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Orthotopic Transplantation of the Full-Length Porcine Intestine After Normothermic Machine Perfusion

Abraham et al., Transplantation Direct. 2022.

https://www.doi.org/10.1097/TXD.0000000000001390

Successful intestinal transplantation currently is hindered by graft injury that occurs during procurement and storage, which contributes to postoperative sepsis and allograft rejection. Improved graft preservation could expand transplantable graft numbers and enhance post-transplant outcomes. Superior transplant outcomes recently have been demonstrated in clinical trials using machine perfusion to preserve the liver. The investigators report the development and optimization of machine perfusion preservation of small intestine and successful transplantation of intestinal allografts in a porcine model. Supported by ORIP (K01OD019911), NIAID, and NIDDK.