoV-2, Baricitinib, immunologic and virologic efficacy, primates
Summary of Study: The authors investigated the immunologic and virologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection. Animals treated with baricitinib showed reduced inflammation, decreased lung infiltration of inflammatory cells, reduced NETosis activity, and more limited lung pathology. These data support a beneficial role for the use of baricitinib as a frontline treatment for inflammation induced by SARS-CoV-2 infection.
References: PMID: 33278358/doi: 10.1016/j.cell.2020.11.007
Contact Info: Steven Bosinger: steven.bosinger@emory.edu
URL: https://www.sciencedirect.com/science/article/pii/S0092867420314665?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: KU Leuven, Belgium
Keywords: SARS-CoV-2, live virus-vectored vaccine candidate, primates
Summary of Study: Vaccine candidate YF-SO (a live virus-vectored SARS-CoV-2 vaccine candidate using the yellow fever 17D(YF17D) vaccine as a vector to express a non-cleavable prefusion form of the SARS-CoV-2 Spike antigen) prevents infection with SARS-CoV-2 in a stringent hamster model as well as in non-human primates.
References: PMID: 33260195/doi: 10.1038/s41586-020-3035-9
Contact Info: Johan Neyts: johan.neyts@kuleuven.be
URL: https://www.nature.com/articles/s41586-020-3035-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: pathogenesis, therapeutics
NPRC/Institute: SWNPRC/Regeneron
Keywords: SARS-CoV-2, neutralizing antibody therapy, primates
Summary of Study: REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10922) can greatly reduce virus load in lower and upper airway and decrease virus induced pathological sequalae when administered prophylactically or therapeutically.
References: doi: 10.1101/2020.08.02.233320
Contact Info: Baum, A., et al; correspondence to C.A. Kyratsous, christos.kyratsous@regeneron.com
URL: https://www.biorxiv.org/content/10.1101/2020.08.02.233320v1
Coronavirus Investigated: SARS-CoV-2, MERS-CoV
NHP Species: multiple species
Year Published: 2019
Study Type/Review: review
NPRC/Institute: Division of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases
Keywords: ARDS, coronavirus, interferon, SARS-CoV, therapeutic, zoonosis
Summary of Study: Many of the treatments used in SARS or MERS patients in outbreak situations were not based on clear in vitro and in vivo model evidence of efficacy, and meta-analyses of treatments failed to show effective therapeutic regimens. Development of a drug discovery pipeline consisting of in vitro and in vivo models of coronavirus infection is needed to identify antivirals targeting essential mechanisms of infection.
References: doi: 10.1080/17460441.2019.1581171
Contact Info: Totura AL, et al.; correspondence to Sina Bavari (sina.bavari.civ@mail.mil)
URL: https://pubmed.ncbi.nlm.nih.gov/30849247/
Coronavirus Investigated: SARS-CoV-2, MERS-CoV
NHP Species: multiple species
Year Published: 2019
Study Type/Review: review
NPRC/Institute: Division of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases
Keywords: ARDS, coronavirus, interferon, SARS-CoV, therapeutic, zoonosis
Summary of Study: Many of the treatments used in SARS or MERS patients in outbreak situations were not based on clear in vitro and in vivo model evidence of efficacy, and meta-analyses of treatments failed to show effective therapeutic regimens. Development of a drug discovery pipeline consisting of in vitro and in vivo models of coronavirus infection is needed to identify antivirals targeting essential mechanisms of infection.
References: doi: 10.1080/17460441.2019.1581171
Contact Info: Totura AL, et al.; correspondence to Sina Bavari (sina.bavari.civ@mail.mil)
URL: https://pubmed.ncbi.nlm.nih.gov/30849247/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2018
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Veterinary Biotechnology, PR China
Keywords: MERS-CoV, neutralizing antibodies, coronavirus, receptor sequence binding
Summary of Study: A recombinant VSV-vectored MERS-CoV vaccine neutralized antibodies and T cell responses in rhesus monkeys after a single intramuscular or intranasal immunization dose.
References: doi: 10.1016/j.antiviral.2017.12.007; PMID: 29246504; PMCID: PMC7113862
Contact Info: Liu R, et al.; correspondence to Zhigao Bu (buzhigao@caas.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/29246504/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2018
Study Type/Review: pathogenesis
NPRC/Institute: NIAID, University of North Carolina, Chapel Hill
Keywords: coronavirus, MERS-CoV, animal models, nonhuman primate
Summary of Study: To achieve high viral loads of MERS-CoV as seen in humans, a spike-modified MERS clone was tested in rhesus macaques. Respiratory disease was mild and transient.
References: doi: 10.1038/s41598-018-28900-1; PMID: 30013082
Contact Info: Cockrell AS, et al.; correspondence to Adam Cockrell (adam_cockrell@unc.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/30013082/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2018
Study Type/Review: pathogenesis
NPRC/Institute: NIAID, Rocky Mountain Laboratories
Keywords: MERS-CoV, immunosuppression, pathology, shedding, macaque
Summary of Study: Immuno-compromised rhesus macaques were evaluated to determine if their immunosuppression resulted in higher MERS-CoV replication and shedding.
References: doi: 10.3389/fimmu.2018.00205; PMID: 29483914
Contact Info: Prescott J, et al.; correspondence to Vincent Munster (vincent.munster@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/29483914/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2018
Study Type/Review: vaccine
NPRC/Institute: Wuhan University, China
Keywords: coronavirus, SARS-CoV, vaccine, animal models, nonhuman primate
Summary of Study: Rhesus macaques were given an inactivated SARS-CoV vaccine to evaluate whether it would cause disease enhancement. Vaccination resulted in low antibodies and did not induce disease enhancement.
References: doi: 10.1007/s12250-018-0009-2; PMID: 29541941; PMCID: PMC6178114
Contact Info: Luo F, et al.; correspondence to Wei Hou (houwei@whu.edu.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/29541941/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2018
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Veterinary Biotechnology, PR China
Keywords: MERS-CoV, neutralizing antibodies, coronavirus, receptor sequence binding
Summary of Study: A recombinant VSV-vectored MERS-CoV vaccine neutralized antibodies and T cell responses in rhesus monkeys after a single intramuscular or intranasal immunization dose.
References: doi: 10.1016/j.antiviral.2017.12.007; PMID: 29246504; PMCID: PMC7113862
Contact Info: Liu R, et al.; correspondence to Zhigao Bu (buzhigao@caas.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/29246504/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2018
Study Type/Review: pathogenesis
NPRC/Institute: NIAID, University of North Carolina, Chapel Hill
Keywords: coronavirus, MERS-CoV, animal models, nonhuman primate
Summary of Study: To achieve high viral loads of MERS-CoV as seen in humans, a spike-modified MERS clone was tested in rhesus macaques. Respiratory disease was mild and transient.
References: doi: 10.1038/s41598-018-28900-1; PMID: 30013082
Contact Info: Cockrell AS, et al.; correspondence to Adam Cockrell (adam_cockrell@unc.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/30013082/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2018
Study Type/Review: pathogenesis
NPRC/Institute: NIAID, Rocky Mountain Laboratories
Keywords: MERS-CoV, immunosuppression, pathology, shedding, macaque
Summary of Study: Immuno-compromised rhesus macaques were evaluated to determine if their immunosuppression resulted in higher MERS-CoV replication and shedding.
References: doi: 10.3389/fimmu.2018.00205; PMID: 29483914
Contact Info: Prescott J, et al.; correspondence to Vincent Munster (vincent.munster@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/29483914/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2018
Study Type/Review: vaccine
NPRC/Institute: Wuhan University, China
Keywords: coronavirus, SARS-CoV, vaccine, animal models, nonhuman primate
Summary of Study: Rhesus macaques were given an inactivated SARS-CoV vaccine to evaluate whether it would cause disease enhancement. Vaccination resulted in low antibodies and did not induce disease enhancement.
References: doi: 10.1007/s12250-018-0009-2; PMID: 29541941; PMCID: PMC6178114
Contact Info: Luo F, et al.; correspondence to Wei Hou (houwei@whu.edu.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/29541941/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2017
Study Type/Review: pathogenesis
NPRC/Institute: University of Pennsylvania
Keywords: MERS, CoV, origin, pathogenesis
Summary of Study: Rhesus macaques infected with MERS-CoV experience self-limiting transient lower respiratory tract infection involving mild to moderate pneumonia, not mimicking severe human disease associated with MERS-CoV. Infection in marmosets causes severe, often lethal disease and recapitulates human disease.
References: doi: 10.12688/f1000research.11827.1; PMID: 29026532; PMCID: PMC5583735
Contact Info: Goldstein SA and Weiss SR; correspondence to Susan R. Weiss (weisssr@mail.med.upenn.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/29026532/
Coronavirus Investigated: MERS-CoV
NHP Species: multiple species
Year Published: 2017
Study Type/Review: pathogenesis
NPRC/Institute: Johns Hopkins Aramco Healthcare, Saudi Arabia
Keywords: MERS-CoV, Saudi Arabia, evolution, spike protein, transmission, vaccine
Summary of Study: Mentions NHP studies of promising vaccine candidates that target spike protein.
References: doi: 10.1007/s11684-017-0521-z; PMID: 28500431; PMCID: PMC7089120
Contact Info: Rabaan AA, et al.; correspondence to Ali A. Rabaan (ali.rabaan@jhah.com)
URL: https://pubmed.ncbi.nlm.nih.gov/28500431/
Coronavirus Investigated: MERS-CoV
NHP Species: baboons
Year Published: 2017
Study Type/Review: pathogenesis
NPRC/Institute: King Saud University, Riyadh, Saudi Arabia
Keywords: Papio hamadryas hamadryas, Commensal, Kingdom of Saudi Arabia, coronaviruses, infections
Summary of Study: Fifty baboons were screened for antibodies to different types of coronaviruses to determine if they could transmit to humans. The animals were positive for human and canine coronaviruses but not for MERS.
References: doi: 10.1017/S0950268817000905; PMID: 28478775; PMCID: PMC7113016
Contact Info: Olarinmoye AO, et al.; correspondence to K. Al-Hezaimi (kalhezaime@ksu.edu.sa)
URL: https://pubmed.ncbi.nlm.nih.gov/28478775/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2017
Study Type/Review: review
NPRC/Institute: Campus de la Universitat Autònoma de Barcelona, Spain
Keywords: Animal model, biosafety level, coronavirus, dipeptidyl peptidase-4, emerging pathogen, human dipeptidyl peptidase-4
Summary of Study: Reviewed different species that could be used as an animal model for MERS. Rhesus macaques had mild, transient disease, while common marmosets experienced severe disease.
References: doi: 10.1016/j.onehlt.2017.03.001; PMID: 28616501; PMCID: PMC5454147
Contact Info: Vergara-Alert J, et al.; correspondence to Joaquim Segalés (joaquim.segales@cresa.uab.cat)
URL: https://pubmed.ncbi.nlm.nih.gov/28616501/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2017
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College
Keywords: MERS-CoV, DDP4, pneumonia, entry receptor
Summary of Study: Description of the histopathological, immunohistochemical, and ultrastructural findings from rhesus macaque and common marmoset animal models of MERS-CoV infection.
References: doi: 10.1371/journal.pone.0172093; PMID: 28234937; PMCID: PMC5325479
Contact Info: Yu P, et al.; correspondence to Chuan Qin (ginchaun@pumc.edu.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/28234937/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2017
Study Type/Review: vaccine
NPRC/Institute: College of Wildlife Resources, Northeast Forestry University, Harbin, China
Keywords: MERS-CoV, immune response, nonhuman primate, vaccine, virus-like particles
Summary of Study: MERS-CoV virus-like particles have excellent immunogenicity in rhesus macaques and represent a promising vaccine candidate.
References: doi: 10.18632/oncotarget.8475; PMID: 27050368; PMCID: PMC5355045
Contact Info: Wang C, et al.; correspondence to Xianzhu Xia (xiaxzh@cae.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/27050368/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2017
Study Type/Review: pathogenesis
NPRC/Institute: University of Pennsylvania
Keywords: MERS, CoV, origin, pathogenesis
Summary of Study: Rhesus macaques infected with MERS-CoV experience self-limiting transient lower respiratory tract infection involving mild to moderate pneumonia, not mimicking severe human disease associated with MERS-CoV. Infection in marmosets causes severe, often lethal disease and recapitulates human disease.
References: doi: 10.12688/f1000research.11827.1; PMID: 29026532; PMCID: PMC5583735
Contact Info: Goldstein SA and Weiss SR; correspondence to Susan R. Weiss (weisssr@mail.med.upenn.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/29026532/
Coronavirus Investigated: MERS-CoV
NHP Species: multiple species
Year Published: 2017
Study Type/Review: pathogenesis
NPRC/Institute: Johns Hopkins Aramco Healthcare, Saudi Arabia
Keywords: MERS-CoV, Saudi Arabia, evolution, spike protein, transmission, vaccine
Summary of Study: Mentions NHP studies of promising vaccine candidates that target spike protein.
References: doi: 10.1007/s11684-017-0521-z; PMID: 28500431; PMCID: PMC7089120
Contact Info: Rabaan AA, et al.; correspondence to Ali A. Rabaan (ali.rabaan@jhah.com)
URL: https://pubmed.ncbi.nlm.nih.gov/28500431/
Coronavirus Investigated: MERS-CoV
NHP Species: baboons
Year Published: 2017
Study Type/Review: pathogenesis
NPRC/Institute: King Saud University, Riyadh, Saudi Arabia
Keywords: Papio hamadryas hamadryas, Commensal, Kingdom of Saudi Arabia, coronaviruses, infections
Summary of Study: Fifty baboons were screened for antibodies to different types of coronaviruses to determine if they could transmit to humans. The animals were positive for human and canine coronaviruses but not for MERS.
References: doi: 10.1017/S0950268817000905; PMID: 28478775; PMCID: PMC7113016
Contact Info: Olarinmoye AO, et al.; correspondence to K. Al-Hezaimi (kalhezaime@ksu.edu.sa)
URL: https://pubmed.ncbi.nlm.nih.gov/28478775/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2017
Study Type/Review: review
NPRC/Institute: Campus de la Universitat Autònoma de Barcelona, Spain
Keywords: Animal model, biosafety level, coronavirus, dipeptidyl peptidase-4, emerging pathogen, human dipeptidyl peptidase-4
Summary of Study: Reviewed different species that could be used as an animal model for MERS. Rhesus macaques had mild, transient disease, while common marmosets experienced severe disease.
References: doi: 10.1016/j.onehlt.2017.03.001; PMID: 28616501; PMCID: PMC5454147
Contact Info: Vergara-Alert J, et al.; correspondence to Joaquim Segalés (joaquim.segales@cresa.uab.cat)
URL: https://pubmed.ncbi.nlm.nih.gov/28616501/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2017
Study Type/Review: vaccine
NPRC/Institute: College of Wildlife Resources, Northeast Forestry University, Harbin, China
Keywords: MERS-CoV, immune response, nonhuman primate, vaccine, virus-like particles
Summary of Study: MERS-CoV virus-like particles have excellent immunogenicity in rhesus macaques and represent a promising vaccine candidate.
References: doi: 10.18632/oncotarget.8475; PMID: 27050368; PMCID: PMC5355045
Contact Info: Wang C, et al.; correspondence to Xianzhu Xia (xiaxzh@cae.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/27050368/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2017
Study Type/Review: pathogenesis
NPRC/Institute: Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College
Keywords: MERS-CoV, DDP4, pneumonia, entry receptor
Summary of Study: Description of the histopathological, immunohistochemical, and ultrastructural findings from rhesus macaque and common marmoset animal models of MERS-CoV infection.
References: doi: 10.1371/journal.pone.0172093; PMID: 28234937; PMCID: PMC5325479
Contact Info: Yu P, et al.; correspondence to Chuan Qin (ginchaun@pumc.edu.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/28234937/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2016
Study Type/Review: vaccine
NPRC/Institute: Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia
Keywords: MERS-CoV, Saudi Arabia, animal models, coronavirus, prevention, therapeutic antibodies, vaccine, viruses, zoonosis
Summary of Study: A combination of both rodents and nonhuman primate models should be considered in evaluating and developing preventive and therapeutic candidates under standardized conditions. Rhesus macaques are shown to exhibit mild disease; common marmosets exhibit severe disease.
References: doi: 10.3201/eid2208.160229; PMID: 27439020; PMCID: PMC4982192
Contact Info: Excler JL, et al.; correspondence Jean Louis Excler (jeanlouis.excler@ivi.int)
URL: https://pubmed.ncbi.nlm.nih.gov/27439020/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2016
Study Type/Review: vaccine
NPRC/Institute: AIDS Institute and Research Center for Infection and Immunology, Department of Microbiology, Li Ka Shing Faculty of Medicine
Keywords: viral infection, innate immunity, mucosal immunology, respiratory tract diseases
Summary of Study: This study provides a comprehensive overview of the spatiotemporal interactions of SARS-CoV, monocytes/macrophages, and the DC network in mucosal tissues and highlights the fact that, while these innate cells contribute to viral clearance, they probably also serve as shelters and vehicles to provide a mechanism for the virus to escape host mucosal innate immunity and disseminate systemically.
References: doi: 10.1038/mi.2015.127; PMID: 26647718
Contact Info: Liu L, et al.; correspondence to L. Liu (liuli71@hku.hk)
URL: https://pubmed.ncbi.nlm.nih.gov/26647718/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2016
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College
Keywords: B-cell peptide epitope, SARS-CoV, antibody-dependent enhancement, epitope sequence-dependent enhancement, peptide, vaccine
Summary of Study: Demonstrated that a SARS-CoV inactivated vaccine could induce antibody-dependent enhancement and lung pathology in rhesus macaques.
References: doi: 10.1021/acsinfecdis.6b00006; PMID: 27627203; PMCID: PMC7075522
Contact Info: Wang Q, et al.; correspondence to Nobuo Sakaguchi (nobusaka@ifrec.osaka-u.ac.jp)
URL: https://pubmed.ncbi.nlm.nih.gov/27627203/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2016
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emerging Viral Pathogens Section
Keywords: animal model, MERS, antibody therapy, human monoclonal antibody therapy, MERS-CoV, respiratory syndrome
Summary of Study: In this report, we describe the clinical and radiographic changes of rhesus monkeys following infection with 5×10(6) PFU MERS-CoV Jordan-n3/2012.
References: doi: 10.1016/j.virol.2016.01.004; PMID: 26828465
Contact Info: Johnson RF, et al.; correspondence to Reed F. Johnson (johnsonreed@mail.nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26828465/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2016
Study Type/Review: review
NPRC/Institute: CDC, Office of Preparedness and Response, NIH
Keywords: MERS-CoV, animal models, antibodies, antivirals, diagnostics, medical countermeasures, monoclonal, nonhuman primate, polyclonal, respiratory infections, therapeutics, vaccines, viruses
Summary of Study: A review of medical countermeasures for MERS and need to prioritize animal model development.
References: doi: 10.3201/eid2207.160022; PMID: 27191188; PMCID: PMC4918159
Contact Info: Uyeki TM, et al.; correspondence to Timothy M. Uyeki (tuyeki@cdc.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/27191188/
Coronavirus Investigated: MERS-CoV
NHP Species: marmosets
Year Published: 2016
Study Type/Review: pathogenesis
NPRC/Institute: The University of Hong Kong, China
Keywords: MERS-CoV, ARDS, Smad7, FGF2
Summary of Study: Common marmosets infected by MERS-CoV developed ARDS and disseminated infection in kidneys and other organs.
References: doi: 10.1038/nmicrobiol.2016.4; PMID: 27572168; PMCID: PMC7097571
Contact Info: Yeung ML, et al.; correspondence to Chuan Qin (qinchuan@pumc.edu.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/27572168/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2016
Study Type/Review: review
NPRC/Institute: NIAID
Keywords: MERS-CoV, animal models, common marmosets, dipeptidyl peptidase 4, mice, pathogenicity, rabbits, respiratory system, review, rhesus macaques, transgenic
Summary of Study: This review provides an overview of the current state of knowledge on human MERS-CoV infections, the probable origin of MERS-CoV, and the available animal models of MERS-CoV infection.
References: doi: 10.1177/0300985815620845; PMID: 26869154
Contact Info: Baseler L, et al.; correspondence to H. Feldmann (feldmannh@niaid.nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26869154/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2016
Study Type/Review: pathogenesis
NPRC/Institute: ASIP
Keywords: MERS-CoV, pneumonia, DDP4
Summary of Study: The rhesus macaque and common marmoset models of MERS-CoV span the wide range of disease severity reported in MERS-CoV-infected humans, which will aid in investigating MERS-CoV disease pathogenesis.
References: doi: 10.1016/j.ajpath.2015.10.025; PMID: 26724387
Contact Info: Baseler LJ, et al.; correspondence to Emmie de Witt (emmie.dewit@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26724387/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2016
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College
Keywords: B-cell peptide epitope, SARS-CoV, antibody-dependent enhancement, epitope sequence-dependent enhancement, peptide, vaccine
Summary of Study: Demonstrated that a SARS-CoV inactivated vaccine could induce antibody-dependent enhancement and lung pathology in rhesus macaques.
References: doi: 10.1021/acsinfecdis.6b00006; PMID: 27627203; PMCID: PMC7075522
Contact Info: Wang Q, et al.; correspondence to Nobuo Sakaguchi (nobusaka@ifrec.osaka-u.ac.jp)
URL: https://pubmed.ncbi.nlm.nih.gov/27627203/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2016
Study Type/Review: review
NPRC/Institute: CDC, Office of Preparedness and Response, NIH
Keywords: MERS-CoV, animal models, antibodies, antivirals, diagnostics, medical countermeasures, monoclonal, nonhuman primate, polyclonal, respiratory infections, therapeutics, vaccines, viruses
Summary of Study: A review of medical countermeasures for MERS and need to prioritize animal model development.
References: doi: 10.3201/eid2207.160022; PMID: 27191188; PMCID: PMC4918159
Contact Info: Uyeki TM, et al.; correspondence to Timothy M. Uyeki (tuyeki@cdc.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/27191188/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2016
Study Type/Review: vaccine
NPRC/Institute: AIDS Institute and Research Center for Infection and Immunology, Department of Microbiology, Li Ka Shing Faculty of Medicine
Keywords: viral infection, innate immunity, mucosal immunology, respiratory tract diseases
Summary of Study: This study provides a comprehensive overview of the spatiotemporal interactions of SARS-CoV, monocytes/macrophages, and the DC network in mucosal tissues and highlights the fact that, while these innate cells contribute to viral clearance, they probably also serve as shelters and vehicles to provide a mechanism for the virus to escape host mucosal innate immunity and disseminate systemically.
References: doi: 10.1038/mi.2015.127; PMID: 26647718
Contact Info: Liu L, et al.; correspondence to L. Liu (liuli71@hku.hk)
URL: https://pubmed.ncbi.nlm.nih.gov/26647718/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2016
Study Type/Review: vaccine
NPRC/Institute: Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia
Keywords: MERS-CoV, Saudi Arabia, animal models, coronavirus, prevention, therapeutic antibodies, vaccine, viruses, zoonosis
Summary of Study: A combination of both rodents and nonhuman primate models should be considered in evaluating and developing preventive and therapeutic candidates under standardized conditions. Rhesus macaques are shown to exhibit mild disease; common marmosets exhibit severe disease.
References: doi: 10.3201/eid2208.160229; PMID: 27439020; PMCID: PMC4982192
Contact Info: Excler JL, et al.; correspondence Jean Louis Excler (jeanlouis.excler@ivi.int)
URL: https://pubmed.ncbi.nlm.nih.gov/27439020/
Coronavirus Investigated: MERS-CoV
NHP Species: marmosets
Year Published: 2016
Study Type/Review: pathogenesis
NPRC/Institute: The University of Hong Kong, China
Keywords: MERS-CoV, ARDS, Smad7, FGF2
Summary of Study: Common marmosets infected by MERS-CoV developed ARDS and disseminated infection in kidneys and other organs.
References: doi: 10.1038/nmicrobiol.2016.4; PMID: 27572168; PMCID: PMC7097571
Contact Info: Yeung ML, et al.; correspondence to Chuan Qin (qinchuan@pumc.edu.cn)
URL: https://pubmed.ncbi.nlm.nih.gov/27572168/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2016
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emerging Viral Pathogens Section
Keywords: animal model, MERS, antibody therapy, human monoclonal antibody therapy, MERS-CoV, respiratory syndrome
Summary of Study: In this report, we describe the clinical and radiographic changes of rhesus monkeys following infection with 5×10(6) PFU MERS-CoV Jordan-n3/2012.
References: doi: 10.1016/j.virol.2016.01.004; PMID: 26828465
Contact Info: Johnson RF, et al.; correspondence to Reed F. Johnson (johnsonreed@mail.nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26828465/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2016
Study Type/Review: review
NPRC/Institute: NIAID
Keywords: MERS-CoV, animal models, common marmosets, dipeptidyl peptidase 4, mice, pathogenicity, rabbits, respiratory system, review, rhesus macaques, transgenic
Summary of Study: This review provides an overview of the current state of knowledge on human MERS-CoV infections, the probable origin of MERS-CoV, and the available animal models of MERS-CoV infection.
References: doi: 10.1177/0300985815620845; PMID: 26869154
Contact Info: Baseler L, et al.; correspondence to H. Feldmann (feldmannh@niaid.nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26869154/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2016
Study Type/Review: pathogenesis
NPRC/Institute: ASIP
Keywords: MERS-CoV, pneumonia, DDP4
Summary of Study: The rhesus macaque and common marmoset models of MERS-CoV span the wide range of disease severity reported in MERS-CoV-infected humans, which will aid in investigating MERS-CoV disease pathogenesis.
References: doi: 10.1016/j.ajpath.2015.10.025; PMID: 26724387
Contact Info: Baseler LJ, et al.; correspondence to Emmie de Witt (emmie.dewit@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26724387/
Coronavirus Investigated: SARS-CoV, MERS-CoV
NHP Species: multiple species
Year Published: 2015
Study Type/Review: review
NPRC/Institute: NIAID
Keywords: animal models, coronaviruses, MERS-CoV, receptor, SARS-CoV
Summary of Study: The authors reviewed a variety of animal models, including NHPs. Individual NHP studies are represented elsewhere in this document.
References: doi: 10.1016/j.virol.2015.02.030; PMID: 25791336
Contact Info: Sutton TC and Subbaro K; correspondence to Kanta Subbarao (ksubbarao@niaid.nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/25791336/
Coronavirus Investigated: SARS-CoV, MERS-CoV
NHP Species: multiple species
Year Published: 2015
Study Type/Review: review
NPRC/Institute: NIAID
Keywords: SARS-CoV, MERS-CoV, animal model
Summary of Study: The authors reviewed a variety of animal models, including NHPs. Individual NHP studies are represented elsewhere in this document.
References: doi: 10.1016/j.coviro.2015.06.009; PMID: 26184451
Contact Info: Gretebeck LM and Subbaro K; correspondence to Kanta Subbarao (ksubbarao@niaid.nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26184451/
Coronavirus Investigated: MERS-CoV
NHP Species: marmosets
Year Published: 2015
Study Type/Review: vaccine
NPRC/Institute: HKU Med, ILAS
Keywords: Kaletra, MERS, animal, common marmoset, coronavirus, interferon, lopinavir, mycophenolate, primate, treatment
Summary of Study: This study assessed three repurposed drugs with potent in vitro anti-MERS-CoV activity (mycophenolate mofetil [MMF], lopinavir/ritonavir, and interferon-β1b) in common marmosets with severe disease resembling MERS in humans.
References: doi: 10.1093/infdis/jiv392; PMID: 26198719
Contact Info: Chan JF, et al.; correspondence to Kwok-Yung Yuen (kyyuen@hku.hk)
URL: https://pubmed.ncbi.nlm.nih.gov/26198719/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2015
Study Type/Review: pathogenesis
NPRC/Institute: NIAID, Emerging Viral Pathogens Section
Keywords: animal model, coronavirus, MERS, MERS-CoV, MERS, nonhuman primate
Summary of Study: This data suggest that common marmosets developed a mild to moderate non-lethal respiratory disease, which was quantifiable by computed tomography (CT), with limited other clinical signs.
References: doi: 10.1016/j.virol.2015.07.013; PMID: 26342468
Contact Info: Johnson RF, et al.; correspondence to Reef F. Johnson (johnsonreed@mail.nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26342468/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review: vaccine
NPRC/Institute: NIAID, Vaccine Research Center
Keywords: antibodies, vaccines, viral infection, virology
Summary of Study: This study developed DNA expression vectors and soluble protein immunogens that elicited cross-reactive neutralizing antibodies against known, circulating strains of MERS-CoV.
References: doi: 10.1038/ncomms8712; PMID: 26218507
Contact Info: Wang L, et al.; correspondence to Wing-Pui Kong (vog.hin.diain@gnokw)
URL: https://pubmed.ncbi.nlm.nih.gov/26218507/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review: pathogenesis
NPRC/Institute: NIAID, Laboratory of Virology
Keywords: animal models, coronavirus, emerging viruses, MERS-CoV, public health
Summary of Study: This article forms part of a symposium in Antiviral Research on “From SARS to MERS: research on highly pathogenic human coronaviruses.”
References: doi: 10.1016/j.antiviral.2015.07.005; PMID: 26192750
Contact Info: Van Doremalen N and Munster VJ; correspondence to Vincent Munster (munster@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26192750/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques, cynomolgus macaques, baboons
Year Published: 2015
Study Type/Review: pathogenesis
NPRC/Institute: City University of New York
Keywords: oligoadenylate synthetase 1, SARS-CoV, primates, convergent polymorphism
Summary of Study: This case investigated the evolution of OAS1 in primates by characterizing intra-specific variation in four species commonly used as models in infectious disease research: the rhesus macaque, the cynomolgus macaque, the olive baboon, and the Guinea baboon.
References: doi: 10.1007/s00251-015-0855-0; PMID: 26156123
Contact Info: Fish I and Boissinot S; correspondence to Stéphane Boissinot (sb5272@nyu.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/26156123/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review: vaccine
NPRC/Institute: NIAID, Department of Pathology and Laboratory Medicine
Keywords: MERS-CoV, SARS-CoV, vaccine
Summary of Study: These studies demonstrate that a consensus MERS spike protein synthetic DNA vaccine can induce protective responses against viral challenge, indicating that this strategy may have value as a possible vaccine modality against this emerging pathogen.
References: doi: 10.1126/scitranslmed.aac7462; PMID: 26290414
Contact Info: Muthumani K, et al.; correspondence to David B. Weiner (dbweiner@mail.med.upenn.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/26290414/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review: pathogenesis
NPRC/Institute: NIAID, Integrated Research Facility, Division of Clinical Research
Keywords: [18F]-FDG-PET, MERS-CoV, animal models, kinetic modeling
Summary of Study: This study extends the use of kinetic modeling of [18F]-FDG uptake during lung inflammation to host immune response after MERS-CoV exposure in rhesus macaques. Compared with SUVs, K i computation increases signal-to-noise ratio of PET data that results in improved accuracy of measurement and method sensitivity.
References: doi: 10.1186/s13550-015-0143-x; PMID: 26573211
Contact Info: Chefer S, et al.; correspondence to S. Chefer (schefer@mail.nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26573211/
Coronavirus Investigated: MERS-CoV
NHP Species: marmosets
Year Published: 2015
Study Type/Review: vaccine
NPRC/Institute: HKU Med, ILAS
Keywords: Kaletra, MERS, animal, common marmoset, coronavirus, interferon, lopinavir, mycophenolate, primate, treatment
Summary of Study: This study assessed three repurposed drugs with potent in vitro anti-MERS-CoV activity (mycophenolate mofetil [MMF], lopinavir/ritonavir, and interferon-β1b) in common marmosets with severe disease resembling MERS in humans.
References: doi: 10.1093/infdis/jiv392; PMID: 26198719
Contact Info: Chan JF, et al.; correspondence to Kwok-Yung Yuen (kyyuen@hku.hk)
URL: https://pubmed.ncbi.nlm.nih.gov/26198719/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques, cynomolgus macaques, baboons
Year Published: 2015
Study Type/Review: pathogenesis
NPRC/Institute: City University of New York
Keywords: oligoadenylate synthetase 1, SARS-CoV, primates, convergent polymorphism
Summary of Study: This case investigated the evolution of OAS1 in primates by characterizing intra-specific variation in four species commonly used as models in infectious disease research: the rhesus macaque, the cynomolgus macaque, the olive baboon, and the Guinea baboon.
References: doi: 10.1007/s00251-015-0855-0; PMID: 26156123
Contact Info: Fish I and Boissinot S; correspondence to Stéphane Boissinot (sb5272@nyu.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/26156123/
Coronavirus Investigated: SARS-CoV, MERS-CoV
NHP Species: multiple species
Year Published: 2015
Study Type/Review: review
NPRC/Institute: NIAID
Keywords: animal models, coronaviruses, MERS-CoV, receptor, SARS-CoV
Summary of Study: The authors reviewed a variety of animal models, including NHPs. Individual NHP studies are represented elsewhere in this document.
References: doi: 10.1016/j.virol.2015.02.030; PMID: 25791336
Contact Info: Sutton TC and Subbaro K; correspondence to Kanta Subbarao (ksubbarao@niaid.nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/25791336/
Coronavirus Investigated: SARS-CoV, MERS-CoV
NHP Species: multiple species
Year Published: 2015
Study Type/Review: review
NPRC/Institute: NIAID
Keywords: SARS-CoV, MERS-CoV, animal model
Summary of Study: The authors reviewed a variety of animal models, including NHPs. Individual NHP studies are represented elsewhere in this document.
References: doi: 10.1016/j.coviro.2015.06.009; PMID: 26184451
Contact Info: Gretebeck LM and Subbaro K; correspondence to Kanta Subbarao (ksubbarao@niaid.nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26184451/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review: vaccine
NPRC/Institute: NIAID, Vaccine Research Center
Keywords: antibodies, vaccines, viral infection, virology
Summary of Study: This study developed DNA expression vectors and soluble protein immunogens that elicited cross-reactive neutralizing antibodies against known, circulating strains of MERS-CoV.
References: doi: 10.1038/ncomms8712; PMID: 26218507
Contact Info: Wang L, et al.; correspondence to Wing-Pui Kong (vog.hin.diain@gnokw)
URL: https://pubmed.ncbi.nlm.nih.gov/26218507/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review: pathogenesis
NPRC/Institute: NIAID, Laboratory of Virology
Keywords: animal models, coronavirus, emerging viruses, MERS-CoV, public health
Summary of Study: This article forms part of a symposium in Antiviral Research on “From SARS to MERS: research on highly pathogenic human coronaviruses.”
References: doi: 10.1016/j.antiviral.2015.07.005; PMID: 26192750
Contact Info: Van Doremalen N and Munster VJ; correspondence to Vincent Munster (munster@nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26192750/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2015
Study Type/Review: pathogenesis
NPRC/Institute: NIAID, Emerging Viral Pathogens Section
Keywords: animal model, coronavirus, MERS, MERS-CoV, MERS, nonhuman primate
Summary of Study: This data suggest that common marmosets developed a mild to moderate non-lethal respiratory disease, which was quantifiable by computed tomography (CT), with limited other clinical signs.
References: doi: 10.1016/j.virol.2015.07.013; PMID: 26342468
Contact Info: Johnson RF, et al.; correspondence to Reef F. Johnson (johnsonreed@mail.nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26342468/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review: pathogenesis
NPRC/Institute: NIAID, Integrated Research Facility, Division of Clinical Research
Keywords: [18F]-FDG-PET, MERS-CoV, animal models, kinetic modeling
Summary of Study: This study extends the use of kinetic modeling of [18F]-FDG uptake during lung inflammation to host immune response after MERS-CoV exposure in rhesus macaques. Compared with SUVs, K i computation increases signal-to-noise ratio of PET data that results in improved accuracy of measurement and method sensitivity.
References: doi: 10.1186/s13550-015-0143-x; PMID: 26573211
Contact Info: Chefer S, et al.; correspondence to S. Chefer (schefer@mail.nih.gov)
URL: https://pubmed.ncbi.nlm.nih.gov/26573211/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review: vaccine
NPRC/Institute: NIAID, Department of Pathology and Laboratory Medicine
Keywords: MERS-CoV, SARS-CoV, vaccine
Summary of Study: These studies demonstrate that a consensus MERS spike protein synthetic DNA vaccine can induce protective responses against viral challenge, indicating that this strategy may have value as a possible vaccine modality against this emerging pathogen.
References: doi: 10.1126/scitranslmed.aac7462; PMID: 26290414
Contact Info: Muthumani K, et al.; correspondence to David B. Weiner (dbweiner@mail.med.upenn.edu)
URL: https://pubmed.ncbi.nlm.nih.gov/26290414/
Coronavirus Investigated: SARS-CoV
NHP Species: cynomolgus macaques, african green monkeys
Year Published: 2014
Study Type/Review: review
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
Keywords: SARS coronavirus, animal model, influenza, respiratory disease
Summary of Study: In this review, SARS-CoV infection is described in nonhuman primates (cynomolgus macaques and African green monkeys [AGMs]) and carnivores (ferrets and cats). This review focuses on the pathology and pathogenesis of SARS-CoV and influenza A virus infections, not only comparing the two viruses, but also comparing the pathology of these virus infections in experimental animals to that in man.
References: doi: 10.1016/j.jcpa.2014.01.004; PMID: 24581932; PMCID: PMC7094469
Contact Info: van den Br