Selected Grantee Publications
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- Aquatic Vertebrate Models
- R21
Validity of Xiphophorus Fish as Models for Human Disease
Schartl and Lu, Disease Models and Mechanisms. 2024.
https://pubmed.ncbi.nlm.nih.gov/38299666/
Xiphophorus is the one of the oldest animal systems for studying melanoma. In this article, the authors summarize current Xiphophorus models for other human diseases. They review how Xiphophorus fishes and their interspecies hybrids can be used for studying human diseases and highlight research opportunities enabled by these unique models (both established and emerging). They identified several emerging Xiphophorus models, including for albinism, micromelanophore pigmentation, fin regeneration, and diet-induced obesity. The research on cancer and reproductive maturation discussed in this review substantiates the value of Xiphophorus as a model for human disease throughout all three phases of validation—face, construct, and predictive—and continues to provide important scientific insights. Supported by ORIP (R24OD031467, R21OD031910) and NCI.
Conduction-Dominated Cryomesh for Organism Vitrification
Guo et al., Advanced Science. 2024.
https://pubmed.ncbi.nlm.nih.gov/38018294/
Vitrification-based cryopreservation via cryomesh is a promising approach for maintaining biodiversity, health care, and sustainable food production via long-term preservation of biological systems. Here, researchers conducted a series of experiments aimed at optimizing the cooling and rewarming rates of cryomesh to increase the viability of various cryopreserved biosystems. They found that vitrification was significantly improved by increasing thermal conductivity, reducing mesh wire diameter and pore size, and minimizing the nitrogen vapor barrier of the conduction-dominated cryomesh. Cooling rates increased twofold to tenfold in a variety of biosystems. The conduction-dominated cryomesh improved the cryopreservation outcomes of coral larvae, Drosophila embryos, and zebrafish embryos by vitrification. These findings suggest that the conduction-dominated cryomesh can improve vitrification in such biosystems for biorepositories, agriculture and aquaculture, and research. Supported by ORIP (R24OD028444, R21OD028758, R24OD034063, R21OD028214), NIDDK, and NIGMS.