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Nonhuman Primate Antibody Resource for Immune Cell Depletion

Grant Number: P40OD028116

NHPRR LogoResearch Emphasis/Objectives

The objective of the NIH Nonhuman Primate Reagent Resource is to facilitate the use of nonhuman primate (NHP) models of disease by providing primate-specific antibody reagents for targeting cell subsets, cell receptors, soluble mediators, and immunoglobulins of the most common primate species used in research. This is accomplished by developing new reagents specific for NHP proteins or immunoglobulins and by optimizing existing reagents intended for in vitro diagnostics or for in vivo use in the NHP species.

Current Research

Current research explores methods for generating and engineering recombinant antibodies against NHP targets and expressing these antibodies at large scale. The NIH Nonhuman Primate Reagent Resource also studies the comparative structure and function of immunoglobulins between various primate species.

Services Provided

The resource provides antibodies for in vivo administration and for in vitro diagnostics in NHPs. A database of commercial reagents that cross-react with 12 different NHP species is maintained on the website. The resource also provides NHP recombinant proteins, immunoglobulin reference reagents, and cell lines.

Contact Information

University of Massachusetts Medical School
460 Walk Hill Street
Boston, MA 02126

Principal Investigator

Diogo Magnani, Ph.D.
Phone: 762-233-7747