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A Resource for Developmental Regulatory Genomics

Grant Number: R24OD023046

Research ObjectivesFlowchart superimposed over a dividing cell. Top of chart is Maternal Inputs, bottom is Effector Gene Sets 1 and 2

This award supports the creation and dissemination of research tools that will enable biologists to elucidate the genomic control of embryogenesis through the experimental dissection of developmental gene regulatory networks in sea urchins and other echinoderms.

Services Provided

(1) Production of recombineered bacterial artificial chromosomes (BACs) that encode fluorescent reporter proteins under the cis-regulatory control of endogenous echinoderm genes. (2) Digital analysis of gene expression by means of NanoString technology. (3) Resources for the genome-wide identification of cis-regulatory modules (CRMs). (4) Photoactivatable morpholino antisense oligo nucleotides for conditional (spatially and temporally regulated) gene knockdowns.

Contact Information

Resource for Developmental Regulatory Genomics
Dr. Charles Ettensohn
Department of Biological Sciences
Carnegie Mellon University
4400 Fifth Avenue
Pittsburgh, PA 15213

Co-Principal Investigators

Dr. Charles Ettensohn
Phone: 412-268-5849
Fax: 412-268-7129

Dr. Veronica Hinman
Phone: 412-268-9348
Fax: 412-268-7129