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Identification of a Heterogeneous and Dynamic Ciliome during Embryonic Development and Cell Differentiation

Elliott et al., Development. 2023.

https://journals.biologists.com/dev/article/150/8/dev201237/307317/Identification-of-a-heterogeneous-and-dynamic

Ciliopathies are a class of diseases that arise when the structure or function of the cilium is compromised. To definitively determine the extent of heterogeneity within the ciliome, investigators compared the ciliomes of six distinct embryonic domains. The data comprehensively revealed that about 30% of the ciliome is differentially expressed across analyzed tissues in the developing embryo. Furthermore, upregulation of numerous ciliary genes correlated with osteogenic cell-fate decisions, suggesting that changes in the ciliome contribute to distinct functions of cell types in vertebrate species. Supported by ORIP (UM1OD023222), NIDCR, and NIGMS.