Selected Grantee Publications

Spatiotemporal Image Reconstruction to Enable High-Frame-Rate Dynamic Photoacoustic Tomography With Rotating-Gantry Volumetric Imagers

Cam et al., Journal of Biomedical Optics . 2024.

https://pubmed.ncbi.nlm.nih.gov/38249994

Dynamic photoacoustic computed tomography (PACT) is a valuable imaging technique for monitoring physiological processes. However, the current imaging techniques are often limited to two-dimensional spatial imaging. While PACT imagers capable of taking three-dimensional spatial images are commercially available, these systems have substantial limitations. Typically, the data are acquired sequentially rather than simultaneously at all views. The objects being imaged are dynamic and can vary during this process; as such, image reconstruction is inherently difficult, and the result is often incomplete. Cam et al. propose an image reconstruction method that can address these challenges and enable volumetric dynamic PACT imaging using existing preclinical imagers, which has the potential to significantly advance preclinical research and facilitate the monitoring of critical physiological biomarkers. Supported by ORIP (R44OD023029) and NIBIB.