Selected Grantee Publications

Using Mass Spectrometry Imaging to Map Fluxes Quantitatively in the Tumor Ecosystem

Schwaiger-Haber et al., Nature Communications. 2023.

https://pubmed.ncbi.nlm.nih.gov/37208361/

Mass spectrometry imaging (MSI) can be used to identify metabolic patterns within different microenvironments of tumors but has not been fully integrated into metabolomics workflows. Investigators developed an integrated approach by combining MSI, stable isotope labeling, and a spatial variant of Isotopologue Spectral Analysis to study metabolic pathways across the brains of mice harboring GL261 glioma, a mouse model for glioblastoma. This study reveals the importance of multiple anabolic pathways, including fatty acid elongation flux, in glioma. Supported by ORIP (R24OD024624).