Selected Grantee Publications

Preclinical Safety and Biodistribution of CRISPR Targeting SIV in Non-Human Primates

Burdo et al., Gene Therapy. 2024.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11090835/

Nonhuman primates have served as a valuable resource for evaluating novel eradication and cure strategies for HIV infection. Using a male rhesus macaque model, researchers demonstrated the safety and utility of CRISPR gene-editing technology for targeting integrated simian immunodeficiency virus (SIV). Their work suggests that a single intravenous inoculation for HIV gene editing can be utilized to reach viral reservoirs throughout the body. Additionally, no off-target effects or abnormal pathology were observed. Together, these findings support the continued development of HIV eradicative cure strategies using CRISPR technology in humans. Supported by ORIP (P40OD012217, U42OD021458).