Selected Grantee Publications

Giardia Hinders Growth by Disrupting Nutrient Metabolism Independent of Inflammatory Enteropathy

Giallourou et al., Nature Communications. 2023.

https://www.nature.com/articles/s41467-023-38363-2

Giardia lamblia is one of the most common intestinal pathogens among children in low- and middle-income countries. Investigators performed translational investigations using the Malnutrition and Enteric Diseases (MAL-ED) male and female cohort, as well as mice of both sexes, to identify mechanistic pathways that might explain Giardia-induced effects on early childhood growth. They identified signatures in the urinary metabolome of young children, suggesting that host growth restriction during infection is mediated by dysregulated amino acid metabolism. Supported by ORIP (P40OD010995), NIAID, and NIDDK.